ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 6, 2026
Head and neck squamous cell carcinoma (HNSCC) remains one of the most common and lethal malignancies worldwide, originating mucosal epithelium of the oral cavity, pharynx, and larynx. [1]. Patient survival is strongly dependent on early diagnosis. In many ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2026
Head and neck squamous cell carcinoma (HNSCC) remains one of the most common and lethal malignancies worldwide, originating mucosal epithelium of the oral cavity, pharynx, and larynx. [1]. Patient survival is strongly dependent on early diagnosis. In many ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022
Plant biotechnology and biofuel research is critical in addressing increasing global demands for energy. Further understanding of biomass producing associated metabolic pathways in plants can be used to exploit and increase the production of biomass for en ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022
Surface-enhanced Raman spectroscopy (SERS) has wide applications in chemical and biosensing as well as imaging. Raman spectra obtained from SERS exhibit characteristic narrow peaks that allow higher degrees of multiplexing than possible with fluorescence i ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020
The discovery of new treatments for cancer is imperative. Recently, we showed in a proof-of-concept study that SYnergistic IMmuno PHOtothermal NanotherapY (SYMPHONY) is a powerful treatment for metastatic bladder cancer and brain tumor in mouse models. Our ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020
Further understanding of biomass producing associated metabolic pathways in plants can be used to increase the production of biomass. In vivo detection of these markers has proved to be limited due to complex sample preparation required by traditional meth ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020
Our group has integrated surface-enhanced Raman scattering (SERS) silver coated gold nanostars on an optical fiber. Fiber-based sensors are an in-situ technology that can simultaneously bring the sensor and light to the sample without disturbing the enviro ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
Direct detection of genetic biomarkers in tissue and body fluids without complex target extraction and amplification processes can revolutionize nucleic acid-based diagnostics by enabling the use of this technology at the point-of-care. The development of ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
While the use of nanomaterials in medical diagnostics has received increasing interest, in vivo detection of nanoparticles using optical techniques is still a challenge. Among other techniques, surface-enhanced Raman scattering (SERS)-labeled nanoparticles ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
Although nanotechnology has led to important advances in in vitro diagnostics, the development of nanosensors for in vivo molecular detection remains very challenging. Here, we demonstrated the proof-of-principle of in vivo detection of nucleic acid target ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
The knowledge over gene expression dynamics and location in plants is crucial for applications ranging from basic biological research to agricultural biotechnology (e.g., biofuel development). However, current methods cannot provide in vivo dynamic detecti ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2019
The ability to monitor gene expression within living plants is of importance in many applications ranging from plant biology research to biofuel development; however, no method currently exists without requiring sample extraction. Herein, we report a multi ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2019
Early detection of molecular targets can greatly impact the clinical diagnosis and outcome of many diseases such as cancer. Methods utilizing optical detection systems and Surface-Enhanced Raman Scattering (SERS)-labeled nanoparticles provide a way of sele ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2019
Gene expression monitoring within whole plants is critical for many applications ranging from plant biology to biofuel development. Herein, we report a unique multimodal method for in vivo imaging and biosensing of nucleic acid biotargets, specifically mic ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2019
Molecular analysis has revolutionized many applications, including bio-safety, bio-engineering and biofuel research; however, there are limited practical tools for in situ detection during field work. New technology is needed to translate molecular advance ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2019
Development of simple techniques for detection of nucleic acids is essential for clinical diagnostics. MicroRNA (miRNA) have been identified as potential biomarkers in early detection of various diseases, including esophageal adenocarcinoma (EAC) and Barre ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018
An optically tunable, solid tissue phantom was developed in order to aid in the verification and validation of non-destructive cancer detection technologies based on fluorescence spectroscopy. The solid tissue phantom contained agarose, hemoglobin, Intrali ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018
Biocompatible gold nanostars (GNS) with tip-enhanced electromagnetic and optical properties have been developed and applied for multifunctional cancer diagnostics and therapy (theranostics). Their multiple sharp branches acting like "lightning rods" can co ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018
Detection of surface-enhanced Raman scattering (SERS) tagged nanoparticles in-vivo is critical for its potential application in cancer diagnostics, inflammation monitoring, and glucose quantification. However, traditional optical methods are typically limi ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017
The development of rapid, easy-to-use, cost-effective, high accuracy, and high sensitive DNA detection methods for molecular diagnostics has been receiving increasing interest. Over the last five years, our laboratory has developed several chip-based DNA d ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017
The development of sensitive and selective biosensing techniques is of great interest for clinical diagnostics. Here, we describe the development and application of a surface enhanced Raman scattering (SERS) sensing technology, referred to as "inverse Mole ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2017
Single cell analysis can aid the study of molecular events responsible for cellular functions and unveil their connections to the biological functions of an organism. Biosensors based on surface enhanced Raman spectroscopy (SERS) can be used to this end an ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2017
The development of rapid, easy-to-use and highly sensitive DNA detection methods has received increasing interest for medical diagnostics and research purposes. Our laboratory has developed several chip-based DNA biosensors including molecular sentinel-on- ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016
Demonstrated herein is a simple method for the induction of J-aggregate formation in a colloidal solution of gold nanoparticles through the use of pseudoisocyanine (PIC) and polyvinyl sulfate. The plasmon-exciton coupling of the nanoparticle J-aggregate co ...
