Trudy G Oliver | Scholars@Duke

Trudy G Oliver
Instructor in the Department of Pharmacology & Cancer Biology

The Oliver Lab is focused on understanding the biology of under-studied subtypes of lung cancer, specifically squamous and small cell lung cancer (SCLC). We investigate mechanisms of tumor initiation, progression, plasticity, and drug resistance to uncover vulnerabilities that can be therapeutically targeted. We capitalize on state-of-the-art mouse and patient-derived models to identify and test novel treatment strategies, with the goal of translating these findings to the clinic.

Current Appointments & Affiliations

Instructor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2022

Contact Information

308 Research Drive, LSRC C138b, Durham, NC 27708
Campus Box 3813, Durham, NC 27708
trudy.oliver@duke.edu (919) 660-2339
Oliver Lab website

Background
Education, Training, & Certifications
- Ph.D., Duke University 2005
Academic Positions Outside Duke
- Adjunct Associate Professor, University of Utah/Huntsman Cancer Institute. 2022 - 2023
- Huntsman Cancer Institute Endowed Chair in Cancer Research, University of Utah. 2018 - 2022
- Associate Professor with Tenure, University of Utah/Huntsman Cancer Institute. 2017 - 2022
- Assistant Professor, University of Utah/Huntsman Cancer Institute. 2011 - 2017
Research
Selected Grants
- Mechanisms of Arginine Deprivation in Small Cell Lung Cancer awarded by National Institutes of Health 2022 - 2026
- Investigating and targeting metabolic vulnerabilities of MYC-driven small cell lung cancer awarded by National Institutes of Health 2022 - 2025
- Genomic and Functional Identification of Chemotherapy Resistance Mechanisms in Small Cell Lung Cancer awarded by Washington University in St. Louis 2022 - 2023
External Relationships
- Genes & Development
- Known Medicine
- Lung Cancer Research Foundation
- US Patent
Publications & Artistic Works
Selected Publications
- Books
  - Cable, Jennifer, Lydia Finley, Benjamin P. Tu, Gary J. Patti, Trudy G. Oliver, Santosha Vardhana, Miyeko Mana, et al. Leveraging insights into cancer metabolism-a symposium report. Vol. 1462, 2020. https://doi.org/10.1111/nyas.14274.
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- Academic Articles
  - Kelenis, Demetra P., Kathia E. Rodarte, Rahul K. Kollipara, Karine Pozo, Shreoshi Pal Choudhuri, Kyle B. Spainhower, Sarah J. Wait, Victor Stastny, Trudy G. Oliver, and Jane E. Johnson. “Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer.” Cancer Res 82, no. 17 (September 2, 2022): 3058–73. https://doi.org/10.1158/0008-5472.CAN-21-3713.
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  - Hamad, Samera H., Stephanie A. Montgomery, Jeremy M. Simon, Brittany M. Bowman, Kyle B. Spainhower, Ryan M. Murphy, Erik S. Knudsen, et al. “Correction: TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice.” Oncogene, August 25, 2022. https://doi.org/10.1038/s41388-022-02442-3.
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  - Hamad, Samera H., Stephanie A. Montgomery, Jeremy M. Simon, Brittany M. Bowman, Kyle B. Spainhower, Ryan M. Murphy, Erik S. Knudsen, et al. “TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice.” Oncogene 41, no. 25 (June 2022): 3423–32. https://doi.org/10.1038/s41388-022-02348-0.
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  - Sutherland, Kate D., Abbie S. Ireland, and Trudy G. Oliver. “Killing SCLC: insights into how to target a shapeshifting tumor.” Genes Dev 36, no. 5–6 (March 1, 2022): 241–58. https://doi.org/10.1101/gad.349359.122.
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  - Ciampricotti, Metamia, Triantafyllia Karakousi, Allison L. Richards, Àlvaro Quintanal-Villalonga, Angeliki Karatza, Rebecca Caeser, Emily A. Costa, et al. “Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer.” Cancer Discov 11, no. 12 (December 1, 2021): 3214–29. https://doi.org/10.1158/2159-8290.CD-21-0441.
