Vivian Hou Chu | Scholars@Duke

Vivian Hou Chu
Associate Professor

Dr. Chu's clinical research is focused on staphylococci and endocarditis (IE). She is the director of the International Collaboration on Endocarditis (ICE), a group of investigators from 78 sites in 32 countries worldwide that is dedicated to further the understanding of infective endocarditis. The ICE database comprises > 5000 cases of endocarditis and is designed to answer questions that could not be answered from a single-center study. The current focus of this group is surgical-decision making in the treatment of endocarditis. Another major focus of Dr. Chu's research is on the relationship between oral hygiene and risk for developing infective endocarditis.

Current Appointments & Affiliations

Associate Professor, Medicine, Infectious Diseases, Medicine 2017
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2006

Contact Information

Duke Box 102359, Div Of Infectious Diseases, Durham, NC 27710
Room 177 Hanes House, Trent Drive, Durham, NC 27710
vivian.chu@duke.edu (919) 668-7174

Background
Education, Training, & Certifications
- Fellow in Infectious Diseases, Medicine, Duke University 2003 - 2006
- Medical Resident, Medicine, Duke University 2000 - 2003
- M.D., Columbia University 2000
Duke Appointment History
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2013 - 2017
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2008 - 2013
- Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2006 - 2008
- Instructor, Temporary in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2006
Recognition
Awards & Honors
- Infectious Disease Division Annual Education Award. Division of Infectious Diseases, Department of Medicine, Duke. 2015
Research
Selected Grants
- Duke Summer Training in Academic Research (Duke's STAR) awarded by National Institutes of Health 2018 - 2023
- Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2021
- Oral Hygiene, Periodontal Disease and Infective Endocarditis awarded by Carolinas Medical Center 2018 - 2019
- Optimizing treatment for E. faecalis infective endocarditis: ampicillin plus ceftriaxone versus ampicillin plus gentamicin awarded by National Institutes of Health 2016 - 2019
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- NIH Summer Research Experience Programs (R25) awarded by National Institutes of Health 2013 - 2018
- DCRI Sub BAA-NIAID-DMID-NIHAI2005025 awarded by National Institutes of Health 2010 - 2017
- Optimizing duration of antibiotics after valve surgery for infective endocarditis awarded by National Institutes of Health 2012 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Arnold, CJ, and Chu, VH. "Cardiovascular Implantable Electronic Device Infections." Infectious Disease Clinics of North America 32, no. 4 (December 2018): 811-825. (Review) Full Text
  - Chu, VH. "Device-Associated Infections." Infectious Disease Clinics of North America 32, no. 4 (December 2018): ix-x. Full Text
  - Thornhill, MH, Gibson, TB, Cutler, E, Dayer, MJ, Chu, VH, Lockhart, PB, O'Gara, PT, and Baddour, LM. "Antibiotic Prophylaxis and Incidence of Endocarditis Before and After the 2007 AHA Recommendations." Journal of the American College of Cardiology 72, no. 20 (November 5, 2018): 2443-2454. Full Text
  - Wang, A, Gaca, JG, and Chu, VH. "Injection Drug Use-Associated Infective Endocarditis-Reply." Jama 320, no. 18 (November 2018): 1939-1940. (Letter) Full Text
  - Holland, TL, Raad, I, Boucher, HW, Anderson, DJ, Cosgrove, SE, Aycock, PS, Baddley, JW, Chaftari, A-M, Chow, S-C, Chu, VH, Carugati, M, Cook, P, Corey, GR, Crowley, AL, Daly, J, Gu, J, Hachem, R, Horton, J, Jenkins, TC, Levine, D, Miro, JM, Pericas, JM, Riska, P, Rubin, Z, Rupp, ME, Schrank, J, Sims, M, Wray, D, Zervos, M, Fowler, VG, and Staphylococcal Bacteremia Investigators, . "Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial." Jama 320, no. 12 (September 2018): 1249-1258. Full Text
