Vadim Y Arshavsky

Journal article J Biol Chem · January 13, 2012 Featured Publication For decades, photoreceptors have been an outstanding model system for elucidating basic principles in sensory transduction and biochemistry and for understanding many facets of neuronal cell biology. In recent years, new knowledge of the kinetics of signal ... Full text Link to item Cite

Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors.

Journal article J Neurosci · October 12, 2011 Featured Publication The members of the R7 regulator of G-protein signaling (RGS) protein subfamily are versatile regulators of G-protein signaling throughout the nervous system. Recent studies indicate that they are often found in complexes with membrane anchor proteins that ... Full text Link to item Cite

Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.

Journal article Neuron · October 6, 2011 Featured Publication Dark and light adaptation of retinal neurons allow our vision to operate over an enormous light intensity range. Here we report a mechanism that controls the light sensitivity and operational range of rod-driven bipolar cells that mediate dim-light vision. ... Full text Link to item Cite

Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.

Journal article Nat Struct Mol Biol · June 19, 2011 Featured Publication The diverse Regulator of G protein Signaling (RGS) family sets the timing of G protein signaling. To understand how the structure of RGS proteins determines their common ability to inactivate G proteins and their selective G protein recognition, we combine ... Full text Link to item Cite

Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.

Journal article Mol Cell Proteomics · March 2011 Featured Publication The retina is a highly ordered tissue whose outermost layers are formed by subcellular compartments of photoreceptors generating light-evoked electrical responses. We studied protein distributions among individual photoreceptor compartments by separating t ... Full text Link to item Cite

Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.

Journal article J Neurosci · May 19, 2010 Featured Publication The remarkable ability of our vision to function under ever-changing conditions of ambient illumination is mediated by multiple molecular mechanisms regulating the light sensitivity of rods and cones. One such mechanism involves massive translocation of si ... Full text Link to item Cite

Functional comparison of RGS9 splice isoforms in a living cell.

Journal article Proc Natl Acad Sci U S A · December 30, 2008 Featured Publication Two isoforms of the GTPase-activating protein, regulator of G protein signaling 9 (RGS9), control such fundamental functions as vision and behavior. RGS9-1 regulates phototransduction in rods and cones, and RGS9-2 regulates dopamine and opioid signaling in ... Full text Link to item Cite

The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors.

Journal article J Cell Biol · November 3, 2008 Featured Publication Photoreceptors are compartmentalized neurons in which all proteins responsible for evoking visual signals are confined to the outer segment. Yet, the mechanisms responsible for establishing and maintaining photoreceptor compartmentalization are poorly unde ... Full text Link to item Cite