Scholars@Duke
Debara Lyn Tucci

Debara Lyn Tucci

Professor Emeritus of Head and Neck Surgery & Communication Sciences
Head and Neck Surgery & Communication Sciences
tucci001@mc.duke.edu
Box 3805 Med Ctr, Durham, NC 27710
1559 Hosp South, Blue Zone, Durham, NC 27710

Scholarly Works - Journal articles

Routine Hearing Screening for Older Adults in Primary Care: Insights of Patients and Clinic Personnel.

Journal article Gerontologist · October 1, 2024 BACKGROUND AND OBJECTIVES: Hearing loss frequently goes undiagnosed and untreated, with serious sequelae. Hearing screening facilitates diagnosis and treatment but is not routinely conducted in primary care. This study addresses the attitudes and insights ... Full text Link to item Cite

Development of Measures for d/Deaf and Hard of Hearing Stigma: Introduction to the Special Supplement on Stigma Measurement Tools.

Journal article Ear Hear · September 2024 People who are d/Deaf or hard of hearing (d/DHH) often experience stigma and discrimination in their daily lives. Qualitative research describing their lived experiences has provided useful, in-depth insights into the pervasiveness of stigma. Quantitative ... Full text Open Access Link to item Cite

Towards universal access: A review of global efforts in ear and hearing care.

Journal article Hear Res · April 2024 Hearing loss affects 1.6 billion people worldwide and disproportionately affects those in low- and middle-income countries. Despite being largely preventable or treatable, ear and hearing conditions result in significant and lifelong morbidity such as dela ... Full text Link to item Cite

Newborn and infant hearing screening for early detection of hearing loss in Nairobi, Kenya.

Journal article Afr Health Sci · March 2024 BACKGROUND: Early detection of hearing loss and subsequent intervention leads to better speech, language and educational outcomes giving way to improved social economic prospects in adult life. This can be achieved through establishing newborn and infant h ... Full text Link to item Cite

Priorities for hearing loss prevention and estimates of global cause-specific burdens of hearing loss: a systematic rapid review.

Journal article Lancet Glob Health · February 2024 BACKGROUND: Hearing loss affects approximately 1·6 billion individuals worldwide. Many cases are preventable. We aimed to estimate the annual number of new hearing loss cases that could be attributed to meningitis, otitis media, congenital rubella syndrome ... Full text Link to item Cite

The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research.

Journal article Nat Med · February 2024 The All of Us Research Program has prioritized the enrollment of people from backgrounds historically underrepresented in medical research to bring precision medicine to the full diversity of the US population and to improve health outcomes for all. ... Full text Link to item Cite

A Pragmatic Clinical Trial of Hearing Screening in Primary Care Clinics: Effect of Setting and Provider Encouragement.

Journal article Ear Hear · January 2024 OBJECTIVES: The prevalence of hearing loss increases with age. Untreated hearing loss is associated with poorer communication abilities and negative health consequences, such as increased risk of dementia, increased odds of falling, and depression. Nonethe ... Full text Open Access Link to item Cite

NIDCD's 5-Year Strategic Plan Describes Scientific Priorities and Commitment to Basic Science.

Journal article J Assoc Res Otolaryngol · June 2023 The National Institute on Deafness and Other Communication Disorders (NIDCD) recently issued a new strategic plan that describes the institute's scientific priorities over the next five years. Developed in collaboration with informed stakeholders, the 2023 ... Full text Link to item Cite

Over-the-counter Hearing Aids-Reply.

Journal article JAMA · April 11, 2023 Full text Link to item Cite

The Impact of Hearing Loss and Its Treatment on Health-Related Quality of Life Utility: a Systematic Review with Meta-analysis.

Journal article J Gen Intern Med · February 2023 BACKGROUND: Hearing loss significantly impacts health-related quality of life (QoL), yet the effects of current treatments on QoL utility remain uncertain. Our objective was to describe the impact of untreated and treated hearing loss on QoL utility to inf ... Full text Link to item Cite

Validation of the Decision model of the Burden of Hearing loss Across the Lifespan (DeciBHAL) in Chile, India, and Nigeria.

Journal article EClinicalMedicine · August 2022 BACKGROUND: There is no published decision model for informing hearing health care resource allocation across the lifespan in low- and middle-income countries. We sought to validate the Decision model of the Burden of Hearing loss Across the Lifespan Inter ... Full text Link to item Cite

A pragmatic clinical trial of hearing screening in primary care clinics: cost-effectiveness of hearing screening.