  - Aslam, S, Xie, R, Cowger, J, Kirklin, JK, Chu, VH, Schueler, S, de By, T, Gould, K, Morrissey, O, Lund, LH, Martin, S, Goldstein, D, and Hannan, M. "Bloodstream infections in mechanical circulatory support device recipients in the International Society of Heart and Lung Transplantation Mechanically Assisted Circulation Support Registry: Epidemiology, risk factors, and mortality." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation 37, no. 8 (August 2018): 1013-1020. Full Text
  - Wang, A, Gaca, JG, and Chu, VH. "Management Considerations in Infective Endocarditis: A Review." Jama 320, no. 1 (July 2018): 72-83. (Review) Full Text
  - Pericàs, JM, Messina, JA, Garcia-de-la-Mària, C, Park, L, Sharma-Kuinkel, BK, Marco, F, Wray, D, Kanafani, ZA, Carugati, M, Durante-Mangoni, E, Tattevin, P, Chu, VH, Moreno, A, Fowler, VG, Miró, JM, and International Collaboration on Endocarditis Microbiology Investigators, . "Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 23, no. 8 (August 2017): 544-549. Full Text
  - Carugati, M, Petti, CA, Arnold, C, Miro, JM, Pericàs, JM, Garcia de la Maria, C, Kanafani, Z, Durante-Mangoni, E, Baddley, J, Wray, D, Klein, JL, Delahaye, F, Fernandez-Hidalgo, N, Hannan, MM, Murdoch, D, Bayer, A, and Chu, VH. "Antistaphylococcal β-Lactams versus Vancomycin for Treatment of Infective Endocarditis Due to Methicillin-Susceptible Coagulase-Negative Staphylococci: a Prospective Cohort Study from the International Collaboration on Endocarditis." Antimicrobial Agents and Chemotherapy 60, no. 10 (October 2016): 6341-6349. Full Text
  - Romaine, A, Ye, D, Ao, Z, Fang, F, Johnson, O, Blake, T, Benjamin, DK, Cotten, CM, Testoni, D, Clark, RH, Chu, VH, Smith, PB, Hornik, CP, and Best Pharmaceuticals for Children Act – Pediatric Trials Network, . "Safety of histamine-2 receptor blockers in hospitalized VLBW infants." Early Human Development 99 (August 2016): 27-30. Full Text
  - Limeres Posse, J, Álvarez Fernández, M, Fernández Feijoo, J, Medina Henríquez, J, Lockhart, PB, Chu, VH, and Diz Dios, P. "Intravenous amoxicillin/clavulanate for the prevention of bacteraemia following dental procedures: a randomized clinical trial." The Journal of antimicrobial chemotherapy 71, no. 7 (July 2016): 2022-2030. Full Text
  - Park, LP, Chu, VH, Peterson, G, Skoutelis, A, Lejko-Zupa, T, Bouza, E, Tattevin, P, Habib, G, Tan, R, Gonzalez, J, Altclas, J, Edathodu, J, Fortes, CQ, Siciliano, RF, Pachirat, O, Kanj, S, Wang, A, and International Collaboration on Endocarditis (ICE) Investigators, . "Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis." Journal of the American Heart Association 5, no. 4 (April 18, 2016): e003016-null. Full Text
  - Gulack, BC, Laughon, MM, Clark, RH, Burgess, T, Robinson, S, Muhammad, A, Zhang, A, Davis, A, Morton, R, Chu, VH, Arnold, CJ, Hornik, CP, and Smith, PB. "Enteral Feeding with Human Milk Decreases Time to Discharge in Infants following Gastroschisis Repair." The Journal of Pediatrics 170 (March 2016): 85-89. Full Text
  - Qi, R, Joo, H-S, Sharma-Kuinkel, B, Berlon, NR, Park, L, Fu, C-L, Messina, JA, Thaden, JT, Yan, Q, Ruffin, F, Maskarinec, S, Warren, B, Chu, VH, Fortes, CQ, Giannitsioti, E, Durante-Mangoni, E, Kanafani, ZA, Otto, M, and Fowler, VG. "Increased in vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus." The Journal of Infection 72, no. 3 (March 2016): 302-308. Full Text
  - Tsalik, EL, Li, Y, Hudson, LL, Chu, VH, Himmel, T, Limkakeng, AT, Katz, JN, Glickman, SW, McClain, MT, Welty-Wolf, KE, Fowler, VG, Ginsburg, GS, Woods, CW, and Reed, SD. "Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients." Annals of the American Thoracic Society 13, no. 3 (March 2016): 401-413. Full Text Open Access Copy