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  - Pe’er, Dana, Seishi Ogawa, Ofer Elhanani, Leeat Keren, Trudy G. Oliver, and David Wedge. “Tumor heterogeneity.” Cancer Cell 39, no. 8 (August 9, 2021): 1015–17. https://doi.org/10.1016/j.ccell.2021.07.009.
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  - Olsen, Rachelle R., Abbie S. Ireland, David W. Kastner, Sarah M. Groves, Kyle B. Spainhower, Karine Pozo, Demetra P. Kelenis, et al. “ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer.” Genes Dev 35, no. 11–12 (June 2021): 847–69. https://doi.org/10.1101/gad.348295.121.
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  - Huang, Fang, Kenneth E. Huffman, Zixi Wang, Xun Wang, Kailong Li, Feng Cai, Chendong Yang, et al. “Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer.” J Clin Invest 131, no. 1 (January 4, 2021). https://doi.org/10.1172/JCI139929.
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  - Tsabar, Michael, Caroline S. Mock, Veena Venkatachalam, Jose Reyes, Kyle W. Karhohs, Trudy G. Oliver, Aviv Regev, Ashwini Jambhekar, and Galit Lahav. “A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest.” Cell Rep 33, no. 6 (November 10, 2020): 108392. https://doi.org/10.1016/j.celrep.2020.108392.
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  - Tsabar, Michael, Caroline S. Mock, Veena Venkatachalam, Jose Reyes, Kyle W. Karhohs, Trudy G. Oliver, Aviv Regev, Ashwini Jambhekar, and Galit Lahav. “A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest.” Cell Rep 32, no. 5 (August 4, 2020): 107995. https://doi.org/10.1016/j.celrep.2020.107995.
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  - Ireland, Abbie S., Alexi M. Micinski, David W. Kastner, Bingqian Guo, Sarah J. Wait, Kyle B. Spainhower, Christopher C. Conley, et al. “MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate.” Cancer Cell 38, no. 1 (July 13, 2020): 60-78.e12. https://doi.org/10.1016/j.ccell.2020.05.001.
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  - Ireland, Abbie S., and Trudy G. Oliver. “Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells.” Immunity 52, no. 5 (May 19, 2020): 729–31. https://doi.org/10.1016/j.immuni.2020.04.009.
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  - Poirier, John T., Julie George, Taofeek K. Owonikoko, Anton Berns, Elisabeth Brambilla, Lauren A. Byers, David Carbone, et al. “New Approaches to SCLC Therapy: From the Laboratory to the Clinic.” J Thorac Oncol 15, no. 4 (April 2020): 520–40. https://doi.org/10.1016/j.jtho.2020.01.016.
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  - Melnikova, Margarita, Ulrike Sophie Wauer, Diana Mendus, Ralf Axel Hilger, Trudy G. Oliver, Kim Mercer, Björn Oliver Gohlke, et al. “Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells.” Mol Oncol 14, no. 4 (April 2020): 686–703. https://doi.org/10.1002/1878-0261.12648.
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  - Stewart, C Allison, Carl M. Gay, Yuanxin Xi, Santhosh Sivajothi, V. Sivakamasundari, Junya Fujimoto, Mohan Bolisetty, et al. “Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer.” Nat Cancer 1 (April 2020): 423–36. https://doi.org/10.1038/s43018-019-0020-z.
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  - Chalishazar, Milind D., Sarah J. Wait, Fang Huang, Abbie S. Ireland, Anandaroop Mukhopadhyay, Younjee Lee, Sophia S. Schuman, et al. “MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.” Clin Cancer Res 25, no. 16 (August 15, 2019): 5107–21. https://doi.org/10.1158/1078-0432.CCR-18-4140.
