Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Anesthesiology Residency, Anesthesiology, Technical University of Munich (Germany) 2011 - 2014
  • M.D., Charite Universitatsmedizin Berlin (Germany) 2004
• 

  Duke Appointment History

  • Medical Instructor in the Department of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2015 - 2017
• Research
• 

  Selected Grants

  • High resolution awake cortical recordings to analyze the role of spreading depolarizations during dynamic stroke evolution awarded by National Institutes of Health 2019 - 2021
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lan, B, Liu, W, Wang, Y-C, Shi, J, Li, Y, Xu, S, Sheng, H, Zhou, Q, Zou, J, Hoffmann, U, Yang, W, and Yao, J. "High-speed widefield photoacoustic microscopy of small-animal hemodynamics." Biomedical Optics Express 9, no. 10 (October 2018): 4689-4701.  Full Text
    • Oka, F, Hoffmann, U, Lee, JH, Shin, HK, Chung, DY, Yuzawa, I, Chen, S-P, Atalay, YB, Nozari, A, Hopson, KP, Qin, T, and Ayata, C. "Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 37, no. 5 (May 2017): 1829-1840.  Full Text
    • Hoffmann, U, Sheng, H, Ayata, C, and Warner, DS. "Anesthesia in Experimental Stroke Research." Translational Stroke Research 7, no. 5 (October 2016): 358-367. (Review)  Full Text
    • Sasaki, T, Hoffmann, U, Kobayashi, M, Sheng, H, Ennaceur, A, Lombard, FW, and Warner, DS. "Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats." Neurocritical care 25, no. 2 (October 2016): 293-305.  Full Text
    • Hoffmann, U, Grosse-Sundrup, M, Eikermann-Haerter, K, Zaremba, S, Ayata, C, Zhang, B, Ma, D, Isaacs, L, and Eikermann, M. "Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents." Anesthesiology 119, no. 2 (August 2013): 317-325.  Full Text
    • Hoffmann, U, Sukhotinsky, I, Eikermann-Haerter, K, and Ayata, C. "Glucose modulation of spreading depression susceptibility." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 33, no. 2 (February 2013): 191-195.  Full Text
    • Hoffmann, U, and Ayata, C. "Neurovascular coupling during spreading depolarizations." Acta Neurochirurgica. Supplement 115 (January 2013): 161-165.  Full Text
    • Hoffmann, U, Sukhotinsky, I, Atalay, YB, Eikermann-Haerter, K, and Ayata, C. "Increased glucose availability does not restore prolonged spreading depression durations in hypotensive rats without brain injury." Experimental neurology 238, no. 2 (December 2012): 130-132.  Full Text
    • Ma, D, Zhang, B, Hoffmann, U, Sundrup, MG, Eikermann, M, and Isaacs, L. "Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo." Angewandte Chemie (International Ed. in English) 51, no. 45 (November 2012): 11358-11362.  Full Text
    • Eikermann, M, Grosse-Sundrup, M, Zaremba, S, Henry, ME, Bittner, EA, Hoffmann, U, and Chamberlin, NL. "Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction." Anesthesiology 116, no. 1 (January 2012): 35-46.  Full Text
    • Eikermann, M, Vetrivelan, R, Grosse-Sundrup, M, Henry, ME, Hoffmann, U, Yokota, S, Saper, CB, and Chamberlin, NL. "The ventrolateral preoptic nucleus is not required for isoflurane general anesthesia." Brain Research 1426 (December 2011): 30-37.  Full Text
    • Hoffmann, U, Lee, JH, Qin, T, Eikermann-Haerter, K, and Ayata, C. "Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 31, no. 7 (July 2011): 1578-1582. (Letter)  Full Text
