Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., University of Michigan at Ann Arbor 1966
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  Duke Appointment History

  • Consulting Professor in Nursing, School of Nursing, Duke University 1999 - 2003
  • Instructor, Temporary in the School of Nursing, School of Nursing, Duke University 1999
• Research
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  Selected Grants

  • Clinical Research Management Program for Nurses awarded by Health Resources and Service Administration 2006 - 2009
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Dren, AT, and Turner, GH. "The drug development process: Challenges, changes, and careers. Part I." ADVANCE for Nurses 2, no. 20 (2000): 20-22. (Academic Article)
    • Dren, AT, and Turner, GH. "The drug development process: Challenges, changes, and careers. Part II." ADVANCE for Nurses 2, no. 21 (2000): 18-28. (Academic Article)
    • Anderson, GD, Yau, MK, Gidal, BE, Harris, SJ, Levy, RH, Lai, AA, Wolf, KB, Wargin, WA, and Dren, AT. "Bidirectional interaction of valproate and lamotrigine in healthy subjects." Clinical Pharmacology and Therapeutics 60, no. 2 (August 1996): 145-156.  Full Text
    • Risner, ME, Womble, GP, Dren, AT, and Manasco, PK. "Long-term clinical trial experience with Lamictal (lamotrigine) treatment of epilepsy." Epilepsia 36, no. Suppl 4 (1995): 66-. (Academic Article)
    • Bergen, D, Ristanovic, R, Rudd, D, Dren, AT, and Klein, K. "Placebo-controlled evaluation of clinical laboratory data and body weight during administration of Lamictal in outpatients with partial seizures." Epilepsia 35, no. Suppl 8 (1994): 1963-. (Academic Article)
    • Matsuo, F, Bergen, D, Faught, E, Messenheimer, JA, Dren, AT, Rudd, GD, and Lineberry, CG. "Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. U.S. Lamotrigine Protocol 0.5 Clinical Trial Group." Neurology 43, no. 11 (November 1993): 2284-2291.  Full Text
    • Dren, AT, Risner, ME, Womble, GP, Yau, MK, Rudd, GD, and Lineberry, CG. "Placebo-controlled add-on experience demonstrating the safety and efficacy of lamotrigine in patients with refractory partial seizures." Journal of Clinical Pharmacology 32 (1992): 766-. (Academic Article)
    • Rudd, GD, Dren, AT, Womble, GP, Risner, ME, and Lineberry, CG. "Comparison of crossover and parallel designs in the clinical evaluation of lamotrigine." Pharmacotherapy 12 (1992): 263-. (Academic Article)
    • Borison, RL, Diamond, BI, and Dren, AT. "Does sigma receptor antagonism predict clinical antipsychotic efficacy?." Psychopharmacol Bull 27, no. 2 (1991): 103-106.  Link to Item
    • DREN, AT, EBERT, DM, WARAWA, EJ, and DODGE, PW. "INTRAVENOUS ANESTHETIC ACTIVITY OF BICYCLIC KETALS STRUCTURALLY RELATED TO KETAMINE AND ETOXADROL." PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 28, no. 1 (September 1987): 122-122.  Link to Item
    • Dren, AT, Gorodetzky, CW, and Cato, A. "Case report: The case of the disappearing white blood cells." J Clin Res Drug Dev 1 (1987): 79-86. (Academic Article)
    • WHITE, HL, and DREN, AT. "SOME PRECLINICAL AND CLINICAL PHARMACOLOGICAL PROPERTIES OF BW-A616U, A REVERSIBLE MAO-A INHIBITOR." CLINICAL NEUROPHARMACOLOGY 9 (1986): 561-562.  Link to Item
    • Davidson, J, Dren, A, Miller, R, Manberg, P, Kilts, C, and Wingfield, M. "BW234: A nondopamine receptor‐blocking antipsychotic drug without extrapyramidal side effects?." Drug Development Research 6, no. 1 (January 1, 1985): 13-17.  Full Text
    • Schwarcz, G, Halaris, A, Dren, A, and Manberg, P. "Open label evaluation of the novel antipsychotic compound BW234U in chronic schizophrenics." Drug Development Research 5, no. 4 (1985): 387-393.  Full Text
    • Warawa, E, Dren, AT, and Ebert, DM. "Synthesis and intravenous general anesthetic activity of 7-aza-II, 12-dioxxa-6-phenuyltricyclo-7,2,1,0 dodecanes." Journal of Medicinal Chemistry 28 (1985). (Academic Article)
    • Feighner, JP, Dren, AT, and Manberg, PJ. "Clinical experience with a new antipsychotic without dopamine blocking properties." Clin Neuropharmacol 7, no. Suppl 1 (1984): 148-149. (Academic Article)