Journal article Cost Eff Resour Alloc · June 25, 2022 BACKGROUND: Hearing loss is a high prevalence condition among older adults, is associated with higher-than-average risk for poor health outcomes and quality of life, and is a public health concern to individuals, families, communities, professionals, gover ... Full text Link to item Cite

Harnessing the Power of Artificial Intelligence in Otolaryngology and the Communication Sciences.

Journal article J Assoc Res Otolaryngol · June 2022 Use of artificial intelligence (AI) is a burgeoning field in otolaryngology and the communication sciences. A virtual symposium on the topic was convened from Duke University on October 26, 2020, and was attended by more than 170 participants worldwide. Th ... Full text Link to item Cite

Development and validation of DeciBHAL-US: A novel microsimulation model of hearing loss across the lifespan in the United States.

Journal article EClinicalMedicine · February 2022 BACKGROUND: Hearing loss affects over 50% of people in the US across their lifespan and there is a lack of decision modeling frameworks to inform optimal hearing healthcare delivery. Our objective was to develop and validate a microsimulation model of hear ... Full text Link to item Cite

Evidence gaps in economic analyses of hearing healthcare: A systematic review.

Journal article EClinicalMedicine · May 2021 BACKGROUND: Hearing loss is a common and costly medical condition. This systematic review sought to identify evidence gaps in published model-based economic analyses addressing hearing loss to inform model development for an ongoing Lancet Commission. METH ... Full text Link to item Cite

Inclusive Excellence-Raising the Standards for Consensus Statements.

Journal article JAMA Otolaryngol Head Neck Surg · March 1, 2021 Full text Link to item Cite

AutoAudio: Deep Learning for Automatic Audiogram Interpretation.

Journal article J Med Syst · August 7, 2020 Hearing loss is the leading human sensory system loss, and one of the leading causes for years lived with disability with significant effects on quality of life, social isolation, and overall health. Coupled with a forecast of increased hearing loss burden ... Full text Link to item Cite

Comparative implementation-effectiveness of three strategies to perform hearing screening among older adults in primary care clinics: study design and protocol.

Journal article BMC Geriatr · May 11, 2020 BACKGROUND: The burden of hearing loss among older adults could be mitigated with appropriate care. This study compares implementation of three hearing screening strategies in primary care, and examines the reliability and validity of patient self-assessme ... Full text Link to item Cite

Research Drives More Accessible, Affordable Hearing Care

Journal article Hearing Journal · May 1, 2020 Full text Cite

Integrative medicine for significant dysfunction from tinnitus: Treatment rationale and protocol for a randomized clinical pilot trial

Journal article Advances in Integrative Medicine · March 1, 2020 Objectives: Following the British Medical Research Council recommendations for pilot trials, this study aims to increase experience with a complex integrative medicine (IM) intervention in a randomized controlled design to assess the feasibility for studyi ... Full text Cite

Sound comparison of seven TMS coils at matched stimulation strength.

Journal article Brain Stimul · 2020 BACKGROUND: Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS: We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced e ... Full text Link to item Cite

Contributions of Contemporary Human Temporal Bone Histopathology to Clinical Otology.

Journal article Otolaryngol Head Neck Surg · November 2019 Contemporary techniques have greatly enhanced the contributions of human temporal bone (HTB) histopathology to our understanding of the mechanisms of human otologic disease and disease treatment. Herein, we review some of the most salient contributions of ... Full text Link to item Cite

Expanding Access: Cost-effectiveness of Cochlear Implantation and Deaf Education in Asia.

Journal article Otolaryngol Head Neck Surg · October 2019 OBJECTIVE: To determine the cost-effectiveness of cochlear implantation (CI) with mainstream education and deaf education with sign language for treatment of children with profound sensorineural hearing loss in low- and lower-middle income countries in Asi ... Full text Link to item Cite

Clinical Consensus Statement: Balloon Dilation of the Eustachian Tube.

Journal article Otolaryngol Head Neck Surg · July 2019 OBJECTIVE: To develop a clinical consensus statement on the use of balloon dilation of the eustachian tube (BDET). METHODS: An expert panel of otolaryngologists was assembled with nominated representatives of general otolaryngology and relevant subspecialt ... Full text Link to item Cite

Hearing loss and psychiatric disorders: a review.

Journal article Psychol Med · April 2019 Hearing loss is one of the most common yet unrecognized impairments experienced by adults, especially as they age. Mental health investigators and practitioners require better understanding of hearing loss, its association with psychiatric disorders, and t ... Full text Link to item Cite

Communication and Healthcare: Self-Reports of People with Hearing Loss in Primary Care Settings.