  - Chu, VH. "When the Cat's Out of the Bag: Searching for Portals of Entry in Infective Endocarditis." Journal of the American College of Cardiology 67, no. 2 (January 2016): 159-161. Full Text
  - Chu, VH, Park, LP, Athan, E, Delahaye, F, Freiberger, T, Lamas, C, Miro, JM, Mudrick, DW, Strahilevitz, J, Tribouilloy, C, Durante-Mangoni, E, Pericas, JM, Fernández-Hidalgo, N, Nacinovich, F, Rizk, H, Krajinovic, V, Giannitsioti, E, Hurley, JP, Hannan, MM, Wang, A, and ICE Investigators, . "Response to Letter Regarding Article, "Association Between Surgical Indications, Operative Risk, and Clinical Outcome in Infective Endocarditis: A Prospective Study From the International Collaboration on Endocarditis"." Circulation 132, no. 14 (October 2015): e184-e185. (Letter) Full Text
  - Arnold, CJ, Ericson, J, Cho, N, Tian, J, Wilson, S, Chu, VH, Hornik, CP, Clark, RH, Benjamin, DK, Smith, PB, and Best Pharmaceuticals for Children Act--Pediatric Trials Network Administrative Core Committee, . "Cefepime and Ceftazidime Safety in Hospitalized Infants." The Pediatric Infectious Disease Journal 34, no. 9 (September 2015): 964-968. Full Text
  - Ericson, JE, Arnold, C, Cheeseman, J, Cho, J, Kaneko, S, Wilson, E, Clark, RH, Benjamin, DK, Chu, V, Smith, PB, Hornik, CP, and Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee, . "Use and Safety of Erythromycin and Metoclopramide in Hospitalized Infants." Journal of Pediatric Gastroenterology and Nutrition 61, no. 3 (September 2015): 334-339. Full Text
  - Lauridsen, TK, Park, L, Tong, SYC, Selton-Suty, C, Peterson, G, Cecchi, E, Afonso, L, Habib, G, Paré, C, Tamin, S, Dickerman, S, Bayer, AS, Johansson, MC, Chu, VH, Samad, Z, Bruun, NE, Fowler, VG, and Crowley, AL. "Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study." Circulation. Cardiovascular Imaging 8, no. 7 (July 2015): e003397-null. Full Text
  - Arnold, CJ, Ericson, J, Kohman, J, Corey, KL, Oh, M, Onabanjo, J, Hornik, CP, Clark, RH, Benjamin, DK, Smith, PB, Chu, VH, and Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee, . "Rifampin use and safety in hospitalized infants." American journal of perinatology 32, no. 6 (May 2015): 565-570. Full Text
  - Arnold, CJ, Johnson, M, Bayer, AS, Bradley, S, Giannitsioti, E, Miró, JM, Tornos, P, Tattevin, P, Strahilevitz, J, Spelman, D, Athan, E, Nacinovich, F, Fortes, CQ, Lamas, C, Barsic, B, Fernández-Hidalgo, N, Muñoz, P, and Chu, VH. "Candida infective endocarditis: an observational cohort study with a focus on therapy." Antimicrobial Agents and Chemotherapy 59, no. 4 (April 2015): 2365-2373. Full Text
  - Chirouze, C, Alla, F, Fowler, VG, Sexton, DJ, Corey, GR, Chu, VH, Wang, A, Erpelding, M-L, Durante-Mangoni, E, Fernández-Hidalgo, N, Giannitsioti, E, Hannan, MM, Lejko-Zupanc, T, Miró, JM, Muñoz, P, Murdoch, DR, Tattevin, P, Tribouilloy, C, Hoen, B, and ICE Prospective Investigators, . "Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 60, no. 5 (March 2015): 741-749. Full Text
  - Chu, VH, Park, LP, Athan, E, Delahaye, F, Freiberger, T, Lamas, C, Miro, JM, Mudrick, DW, Strahilevitz, J, Tribouilloy, C, Durante-Mangoni, E, Pericas, JM, Fernández-Hidalgo, N, Nacinovich, F, Rizk, H, Krajinovic, V, Giannitsioti, E, Hurley, JP, Hannan, MM, Wang, A, and International Collaboration on Endocarditis (ICE) Investigators*, . "Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis." Circulation 131, no. 2 (January 2015): 131-140. Full Text
  - Delahaye, F, Chu, VH, Altclas, J, Barsic, B, Delahaye, A, Freiberger, T, Gordon, DL, Hannan, MM, Hoen, B, Kanj, SS, Lejko-Zupanc, T, Mestres, CA, Pachirat, O, Pappas, P, Lamas, C, Selton-Suty, C, Tan, R, Tattevin, P, Wang, A, and International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators, . "One-year outcome following biological or mechanical valve replacement for infective endocarditis." International Journal of Cardiology 178 (January 2015): 117-123. Full Text
