Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., University of Michigan at Ann Arbor 1966
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  Duke Appointment History

  • Consulting Professor in Nursing, School of Nursing, Duke University 1999 - 2003
  • Instructor, Temporary in the School of Nursing, School of Nursing, Duke University 1999
• Research
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  Selected Grants

  • Clinical Research Management Program for Nurses awarded by Health Resources and Service Administration 2006 - 2009
• Publications & Artistic Works
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  Selected Publications

  • Journal Articles

    • Dren, AT, and Turner, GH. "The drug development process: Challenges, changes, and careers. Part I." ADVANCE for Nurses 2, no. 20 (2000): 20-22. (Academic Article)
    • Dren, AT, and Turner, GH. "The drug development process: Challenges, changes, and careers. Part II." ADVANCE for Nurses 2, no. 21 (2000): 18-28. (Academic Article)
    • Anderson, GD, Yau, MK, Gidal, BE, Harris, SJ, Levy, RH, Lai, AA, Wolf, KB, Wargin, WA, and Dren, AT. "Bidirectional interaction of valproate and lamotrigine in healthy subjects." Clin Pharmacol Ther 60, no. 2 (August 1996): 145-156.  Full Text  Link to Item
    • Risner, ME, Womble, GP, Dren, AT, and Manasco, PK. "Long-term clinical trial experience with Lamictal (lamotrigine) treatment of epilepsy." Epilepsia 36, no. Suppl 4 (1995): 66-. (Academic Article)
    • Bergen, D, Ristanovic, R, Rudd, D, Dren, AT, and Klein, K. "Placebo-controlled evaluation of clinical laboratory data and body weight during administration of Lamictal in outpatients with partial seizures." Epilepsia 35, no. Suppl 8 (1994): 1963-. (Academic Article)
    • Matsuo, F, Bergen, D, Faught, E, Messenheimer, JA, Dren, AT, Rudd, GD, and Lineberry, CG. "Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. U.S. Lamotrigine Protocol 0.5 Clinical Trial Group." Neurology 43, no. 11 (November 1993): 2284-2291.  Link to Item
    • Dren, AT, Risner, ME, Womble, GP, Yau, MK, Rudd, GD, and Lineberry, CG. "Placebo-controlled add-on experience demonstrating the safety and efficacy of lamotrigine in patients with refractory partial seizures." Journal of Clinical Pharmacology 32 (1992): 766-. (Academic Article)
    • Rudd, GD, Dren, AT, Womble, GP, Risner, ME, and Lineberry, CG. "Comparison of crossover and parallel designs in the clinical evaluation of lamotrigine." Pharmacotherapy 12 (1992): 263-. (Academic Article)
    • Borison, RL, Diamond, BI, and Dren, AT. "Does sigma receptor antagonism predict clinical antipsychotic efficacy?." Psychopharmacol Bull 27, no. 2 (1991): 103-106.  Link to Item
    • DREN, AT, EBERT, DM, WARAWA, EJ, and DODGE, PW. "INTRAVENOUS ANESTHETIC ACTIVITY OF BICYCLIC KETALS STRUCTURALLY RELATED TO KETAMINE AND ETOXADROL." PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 28, no. 1 (September 1987): 122-122.  Link to Item
    • Dren, AT, Gorodetzky, CW, and Cato, A. "Case report: The case of the disappearing white blood cells." J Clin Res Drug Dev 1 (1987): 79-86. (Academic Article)
    • WHITE, HL, and DREN, AT. "SOME PRECLINICAL AND CLINICAL PHARMACOLOGICAL PROPERTIES OF BW-A616U, A REVERSIBLE MAO-A INHIBITOR." CLINICAL NEUROPHARMACOLOGY 9 (1986): 561-562.  Link to Item
    • Davidson, J, Dren, A, Miller, R, Manberg, P, Kilts, C, and Wingfield, M. "BW234: A nondopamine receptor-blocking antipsychotic drug without extrapyramidal side effects?." Drug Development Research 6, no. 1 (1985): 13-17.  Full Text
    • Schwarcz, G, Halaris, A, Dren, A, and Manberg, P. "Open-label evaluation of the novel antipsychotic compound BW234U in chronic schizophrenics." Drug Development Research 5, no. 4 (1985): 387-393. (Academic Article)  Full Text
    • Warawa, E, Dren, AT, and Ebert, DM. "Synthesis and intravenous general anesthetic activity of 7-aza-II, 12-dioxxa-6-phenuyltricyclo-7,2,1,0 dodecanes." Journal of Medicinal Chemistry 28 (1985). (Academic Article)
    • Feighner, JP, Dren, AT, and Manberg, PJ. "Clinical experience with a new antipsychotic without dopamine blocking properties." Clin Neuropharmacol 7, no. Suppl 1 (1984): 148-149. (Academic Article)