Journal article Clin Gerontol · 2019 Objectives: To assess the experiences of people with hearing loss in healthcare environments to characterize miscommunication and unmet needs, and guide recommendations for improving outcomes and access. Methods: Anonymous survey developed by subject-matte ... Full text Link to item Cite

Geographic and Racial Disparities in Infant Hearing Loss.

Journal article Otolaryngol Head Neck Surg · December 2018 OBJECTIVE: Approximately 1 to 2 of every 1000 American newborns has hearing loss identified by newborn screening. This study was designed to determine if infant hearing loss is more common in socioeconomically disadvantaged communities. STUDY DESIGN: In th ... Full text Open Access Link to item Cite

Steroid Use for Sudden Sensorineural Hearing Loss: A CHEER Network Study.

Journal article Otolaryngol Head Neck Surg · November 2018 OBJECTIVE: The objective of this study was to describe patterns of corticosteroid treatment for sudden sensorineural hearing loss and to evaluate effectiveness based on delivery mode (oral vs intratympanic vs both). STUDY DESIGN: Cross-sectional repeated m ... Full text Link to item Cite

Patterns of Migraine Disease in Otolaryngology: A CHEER Network Study.

Journal article Otolaryngol Head Neck Surg · July 2018 Objective To evaluate the prevalence of migraine disease in an otolaryngologic cohort and migraine-related otologic and sinonasal symptoms in this population. Study Design Cross-sectional study utilizing the CHEER (Creating Healthcare Excellence through Ed ... Full text Link to item Cite

Hearing loss on social media: Who is winning hearts and minds?

Journal article Laryngoscope · June 2018 OBJECTIVES/HYPOTHESIS: To analyze specific patterns of Twitter usage using common references to hearing loss, and characterize the virtual public that comprises the hearing loss community to inform hearing loss stakeholders for opportunities for engagement ... Full text Link to item Cite

Global Hearing Loss Prevention.

Journal article Otolaryngol Clin North Am · June 2018 Hearing loss is the fourth leading contributor to years lived with a disability worldwide. Most recent estimates indicate that one-half of a billion people suffer from disabling hearing loss worldwide. The social and economic burden is significant. When at ... Full text Link to item Cite

Hearing Loss in Adults.

Journal article N Engl J Med · December 21, 2017 Full text Link to item Cite

Global hearing health care: new findings and perspectives.

Journal article Lancet · December 2, 2017 In 2015, approximately half a billion people had disabling hearing loss, about 6·8% of the world's population. These numbers are substantially higher than estimates published before 2013, and point to the growing importance of hearing loss and global heari ... Full text Link to item Cite

The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation.

Journal article J Otol · September 2017 OBJECTIVES: Recent studies have introduced middle ear volume (MEV) as a novel determinant of perforation-induced conductive hearing loss (CHL) in a mechanism driven by trans-tympanic membrane pressure differences. The primary aims of this preliminary repor ... Full text Link to item Cite

Emerging Therapies for Sensorineural Hearing Loss.

Journal article Otol Neurotol · July 2017 OBJECTIVE: To critically review and evaluate the proposed mechanisms and documented results of the therapeutics currently in active clinical drug trials for the treatment of sensorineural hearing loss. DATA SOURCES: US National Institutes of Health (NIH) C ... Full text Link to item Cite

Disagreement in middle ear volume estimation between tympanometry and three-dimensional volume reconstruction in the context of tympanic membrane perforation.

Journal article J Otol · June 2017 INTRODUCTION: Middle ear volume (MEV) is a clinically relevant parameter across middle ear diseases. MEV values between these techniques have never before been tested for agreement in ears with perforated tympanic membranes (TMs). METHODS: Middle ears were ... Full text Link to item Cite

Nonadherence to Guideline Recommendations for Tympanostomy Tube Insertion in Children Based on Mega-database Claims Analysis.

Journal article Otolaryngol Head Neck Surg · January 2017 Objective To estimate the nonadherence rate of pressure equalization (tympanostomy) tube (PET) placement in the preceding 3-year period before release of the 2013 American Academy of Otolaryngology-Head and Neck Surgery Foundation clinical practice guideli ... Full text Link to item Cite

Provincial Variation of Cochlear Implantation Surgical Volumes and Cost in Canada.

Journal article Otolaryngol Head Neck Surg · January 2017 Objectives To investigate provincial cochlear implantation (CI) annual volume and cost trends. Study Design Database analysis. Setting National surgical volume and cost database. Subjects and Methods Aggregate-level provincial CI volumes and cost data for ... Full text Link to item Cite

Knowledge and care seeking practices for ear infections among parents of under five children in Kigali, Rwanda: a cross-sectional study.