  - Alagna, L, Park, LP, Nicholson, BP, Keiger, AJ, Strahilevitz, J, Morris, A, Wray, D, Gordon, D, Delahaye, F, Edathodu, J, Miró, JM, Fernández-Hidalgo, N, Nacinovich, FM, Shahid, R, Woods, CW, Joyce, MJ, Sexton, DJ, and Chu, VH. "Repeat endocarditis: analysis of risk factors based on the International Collaboration on Endocarditis - Prospective Cohort Study." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 20, no. 6 (June 2014): 566-575. Full Text
  - Bin Abdulhak, AA, Baddour, LM, Erwin, PJ, Hoen, B, Chu, VH, Mensah, GA, and Tleyjeh, IM. "Global and regional burden of infective endocarditis, 1990-2010: a systematic review of the literature." Global Heart 9, no. 1 (March 2014): 131-143. (Review) Full Text
  - Alagna, L, Park, LP, Nicholson, BP, Keiger, AJ, Strahilevitz, J, Morris, A, Wray, D, Gordon, D, Delahaye, F, Edathodu, J, Miró, JM, Fernández-Hidalgo, N, Nacinovich, FM, Shahid, R, Woods, CW, Joyce, MJ, Sexton, DJ, and Chu, VH. "Repeat endocarditis: Analysis of risk factors based on the International collaboration on endocarditis - Prospective cohort study." Clinical Microbiology and Infection 20, no. 6 (January 1, 2014): 566-575. Full Text
  - Carugati, M, Bayer, AS, Miró, JM, Park, LP, Guimarães, AC, Skoutelis, A, Fortes, CQ, Durante-Mangoni, E, Hannan, MM, Nacinovich, F, Fernández-Hidalgo, N, Grossi, P, Tan, R-S, Holland, T, Fowler, VG, Corey, RG, Chu, VH, and International Collaboration on Endocarditis, . "High-dose daptomycin therapy for left-sided infective endocarditis: a prospective study from the international collaboration on endocarditis." Antimicrobial Agents and Chemotherapy 57, no. 12 (December 2013): 6213-6222. Full Text
  - Chirouze, C, Athan, E, Alla, F, Chu, VH, Ralph Corey, G, Selton-Suty, C, Erpelding, M-L, Miro, JM, Olaison, L, Hoen, B, and International Collaboration on Endocarditis Study Group, . "Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 19, no. 12 (December 2013): 1140-1147. Full Text
  - Lalani, T, Chu, VH, Park, LP, Cecchi, E, Corey, GR, Durante-Mangoni, E, Fowler, VG, Gordon, D, Grossi, P, Hannan, M, Hoen, B, Muñoz, P, Rizk, H, Kanj, SS, Selton-Suty, C, Sexton, DJ, Spelman, D, Ravasio, V, Tripodi, MF, Wang, A, and International Collaboration on Endocarditis–Prospective Cohort Study Investigators, . "In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis." Jama Internal Medicine 173, no. 16 (September 2013): 1495-1504. Full Text
  - Chu, VH, and Sexton, DJ. "Editorial commentary: telephone consultation for Staphylococcus aureus bacteremia: opening Pandora's box." Clin Infect Dis 56, no. 4 (February 2013): 536-538. Full Text Link to Item
  - Barsic, B, Dickerman, S, Krajinovic, V, Pappas, P, Altclas, J, Carosi, G, Casabé, JH, Chu, VH, Delahaye, F, Edathodu, J, Fortes, CQ, Olaison, L, Pangercic, A, Patel, M, Rudez, I, Tamin, SS, Vincelj, J, Bayer, AS, Wang, A, and International Collaboration on Endocarditis–Prospective Cohort Study Investigators, . "Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 56, no. 2 (January 2013): 209-217. Full Text
  - Baršić, B, Wang, A, and Chu, VH. "Reply to Tleyjeh and Baddour." Clinical Infectious Diseases 56, no. 12 (2013): 1845--. Full Text
  - Chambers, ST, Murdoch, D, Morris, A, Holland, D, Pappas, P, Almela, M, Fernández-Hidalgo, N, Almirante, B, Bouza, E, Forno, D, del Rio, A, Hannan, MM, Harkness, J, Kanafani, ZA, Lalani, T, Lang, S, Raymond, N, Read, K, Vinogradova, T, Woods, CW, Wray, D, Corey, GR, Chu, VH, and International Collaboration on Endocarditis Prospective Cohort Study Investigators, . "HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort." Plos One 8, no. 5 (January 2013): e63181-null. Full Text