    • Lee, CM, Zaugg, HE, Michaels, RJ, Dren, AT, Plotnikoff, NP, and Young, PR. "New azacannabinoids highly active in the central nervous system." J Med Chem 26, no. 2 (February 1983): 278-280.  Link to Item
    • Guy, W, Manov, G, and Wilson, WH. "Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose-range study." Drug Development Research 3, no. 3 (1983): 245-252.
    • Davidson, J, Miller, R, Wingfield, M, Zung, W, and Dren, AT. "The first clinical study of BW-234U in schizophrenia." Psychopharmacology bulletin 18, no. 4 (October 1982): 173-176.
    • Minard, FN, Cain, JC, Grant, DS, and Dren, AT. "N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain." J Pharm Pharmacol 31, no. 2 (February 1979): 91-93.  Link to Item
    • Bopp, BA, Dren, AT, Ebert, DM, and Geiszler, AO. "Local anesthetic activity and acute toxicity of N-heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate." J Pharm Sci 67, no. 6 (June 1978): 882-884.  Link to Item
    • Dren, AT, Bopp, BA, Ebert, DM, Geiszler, AO, Holland, JB, Horrom, BW, and Dunnigan, DA. "Local anesthetic activity and acute toxicity of N-substituted 1,2,3,4-tetrahydro-1- and 2-naphthylamines." J Pharm Sci 67, no. 6 (June 1978): 880-882.  Link to Item
    • Lee, CM, Michaels, RJ, Zaugg, HE, Dren, AT, Plotnikoff, NP, and Young, PR. "Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives." J Med Chem 20, no. 11 (November 1977): 1508-1511.  Link to Item
    • Kirkpatrick, WE, Okabe, T, Hillyard, IW, Robins, RK, Dren, AT, and Novinson, T. "3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates." J Med Chem 20, no. 3 (March 1977): 386-393.  Link to Item
    • Razdan, RK, Handrick, GR, Dalzell, HC, Howes, JF, Winn, M, Plotnikoff, NP, Dodge, PW, and Dren, AT. "Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs." J Med Chem 19, no. 4 (April 1976): 552-554.  Link to Item
    • Razdan, RK, Terris, BZ, Handrick, GR, Dalzell, HC, Pars, HG, Howes, JF, Plotnikoff, N, Dodge, P, Dren, A, Kyncl, J, Shoer, L, and Thompson, WR. "Drugs derived from cannabinoids. 3. Sulfur analogs, thiopyranobenzopyrans and thienobenzopyrans." Journal of medicinal chemistry 19, no. 4 (April 1976): 549-551. (Academic Article)  Full Text
    • Razdan, RK, Terris, BZ, Pars, HG, Plotnikoff, NP, Dodge, PW, Dren, AT, Kyncl, J, and Somani, P. "Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs." J Med Chem 19, no. 4 (April 1976): 454-461.  Link to Item
    • Winn, M, Arendsen, D, Dodge, P, Dren, A, Dunnigan, D, Hallas, R, Hwang, K, Kyncl, J, Lee, YH, Plotnikoff, N, Young, P, and Zaugg, H. "Drugs derived from cannabinoids. 5. Delta 6a, 10a-tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains." Journal of Medicinal Chemistry 19, no. 4 (April 1976): 461-471. (Academic Article)
    • Dren, AT, and Domino, EF. "Cholinergic and adrenergic activating agents as antagonists of the EEG effects of hemicholinium-3." Arch Int Pharmacodyn Ther 175, no. 1 (September 1968): 63-72.  Link to Item
    • Dren, AT, and Domino, EF. "Effects of hemicholinium (HC-3) on EEG activation and brain acetylcholine in the dog." J Pharmacol Exp Ther 161, no. 1 (May 1968): 141-154.  Link to Item
    • Rosecrans, JA, Dren, AT, and Domino, EF. "Effects of physostigmine on rat brain acetylcholine, acetylcholinesterase and conditioned pole jumping." Int J Neuropharmacol 7, no. 2 (March 1968): 127-134.  Link to Item
    • Domino, EF, Yamamoto, K, and Dren, AT. "Role of cholinergic mechanisms in states of wakefulness and sleep." Prog Brain Res 28 (1968): 113-133.  Full Text  Link to Item
    • Dren, AT. "EEG Evaluation of Drug Action." INTEK 4 (1968): 1-3. (Academic Article)
    • Domino, EF, Dren, AT, and Yamamoto, KI. "Pharmacologic evidence for cholinergic mechanisms in neocortical and limbic activating systems." Prog Brain Res 27 (1967): 337-364.  Full Text  Link to Item
• Teaching & Mentoring
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  Recent Courses

  • NURSING 580: Nurse as Scholar I: Science Development, Study Design & Statistics 2018

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