Scholars@Duke
Tzu-chieh Liao

Scholarly Works - Journal articles

Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi.

Journal article Proc Natl Acad Sci U S A · January 7, 2025 Invasive fungal infections are a leading cause of death worldwide. Translating molecular insights into clinical benefits is challenging because fungal pathogens and their hosts share similar eukaryotic physiology. Consequently, current antifungal treatment ... Full text Link to item Cite

Integrin α3 promotes TH17 cell polarization and extravasation during autoimmune neuroinflammation.

Journal article Sci Immunol · October 20, 2023 Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) caused by CNS-infiltrating leukocytes, including TH17 cells that are critical mediators of disease pathogenesis. Although targeting leukocyte trafficking is effective in t ... Full text Link to item Cite

Mucosal plasma cells are required to protect the upper airway and brain from infection.

Journal article Immunity · November 8, 2022 While blood antibodies mediate protective immunity in most organs, whether they protect nasal surfaces in the upper airway is unclear. Using multiple viral infection models in mice, we found that blood-borne antibodies could not defend the olfactory epithe ... Full text Link to item Cite

Granulocytic MDSC with Deficient CCR5 Alleviates Lipogenesis and Inflammation in Nonalcoholic Fatty Liver Disease.

Journal article International journal of molecular sciences · October 2022 C-C chemokine receptor type 5 (CCR5) positively contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a common metabolic liver disease associated with chronic inflammation. CCR5 signaling also facilitates the immunosuppressive activi ... Full text Cite

RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.

Journal article Proceedings of the National Academy of Sciences of the United States of America · May 2022 Null mutations of spliceosome components or cofactors are homozygous lethal in eukaryotes, but viable hypomorphic mutations provide an opportunity to understand the physiological impact of individual splicing proteins. We describe a viable missense allele ... Full text Cite

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.

Journal article The Journal of experimental medicine · April 2020 In a forward genetic screen of N-ethyl-N-nitrosourea (ENU)-induced mutant mice for aberrant immune function, we identified mice with a syndromic disorder marked by growth retardation, diabetes, premature death, and severe lymphoid and myeloid hypoplasia to ... Full text Open Access Cite

Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.

Journal article Molecular & cellular proteomics : MCP · January 2020 We previously reported that tumor inflammasomes play a key role in tumor control and act as favorable prognostic markers in nasopharyngeal carcinoma (NPC). Activated inflammasomes frequently form distinguishable specks and govern the cellular secretion of ... Full text Cite

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

Journal article Science (New York, N.Y.) · May 2019 Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb regio ... Full text Cite