  - Chirouze, C, Athan, E, Alla, F, Chu, VH, Ralph Corey, G, Selton-Suty, C, Erpelding, ML, Miro, JM, Olaison, L, and Hoen, B. "Enterococcal endocarditis in the beginning of the 21st century: Analysis from the international collaboration on endocarditis-prospective cohort study." Clinical Microbiology and Infection 19, no. 12 (January 1, 2013): 1140-1147. Full Text
  - Federspiel, JJ, Stearns, SC, Peppercorn, AF, Chu, VH, and Fowler, VG. "Increasing US rates of endocarditis with Staphylococcus aureus: 1999-2008." Archives of Internal Medicine 172, no. 4 (February 2012): 363-365. (Letter) Full Text
  - Athan, E, Chu, VH, Tattevin, P, Selton-Suty, C, Jones, P, Naber, C, Miró, JM, Ninot, S, Fernández-Hidalgo, N, Durante-Mangoni, E, Spelman, D, Hoen, B, Lejko-Zupanc, T, Cecchi, E, Thuny, F, Hannan, MM, Pappas, P, Henry, M, Jr, VGF, Crowley, AL, and Wang, A. "Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices." JAMA - Journal of the American Medical Association 307, no. 16 (2012): 1727-1735. Full Text
  - Goswami, ND, Johnson, MD, and Chu, VH. "Ertapenem for treatment of osteomyelitis: a case series. (Published online)" BMC Res Notes 4 (November 2, 2011): 478-. Full Text Link to Item
  - Kiefer, T, Park, L, Tribouilloy, C, Cortes, C, Casillo, R, Chu, V, Delahaye, F, Durante-Mangoni, E, Edathodu, J, Falces, C, Logar, M, Miró, JM, Naber, C, Tripodi, MF, Murdoch, DR, Moreillon, P, Utili, R, and Wang, A. "Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure." Jama 306, no. 20 (November 2011): 2239-2247. Full Text
  - Nienaber, JJC, Sharma Kuinkel, BK, Clarke-Pearson, M, Lamlertthon, S, Park, L, Rude, TH, Barriere, S, Woods, CW, Chu, VH, Marín, M, Bukovski, S, Garcia, P, Corey, GR, Korman, T, Doco-Lecompte, T, Murdoch, DR, Reller, LB, Fowler, VG, and International Collaboration on Endocarditis-Microbiology Investigators, . "Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins." J Infect Dis 204, no. 5 (September 1, 2011): 704-713. Full Text Link to Item
  - Thornhill, MH, Dayer, MJ, Forde, JM, Corey, GR, Chu, VH, Couper, DJ, and Lockhart, PB. "Impact of the NICE guideline recommending cessation of antibiotic prophylaxis for prevention of infective endocarditis: before and after study." Bmj (Clinical Research Ed.) 342 (January 2011): d2392-null. Full Text
  - Thornhill, MH, Dayer, MJ, Forde, JM, Corey, GR, Chu, VH, Couper, DJ, and Lockhart, PB. "Impact of the NICE guideline recommending cessation of antibiotic prophylaxis for prevention of infective endocarditis: before and after study." BMJ (Clinical research ed.) 342 (2011): d2392-. Full Text
  - Lalani, T, Cabell, CH, Benjamin, DK, Lasca, O, Naber, C, Fowler, VG, Corey, GR, Chu, VH, Fenely, M, Pachirat, O, Tan, R-S, Watkin, R, Ionac, A, Moreno, A, Mestres, CA, Casabé, J, Chipigina, N, Eisen, DP, Spelman, D, Delahaye, F, Peterson, G, Olaison, L, Wang, A, and International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, . "Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias." Circulation 121, no. 8 (March 2010): 1005-1013. Full Text Open Access Copy
  - Eisen, DP, Corey, GR, McBryde, ES, Fowler, VG, Miro, JM, Cabell, CH, Street, AC, Paiva, MG, Ionac, A, Tan, R-S, Tribouilloy, C, Pachirat, O, Jones, SB, Chipigina, N, Naber, C, Pan, A, Ravasio, V, Gattringer, R, Chu, VH, Bayer, AS, and ICE Investigators, . "Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid." J Infect 58, no. 5 (May 2009): 332-338. Full Text Link to Item
  - Chu, VH, Miro, JM, Hoen, B, Cabell, CH, Pappas, PA, Jones, P, Stryjewski, ME, Anguera, I, Braun, S, Muñoz, P, Commerford, P, Tornos, P, Francis, J, Oyonarte, M, Selton-Suty, C, Morris, AJ, Habib, G, Almirante, B, Sexton, DJ, Corey, GR, Fowler, VG, and International Collaboration on Endocarditis-Prospective Cohort Study Group, . "Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study." Heart (British Cardiac Society) 95, no. 7 (April 2009): 570-576. Full Text
