Scholars@Duke
W. Robert Lee

W. Robert Lee

Professor Emeritus of Radiation Oncology
Radiation Oncology
w.robert.lee@duke.edu
Box 3085 Med Ctr, Durham, NC 27710
201 Trent Drive, Box 3085, Durham, NC 27710

Featured Works

Variation in the definition of clinical target volumes for pelvic nodal conformal radiation therapy for prostate cancer.

Journal article Int J Radiat Oncol Biol Phys · June 1, 2009 Featured Work PURPOSE: We conducted a comparative study of clinical target volume (CTV) definition of pelvic lymph nodes by multiple genitourinary (GU) radiation oncologists looking at the levels of discrepancies amongst this group. METHODS AND MATERIALS: Pelvic compute ... Full text Link to item Cite

RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer.

Journal article Int J Radiat Oncol Biol Phys · June 1, 2009 Featured Work PURPOSE: Radiation therapy to the pelvic lymph nodes in high-risk prostate cancer is required on several Radiation Therapy Oncology Group (RTOG) clinical trials. Based on a prior lymph node contouring project, we have shown significant disagreement in the ... Full text Link to item Cite

The ethics of hypofractionation for prostate cancer.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2009 Featured Work Full text Link to item Cite

Extreme hypofractionation for prostate cancer.

Journal article Expert Rev Anticancer Ther · January 2009 Featured Work In ideal circumstances the fractionation schedule of radiotherapy should match the fractionation sensitivity of the tumor relative to the nearby normal tissues. A number of recent publications have suggested that the alpha/beta ratio for prostate tumors is ... Full text Link to item Cite

Technology assessment: vigilance required.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2008 Featured Work Full text Link to item Cite

On-line re-optimization of prostate IMRT plans for adaptive radiation therapy.

Journal article Phys Med Biol · February 7, 2008 Featured Work For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques s ... Full text Link to item Cite

Pretreatment prostate-specific antigen velocity is associated with freedom from biochemical recurrence of prostate cancer after low-dose-rate prostate brachytherapy alone.

Journal article Brachytherapy · 2008 Featured Work PURPOSE: This report examines the relationship between pretreatment prostate-specific antigen (PSA) velocity (PSAV) and freedom from biochemical recurrence (FFBR) in men with prostate cancer treated with low-dose-rate prostate brachytherapy (LDRPB). METHOD ... Full text Link to item Cite

Hypofractionation for prostate cancer: a critical review.

Journal article Semin Radiat Oncol · January 2008 Featured Work In ideal circumstances, the fractionation schedule of radiotherapy should match the fractionation sensitivity of the tumor relative to the nearby normal tissues. A number of recent publications have suggested that the alpha-beta ratio (alpha/beta) for pros ... Full text Link to item Cite

Reducing biochemical recurrence rates in EBRT-treated prostate cancer patients: the influence of dose and dose per fraction.

Journal article Future Oncol · December 2007 Featured Work In the last 15-20 years, technological improvements in radiation treatment planning and delivery have allowed radiation oncologists to increase the total dose to the prostate gland. The results of four randomized trials using conventional daily doses (1.8- ... Full text Link to item Cite

Male breast cancer during treatment with leuprolide for prostate cancer.

Journal article Clin Adv Hematol Oncol · July 2007 Featured Work Link to item Cite

Late toxicity and biochemical recurrence after external-beam radiotherapy combined with permanent-source prostate brachytherapy: analysis of Radiation Therapy Oncology Group study 0019.

Journal article Cancer · April 15, 2007 Featured Work BACKGROUND: The combination of external-beam radiotherapy and brachytherapy is used commonly to treat men with prostate cancer. In this analysis, the authors examined the rate of biochemical recurrence (BR) and late grade > or =3 genitourinary (GU) and gas ... Full text Link to item Cite

A simple model predicts freedom from biochemical recurrence after low-dose rate prostate brachytherapy alone.

Journal article Am J Clin Oncol · April 2007 Featured Work OBJECTIVE: The objective of this study was to describe a simple model that predicts freedom from biochemical recurrence (FFBR) in men with prostate cancer after treatment with low-dose rate prostate brachytherapy (LDRPB) alone. MATERIALS AND METHODS: One h ... Full text Link to item Cite

Does a delay in initiating definitive therapy affect biochemical recurrence rates in men with clinically localized prostate cancer?

Journal article Urol Oncol · 2007 Featured Work PURPOSE: To assess whether a delay in initiating definitive therapy for clinically localized prostate cancer affects outcome. METHODS: We retrospectively reviewed 393 men with localized prostate cancer treated with radiation therapy or surgery without syst ... Full text Link to item Cite

Prostate brachytherapy: a descriptive analysis from CaPSURE.