Journal article BMC Ear Nose Throat Disord · 2017 BACKGROUND: Infections affecting the middle ear are a common childhood occurrence. Some cases may present with ear discharge through a tympanic membrane perforation which may heal spontaneously. However, up to 5% or more cases of those affected have persis ... Full text Link to item Cite

Quality of Life and Cost-Effectiveness of Cochlear Implants: A Narrative Review.

Journal article Audiol Neurootol · 2017 OBJECTIVES: To review evidence regarding the health-related quality of life (HRQoL) and cost-effectiveness of unilateral and bilateral cochlear implantation (CI) among children and adults with severe-to-profound hearing loss. STUDY DESIGN: Narrative review ... Full text Link to item Cite

Prevalence of Middle Ear Infections and Associated Risk Factors in Children under 5 Years in Gasabo District of Kigali City, Rwanda.

Journal article Int J Pediatr · 2017 Middle ear infections are common in children, and delay in diagnosis and treatment may result in complications such as delays in speech and language development and deafness. The aim of this study was to determine the prevalence and care seeking behaviour ... Full text Link to item Cite

Access to Health Care and Hearing Evaluation in US Adults.

Journal article Ann Otol Rhinol Laryngol · September 2016 OBJECTIVES: To explore self-reported hearing testing access for adults in a nationally representative survey. METHODS: Demographic and audiologic adult survey respondent variables in the National Health and Nutrition Examination Survey (NHANES) database 20 ... Full text Link to item Cite

National Utilization and Forecasting of Ototopical Antibiotics: Medicaid Data Versus "Dr. Google".

Journal article Otol Neurotol · September 2016 OBJECTIVES: To forecast national Medicaid prescription volumes for common ototopical antibiotics, and correlate prescription volumes with internet user search interest using Google Trends (GT). STUDY DESIGN: National United States Medicaid prescription and ... Full text Link to item Cite

Moving Beyond GDP: Cost Effectiveness of Cochlear Implantation and Deaf Education in Latin America.

Journal article Otol Neurotol · September 2016 HYPOTHESIS: Cochlear implantation (CI) and deaf education are cost effective management strategies of childhood profound sensorineural hearing loss in Latin America. BACKGROUND: CI has been widely established as cost effective in North America and Europe a ... Full text Link to item Cite

Variation in the Use of Vestibular Diagnostic Testing for Patients Presenting to Otolaryngology Clinics with Dizziness.

Journal article Otolaryngol Head Neck Surg · July 2016 OBJECTIVE: We used a national otolaryngology practice-based research network database to characterize the utilization of vestibular function testing in patients diagnosed with dizziness and/or a vestibular disorder. STUDY DESIGN: Database review. SETTING: ... Full text Link to item Cite

Evaluation of Compliance for Treatment of Sudden Hearing Loss: A CHEER Network Study.

Journal article Otolaryngol Head Neck Surg · July 2016 OBJECTIVE: The objective of this study is to describe the presentation and management of sudden sensorineural hearing loss for patients seen in academic and community-based practices within the context of the American Academy of Otolaryngology-Head and Nec ... Full text Link to item Cite

A Systematic Review of Diuretics in the Medical Management of Ménière's Disease.

Journal article Otolaryngol Head Neck Surg · May 2016 OBJECTIVE: (1) Review evidence for the use of oral diuretic medications in the management of Ménière's disease. (2) Analyze therapy-related hearing and vertigo outcomes. DATA SOURCES: Literature was obtained through directed searches of MEDLINE, EMBASE, We ... Full text Link to item Cite

Mini Review of the Cost-Effectiveness of Unilateral Osseointegrated Implants in Adults: Possibly Cost-Effective for the Correct Indication.

Journal article Audiol Neurootol · 2016 An osseointegrated implant (e.g. bone-anchored hearing aid, BAHA) is a surgically implantable device for unilateral sensorineural and unilateral or bilateral conductive hearing loss in patients who otherwise cannot use or do not prefer a conventional air c ... Full text Link to item Cite

Access to and Uptake of Cochlear Implantation Among Children in North Carolina.

Journal article N C Med J · 2016 BACKGROUND: Cochlear implantation (CI) is a highly effective intervention for children with advanced hearing loss who cannot benefit from amplification. Despite the established benefits of CI, it is likely that not all children who are potential candidates ... Full text Link to item Cite

Cost Effectiveness of Childhood Cochlear Implantation and Deaf Education in Nicaragua: A Disability Adjusted Life Year Model.

Journal article Otol Neurotol · September 2015 INTRODUCTION: Cochlear implantation (CI) is a common intervention for severe-to-profound hearing loss in high-income countries, but is not commonly available to children in low resource environments. Owing in part to the device costs, CI has been assumed t ... Full text Link to item Cite

GDP Matters: Cost Effectiveness of Cochlear Implantation and Deaf Education in Sub-Saharan Africa.

