Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pediatric Urology Fellow, Surgery/Urology, Johns Hopkins University School of Medicine 2006 - 2008
  • Urology Resident, Surgery/Urology, University of Arizona College of Medicine 2002 - 2006
  • General Surgery Resident, Surgery, University of Arizona College of Medicine 2000 - 2002
  • M.D., University of Illinois College of Medicine 2000
  • Ph.D., University of Illinois -- Urbana-Champaign 1998
  • A.B., Cornell University 1991
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Surgery, Surgery, Urology, Surgery 2015
• Research
• 

  Selected Grants

  • Duke KURe Program awarded by National Institutes of Health 2013 - 2023
  • BOTOX in the Treatment of Urinary Incontinence Due to Neurognic Detrusor Overactivity in Patients 5 to 17 Years of Age awarded by Allergan, Inc. 2017 - 2022
  • LT Botox for UI awarded by Allergan, Inc. 2017 - 2019
  • Inflammasomes Mediate Inflammation in Bladder Outlet Obstruction awarded by National Institutes of Health 2015 - 2019
  • Diabetes and Diabetic Uropathy awarded by National Institutes of Health 2017 - 2018
  • Purves/Inouye AUA Resident Award awarded by American Urological Association Foundation 2016 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hughes, FM, Hirshman, NA, Inouye, BM, Jin, H, Stanton, EW, Yun, CE, Davis, LG, Routh, JC, and Purves, JT. "NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation." Diabetes (November 13, 2018).  Full Text
    • Kelly, MS, Routh, JC, Davis, LG, Purves, JT, Wiener, JS, and Maciejewski, ML. "Lower Urinary Tract Symptoms in Older Children With and Without Diabetes Mellitus." Clinical Pediatrics 57, no. 13 (November 2018): 1576-1581.  Full Text
    • Dunton, CL, Purves, JT, Hughes, FM, Jin, H, and Nagatomi, J. "Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells." International Urology and Nephrology 50, no. 9 (September 1, 2018): 1607-1617.  Full Text
    • Jiang, R, Wolf, S, Alkazemi, MH, Pomann, G-M, Purves, JT, Wiener, JS, and Routh, JC. "The evaluation of three comorbidity indices in predicting postoperative complications and readmissions in pediatric urology." Journal of Pediatric Urology 14, no. 3 (June 2018): 244.e1-244.e7.  Full Text
    • Inouye, BM, Purves, JT, Routh, JC, Maruf, M, Friedlander, D, Jayman, J, and Gearhart, JP. "How to close classic bladder exstrophy: Are subspecialty training and technique important?." Journal of Pediatric Urology (March 29, 2018).  Full Text
    • Lütolf, R, Hughes, FM, Inouye, BM, Jin, H, McMains, JC, Pak, ES, Hannan, JL, and Purves, JT. "NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats." Neurourology and Urodynamics 37, no. 3 (March 2018): 952-959.  Full Text  Open Access Copy
    • Tejwani, R, Jiang, R, Wolf, S, Adkins, DW, Young, BJ, Alkazemi, M, Wiener, JS, Pomann, G-M, Purves, JT, and Routh, JC. "Contemporary Demographic, Treatment, and Geographic Distribution Patterns for Disorders of Sex Development." Clinical Pediatrics 57, no. 3 (March 2018): 311-318.  Full Text
    • Inouye, BM, Hughes, FM, Sexton, SJ, and Purves, JT. "The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology." Current Urology 11, no. 2 (February 2018): 57-72. (Review)  Full Text  Open Access Copy
    • Inouye, BM, Hughes, FM, Jin, H, Lütolf, R, Potnis, KC, Routh, JC, Rouse, DC, Foo, W-C, and Purves, JT. "Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria." Research and Reports in Urology 10 (January 2018): 219-225.  Full Text
    • Hughes, FM, Sexton, SJ, Jin, H, Govada, V, and Purves, JT. "Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β." American Journal of Physiology Renal Physiology 313, no. 3 (September 2017): F603-F610.  Full Text  Open Access Copy
    • Tejwani, R, Young, BJ, Wang, H-HS, Wolf, S, Purves, JT, Wiener, JS, and Routh, JC. "Open versus minimally invasive surgical approaches in pediatric urology: Trends in utilization and complications." Journal of Pediatric Urology 13, no. 3 (June 2017): 283.e1-283.e9.  Full Text
    • Purves, JT, Spruill, L, Rovner, E, Borisko, E, McCants, A, Mugo, E, Wingard, A, Trusk, TC, Bacro, T, and Hughes, FM. "A three dimensional nerve map of human bladder trigone." Neurourology and Urodynamics 36, no. 4 (April 2017): 1015-1019.  Full Text  Open Access Copy
    • Purves, JT, and Hughes, FM. "Inflammasomes in the urinary tract: a disease-based review." American Journal of Physiology Renal Physiology 311, no. 4 (October 2016): F653-F662. (Review)  Full Text  Open Access Copy
    • Young, BJ, Tejwani, R, Wang, H-HS, Wolf, S, Purves, JT, Wiener, JS, and Routh, JC. "Is the Economic Impact and Utilization of Imaging Studies for Pediatric Urolithiasis Across the United States Increasing?." Urology 94 (August 2016): 208-213.  Full Text
    • Hughes, FM, Hill, HM, Wood, CM, Edmondson, AT, Dumas, A, Foo, W-C, Oelsen, JM, Rac, G, and Purves, JT. "The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction." The Journal of Urology 195, no. 5 (May 2016): 1598-1605.  Full Text  Open Access Copy
    • Ellett, J, Prasad, MM, Purves, JT, and Stec, AA. "Post-surgical infections and perioperative antibiotics usage in pediatric genitourinary procedures." Journal of Pediatric Urology 11, no. 6 (December 2015): 358.e1-358.e6.  Full Text
