Scholars@Duke
Trudy G Oliver

Trudy G Oliver

George Barth Geller Distinguished Professor for Research in Pharmacology
Pharmacology & Cancer Biology
Campus Box 3813, Durham, NC 27708
308 Research Drive, LSRC C138B, Durham, NC 27708

Scholarly Works - Other

Supplementary Table S8 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Human patient data hillock-like cells per patient, related to Fig. 4</p> ... Full text Cite

Supplementary Table S14 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>SEACR peaks annotated using HOMER from KLF4 Cut&Run in SNL tumor organoids, related to Fig. 7</p> ... Full text Cite

Supplementary Table S11 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Differentially expressed genes in hillock-like tumor organoid cells derived from scRNA-seq data, related to Supplementary Fig. S5</p> ... Full text Cite

Supplementary Fig. S10 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Differentially expressed cell surface protein-encoding genes by cell state using scRNA-seq data and survival analysis of human LUSC, related to Fig. 8.</p> ... Full text Cite

Supplementary Table S7 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Reactome pathway enrichment in luminal hillock-like SNL primary tumor cells, related to Fig. 4</p> ... Full text Cite

Data from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <div>Abstract <p>Lung squamous cell carcinoma (LUSC) is a basal-like subtype of lung cancer with limited treatment options. Although prior studies have identified tumor-propagating cell (TPC) states in squamous tumors, further work is n ... Full text Cite

Supplementary Fig. S8 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>KLF4 regulates resistance to cisplatin but not paclitaxel, related to Fig. 7.</p> ... Full text Cite

Supplementary Table S6 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Differentially expressed genes in SNL tumor cells derived from scRNA-seq data, related to Fig. 4 and Supplementary Fig. S4</p> ... Full text Cite

Supplementary Fig. S4 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>The hillock state in squamous tumors may be immunomodulatory and is relatively non-proliferative, related to Fig. 4.</p> ... Full text Cite

Supplementary Fig. S7 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>KLF4 regulates the KRT13+ hillock-like-state, related to Fig. 7.</p> ... Full text Cite

Supplementary Table S1 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Hillock score genes for mouse and human, related to Fig. 3</p> ... Full text Cite

Supplementary Table S15 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Differentially regulated genes encoding for cell surface proteins, related to Fig. 8</p> ... Full text Cite

Supplementary Fig. S6 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Identifying candidate regulators of the hillock cell state and KLF4 as a regulator of KRT13, related to Fig. 6.</p> ... Full text Cite

Supplementary Fig. S9 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Hillock-like cells are present in squamous tumors of the esophagus and head and neck, related to Fig. 8.</p> ... Full text Cite

Supplementary Table S13 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Differentially expressed genes in BEAS-2B cells with TRE-KLF4 and SNL tumor organoids with sgKLF4i-1, related to Fig. 7</p> ... Full text Cite

Supplementary Fig. S2 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Tmprss11b correlates with Krt13 expression, related to Fig. 3.</p> ... Full text Cite

Supplementary Table S2 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Basal, tuft, goblet, ciliated, and club scores, related to Fig. 3</p> ... Full text Cite

Supplementary Table S10 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Immune cell population correlation to the hillock-like cell state by CIBERSORT deconvolution, related to Fig. 4</p> ... Full text Cite

Supplementary Fig. S3 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Defining cell states by transcriptional profiles in SNL tumors, related to Fig. 3.</p> ... Full text Cite

Supplementary Table S5 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Luminal hillock score genes for mouse and human, related to Fig. 3</p> ... Full text Cite

Supplementary Table S9 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Differentially expressed genes in hillock-like human tumor cells derived from scRNA-seq data, related to Fig. 4</p> ... Full text Cite

Supplementary Table S4 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Basal hillock score genes for mouse and human, related to Fig. 3</p> ... Full text Cite

Supplementary Table S3 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>Mucinous adenocarcinoma score genes for mouse and human, related to Fig. 3</p> ... Full text Cite

Supplementary Table S12 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>ENCODE and ChEA Consensus TFs from ChIP-X from mouse and human hillock-like and basal-like cells, related to Supplementary Fig. S6</p> ... Full text Cite

Supplementary Fig. S5 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>NGFR + cells give rise to KRT13+ hillock-like cells, related to Fig. 5.</p> ... Full text Cite

Supplementary Fig. S1 from KLF4 Promotes a KRT13<sup>+</sup> Hillock-Like State in Lung Squamous Cell Carcinoma

Other · September 15, 2026 <p>NGFR + tumor cells sorted from SNL tumors for scRNA-seq, related to Fig. 2.</p> ... Full text Cite

Data from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <div>Abstract<p>Most patients with prostate adenocarcinoma develop resistance to therapies targeting the androgen receptor (AR). Consequently, a portion of these patients develop AR-independent neuroendocrine (NE) prostate cancer (NEPC) ... Full text Cite