Journal article Otol Neurotol · September 2015 HYPOTHESIS: Cochlear implantation and deaf education are cost effective in Sub-Saharan Africa. BACKGROUND: Cost effectiveness of pediatric cochlear implantation has been well established in developed countries but is unknown in low resource settings, where ... Full text Link to item Cite

Complementary Therapies for Significant Dysfunction from Tinnitus: Treatment Review and Potential for Integrative Medicine.

Journal article Evid Based Complement Alternat Med · 2015 Tinnitus is a prevalent and costly chronic condition; no universally effective treatment exists. Only 20% of patients who report tinnitus actually seek treatment, and when treated, most patients commonly receive sound-based and educational (SBE) therapy. A ... Full text Link to item Cite

Hospital Anxiety and Depression Scale: Factor Structure, Internal Consistency and Convergent Validity in Patients with Dizziness.

Journal article Audiol Neurootol · 2015 Psychiatric comorbidities, particularly anxiety-related pathologies, are often observed in dizzy patients. The Hospital Anxiety and Depression Scale (HADS) is a widely used self-report instrument used to screen for anxiety and depression in medical outpati ... Full text Link to item Cite

Provider and patient drivers of ototopical antibiotic prescription variability.

Journal article Am J Otolaryngol · 2015 OBJECTIVE: To determine if providers prescribe more affordable topical antibacterial therapy for patients who are economically disadvantaged or come from economically disadvantaged communities. STUDY DESIGN: Prescription drug database review. SETTING: Larg ... Full text Link to item Cite

Surgical Training and Education in Promoting Professionalism: a comparative assessment of virtue-based leadership development in otolaryngology-head and neck surgery residents.

Journal article Med Educ Online · October 29, 2013 INTRODUCTION: Surgical Training and Education in Promoting Professionalism (STEPP) was developed in 2011 to train tomorrow's leaders during residency. It is based on virtue ethics and takes an approach similar to West Point military academy. The purpose of ... Full text Link to item Cite

A randomized, double-blind, placebo-controlled clinical study to assess safety and clinical activity of OTO-104 given as a single intratympanic injection in patients with unilateral Ménière's disease.

Journal article Otol Neurotol · September 2012 OBJECTIVE: To evaluate the safety, tolerability, and clinical activity of a single intratympanic injection of OTO-104, sustained-release dexamethasone formulation, in patients with unilateral Ménière's disease. STUDY DESIGN: Prospective, double-blind, rand ... Full text Link to item Cite

Management of hearing in pediatric NF2.

Journal article Otol Neurotol · August 2012 OBJECTIVE: This study will demonstrate an individualized approach to hearing preservation and tumor management in pediatric patients with neurofibromatosis type 2 (NF2). The unique nature of each case discussed will provide valuable guiding principles for ... Full text Link to item Cite

Evaluation of the patient with recurrent vertigo.

Journal article Arch Otolaryngol Head Neck Surg · June 2012 The evaluation of the patient with recurrent vertigo requires knowledge of vestibular anatomy and physiology. The patient's medical history and physical examination provide the majority of the information necessary for diagnosis. Many diagnostic tests are ... Full text Link to item Cite

Clinical practice guideline: sudden hearing loss.

Journal article Otolaryngol Head Neck Surg · March 2012 OBJECTIVE: Sudden hearing loss (SHL) is a frightening symptom that often prompts an urgent or emergent visit to a physician. This guideline provides evidence-based recommendations for the diagnosis, management, and follow-up of patients who present with SH ... Full text Link to item Cite

The Otology Data Collection project: report from the CHEER network.

Journal article Otolaryngol Head Neck Surg · October 2011 OBJECTIVE: To describe and communicate data collected in the CHEER (Creating Healthcare Excellence through Education and Research) infrastructure proof-of-concept study to facilitate understanding of the potential capabilities of practice-based research ne ... Full text Link to item Cite

Implementation and testing of research infrastructure for practice-based research in hearing and communication disorders.

Journal article Otolaryngol Head Neck Surg · October 2011 OBJECTIVE: To describe site capability and experience of the CHEER network (Creating Healthcare Excellence through Education and Research) to rapidly collect descriptive data on patients with tinnitus and dizziness visiting participating CHEER sites. STUDY ... Full text Link to item Cite

Cochlear implants matching the prosthesis to the brain and facilitating desired plastic changes in brain function.