    • Hughes, FM, Turner, DP, and Todd Purves, J. "The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells)." International Urology and Nephrology 47, no. 12 (December 2015): 1953-1964.  Full Text  Open Access Copy
    • Shunmugavel, A, Khan, M, Hughes, FM, Purves, JT, Singh, A, and Singh, I. "S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling." Neurourology and Urodynamics 34, no. 6 (August 2015): 519-526.  Full Text
    • Schneider, MP, Hughes, FM, Engmann, AK, Purves, JT, Kasper, H, Tedaldi, M, Spruill, LS, Gullo, M, Schwab, ME, and Kessler, TM. "A novel urodynamic model for lower urinary tract assessment in awake rats." Bju International 115 Suppl 6 (April 2015): 8-15.  Full Text
    • Schroeder, J, Thacker, PG, and Purves, TJ. "Magnetic resonance urography of renal papillary necrosis." Pediatric Radiology 44, no. 4 (April 2014): 491-493. (Letter)  Full Text
    • Hughes, FM, Vivar, NP, Kennis, JG, Pratt-Thomas, JD, Lowe, DW, Shaner, BE, Nietert, PJ, Spruill, LS, and Purves, JT. "Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation." American Journal of Physiology Renal Physiology 306, no. 3 (February 2014): F299-F308.  Full Text
    • Purves, JT. "Editorial comment." The Journal of Urology 190, no. 3 (September 2013): 1020-1020.  Full Text
    • Hughes, FM, McKeithan, P, Ellett, J, Armeson, KE, and Purves, JT. "Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation." Urology 81, no. 1 (January 2013): 209.e9-209.14.  Full Text
    • Schaeffer, AJ, Stec, AA, Purves, JT, Cervellione, RM, Nelson, CP, and Gearhart, JP. "Complete primary repair of bladder exstrophy: a single institution referral experience." The Journal of Urology 186, no. 3 (September 2011): 1041-1046.  Full Text
    • Purves, JT. "Modern approaches in primary exstrophy closure." Seminars in Pediatric Surgery 20, no. 2 (May 2011): 79-84. (Review)  Full Text
    • Stine, ZE, Huynh, JL, Loftus, SK, Gorkin, DU, Salmasi, AH, Novak, T, Purves, T, Miller, RA, Antonellis, A, Gearhart, JP, Pavan, WJ, and McCallion, AS. "Oligodendroglial and pan-neural crest expression of Cre recombinase directed by Sox10 enhancer." Genesis (New York, N.Y. : 2000) 47, no. 11 (November 2009): 765-770.  Full Text
    • Hernandez, DJ, Purves, T, and Gearhart, JP. "Complications of surgical reconstruction of the exstrophy-epispadias complex." Journal of Pediatric Urology 4, no. 6 (December 2008): 460-466. (Review)  Full Text
    • Purves, JT, Miles-Thomas, J, Migeon, C, and Gearhart, JP. "Complete androgen insensitivity: the role of the surgeon." The Journal of Urology 180, no. 4 Suppl (October 2008): 1716-1719.  Full Text
    • Purves, JT, and Gearhart, JP. "Paraexstrophy skin flaps for the primary closure of exstrophy in boys: outmoded or updated?." The Journal of Urology 180, no. 4 Suppl (October 2008): 1675-1678.  Full Text
    • Schaeffer, AJ, Purves, JT, King, JA, Sponseller, PD, Jeffs, RD, and Gearhart, JP. "Complications of primary closure of classic bladder exstrophy." The Journal of Urology 180, no. 4 Suppl (October 2008): 1671-1674.  Full Text
    • Purves, JT, Baird, AD, and Gearhart, JP. "The modern staged repair of bladder exstrophy in the female: a contemporary series." Journal of Pediatric Urology 4, no. 2 (April 2008): 150-153.  Full Text
    • Purves, JT, and Gearhart, JP. "Complications of radical soft-tissue mobilization procedure as a primary closure of exstrophy." Journal of Pediatric Urology 4, no. 1 (February 2008): 65-69.  Full Text
    • Purves, JT, and Gearhart, JP. "Pelvic Osteotomy in the Modern Treatment of the Exstrophy-Epispadias Complex." Eau Ebu Update Series 5, no. 5 (October 2007): 188-196.  Full Text
    • Phull, H, Salkini, M, Purves, T, Funk, J, Copeland, D, and Comiter, CV. "Angiotensin II plays a role in acute murine experimental autoimmune cystitis." Bju International 100, no. 3 (September 2007): 664-667.  Full Text
    • Purves, JT, Graham, ML, and Ramakumar, S. "Application of fibrin glue to damaged bladder mucosa in a case of BK viral hemorrhagic cystitis." Urology 66, no. 3 (September 2005): 641-643.  Full Text
    • Ramakumar, S, Phull, H, Purves, T, Funk, J, Copeland, D, Ulreich, JB, Lai, L-W, and Lien, Y-HH. "Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model." The Journal of Urology 174, no. 3 (September 2005): 1133-1136.  Full Text
    • Yeung, C, Purves, T, Kloss, AA, Kuhl, TL, Sligar, S, and Leckband, D. "Cytochrome c Recognition of Immobilized, Orientational Variants of Cytochrome b 5 :  Direct Force and Equilibrium Binding Measurements." Langmuir 15, no. 20 (September 1999): 6829-6836.  Full Text
    • Inoue, MS, Purves, J, and Selden, M. "Okinawa citizens, US bases, and the dugong." Bulletin of Concerned Asian Scholars 29, no. 4 (October 1, 1997): 82-86. (Academic Article)  Link to Item
    • Hughes Jr., FM, Sexton, SJ, Ledig, PD, Yun, CE, Jin, H, and Purves, JT. "Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction is attenuated with the NLRP3 inhibitor glyburide." American Journal of Physiology Renal Physiology .  Link to Item