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  - Dammert, Marcel A., Johannes Brägelmann, Rachelle R. Olsen, Stefanie Böhm, Niloufar Monhasery, Christopher P. Whitney, Milind D. Chalishazar, et al. “MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.” Nat Commun 10, no. 1 (August 2, 2019): 3485. https://doi.org/10.1038/s41467-019-11371-x.
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  - Guo, Bingqian, and Trudy G. Oliver. “Partners in Crime: Neutrophil-CTC Collusion in Metastasis.” Trends Immunol 40, no. 7 (July 2019): 556–59. https://doi.org/10.1016/j.it.2019.04.009.
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  - Rudin, Charles M., John T. Poirier, Lauren Averett Byers, Caroline Dive, Afshin Dowlati, Julie George, John V. Heymach, et al. “Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.” Nat Rev Cancer 19, no. 7 (July 2019): 415. https://doi.org/10.1038/s41568-019-0164-2.
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  - Rudin, Charles M., John T. Poirier, Lauren Averett Byers, Caroline Dive, Afshin Dowlati, Julie George, John V. Heymach, et al. “Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.” Nat Rev Cancer 19, no. 5 (May 2019): 289–97. https://doi.org/10.1038/s41568-019-0133-9.
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  - Mollaoglu, Gurkan, Alex Jones, Sarah J. Wait, Anandaroop Mukhopadhyay, Sangmin Jeong, Rahul Arya, Soledad A. Camolotto, et al. “The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.” Immunity 49, no. 4 (October 16, 2018): 764-779.e9. https://doi.org/10.1016/j.immuni.2018.09.020.
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  - Wagner, Alex H., Siddhartha Devarakonda, Zachary L. Skidmore, Kilannin Krysiak, Avinash Ramu, Lee Trani, Jason Kunisaki, et al. “Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.” Nat Commun 9, no. 1 (September 17, 2018): 3787. https://doi.org/10.1038/s41467-018-06162-9.
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  - Huang, Fang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, et al. “Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.” Cell Metab 28, no. 3 (September 4, 2018): 369-382.e5. https://doi.org/10.1016/j.cmet.2018.06.005.
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  - Zhang, Wei, Luc Girard, Yu-An Zhang, Tomohiro Haruki, Mahboubeh Papari-Zareei, Victor Stastny, Hans K. Ghayee, et al. “Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes.” Transl Lung Cancer Res 7, no. 1 (February 2018): 32–49. https://doi.org/10.21037/tlcr.2018.02.02.
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  - Cardnell, Robert J., Lerong Li, Triparna Sen, Rasha Bara, Pan Tong, Junya Fujimoto, Abbie S. Ireland, et al. “Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies.” Oncotarget 8, no. 43 (September 26, 2017): 73419–32. https://doi.org/10.18632/oncotarget.20621.
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  - Brägelmann, Johannes, Stefanie Böhm, Matthew R. Guthrie, Gurkan Mollaoglu, Trudy G. Oliver, and Martin L. Sos. “Family matters: How MYC family oncogenes impact small cell lung cancer.” Cell Cycle 16, no. 16 (August 18, 2017): 1489–98. https://doi.org/10.1080/15384101.2017.1339849.
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  - Mollaoglu, Gurkan, Matthew R. Guthrie, Stefanie Böhm, Johannes Brägelmann, Ismail Can, Paul M. Ballieu, Annika Marx, et al. “MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition.” Cancer Cell 31, no. 2 (February 13, 2017): 270–85. https://doi.org/10.1016/j.ccell.2016.12.005.
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  - Terry, M. R., R. Arya, A. Mukhopadhyay, K. C. Berrett, P. M. Clair, B. Witt, M. E. Salama, A. Bhutkar, and T. G. Oliver. “Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.” Cell Death Differ 22, no. 5 (May 2015): 719–30. https://doi.org/10.1038/cdd.2014.159.
