Current Appointments & Affiliations
James B. Duke Distinguished Professor of Medicine
·
2005 - Present
Medicine, Cardiology,
Medicine
Professor of Medicine
·
2004 - Present
Medicine, Cardiology,
Medicine
Professor of Pathology
·
2004 - Present
Pathology,
Clinical Science Departments
Recent Publications
Hemoglobin inhibits fibroblast-to-cardiomyocyte reprogramming via TLR2/TLR4-dependent chromatin compaction.
Journal Article Mol Ther Nucleic Acids · June 16, 2026 Fibroblast-to-cardiomyocyte reprogramming is influenced by signals present in the injured heart. However, the nature of those signals is unclear. The efficacy of fibroblast-to-cardiomyocyte reprogramming was found to be negatively impacted by extracts deri ... Full text Link to item CiteEngineering extracellular vesicles for targeted therapeutic delivery in the heart.
Journal Article Biosci Rep · April 22, 2026 Heart failure is a leading cause of morbidity and mortality, highlighting the need for improved therapeutic strategies. Critical to the success of therapies is efficient and targeted delivery systems. Extracellular vesicle-based delivery systems have emerg ... Full text Link to item CiteCardiovascular Science, Medicine, and Society: The Brave New World: The ACC Braunwald Lecture 2025.
Journal Article J Am Coll Cardiol · April 21, 2026 Recent scientific and technological advances have dramatically expanded the possibilities in cardiovascular medicine. Landmark clinical trials have introduced transformative therapies for lipid disorders, heart failure, and obesity, offering clinicians pow ... Full text Link to item CiteRecent Grants
Novel approaches for cardiac reprogramming: Exosome delivery of reprogramming miRNAs and repressor targeting siRNAs
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2025 - 2029Mandel 2024-2027
ResearchPrincipal Investigator · Awarded by Edna and Fred L. Mandel, Jr. Foundation · 2024 - 2026Mandel 2021-2024
ResearchPrincipal Investigator · Awarded by Edna and Fred L. Mandel, Jr. Foundation · 2018 - 2025View All Grants
Education
McGill University (Canada) ·
1972
M.D.