Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Anesthesiology Residency, Anesthesiology, Technical University of Munich (Germany) 2011 - 2014
  • M.D., Charite Universitatsmedizin Berlin (Germany) 2004
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2017 - 2020
  • Medical Instructor in the Department of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2015 - 2017
• Research
• 

  Selected Grants

  • Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2026
  • Platelet-mast cell interactions in pathogen induced vascular pathology awarded by National Institutes of Health 2021 - 2025
  • High resolution awake cortical recordings to analyze the role of spreading depolarizations during dynamic stroke evolution awarded by National Institutes of Health 2019 - 2021
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Chen, Maomao, Xiaoyu Duan, Bangxin Lan, Tri Vu, Xiaoyi Zhu, Qiangzhou Rong, Wei Yang, Ulrike Hoffmann, Jun Zou, and Junjie Yao. “High-speed functional photoacoustic microscopy using a water-immersible two-axis torsion-bending scanner.” Photoacoustics 24 (December 2021): 100309. https://doi.org/10.1016/j.pacs.2021.100309.
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    • Li, Ran, Yuntian Shen, Xuan Li, Liping Lu, Zhuoran Wang, Huaxin Sheng, Ulrike Hoffmann, and Wei Yang. “Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.” Shock 56, no. 5 (November 1, 2021): 755–61. https://doi.org/10.1097/SHK.0000000000001732.
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    • Zhang, Dong, Ran Li, Maomao Chen, Tri Vu, Huaxin Sheng, Wei Yang, Ulrike Hoffmann, Jianwen Luo, and Junjie Yao. “Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.” J Biophotonics 14, no. 7 (July 2021): e202000478. https://doi.org/10.1002/jbio.202000478.
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    • Turner, Dennis A., Simone Degan, Ulrike Hoffmann, Francesca Galeffi, and Carol A. Colton. “CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls.” Alzheimers Dement 17, no. 7 (July 2021): 1109–20. https://doi.org/10.1002/alz.12289.
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    • Creed, Jennifer, Viviana Cantillana-Riquelme, Bai Hui Yan, Shuang Ma, Dongmei Chu, Haichen Wang, Dennis A. Turner, Daniel T. Laskowitz, and Ulrike Hoffmann. “Argon Inhalation for 24 h After Closed-Head Injury Does not Improve Recovery, Neuroinflammation, or Neurologic Outcome in Mice.” Neurocritical Care 34, no. 3 (June 2021): 833–43. https://doi.org/10.1007/s12028-020-01104-0.
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    • Wang, Wei, Ran Li, Wanying Miao, Cody Evans, Liping Lu, Jingjun Lyu, Xuan Li, et al. “Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.” J Am Heart Assoc 10, no. 11 (June 2021): e019142. https://doi.org/10.1161/JAHA.120.019142.
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    • Wang, Zhuoran, Xuan Li, Ivan Spasojevic, Liping Lu, Yuntian Shen, Xingguang Qu, Ulrike Hoffmann, et al. “Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.” Exp Neurol 339 (May 2021): 113646. https://doi.org/10.1016/j.expneurol.2021.113646.
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    • Zhao, Qiang, Yuntian Shen, Ran Li, Jiangbo Wu, Jingjun Lyu, Maorong Jiang, Liping Lu, et al. “Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression.” J Cereb Blood Flow Metab 41, no. 5 (May 2021): 1091–1102. https://doi.org/10.1177/0271678X20948612.
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    • Ma, Shuang, Dongmei Chu, Litao Li, Jennifer A. Creed, Yu-Mi Ryang, Huaxin Sheng, Wei Yang, David S. Warner, Dennis A. Turner, and Ulrike Hoffmann. “Argon Inhalation for 24 Hours After Onset of Permanent Focal Cerebral Ischemia in Rats Provides Neuroprotection and Improves Neurologic Outcome.” Crit Care Med 47, no. 8 (August 2019): e693–99. https://doi.org/10.1097/CCM.0000000000003809.
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    • Lan, Bangxin, Wei Liu, Ya-Chao Wang, Junhui Shi, Yang Li, Song Xu, Huaxin Sheng, et al. “High-speed widefield photoacoustic microscopy of small-animal hemodynamics.” Biomed Opt Express 9, no. 10 (October 1, 2018): 4689–4701. https://doi.org/10.1364/BOE.9.004689.