  • Book Sections

    • Lakshmanan, Y, and Purves, JT. "TISSUE ENGINEERING IN PEDIATRIC UROLOGY." In Pediatric Urology, 205-211.: Elsevier, 2010.  Full Text
    • Purves, JT, and Gearhart, JP. "THE BLADDER EXSTROPHY–EPISPADIAS–CLOACAL EXSTROPHY COMPLEX." In Pediatric Urology, 386-415.: Elsevier, 2010.  Full Text

  • Conference Papers

    • Inouye, B, Hughes, FM, Lütolf, R, Rouse, C, Foo, W-C, and Purves, JT. "PD12-06 INFLAMMASOME ACTIVATION EARLY IN THE DEVELOPMENT OF DIABETIC BLADDER DYSFUNCTION." April 2017.  Full Text
    • Inouye, BM, Brooks, JM, Degoski, DJ, Hughes, FM, Purves, JT, and Fraser, MO. "ABERRANT BLADDER REFLEXES CAN DRIVE HIND LIMB LOCOMOTOR ACTIVITY FOLLOWING COMPLETE SUPRASACRAL SPINAL CORD INJURY." Winter Meeting of the Society-of-Urodynamics-Female-Pelvic-Medicine-and-Urogenital-Reconstruction. Scottsdale, AZ. February 28, 2017 - March 4, 2017.: WILEY-BLACKWELL, February 1, 2017.  Link to Item
    • Purves, T, Novak, T, King, J, and Gearhart, JP. "Modified Young-Dees-Leadbetter bladder neck reconstruction after exstrophy repair." October 2009.  Full Text
    • Phull, H, Salkini, M, Escobar, C, Purves, T, and Comiter, CV. "The role of angiotensin II in stress urinary incontinence: A rat model." January 2007.  Full Text

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