Overview
The Oliver Lab is focused on understanding the biology of under-studied subtypes of lung cancer, specifically squamous and small cell lung cancer (SCLC). We investigate mechanisms of tumor initiation, progression, plasticity, and drug resistance to uncover vulnerabilities that can be therapeutically targeted. We capitalize on state-of-the-art mouse and patient-derived models to identify and test novel treatment strategies, with the goal of translating these findings to the clinic.
Current Appointments & Affiliations
Professor of Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma.
Journal Article Mol Cancer Res · March 10, 2025 Small-cell lung carcinoma (SCLC) tumors are heterogeneous, with a subpopulation of cells primed for tumor initiation. Here, we show that Kinase Suppressor of Ras 2 (KSR2) promotes the self-renewal and clonogenicity of SCLC cells. KSR2 is a molecular scaffo ... Full text Link to item CiteSupplementary Data Figure S6 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
Other · January 10, 2025 <p>Differential expression of genes and gene signatures in RPM and RPMA allografts.</p> ... Full text CiteSupplementary Data Figure S4 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
Other · January 10, 2025 <p>Sorting parameters for TdTom + tumor cells used for seeding secondary allograft tumors.</p> ... Full text CiteRecent Grants
Duke Research Training Program in Surgical Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029NEUROD1 function in SCLC fate and plasticity
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education, Training & Certifications
Duke University ·
2005
Ph.D.
Oklahoma Baptist University ·
2001
B.S.