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    • Oka, Fumiaki, Ulrike Hoffmann, Jeong Hyun Lee, Hwa Kyoung Shin, David Y. Chung, Izumi Yuzawa, Shih-Pin Chen, et al. “Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents.” J Cereb Blood Flow Metab 37, no. 5 (May 2017): 1829–40. https://doi.org/10.1177/0271678X16659303.
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    • Hoffmann, Ulrike, Huaxin Sheng, Cenk Ayata, and David S. Warner. “Anesthesia in Experimental Stroke Research.” Transl Stroke Res 7, no. 5 (October 2016): 358–67. https://doi.org/10.1007/s12975-016-0491-5.
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    • Sasaki, Toshihiro, Ulrike Hoffmann, Motomu Kobayashi, Huaxin Sheng, Abdelkader Ennaceur, Frederick W. Lombard, and David S. Warner. “Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.” Neurocrit Care 25, no. 2 (October 2016): 293–305. https://doi.org/10.1007/s12028-016-0250-1.
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    • Hoffmann, Ulrike, Martina Grosse-Sundrup, Katharina Eikermann-Haerter, Sebastina Zaremba, Cenk Ayata, Ben Zhang, Da Ma, Lyle Isaacs, and Matthias Eikermann. “Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents.” Anesthesiology 119, no. 2 (August 2013): 317–25. https://doi.org/10.1097/ALN.0b013e3182910213.
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    • Hoffmann, Ulrike, Inna Sukhotinsky, Katharina Eikermann-Haerter, and Cenk Ayata. “Glucose modulation of spreading depression susceptibility.” J Cereb Blood Flow Metab 33, no. 2 (February 2013): 191–95. https://doi.org/10.1038/jcbfm.2012.132.
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    • Hoffmann, Ulrike, and Cenk Ayata. “Neurovascular coupling during spreading depolarizations.” Acta Neurochir Suppl 115 (2013): 161–65. https://doi.org/10.1007/978-3-7091-1192-5_31.
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    • Hoffmann, Ulrike, Inna Sukhotinsky, Yahya Burak Atalay, Katharina Eikermann-Haerter, and Cenk Ayata. “Increased glucose availability does not restore prolonged spreading depression durations in hypotensive rats without brain injury.” Exp Neurol 238, no. 2 (December 2012): 130–32. https://doi.org/10.1016/j.expneurol.2012.08.013.
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    • Ma, Da, Ben Zhang, Ulrike Hoffmann, Martina Grosse Sundrup, Matthias Eikermann, and Lyle Isaacs. “Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.” Angew Chem Int Ed Engl 51, no. 45 (November 5, 2012): 11358–62. https://doi.org/10.1002/anie.201206031.
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    • Eikermann, Matthias, Martina Grosse-Sundrup, Sebastian Zaremba, Mark E. Henry, Edward A. Bittner, Ulrike Hoffmann, and Nancy L. Chamberlin. “Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction.” Anesthesiology 116, no. 1 (January 2012): 35–46. https://doi.org/10.1097/ALN.0b013e31823d010a.
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    • Eikermann, Matthias, Ramalingam Vetrivelan, Martina Grosse-Sundrup, Mark E. Henry, Ulrike Hoffmann, Shigefumi Yokota, Clifford B. Saper, and Nancy L. Chamberlin. “The ventrolateral preoptic nucleus is not required for isoflurane general anesthesia.” Brain Res 1426 (December 2, 2011): 30–37. https://doi.org/10.1016/j.brainres.2011.10.018.
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    • Hoffmann, Ulrike, Jeong Hyun Lee, Tao Qin, Katharina Eikermann-Haerter, and Cenk Ayata. “Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.” J Cereb Blood Flow Metab 31, no. 7 (July 2011): 1578–82. https://doi.org/10.1038/jcbfm.2011.50.
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    • Eikermann-Haerter, Katharina, Izumi Yuzawa, Tao Qin, Yumei Wang, Kwangyeol Baek, Young Ro Kim, Ulrike Hoffmann, et al. “Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice.” J Neurosci 31, no. 15 (April 13, 2011): 5755–63. https://doi.org/10.1523/JNEUROSCI.5346-10.2011.
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    • Hoffmann, Ulrike, Ergin Dileköz, Chiho Kudo, and Cenk Ayata. “Oxcarbazepine does not suppress cortical spreading depression.” Cephalalgia 31, no. 5 (April 2011): 537–42. https://doi.org/10.1177/0333102410388433.
