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Trudy G Oliver

Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
Campus Box 3813, Durham, NC 27708
308 Research Drive, LSRC C138B, Durham, NC 27708

Overview


The Oliver Lab is focused on understanding the biology of under-studied subtypes of lung cancer, specifically squamous and small cell lung cancer (SCLC). We investigate mechanisms of tumor initiation, progression, plasticity, and drug resistance to uncover vulnerabilities that can be therapeutically targeted. We capitalize on state-of-the-art mouse and patient-derived models to identify and test novel treatment strategies, with the goal of translating these findings to the clinic.

Current Appointments & Affiliations


Professor of Pharmacology and Cancer Biology · 2023 - Present Pharmacology & Cancer Biology, Basic Science Departments
Member of the Duke Cancer Institute · 2022 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published April 17, 2023
Trudy Oliver Tracks a Deadly, Shape-Shifting Tumor
Published October 25, 2022
A New Generation of Tools To Fight Cancer

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Recent Publications


KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma.

Journal Article Mol Cancer Res · March 10, 2025 Small-cell lung carcinoma (SCLC) tumors are heterogeneous, with a subpopulation of cells primed for tumor initiation. Here, we show that Kinase Suppressor of Ras 2 (KSR2) promotes the self-renewal and clonogenicity of SCLC cells. KSR2 is a molecular scaffo ... Full text Link to item Cite

Supplementary Data Figure S6 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>Differential expression of genes and gene signatures in RPM and RPMA allografts.</p> ... Full text Cite

Supplementary Data Figure S4 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>Sorting parameters for TdTom + tumor cells used for seeding secondary allograft tumors.</p> ... Full text Cite
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Recent Grants


Duke Research Training Program in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

NEUROD1 function in SCLC fate and plasticity

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

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Education, Training & Certifications


Duke University · 2005 Ph.D.
Oklahoma Baptist University · 2001 B.S.

External Links


Oliver Lab website