  - Murdoch, DR, Corey, GR, Hoen, B, Miró, JM, Fowler, VG, Bayer, AS, Karchmer, AW, Olaison, L, Pappas, PA, Moreillon, P, Chambers, ST, Chu, VH, Falcó, V, Holland, DJ, Jones, P, Klein, JL, Raymond, NJ, Read, KM, Tripodi, MF, Utili, R, Wang, A, Woods, CW, Cabell, CH, and International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, . "Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study." Archives of Internal Medicine 169, no. 5 (March 2009): 463-473. Full Text
  - Stryjewski, ME, Kanafani, ZA, Chu, VH, Pappas, PA, Harding, T, Drew, LA, Benjamin, DK, Reller, LB, Lee, BA, Corey, GR, and Fowler, VG. "Staphylococcus aureus bacteremia among patients with health care-associated fever." Am J Med 122, no. 3 (March 2009): 281-289.e2. Full Text Link to Item
  - Chu, VH, Miro, JM, Hoen, B, Cabell, CH, Pappas, PA, Jones, P, Stryjewski, ME, Anguera, I, Braun, S, Mũnoz, P, Commerford, P, Tornos, P, Francis, J, Oyonarte, M, Selton-Suty, C, Morris, AJ, Habib, G, Almirante, B, Sexton, DJ, Corey, GR, and Jr, VGF. "Coagulase-negative staphylococcal prosthetic valve endocarditis-a contemporary update based on the International Collaboration on Endocarditis: Prospective cohort study." Heart 95, no. 7 (2009): 570-576. Full Text
  - Monk, AB, Boundy, S, Chu, VH, Bettinger, JC, Robles, JR, Fowler, VG, and Archer, GL. "Analysis of the genotype and virulence of Staphylococcus epidermidis isolates from patients with infective endocarditis." Infection and Immunity 76, no. 11 (November 2008): 5127-5132. Full Text
  - Lalani, T, Federspiel, JJ, Boucher, HW, Rude, TH, Bae, I-G, Rybak, MJ, Tonthat, GT, Corey, GR, Stryjewski, ME, Sakoulas, G, Chu, VH, Alder, J, Steenbergen, JN, Luperchio, SA, Campion, M, Woods, CW, and Fowler, VG. "Associations between the genotypes of Staphylococcus aureus bloodstream isolates and clinical characteristics and outcomes of bacteremic patients." Journal of Clinical Microbiology 46, no. 9 (September 2008): 2890-2896. Full Text
  - Baddley, JW, Benjamin, DK, Patel, M, Miró, J, Athan, E, Barsic, B, Bouza, E, Clara, L, Elliott, T, Kanafani, Z, Klein, J, Lerakis, S, Levine, D, Spelman, D, Rubinstein, E, Tornos, P, Morris, AJ, Pappas, P, Fowler, VG, Chu, VH, Cabell, C, and International Collaboration on Endocarditis-Prospective Cohort Study Group (ICE-PCS), . "Candida infective endocarditis." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology 27, no. 7 (July 2008): 519-529. Full Text
  - Liao, L, Kong, DF, Samad, Z, Pappas, PA, Jollis, JG, Lin, SS, Wang, A, Fowler, VG, Chu, VH, Sexton, DJ, Corey, GR, and Cabell, CH. "Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis." Heart 94, no. 5 (May 2008): e18-. Full Text Link to Item
  - Petti, CA, Simmon, KE, Miro, JM, Hoen, B, Marco, F, Chu, VH, Athan, E, Bukovski, S, Bouza, E, Bradley, S, Fowler, VG, Giannitsioti, E, Gordon, D, Reinbott, P, Korman, T, Lang, S, Garcia-de-la-Maria, C, Raglio, A, Morris, AJ, Plesiat, P, Ryan, S, Doco-Lecompte, T, Tripodi, F, Utili, R, Wray, D, Federspiel, JJ, Boisson, K, Reller, LB, Murdoch, DR, Woods, CW, and International Collaboration on Endocarditis-Microbiology Investigators, . "Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective." Journal of Clinical Microbiology 46, no. 5 (May 2008): 1780-1784. Full Text
  - Chu, VH, Woods, CW, Miro, JM, Hoen, B, Cabell, CH, Pappas, PA, Federspiel, J, Athan, E, Stryjewski, ME, Nacinovich, F, Marco, F, Levine, DP, Elliott, TS, Fortes, CQ, Tornos, P, Gordon, DL, Utili, R, Delahaye, F, Corey, GR, Fowler, VG, and International Collaboration on Endocarditis-Prospective Cohort Study Group, . "Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis." Clin Infect Dis 46, no. 2 (January 15, 2008): 232-242. Full Text Link to Item
  - Chu, VH. "Coagulase-negative staphylococci and endocarditis: Reappraisal in the 21st century." Enfermedades Infecciosas y Microbiologia Clinica 26, no. 5 (2008): 261-262.