Journal article Prog Brain Res · 2011 The cochlear implant (CI) is one of the great success stories of modern medicine. A high level of function is provided for most patients. However, some patients still do not achieve excellent or even good results using the present-day devices. Accumulating ... Full text Link to item Cite

Roaring in the ears: patulous Eustachian tube in bulbar amyotrophic lateral sclerosis.

Journal article Amyotroph Lateral Scler · August 2010 We report a 64-year-old female with predominantly bulbar amyotrophic lateral sclerosis who experienced 'roaring' in her ears. She was diagnosed with patulous Eustachian tube, which is presumed to occur secondary to bulbar weakness. The roaring adversely af ... Full text Link to item Cite

Bevacizumab fails to treat temporal paraganglioma: discussion and case illustration.

Journal article J Neurooncol · July 2010 Temporal paragangliomas are highly vascular tumors treated primarily by surgical resection. However, surgery to remove these tumors is associated with significant morbidity, including cranial nerve dysfunction. Interestingly, these tumors have been shown t ... Full text Link to item Cite

Building a national research network for clinical investigations in otology and neurotology.

Journal article Otol Neurotol · February 2010 BACKGROUND: Practice-based research networks (PBRNs) are the preferred research setting for descriptive/epidemiologic studies and studies that explore the effectiveness of treatments for disease that are managed in community settings, away from the rubric ... Full text Link to item Cite

A summary of the literature on global hearing impairment: current status and priorities for action.

Journal article Otol Neurotol · January 2010 BACKGROUND: Hearing loss (HL) and deafness are global issues that affect at least 278 million people worldwide. Two thirds of the people who have HL worldwide live in developing countries. Importantly, it is estimated that 50% of this HL can be prevented. ... Full text Link to item Cite

Ventral cochlear nucleus responses to contralateral sound are mediated by commissural and olivocochlear pathways.

Journal article J Neurophysiol · August 2009 In the normal guinea pig, contralateral sound inhibits more than a third of ventral cochlear nucleus (VCN) neurons but excites <4% of these neurons. However, unilateral conductive hearing loss (CHL) and cochlear ablation (CA) result in a major enhancement ... Full text Link to item Cite

Paraganglioma of the head and neck: long-term local control with radiotherapy.

Journal article Am J Clin Oncol · June 2009 OBJECTIVES: Paragangliomas are rare neuroendocrine neoplasms of the head and neck. Treatment strategies include resection, definitive external beam radiation therapy (EBRT), stereotactic radiosurgery (SRS), or observation alone. Due to their rarity and ind ... Full text Link to item Cite

Reversible conductive hearing loss: restored activity in the central auditory system.

Journal article Audiol Neurootol · 2009 The effect of a reversible, unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied using young gerbils. All animals had a unilateral conductive hearing loss (CHL), induced by atresia, on postnatal day 21 (P21). O ... Full text Link to item Cite

Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation.

Journal article Hear Res · March 2008 The effect of unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied in postnatal day 21 gerbils. Three weeks following a unilateral conductive hearing loss (CHL) or cochlear ablation (CA), animals were injected ... Full text Link to item Cite

Consequences of unilateral hearing loss: time dependent regulation of protein synthesis in auditory brainstem nuclei.

Journal article Hear Res · November 2007 Conductive hearing impairment results in marked changes in neuronal activity in the central auditory system, particularly in young animals [Tucci, D.L., Cant, N.B., Durham, D., 1999. Conductive hearing loss results in a decrease in central auditory system ... Full text Link to item Cite

Treatment of tinnitus with gabapentin: a pilot study.

Journal article Otol Neurotol · January 2007 OBJECTIVE: To evaluate the effectiveness of gabapentin (Neurontin) improve the disease-specific quality of life in patients with moderate tinnitus. STUDY DESIGN: Randomized, double blind, placebo-controlled clinical trial. SETTING: Single-center academic o ... Full text Link to item Cite

Meniett clinical trial: long-term follow-up.

Journal article Arch Otolaryngol Head Neck Surg · December 2006 OBJECTIVE: To delineate 2-year efficacy of Meniett device therapy in people with classic, unilateral, Ménière's disease unresponsive to traditional medical treatment. DESIGN: A 2-year long-term unblinded follow-up after a prior randomized, placebo-controll ... Full text Link to item Cite

Responses of ventral cochlear nucleus neurons to contralateral sound after conductive hearing loss.

Journal article J Neurophysiol · December 2005 Conductive hearing loss (CHL) is an attenuation of signals stimulating the cochlea, without damage to the auditory end organ. It can cause central auditory processing deficits that outlast the CHL itself. Measures of oxidative metabolism show a decrease in ... Full text Link to item Cite

The effects of transtympanic micropressure treatment in people with unilateral Meniere's disease.