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  - Mukhopadhyay, Anandaroop, and Trudy G. Oliver. “Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer.” Mol Cell Oncol 2, no. 2 (April 2015): e969651. https://doi.org/10.4161/23723548.2014.969651.
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  - Oliver, Trudy G., Jesal Patel, and Wallace Akerley. “Squamous non-small cell lung cancer as a distinct clinical entity.” Am J Clin Oncol 38, no. 2 (April 2015): 220–26. https://doi.org/10.1097/COC.0b013e3182a0e850.
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  - Mukhopadhyay, Anandaroop, Kristofer C. Berrett, Ushma Kc, Phillip M. Clair, Stelian M. Pop, Shamus R. Carr, Benjamin L. Witt, and Trudy G. Oliver. “Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.” Cell Rep 8, no. 1 (July 10, 2014): 40–49. https://doi.org/10.1016/j.celrep.2014.05.036.
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  - Oliver, T. G. “Bosom buddies: Close connections between breast and bladder cancer.” Science Translational Medicine 6, no. 225 (February 26, 2014). https://doi.org/10.1126/scitranslmed.3008709.
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  - Oliver, T. G. “RIG-ging biomarkers for therapeutic response.” Science Translational Medicine 6, no. 219 (January 15, 2014). https://doi.org/10.1126/scitranslmed.3008281.
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  - Oliver, T. G. “Waking a sleeping giant...on purpose?” Science Translational Medicine 5, no. 213 (November 27, 2013). https://doi.org/10.1126/scitranslmed.3008069.
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  - Oliver, T. G. “An anti-depressing discovery for lung cancer treatment.” Science Translational Medicine 5, no. 207 (October 16, 2013). https://doi.org/10.1126/scitranslmed.3007757.
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  - Curry, Natasha L., Mari Mino-Kenudson, Trudy G. Oliver, Omer H. Yilmaz, Vedat O. Yilmaz, Jade Y. Moon, Tyler Jacks, David M. Sabatini, and Nada Y. Kalaany. “Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.” Cancer Discov 3, no. 8 (August 2013): 908–21. https://doi.org/10.1158/2159-8290.CD-12-0507.
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  - Oliver, T. G. “Cancer: An inferiority complex for chemo.” Science Translational Medicine 5, no. 195 (July 24, 2013). https://doi.org/10.1126/scitranslmed.3006983.
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  - Oliver, T. G. “A two hit wonder for melanoma treatment.” Science Translational Medicine 5, no. 189 (June 12, 2013). https://doi.org/10.1126/scitranslmed.3006713.
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  - Oliver, T. G. “Dangerous liaisons: When two wrongs just might make a right.” Science Translational Medicine 5, no. 183 (May 1, 2013). https://doi.org/10.1126/scitranslmed.3006370.
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  - Oliver, T. G. “Ovarian stem cells find their niche.” Science Translational Medicine 5, no. 177 (March 20, 2013). https://doi.org/10.1126/scitranslmed.3006108.
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  - Xue, Wen, Etienne Meylan, Trudy G. Oliver, David M. Feldser, Monte M. Winslow, Roderick Bronson, and Tyler Jacks. “Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma.” Cancer Discov 1, no. 3 (August 2011): 236–47. https://doi.org/10.1158/2159-8290.CD-11-0073.
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  - Oliver, Trudy G., Etienne Meylan, Gregory P. Chang, Wen Xue, James R. Burke, Timothy J. Humpton, Diana Hubbard, Arjun Bhutkar, and Tyler Jacks. “Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.” Mol Cell 43, no. 1 (July 8, 2011): 57–71. https://doi.org/10.1016/j.molcel.2011.06.012.