    • Lee, CM, Zaugg, HE, Michaels, RJ, Dren, AT, Plotnikoff, NP, and Young, PR. "New azacannabinoids highly active in the central nervous system." J Med Chem 26, no. 2 (February 1983): 278-280.  Link to Item
    • Guy, W, Manov, G, Wilson, WH, Ban, TA, Fjetland, OK, Manberg, PJ, and Dren, AT. "Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study." Drug Development Research 3, no. 3 (January 1, 1983): 245-252.  Full Text
    • Davidson, J, Miller, R, Wingfield, M, Zung, W, and Dren, AT. "The first clinical study of BW-234U in schizophrenia." Psychopharmacology bulletin 18, no. 4 (October 1982): 173-176.
    • Minard, FN, Cain, JC, Grant, DS, and Dren, AT. "N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain." J Pharm Pharmacol 31, no. 2 (February 1979): 91-93.  Link to Item
    • Bopp, BA, Dren, AT, Ebert, DM, and Geiszler, AO. "Local anesthetic activity and acute toxicity of N-heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate." J Pharm Sci 67, no. 6 (June 1978): 882-884.  Link to Item
    • Dren, AT, Bopp, BA, Ebert, DM, Geiszler, AO, Holland, JB, Horrom, BW, and Dunnigan, DA. "Local anesthetic activity and acute toxicity of N-substituted 1,2,3,4-tetrahydro-1- and 2-naphthylamines." J Pharm Sci 67, no. 6 (June 1978): 880-882.  Link to Item
    • Lee, CM, Michaels, RJ, Zaugg, HE, Dren, AT, Plotnikoff, NP, and Young, PR. "Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives." J Med Chem 20, no. 11 (November 1977): 1508-1511.  Link to Item
    • Kirkpatrick, WE, Okabe, T, Hillyard, IW, Robins, RK, Dren, AT, and Novinson, T. "3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates." Journal of Medicinal Chemistry 20, no. 3 (March 1977): 386-393.  Full Text
    • Razdan, RK, Handrick, GR, Dalzell, HC, Howes, JF, Winn, M, Plotnikoff, NP, Dodge, PW, and Dren, AT. "Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs." J Med Chem 19, no. 4 (April 1976): 552-554.  Link to Item
    • Razdan, RK, Terris, BZ, Pars, HG, Plotnikoff, NP, Dodge, PW, Dren, AT, Kyncl, J, and Somani, P. "Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs." J Med Chem 19, no. 4 (April 1976): 454-461.  Link to Item
    • Razdan, RK, Zitko Terris, B, Handrick, GR, Dalzell, HC, Pars, HG, Howes, JF, Plotnikoff, NP, Dodge, PW, and Dren, AT. "Drugs derived from cannabinoids. 3. Sulfur analogs, thiopyranobenzopyrans and thienobenzopyrans." Journal of Medicinal Chemistry 19, no. 4 (April 1976): 549-551.  Full Text
    • Winn, M, Arendsen, D, Dodge, PW, Dren, A, Dunnigan, D, Hallas, R, Hwang, K, Kyncl, J, and Lee, Y-H. "Drugs derived from cannabinoids. 5. .DELTA.6a,10a,-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains." Journal of Medicinal Chemistry 19, no. 4 (April 1976): 461-471.  Full Text
    • Dren, AT, and Domino, EF. "Cholinergic and adrenergic activating agents as antagonists of the EEG effects of hemicholinium-3." Arch Int Pharmacodyn Ther 175, no. 1 (September 1968): 63-72.  Link to Item
    • Dren, AT, and Domino, EF. "Effects of hemicholinium (HC-3) on EEG activation and brain acetylcholine in the dog." J Pharmacol Exp Ther 161, no. 1 (May 1968): 141-154.  Link to Item
    • Rosecrans, JA, Dren, AT, and Domino, EF. "Effects of physostigmine on rat brain acetylcholine, acetylcholinesterase and conditioned pole jumping." Int J Neuropharmacol 7, no. 2 (March 1968): 127-134.  Link to Item
    • Domino, EF, Yamamoto, K, and Dren, AT. "Role of cholinergic mechanisms in states of wakefulness and sleep." Prog Brain Res 28 (1968): 113-133.  Full Text  Link to Item
    • Dren, AT. "EEG Evaluation of Drug Action." INTEK 4 (1968): 1-3. (Academic Article)
    • Domino, EF, Dren, AT, and Yamamoto, KI. "Pharmacologic evidence for cholinergic mechanisms in neocortical and limbic activating systems." Prog Brain Res 27 (1967): 337-364.  Full Text  Link to Item
• Teaching & Mentoring
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  Recent Courses

  • NURSING 580: Nurse as Scholar I: Science Development, Study Design & Statistics 2019

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