  - Lalani, T, Chu, VH, Grussemeyer, CA, Reed, SD, Bolognesi, MP, Friedman, JY, Griffiths, RI, Crosslin, DR, Kanafani, ZA, Kaye, KS, Ralph Corey, G, and Fowler, VG. "Clinical outcomes and costs among patients with Staphylococcus aureus bacteremia and orthopedic device infections." Scand J Infect Dis 40, no. 11-12 (2008): 973-977. Full Text Link to Item
  - Morpeth, S, Murdoch, D, Cabell, CH, Karchmer, AW, Pappas, P, Levine, D, Nacinovich, F, Tattevin, P, Fernández-Hidalgo, N, Dickerman, S, Bouza, E, Río, AD, Lejko-Zupanc, T, Ramos, ADO, Iarussi, D, Klein, J, Chirouze, C, Bedimo, R, Corey, GR, Jr, VGF, and Investigators, ICOEPCSICE-PCS. "Non-HACEK gram-negative bacillus endocarditis." Annals of internal medicine 147, no. 12 (December 2007): 829-835. (Academic Article)
  - Stryjewski, ME, Hall, RP, Chu, VH, Kanafani, ZA, O'Riordan, WD, Weinstock, MS, Stienecker, RS, Streilein, R, Dorschner, RA, Fowler, VG, Corey, GR, and Gallo, RL. "Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis." J Infect Dis 196, no. 9 (November 1, 2007): 1425-1430. Full Text Link to Item
  - Chu, VH, and Bayer, AS. "Use of echocardiography in the diagnosis and management of infective endocarditis." Curr Infect Dis Rep 9, no. 4 (July 2007): 283-290. Link to Item
  - Aksoy, O, Sexton, DJ, Wang, A, Pappas, PA, Kourany, W, Chu, V, Fowler, VG, Woods, CW, Engemann, JJ, Corey, GR, Harding, T, and Cabell, CH. "Early surgery in patients with infective endocarditis: a propensity score analysis." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 44, no. 3 (February 2007): 364-372. Full Text
  - Stryjewski, ME, Szczech, LA, Benjamin, DK, Inrig, JK, Kanafani, ZA, Engemann, JJ, Chu, VH, Joyce, MJ, Reller, LB, Corey, GR, and Fowler, VG. "Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 44, no. 2 (January 2007): 190-196. Full Text
  - Lalani, T, Kanafani, ZA, Chu, VH, Moore, L, Corey, GR, Pappas, P, Woods, CW, Cabell, CH, Hoen, B, Selton-Suty, C, Doco-Lecompte, T, Chirouze, C, Raoult, D, Miro, JM, Mestres, CA, Olaison, L, Eykyn, S, Abrutyn, E, Fowler, VG, and International Collaboration on Endocarditis Merged Database Study Group, . "Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology 25, no. 6 (June 2006): 365-368. Full Text
  - Stryjewski, ME, Chu, VH, O'Riordan, WD, Warren, BL, Dunbar, LM, Young, DM, Vallée, M, Fowler, VG, Morganroth, J, Barriere, SL, Kitt, MM, Corey, GR, and FAST 2 Investigator Group, . "Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study." Antimicrobial Agents and Chemotherapy 50, no. 3 (March 2006): 862-867. Full Text
  - Chu, VH, Crosslin, DR, Friedman, JY, Reed, SD, Cabell, CH, Griffiths, RI, Masselink, LE, Kaye, KS, Corey, GR, Reller, LB, Stryjewski, ME, Schulman, KA, and Fowler, VG. "Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes." Am J Med 118, no. 12 (December 2005): 1416-. Full Text Link to Item
  - Chu, VH, Sexton, DJ, Cabell, CH, Reller, LB, Pappas, PA, Singh, RK, Fowler, VG, Corey, GR, Aksoy, O, and Woods, CW. "Repeat infective endocarditis: differentiating relapse from reinfection." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 41, no. 3 (August 2005): 406-409. Full Text
  - Stryjewski, ME, O'Riordan, WD, Lau, WK, Pien, FD, Dunbar, LM, Vallee, M, Fowler, VG, Chu, VH, Spencer, E, Barriere, SL, Kitt, MM, Cabell, CH, Corey, GR, and FAST Investigator Group, . "Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria." Clin Infect Dis 40, no. 11 (June 1, 2005): 1601-1607. Full Text Link to Item