Full textCite
ConferenceIfmbe Proceedings · January 1, 2015
The development of sensitive and selective techniques for multiplex detection of DNA biomarkers is paramount for clinical diagnosis. Various multiplex DNA detection techniques have been reported. However, most of these techniques require multiple incubatio ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2015
Surface-enhanced Raman scattering (SERS) provides a non-destructive sensing method with high sensitivity and multiplex detection capability since SERS takes advantage of high enhancement from surface plasmon resonance and unique â€fingerprint†spectral si ...
Full textCite
ConferenceOptics Infobase Conference Papers · January 1, 2007
A ratio-metric method was proposed to extract intrinsic fluorescence from synchronous fluorescence spectra distorted by absorption and scattering. Its applicable range was investigated using Monte Carlo simulations and the accuracy was tested with phantom ...
Full textCite
Conference2003 International Semiconductor Device Research Symposium Isdrs 2003 Proceedings · January 1, 2003
There is an increasing need to develop rapid, simple, cost-effective sensor devices for screening multiple pathogens for homeland defense applications. With its multifunctional capability, the multifunctional biochip (MFB) is a unique system that allows si ...
Full textCite
ConferenceJournal of Analytical and Applied Pyrolysis · January 1, 2003
Laser-induced fluorescence (LIF) spectroscopy can serve as a rapid analytical method for the quantitative analysis of polycyclic aromatic hydrocarbons (PAHs). The high quantum yields of this class of compounds, along with large absorption cross-sections, m ...
Full textCite
ConferenceOptics Infobase Conference Papers · January 1, 1998
Recently, extensive efforts have been devoted to investigating new generations of data storage devices based on nonmagnetic principles, such as optical data storage systems. Optical data storage systems can provide a unique combination of superior performa ...
Cite
ConferenceProceedings of SPIE the International Society for Optical Engineering · November 13, 1996
This paper describes the development of a multispectral imaging (MSI) device using AN acousto-optic tunable filter (AOTF). A two-dimensional charge-coupled device (CCD) was used as a detector. The AOTF was used as a wavelength selector. Unlike a tunable gr ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · April 12, 1995
Laserinduced fluorescence (LIF) was used for direct in-viva cancer diagnosis of the esophagus without requiring biopsy. The methodology was applied to differentiate normal and malignant tumors of the esophagus. Endogenous fluorescence of normal and maligna ...
Full textCite
ConferenceProceedings of SPIE the International Society for Optical Engineering · July 19, 1994
Laser-induced fluorescence spectroscopy was employed to measure fluorescence emission of normal and malignant tissue during endoscopy in patients with esophageal adenocarcinoma. A nitrogen/dye laser tuned at 410 nm was used for excitation source. The fluor ...
Full textCite
ConferenceASTM Special Technical Publication · January 1, 1990
This paper provides an overview of the photophysical processes and analytical applications of high-resolution luminescence spectroscopy using solid samples. Experimental results are discussed within the framework of a theoretical model involving isolated g ...
Full textCite