Journal article Arch Otolaryngol Head Neck Surg · June 2004 OBJECTIVE: To evaluate the efficacy of a portable low-intensity alternating pressure generator, the Meniett device, in controlling the symptoms of Ménière's disease. DESIGN: A randomized, placebo-controlled, double-blind, multicenter clinical trial of 4 mo ... Full text Link to item Cite

Intracanalicular meningioma mimicking vestibular schwannoma.

Journal article AJNR Am J Neuroradiol · October 2002 Featured Publication Three cases of intracanalicular meningioma mimicking vestibular schwannoma are presented. In each case, a contrast-enhancing mass filling the internal auditory canal was identified on MR images and was originally diagnosed as a vestibular schwannoma. Altho ... Link to item Cite

Treatment of sudden sensorineural hearing loss with systemic steroids and valacyclovir.

Journal article Otol Neurotol · May 2002 Featured Publication OBJECTIVE: To determine if the addition of an antiviral medication to systemic steroids improves recovery in the treatment of idiopathic sudden sensorineural hearing loss. STUDY DESIGN: Randomized, double-blind, placebo-controlled prospective multicenter c ... Full text Link to item Cite

Treatment of an iatrogenic petrous carotid artery pseudoaneurysm with a Symbiot covered stent: technical case report.

Journal article Neurosurgery · March 2002 Featured Publication OBJECTIVE AND IMPORTANCE: Surgery involving the middle ear or the temporal bone may cause an injury to the petrous carotid artery resulting in a pseudoaneurysm. Conventional treatment of such pseudoaneurysms has ranged from carotid occlusion to conservativ ... Full text Link to item Cite

Conductive hearing loss results in changes in cytochrome oxidase activity in gerbil central auditory system.

Journal article J Assoc Res Otolaryngol · March 2002 Conductive hearing loss (CHL) restricts auditory input to an intact peripheral auditory system. Effects of deprivation on the central auditory system (CAS) have been debated, although a number of studies support the hypothesis that CHL can cause modificati ... Full text Link to item Cite

Effects of conductive hearing loss on auditory nerve activity in gerbil.

Journal article Hear Res · February 2002 Featured Publication The goal of this research was to define the effects of conductive hearing loss (CHL) produced by malleus removal (MR) on auditory nerve activity in the absence of acoustic stimulation. Subjects were gerbils in two age groups: 21 days (P21) and 42 days (P42 ... Full text Link to item Cite

Effects of conductive hearing loss on gerbil central auditory system activity in silence.

Journal article Hear Res · May 2001 Featured Publication Animal models of conductive hearing loss (CHL) show altered structure and function in the central auditory system (CAS), particularly following unilateral deprivation. Assessment of neuronal activity as measured by 2-deoxyglucose (2-DG) uptake following CH ... Full text Link to item Cite

Sudden sensorineural hearing loss: a viral etiology?

Journal article Arch Otolaryngol Head Neck Surg · September 2000 Featured Publication Full text Link to item Cite

Conductive hearing loss results in a decrease in central auditory system activity in the young gerbil.

Journal article Laryngoscope · September 1999 OBJECTIVES/HYPOTHESIS: The impact of childhood conductive HL (CHL) on development of auditory function has long been debated. The present study was conducted to define and compare the consequences of CHL and cochlear ablation (CA) in young and adult animal ... Full text Link to item Cite

Vestibular rehabilitation strategies in Meniere's disease.

Journal article Otolaryngol Clin North Am · December 1997 Once the episodic spells of vertigo associated with Meniere's disease have abated, vestibular rehabilitation exercises play an important role in promoting adaptation to the decreased vestibular input. Outlines of different treatment approaches for three ty ... Link to item Cite

Cochlear implant studies at Research Triangle Institute and Duke University Medical Center.

Journal article Scand Audiol Suppl · 1997 Examples from several areas of cochlear implant research are presented, with emphasis on the continuous interleaved sampling (CIS) approach to speech processor design. Within-subject comparisons of such processors with the compressed analog (CA) approach o ... Link to item Cite

Evaluation of MRI compatibility of the modified nucleus multichannel auditory brainstem and cochlear implants.

Journal article Am J Otol · September 1996 Magnetic resonance imaging (MRI) has been contraindicated for users of cochlear implants because of the internal magnet and other possible interactions. Users of the Nucleus Mini-22 Cochlear Implant (CI) or the experimental Multichannel Auditory Brainstem ... Link to item Cite

Cochlear implantation in patients with cochlear malformations.