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    • Khuman, Jugta, William P. Meehan, Xiaoxia Zhu, Jianhua Qiu, Ulrike Hoffmann, Jimmy Zhang, Eric Giovannone, Eng H. Lo, and Michael J. Whalen. “Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice.” J Cereb Blood Flow Metab 31, no. 2 (February 2011): 778–89. https://doi.org/10.1038/jcbfm.2010.172.
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    • Hoffmann, Ulrike, Ergin Dileköz, Chiho Kudo, and Cenk Ayata. “Gabapentin suppresses cortical spreading depression susceptibility.” J Cereb Blood Flow Metab 30, no. 9 (September 2010): 1588–92. https://doi.org/10.1038/jcbfm.2010.92.
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    • Hoffmann, Ulrike, Jörn Pomper, Johannes Graulich, Melanie Zeller, Sebastian Schuchmann, Siegrun Gabriel, Rolf F. Maier, and Uwe Heinemann. “Changes of neuronal activity in areas CA1 and CA3 during anoxia and normoxic or hyperoxic reoxygenation in juvenile rat organotypic hippocampal slice cultures.” Brain Res 1069, no. 1 (January 19, 2006): 207–15. https://doi.org/10.1016/j.brainres.2005.11.025.
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    • Pomper, Jörn K., Stephan Haack, Gabor C. Petzold, Katharina Buchheim, Siegrun Gabriel, Ulrike Hoffmann, and Uwe Heinemann. “Repetitive spreading depression-like events result in cell damage in juvenile hippocampal slice cultures maintained in normoxia.” J Neurophysiol 95, no. 1 (January 2006): 355–68. https://doi.org/10.1152/jn.00186.2005.
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    • Pomper, Jörn K., Ulrike Hoffmann, Richard Kovács, Siegrun Gabriel, and Uwe Heinemann. “Hyperoxia is not an essential condition for status epilepticus induced cell death in organotypic hippocampal slice cultures.” Epilepsy Res 59, no. 1 (March 2004): 61–65. https://doi.org/10.1016/j.eplepsyres.2004.03.002.
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    • Weber, Astrid, Rolf F. Maier, Ulrike Hoffmann, Martin Grips, Marc Hoppenz, Ayse G. Aktas, Uwe Heinemann, Michael Obladen, and Sebastian Schuchmann. “Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures.” Brain Res 958, no. 2 (December 27, 2002): 305–11. https://doi.org/10.1016/s0006-8993(02)03604-1.
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    • Graulich, Johannes, Ulrike Hoffmann, Rolf F. Maier, Karsten Ruscher, Jörn K. Pomper, Hae-Kyung Ko, Siegrun Gabriel, Michael Obladen, and Uwe Heinemann. “Acute neuronal injury after hypoxia is influenced by the reoxygenation mode in juvenile hippocampal slice cultures.” Brain Res Dev Brain Res 137, no. 1 (July 30, 2002): 35–42. https://doi.org/10.1016/s0165-3806(02)00365-6.
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    • Pomper, J. K., J. Graulich, R. Kovacs, U. Hoffmann, S. Gabriel, and U. Heinemann. “High oxygen tension leads to acute cell death in organotypic hippocampal slice cultures.” Brain Res Dev Brain Res 126, no. 1 (January 31, 2001): 109–16. https://doi.org/10.1016/s0165-3806(00)00132-2.
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    • Sommerer, A., T. Busch, U. Hoffmann, S. Wolf, K. Kämpf, K. Falke, and U. Kaisers. “Low doses of almitrine compared to inhaled nitric oxide (iNO) in an animal model of acute lung injury (ALI): Effects on pulmonary gas exchange.” Critical Care Medicine 27, no. 1 SUPPL. (December 1, 1999).
    • Busch, T., S. Wolf, A. Sommerer, U. Hoffmann, H. Lohbrunner, K. J. Falke, and U. Kaisers. “Partial liquid ventilation (PLV) compared to inhaled nitric oxide (INO) in an animal model of acute lung injury (ALI): Effects on pulmonary gas exchange.” Critical Care Medicine 27, no. 12 SUPPL. (January 1, 1999). https://doi.org/10.1097/00003246-199912001-00300.
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