  - El-Ahdab, F, Benjamin, DK, Wang, A, Cabell, CH, Chu, VH, Stryjewski, ME, Corey, GR, Sexton, DJ, Reller, LB, and Fowler, VG. "Risk of endocarditis among patients with prosthetic valves and Staphylococcus aureus bacteremia." Am J Med 118, no. 3 (March 2005): 225-229. Full Text Link to Item
  - Shah, PM, Chu, VH, Cabell, CH, Corey, GR, Miro, JM, Stryjewski, ME, Pappas, P, Habib, G, and Jr, VGF. "Classification of community-acquired endocarditis due to coagulase-negative staphylococci [4] (multiple letters)." Clinical Infectious Diseases 40, no. 11 (2005): 1704-1705.
  - Chu, VH, Cabell, CH, Abrutyn, E, Corey, GR, Hoen, B, Miro, JM, Olaison, L, Stryjewski, ME, Pappas, P, Anstrom, KJ, Eykyn, S, Habib, G, Benito, N, Fowler, VG, and International Collaboration on Endocarditis Merged Database Study Group, . "Native valve endocarditis due to coagulase-negative staphylococci: report of 99 episodes from the International Collaboration on Endocarditis Merged Database." Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America 39, no. 10 (November 2004): 1527-1530. Full Text
  - Stryjewski, ME, Chu, VH, Cabell, CH, and Fowler, VG. "Issues in the Management of Endocarditis Caused by Resistant Gram-positive Organisms." Curr Infect Dis Rep 6, no. 4 (August 2004): 283-291. Link to Item
  - Cabell, CH, Heidenreich, PA, Chu, VH, Moore, CM, Stryjewski, ME, Corey, GR, and Fowler, VG. "Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999." American Heart Journal 147, no. 4 (April 2004): 582-586. Full Text
  - Chu, VH, Cabell, CH, Benjamin, DK, Kuniholm, EF, Fowler, VG, Engemann, J, Sexton, DJ, Corey, GR, and Wang, A. "Early predictors of in-hospital death in infective endocarditis." Circulation 109, no. 14 (April 2004): 1745-1749. Full Text
- Book Sections
  - Chu, VH. "HACEK." In Clinical Infectious Disease, Second Edition, 904-906. January 1, 2015. Full Text
  - Chu, VH, and Sexton, DJ. "Hacek." In Clinical Infectious Disease, 965-968. January 1, 2010. Full Text
Teaching & Mentoring
Recent Courses
- CRSP 301B: RESEARCH IN CLINICAL RESEARCH 2018
Advising & Mentoring
- Dr. Chu is the co-director of the 3^rd year Duke medical student Clinical Research Study Program (CRSP). This program oversees the clinical research experience of ~10-20 year medical students per year. The program provides mentorship, didactics, and ensures that students actively engage in a specific research project with the goal of a manuscript acceptable for peer-review.
  
  As the Associate Director of Education for Duke’s Clinical and Translational Sciences Award (CTSA) program (U54) 2013 – 2018, Dr. Chu is working to develop educational and career development programs to enhance the success and productivity of clinical/translational researchers.
  
  Dr. Chu is program director of the North Carolina Collaborative Summer Research Experience Program, an 8-week summer program to engage high school students and undergraduates in clinical research and career development in the health sciences. This is funded through the NIH (R25) 2013-2018.
  
  Dr. Chu is also the faculty director for the Duke Clinical Research Undergraduate Experience (dCRUE) which is a weekly dinner lecture series that exposes Duke University undergraduates to clinical and translational research.

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Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Book Sections

Recent Courses

Advising & Mentoring