Journal article Arch Otolaryngol Head Neck Surg · August 1995 OBJECTIVE: To report operative findings, postoperative course, and postimplantation performance in patients with cochlear malformations who underwent cochlear implantation. DESIGN: Case study and intervention study (before-after trial). Minimum follow-up o ... Full text Link to item Cite

Stability of hearing preservation following acoustic neuroma surgery.

Journal article Am J Otol · March 1994 Identification of small acoustic neuromas has become commonplace. Frequently, affected individuals are identified prior to the development of significant hearing loss. Whereas many studies have focused on hearing preservation surgery, few have reported on ... Link to item Cite

The cochlear nuclear complex: MR location and abnormalities.

Journal article AJNR Am J Neuroradiol · 1993 PURPOSE: To determine the usefulness of MR imaging in locating known structural landmarks of the cochlear nuclear complex (CNC), and to determine the frequency of CNC abnormalities, based on these landmarks, in patients referred for MR evaluation of unilat ... Link to item Cite

Primary lymphoma of the temporal bone.

Journal article Arch Otolaryngol Head Neck Surg · January 1992 Involvement of the temporal bone by lymphoreticular neoplasm is rare; all reported cases have been of secondary involvement. This article presents what we believe to be the first two reported cases of primary temporal bone lymphoma. The patients, an elderl ... Full text Link to item Cite

Anatomical correlates of functional recovery in the avian inner ear following aminoglycoside ototoxicity.

Journal article Laryngoscope · November 1991 Tucci and Rubel have demonstrated functional recovery of the chick cochlea following aminoglycoside ototoxicity. The cochleae of these same animals were examined by scanning electron microscopy (SEM) in order to further understand this recovery process. Ha ... Full text Link to item Cite

Physiologic status of regenerated hair cells in the avian inner ear following aminoglycoside ototoxicity.

Journal article Otolaryngol Head Neck Surg · September 1990 Regeneration of avian inner ear hair cells has been demonstrated after administration of aminoglycoside and after acoustic trauma. However, no published study to date has documented functional recovery of these regenerated sensory receptor cells. Newborn c ... Full text Link to item Cite

Trends in rehabilitation after cochlear implantation.

Journal article Arch Otolaryngol Head Neck Surg · May 1990 Although postimplant rehabilitation is generally considered to be an important aspect of a cochlear implant program, the literature reports widely varying practices in the implementation of such programs. The National Institutes of Health consensus stateme ... Full text Link to item Cite

Use of the bone conduction ABR Wave I response in determination of cochlear reserve.

Journal article Am J Otol · March 1990 Interest in bone-conducted stimulus auditory brainstem response (BC-ABR) testing has centered around evaluation of cochlear integrity in neonates and in patients who are difficult to evaluate audiometrically. The present study was designed to evaluate the ... Link to item Cite

Coherence analysis of scalp responses to amplitude-modulated tones.

Journal article Acta Otolaryngol · 1990 Magnitude squared coherence is a method of auditory evoked potential (AEP) frequency-domain analysis, measuring the degree to which the AEP is determined by the stimulus as a function of frequency. In 10 normal-hearing human subjects, scalp responses to an ... Full text Link to item Cite

Changes in spontaneous activity and CNS morphology associated with conductive and sensorineural hearing loss in chickens.

Journal article Ann Otol Rhinol Laryngol · 1987 The effects of a conductive or mixed (conductive and sensorineural) hearing loss on anatomical and physiological properties of the chicken auditory system were examined. Animals used in the anatomical studies underwent either a columella (ossicle) removal, ... Full text Link to item Cite

Afferent influences on brain stem auditory nuclei of the chicken: effects of conductive and sensorineural hearing loss on n. magnocellularis.

Journal article J Comp Neurol · August 22, 1985 Nucleus magnocellularis is the avian homologue of the spherical cell region of the mammalian anteroventral cochlear nucleus. Its primary excitatory synaptic input is from large end bulbs of Held from the eighth nerve ganglion cells. We have examined the ef ... Full text Link to item Cite

Amphetamine effects on long term potentiation in dentate granule cells.

Journal article Pharmacol Biochem Behav · January 1983 Long term potentiation (LTP) has received considerable attention as a neurophysiological analog of memory. Amphetamine, as well as several other catecholamine agonists, can enhance behaviorally-assessed memory storage in a variety of training situations. T ... Full text Link to item Cite

Effects of ear canal pressure on threshold and growth of the acoustic reflex.

Journal article Ear Hear · 1982 Acoustic reflex (AR) threshold and growth were measured in one ear for each of 20 normal-hearing individuals as pressure in the ear canal was varied between +/- 120 mm of H2O. These same parameters were studied in 10 of the subjects after disruption of the ... Full text Link to item Cite