Overview
My research has focused on cancer cell metabolism and the molecular pathways that regulate posttranslational modifications. In addition, we explore cancer initiation, cell survival, progression, and metastasis using a variety of in vitro, ex vivo, and in vivo genetical approaches, including gene knockdown, CRISPR/Cas9 knockout, molecular biology techniques, biochemical approaches, and genetically engineered mouse and Nude mice models, to characterize molecular mechanisms regulated by metabolic pathways and develop potential metabolic strategies for cancer therapy.
Recent Publications
ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression.
Journal Article Nat Cell Biol · May 2025 MPC1 and MPC2 are two well-known components of the mitochondrial pyruvate carrier (MPC) complex maintaining MPC activity to transport pyruvate into mitochondria for tricarboxylic acid (TCA) cycle entry in mammalian cells. It is currently unknown whether th ... Full text Link to item CitePotential role of Hematopoietic PBX-Interacting Protein (HPIP) in trophoblast fusion and invasion: Implications in pre-eclampsia pathogenesis.
Journal Article Cellular signalling · April 2025 Pre-eclampsia is a known hypertensive disorder of pregnancy. While abnormal placentation and poor trophoblast invasion into maternal endometrium during blastocyst implantation are primary causes of pre-eclampsia, the underlying mechanisms remain elusive. H ... Full text CiteIMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation.
Journal Article J Exp Med · November 4, 2024 Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. H ... Full text Link to item CiteRecent Grants
Unravel a novel metabolic pathway orchestrating prostate cancer progression and therapeutic resistance
ResearchPostdoctoral Associate · Awarded by National Cancer Institute · 2023 - 2027Regulation of oncogenic Akt ubiquitination and activation by diverse mechanisms in cancer
ResearchPostdoctoral Associate · Awarded by National Cancer Institute · 2023 - 2026View All Grants