Overview
Uptal Patel, MD is an Adjunct Professor interested in population health with a broad range of clinical and research experience. As an adult and pediatric nephrologist with training in health services and epidemiology, his work seeks to improve population health for patients with kidney diseases through improvements in prevention, diagnosis and treatment. He has led clinical and translational research programs to improve detection and management of kidney disease in a variety of populations.
His current efforts seek to advance targeted therapies for immune-mediated diseases as the Senior Vice President and Head of Development at HI-Bio, at Biogen. Prior to being CMO at HI-Bio, he led clinical strategy, translation, and development of the kidney portfolios at AstraZeneca (within the early cardiovascular, renal, and metabolism therapeutic area) and Gilead Sciences (within the inflammation therapeutic area).
He currently also serves as Chair of the Board of Directors for theĀ Kidney Health Initiative, a public-private partnership between the American Society of Nephrology and the FDA to catalyze innovation and the development of safe and effective patient-centered therapies for people with kidney diseases. He completed training at the University of Michigan in internal medicine, pediatrics, adult nephrology, pediatric nephrology, and health services research after attending medical school at UCSF.
Current Appointments & Affiliations
Recent Publications
Estimating the efficacy of felzartamab to treat antibody-mediated rejection using the iBox prognostication system.
Journal Article Am J Transplant · May 2025 Full text Link to item CiteEffect of felzartamab on the molecular phenotype of antibody-mediated rejection in kidney transplant biopsies
Journal Article Nature Medicine · January 1, 2025 A recent randomized controlled trial demonstrated that treatment with anti-CD38 monoclonal antibody felzartamab suppressed antibody-mediated rejection (ABMR) in kidney transplant patients but with recurrence after treatment in some patients. Here we examin ... Full text CiteSelonsertib in Patients with Diabetic Kidney Disease: A Phase 2b Randomized Active Run-In Clinical Trial.
Journal Article J Am Soc Nephrol · December 1, 2024 KEY POINTS: In a randomized, placebo-controlled, phase 2b study, we compared the effects of selonsertib with placebo on eGFR decline in people with type 2 diabetes and CKD. Patients taking selonsertib had slower eGFR decline but were more likely to reach a ... Full text Link to item CiteRecent Grants
Putting Patients at the Center of Kidney Care Transitions
ResearchCo Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2016 - 2023Integrated Population Program for Diabetic Kidney Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2018Health Literacy and Social Determinants among Individuals with Chronic Kidney Disease in an Underserved Community
FellowshipPrincipal Investigator · Awarded by American Kidney Fund · 2015 - 2017View All Grants