Book section · January 1, 2022
Timely diagnosis of infectious diseases is critical to healthcare, especially in the time of pandemics. However, most current methods of infectious disease diagnosis are laboratory-based, which typically have a long turn-around time. This causes delays in ...
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Book section · January 1, 2017
One of the key challenges in biology and medicine has been molecular analysis of single living cells aimed at providing an understanding of the underlying complex mechanisms in the basic, structural, and functional unit of life. This is important in unders ...
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Book section · January 1, 2017
Over the past two decades, optic and photonic technologies have become exceedingly ubiquitous in the key enabling devices that are central to many aspects of everyday life. The importance of these paradigm-shifting technologies has so been recognized and a ...
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Book section · January 1, 2014
Surface-enhanced Raman scattering (SERS) spectroscopy can be a useful tool in regard to disease diagnosis and prevention. Advantage of SERS over conventional Raman spectroscopy is its significantly increased signal (up to factor of 106-108) which allows de ...
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Book section · April 29, 2008
This chapter describes the detection of specific target DNA sequences using a novel 'molecular sentinel' (MS) biosensing approach using surface-enhanced Raman scattering (SERS) detection. The SERS-based MS nanoprobe consists of a metal nanoparticle and a s ...
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Book section · January 1, 2003
This chapter presents a summary account of various amplification techniques for analysis of biological molecules (species) that use some form of optical detection as the endpoint. The analyte species possibly under consideration include lipids, carbohydrat ...
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Book section · January 1, 2003
The potential of optical tomography as a new diagnostic tool has stimulated considerable interest in the last 10 years. Although limited to about the first 5 cm of the body, the technique offers several advantages often not available in established imaging ...
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Book section · January 1, 2003
Previous chapters in this handbook have extensively described new methods in the field of biophotonics and reviewed applications. The scope of this chapter is to present, from the biologist’s point of view, a synthesis of the current and potential applicat ...
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Book section · January 1, 2003
Biochips and microarrays are technologies that will benefit directly from the research advances of the postsequencing era in genomics. Experimental genomics, in combination with the growing body of sequence information, promises to revolutionize the way ce ...
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Book section · January 1, 2003
Throughout human history, light has played an important role in medicine. In prehistoric times, the healing power of light was often attributed to mythological, religious, and supernatural powers. The history of light therapy dates back to the ancient Egyp ...
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Book section · January 1, 2003
In the past several decades, fluorescence spectroscopy has had a dramatic effect on many different fields of research. One field that has seen significant advancements is biomedical diagnostics. Within this field, fluorescence spectroscopy has been applied ...
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Book section · January 1, 2003
This chapter presents an overview of the basic instrumentation used in photonic applications. The chapter is intended to provide an introduction to the basic setups, apparatus, and system components for readers from other research fields who wish to become ...
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Book section · January 1, 2003
Human beings, along with other mammals, consciously interact with the surrounding world by means of seven sensing mechanisms. In addition to the five senses, the abilities to detect temperature and variations in elevation are almost as important. One canno ...
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Book section · January 1, 2003
The electromagnetic spectrum provides a diverse set of photonic tools for probing, manipulating, and interacting with biological systems. A great variety of electromagnetic phenomena are used in biomedicine to detect and treat disease and to advance scient ...
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Book section · January 1, 2003
Over the years, new techniques in chemical and biological sensing have set the stage for great advances in the field of biological research. One of the most recent technological advances in this area has been the development of nanosensors. A nanosensor is ...
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Book section · January 1, 2003
This chapter provides several tables summarizing spectroscopic properties of various biologically and medically relevant species and samples. It is divided into two main sections: (1) Fundamental Spectroscopic Properties of Biologically and Medically Relev ...
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Book section · January 1, 2003
Raman spectroscopy is based on vibrational transitions that yield very narrow spectral features characteristic of the investigated sample. Thus, it has long been regarded as a valuable tool for the identification of chemical and biological samples as well ...
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