Supplementary Data Figure S3 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <p>Castration does not alter growth or heterogeneity of RPM and RPMA allograft tumors</p> ... Full text Cite

Gels and unmerged images from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <p>PCR genotyping gels and unmerged images from immunofluorescence.</p> ... Full text Cite

Supplementary Data Figure S4 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <p>Sorting parameters for TdTom + tumor cells used for seeding secondary allograft tumors.</p> ... Full text Cite

Supplementary Data Figure S5 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <p>Genotypes of RPMA organoids and differences in metastatic burden.</p> ... Full text Cite

Supplementary Data Figure S1 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <p>Genotypes of prostate organoids and resulting allograft tumors.</p> ... Full text Cite

Supplementary Data Figure S2 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <p>IHC characterization of RPM tumors and histopathology assessment of allografts.</p> ... Full text Cite

Supplementary Data Figure S6 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · June 17, 2026 <p>Differential expression of genes and gene signatures in RPM and RPMA allografts.</p> ... Full text Cite

Supplemental methods, supplemental tables 1-4, and supplemental figures 1-14 from BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation

Other · November 27, 2025 <p>Table S1. The list of the SCLC cell lines (N=52) used in this study. Table S2. The list of 384 genes that constitute the NEUROD1 gene signature. Table S3. The siRNA screen results in H446 and COR-L279 cells. Table S4. Sensitivity (IC50) of ... Full text Cite

Supplementary tables 5-17 - Data tables generated during RNA-seq and ChIP-seq analysis, and the information on the siRNA screens. from BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation

Other · November 27, 2025 <p>Table S5. The list of genes significantly altered in H446 cells after NEUROD1 KO. Table S6. The list of NEUROD1 peaks identified in H446 control cells (control gRNA, cl.10) Table S7. The list of NEUROD1 target genes identified by BETA. Tab ... Full text Cite

Data from BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation

Other · November 27, 2025 <div>Abstract<p>Small-cell lung cancer (SCLC) is a recalcitrant malignancy that urgently needs new therapies. Four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1) have been identified in SCLC, and each defines the transc ... Full text Cite

Supplementary Data Figure S6 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>Differential expression of genes and gene signatures in RPM and RPMA allografts.</p> ... Full text Cite

Supplementary Data Figure S4 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>Sorting parameters for TdTom + tumor cells used for seeding secondary allograft tumors.</p> ... Full text Cite

Gels and unmerged images from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>PCR genotyping gels and unmerged images from immunofluorescence.</p> ... Full text Cite

Supplementary Data Figure S5 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>Genotypes of RPMA organoids and differences in metastatic burden.</p> ... Full text Cite

Supplementary Data Figure S2 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>IHC characterization of RPM tumors and histopathology assessment of allografts.</p> ... Full text Cite

Supplementary Data Figure S3 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>Castration does not alter growth or heterogeneity of RPM and RPMA allograft tumors</p> ... Full text Cite

Supplementary Data Figure S1 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · January 10, 2025 <p>Genotypes of prostate organoids and resulting allograft tumors.</p> ... Full text Cite

Supplementary Data Figure S3 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · November 4, 2024 <p>Castration does not alter growth or heterogeneity of RPM and RPMA allograft tumors</p> ... Full text Cite

Supplementary Data Figure S2 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · November 4, 2024 <p>IHC characterization of RPM tumors and histopathology assessment of allografts.</p> ... Full text Cite

Gels and unmerged images from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · November 4, 2024 <p>PCR genotyping gels and unmerged images from immunofluorescence.</p> ... Full text Cite

Supplementary Data Figure S6 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · November 4, 2024 <p>Differential expression of genes and gene signatures in RPM and RPMA allografts.</p> ... Full text Cite

Supplementary Data Figure S1 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · November 4, 2024 <p>Genotypes of prostate organoids and resulting allograft tumors.</p> ... Full text Cite

Supplementary Data Figure S5 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · November 4, 2024 <p>Genotypes of RPMA organoids and differences in metastatic burden.</p> ... Full text Cite

Supplementary Data Figure S4 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Other · November 4, 2024 <p>Sorting parameters for TdTom + tumor cells used for seeding secondary allograft tumors.</p> ... Full text Cite

Supplementary Figure from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Figure from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Data from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 <div>Abstract<p>Genomic studies support the classification of small cell lung cancer (SCLC) into subtypes based on the expression of lineage-defining transcription factors ASCL1 and NEUROD1, which together are expressed in ∼86% of SCLC. ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite

Data from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 <div>Abstract<p>Genomic studies support the classification of small cell lung cancer (SCLC) into subtypes based on the expression of lineage-defining transcription factors ASCL1 and NEUROD1, which together are expressed in ∼86% of SCLC. ... Full text Cite

Supplementary Figure from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Other · March 31, 2023 Supplementary Figure from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer ... Full text Cite