    • Eikermann-Haerter, K, Yuzawa, I, Qin, T, Wang, Y, Baek, K, Kim, YR, Hoffmann, U, Dilekoz, E, Waeber, C, Ferrari, MD, van den Maagdenberg, AMJM, Moskowitz, MA, and Ayata, C. "Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 15 (April 2011): 5755-5763.  Full Text
    • Hoffmann, U, Dileköz, E, Kudo, C, and Ayata, C. "Oxcarbazepine does not suppress cortical spreading depression." Cephalalgia : an International Journal of Headache 31, no. 5 (April 2011): 537-542.  Full Text
    • Khuman, J, Meehan, WP, Zhu, X, Qiu, J, Hoffmann, U, Zhang, J, Giovannone, E, Lo, EH, and Whalen, MJ. "Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 31, no. 2 (February 2011): 778-789.  Full Text
    • Hoffmann, U, Lee, JH, Qin, T, Eikermann-Haerter, K, and Ayata, C. "Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations." Journal of Cerebral Blood Flow and Metabolism 31, no. 7 (2011): 1578-1582.  Full Text
    • Hoffmann, U, Dileköz, E, Kudo, C, and Ayata, C. "Gabapentin suppresses cortical spreading depression susceptibility." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 30, no. 9 (September 2010): 1588-1592. (Letter)  Full Text
    • Hoffmann, U, Pomper, J, Graulich, J, Zeller, M, Schuchmann, S, Gabriel, S, Maier, RF, and Heinemann, U. "Changes of neuronal activity in areas CA1 and CA3 during anoxia and normoxic or hyperoxic reoxygenation in juvenile rat organotypic hippocampal slice cultures." Brain research 1069, no. 1 (January 2006): 207-215.  Full Text
    • Pomper, JK, Haack, S, Petzold, GC, Buchheim, K, Gabriel, S, Hoffmann, U, and Heinemann, U. "Repetitive spreading depression-like events result in cell damage in juvenile hippocampal slice cultures maintained in normoxia." Journal of Neurophysiology 95, no. 1 (January 2006): 355-368.  Full Text
    • Pomper, JK, Hoffmann, U, Kovács, R, Gabriel, S, and Heinemann, U. "Hyperoxia is not an essential condition for status epilepticus induced cell death in organotypic hippocampal slice cultures." Epilepsy research 59, no. 1 (March 2004): 61-65.  Full Text
    • Weber, A, Maier, RF, Hoffmann, U, Grips, M, Hoppenz, M, Aktas, AG, Heinemann, U, Obladen, M, and Schuchmann, S. "Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures." Brain research 958, no. 2 (December 2002): 305-311.  Full Text
    • Graulich, J, Hoffmann, U, Maier, RF, Ruscher, K, Pomper, JK, Ko, H-K, Gabriel, S, Obladen, M, and Heinemann, U. "Acute neuronal injury after hypoxia is influenced by the reoxygenation mode in juvenile hippocampal slice cultures." Brain research. Developmental brain research 137, no. 1 (July 2002): 35-42.  Full Text
    • Pomper, JK, Graulich, J, Kovacs, R, Hoffmann, U, Gabriel, S, and Heinemann, U. "High oxygen tension leads to acute cell death in organotypic hippocampal slice cultures." Brain Research. Developmental Brain Research 126, no. 1 (January 2001): 109-116.  Full Text
    • Busch, T, Wolf, S, Sommerer, A, Hoffmann, U, Lohbrunner, H, Falke, KJ, and Kaisers, U. "Partial liquid ventilation (PLV) compared to inhaled nitric oxide (INO) in an animal model of acute lung injury (ALI): Effects on pulmonary gas exchange." Critical Care Medicine 27, no. 12 SUPPL. (December 1, 1999).
    • Sommerer, A, Busch, T, Hoffmann, U, Wolf, S, Kämpf, K, Falke, K, and Kaisers, U. "Low doses of almitrine compared to inhaled nitric oxide (iNO) in an animal model of acute lung injury (ALI): Effects on pulmonary gas exchange." Critical Care Medicine 27, no. 1 SUPPL. (December 1, 1999).

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