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  - Doles, Jason, Trudy G. Oliver, Eleanor R. Cameron, Gerald Hsu, Tyler Jacks, Graham C. Walker, and Michael T. Hemann. “Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy.” Proc Natl Acad Sci U S A 107, no. 48 (November 30, 2010): 20786–91. https://doi.org/10.1073/pnas.1011409107.
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  - Oliver, Trudy G., Kim L. Mercer, Leanne C. Sayles, James R. Burke, Diana Mendus, Katherine S. Lovejoy, Mei-Hsin Cheng, et al. “Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.” Genes Dev 24, no. 8 (April 15, 2010): 837–52. https://doi.org/10.1101/gad.1897010.
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  - Cowley, Dale O., Jaime A. Rivera-Pérez, Mark Schliekelman, Yizhou Joseph He, Trudy G. Oliver, Lucy Lu, Ryan O’Quinn, E. D. Salmon, Terry Magnuson, and Terry Van Dyke. “Aurora-A kinase is essential for bipolar spindle formation and early development.” Mol Cell Biol 29, no. 4 (February 2009): 1059–71. https://doi.org/10.1128/MCB.01062-08.
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  - Schliekelman, Mark, Dale O. Cowley, Ryan O’Quinn, Trudy G. Oliver, Lucy Lu, E. D. Salmon, and Terry Van Dyke. “Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.” Cancer Res 69, no. 1 (January 1, 2009): 45–54. https://doi.org/10.1158/0008-5472.CAN-07-6330.
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  - Fogarty, Marie P., Brian A. Emmenegger, Linda L. Grasfeder, Trudy G. Oliver, and Robert J. Wechsler-Reya. “Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.” Proc Natl Acad Sci U S A 104, no. 8 (February 20, 2007): 2973–78. https://doi.org/10.1073/pnas.0605770104.
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  - Oliver, Trudy G., Tracy Ann Read, Jessica D. Kessler, Anriada Mehmeti, Jonathan F. Wells, Trang T. T. Huynh, Simon M. Lin, and Robert J. Wechsler-Reya. “Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.” Development 132, no. 10 (May 2005): 2425–39. https://doi.org/10.1242/dev.01793.
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  - Oliver, Trudy G., and Robert J. Wechsler-Reya. “Getting at the root and stem of brain tumors.” Neuron 42, no. 6 (June 24, 2004): 885–88. https://doi.org/10.1016/j.neuron.2004.06.011.
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  - Oliver, Trudy G., Linda L. Grasfeder, Audra L. Carroll, Constanze Kaiser, Christine L. Gillingham, Simon M. Lin, Rasika Wickramasinghe, Matthew P. Scott, and Robert J. Wechsler-Reya. “Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.” Proc Natl Acad Sci U S A 100, no. 12 (June 10, 2003): 7331–36. https://doi.org/10.1073/pnas.0832317100.
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- Preprints
  - Huisman, Dianna, Danielle Frodyma, Robert Svoboda, Heidi Vieira, Deepan Chatterjee, Sydney Skupa, James Askew, et al. “Kinase Suppressor of Ras 2 regulates small-cell lung carcinoma tumor propagating cells.” BioRxiv, 2022. https://doi.org/10.1101/2022.02.11.480157.
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  - Chen, Haobin, Lisa Gesumaria, Young-Kwon Park, Trudy Oliver, Dinah Singer, Kai Ge, and David Shrump. “BET Inhibitors Target the SCLC-N subtype Small Cell Lung Cancer by Blocking NEUROD1 Transactivation.” BioRxiv, 2021. https://doi.org/10.1101/2021.10.25.465771.
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  - Groves, Sarah Maddox, Abbie Ireland, Qi Liu, Alan Simmons, Ken Lau, Wade Iams, Darren Tyson, Christine Lovly, Trudy Oliver, and Vito Quaranta. “Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes.” BioRxiv, 2021. https://doi.org/10.1101/2021.01.22.427865.
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Education, Training, & Certifications

Academic Positions Outside Duke

Selected Grants

External Relationships

Selected Publications

Books

Academic Articles

Preprints