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Uptal Dinesh Patel

Adjunct Professor in the Department of Medicine
Medicine, Nephrology
Duke Box 3646, 2400 Pratt Street, Durham, NC 27705
6000 Shoreline Ct Ste 304, South San Francisco, CA 94080-7606

Overview


Uptal Patel, MD is an Adjunct Professor interested in population health with a broad range of clinical and research experience. As an adult and pediatric nephrologist with training in health services and epidemiology, his work seeks to improve population health for patients with kidney diseases through improvements in prevention, diagnosis and treatment. He has led clinical and translational research programs to improve detection and management of kidney disease in a variety of populations.

His current efforts seek to advance targeted therapies for immune-mediated diseases as the Senior Vice President and Head of Development at HI-Bio, at Biogen. Prior to being CMO at HI-Bio, he led clinical strategy, translation, and development of the kidney portfolios at AstraZeneca (within the early cardiovascular, renal, and metabolism therapeutic area) and Gilead Sciences (within the inflammation therapeutic area).

He currently also serves as Chair of the Board of Directors for theĀ Kidney Health Initiative, a public-private partnership between the American Society of Nephrology and the FDA to catalyze innovation and the development of safe and effective patient-centered therapies for people with kidney diseases. He completed training at the University of Michigan in internal medicine, pediatrics, adult nephrology, pediatric nephrology, and health services research after attending medical school at UCSF.

Current Appointments & Affiliations


Adjunct Professor in the Department of Medicine · 2016 - Present Medicine, Nephrology, Medicine
Affiliate, Duke Global Health Institute · 2015 - Present Duke Global Health Institute, University Institutes and Centers

Recent Publications


Randomized, double-blind, placebo-controlled phase 2a study assessing the efficacy and safety of felzartamab for IgA nephropathy.

Journal Article Kidney Int · October 2025 INTRODUCTION: Felzartamab is a fully human anti-CD38 monoclonal antibody under investigation for treatment of IgA nephropathy (IgAN). IGNAZ (NCT05065970) is a randomized, double blind, placebo-controlled Phase 2a study that assessed the efficacy and safety ... Full text Link to item Cite

Effect of felzartamab on the molecular phenotype of antibody-mediated rejection in kidney transplant biopsies.

Journal Article Nat Med · May 2025 A recent randomized controlled trial demonstrated that treatment with anti-CD38 monoclonal antibody felzartamab suppressed antibody-mediated rejection (ABMR) in kidney transplant patients but with recurrence after treatment in some patients. Here we examin ... Full text Link to item Cite
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Recent Grants


Putting Patients at the Center of Kidney Care Transitions

ResearchCo Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2016 - 2023

Integrated Population Program for Diabetic Kidney Disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2018

Health Literacy and Social Determinants among Individuals with Chronic Kidney Disease in an Underserved Community

FellowshipPrincipal Investigator · Awarded by American Kidney Fund · 2015 - 2017

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Education


University of California San Francisco, School of Medicine · 1997 M.D.