Journal article Brachytherapy · 2007 Featured Work PURPOSE: The purpose of this study was to describe demographic and clinical characteristics in a large disease registry of prostate cancer patients treated with prostate brachytherapy (PB) and to identify factors influencing the use of supplemental externa ... Full text Link to item Cite

Results of a phase II trial of transrectal ultrasound-guided permanent radioactive implantation of the prostate for definitive management of localized adenocarcinoma of the prostate (radiation therapy oncology group 98-05).

Journal article Int J Radiat Oncol Biol Phys · January 1, 2007 Featured Work PURPOSE: To evaluate the effectiveness of transrectal ultrasound-guided permanent radioactive (125)I implantation of the prostate for organ-confined adenocarcinoma of the prostate compared with historical data of prostatectomy and external beam radiotherap ... Full text Link to item Cite

Computer-based learning in medical education: a critical view.

Journal article J Am Coll Radiol · October 2006 Featured Work A number of reports in the past decade have concluded that the medical education system must be reformed. These reports often call for the incorporation of new technologies into the educational process. One technology that has found its way into the medica ... Full text Link to item Cite

Confidence intervals and survival estimates: a systematic review of 3 oncology journals.

Journal article Am J Clin Oncol · August 2006 Featured Work PURPOSE: Kaplan-Meier methods generate an estimate of survival when follow-up is less than complete. Confidence intervals (CI) provide a range of values that is likely to contain the true result. We hypothesized that reporting of CI around survival estimat ... Full text Link to item Cite

Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy.

Journal article Urology · June 2006 Featured Work OBJECTIVES: To report a prospective trial of lycopene supplementation in biochemically relapsed prostate cancer. METHODS: A total of 36 men with biochemically relapsed prostate cancer were enrolled in a dose-escalating, Phase I-II trial of lycopene supplem ... Full text Link to item Cite

Update on brachytherapy in localized prostate cancer: the importance of dosimetry.

Journal article Curr Opin Urol · May 2006 Featured Work PURPOSE OF REVIEW: Prostate brachytherapy has become a common treatment modality for clinical localized adenocarcinoma of the prostate. This is the result of prostate screening and improved technology that currently allows for an outpatient procedure that ... Full text Link to item Cite

A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2006 Featured Work PURPOSE: To estimate the rate of acute and late Grade 3-5 genitourinary and gastrointestinal toxicity after treatment with external beam radiotherapy and permanent source brachytherapy in a multi-institutional, cooperative group setting. METHODS AND MATERI ... Full text Link to item Cite

Percentage of positive biopsies associated with freedom from biochemical recurrence after low-dose-rate prostate brachytherapy alone for clinically localized prostate cancer.

Journal article Urology · February 2006 Featured Work OBJECTIVES: To examine the relationship between the percentage of positive biopsies (PPBs) and freedom from biochemical recurrence (FFBR) in men treated with low-dose-rate prostate brachytherapy (LDRPB) alone. The PPBs has been associated with FFBR in men ... Full text Link to item Cite

A descriptive analysis of postimplant dosimetric parameters from Radiation Therapy Oncology Group P0019.

Journal article Brachytherapy · 2006 Featured Work BACKGROUND: To date, there are few descriptive analyses of postimplant dosimetry from multi-institutional clinical trials. The purpose of this report is to describe the postimplant dosimetry achieved in Radiation Therapy Oncology Group (RTOG) 0019. METHODS ... Full text Link to item Cite

Health-related quality of life in men receiving prostate brachytherapy on RTOG 98-05.

Journal article Int J Radiat Oncol Biol Phys · July 15, 2005 Featured Work PURPOSE: To prospectively assess health-related quality of life (HRQOL) during the first year after treatment with prostate brachytherapy (PB) alone for T1c-2a prostate cancer. MATERIALS AND METHODS: Ninety-eight patients from 24 institutions were eligible ... Full text Link to item Cite

Is NNT AOK?

Journal article Int J Radiat Oncol Biol Phys · March 1, 2005 Featured Work Full text Link to item Cite

Dosimetric quantifiers for low-dose-rate prostate brachytherapy: is V(100) superior to D(90)?

Journal article Brachytherapy · 2005 Featured Work PURPOSE: The purpose of the present report is to describe the relationship between two dosimetric quantifiers (V(100) and D(90)) and freedom from biochemical recurrence (FFBR) in a cohort of men treated with low-dose-rate prostate brachytherapy (LDRPB) alo ... Full text Link to item Cite

Changes in graduate medical education: a view from radiation oncology.

Journal article J Am Coll Radiol · August 2004 Featured Work The accreditation process of graduate medical education is changing. This change presents new challenges to teachers of radiation oncology. With the help of the ACR and other institutions, radiation oncology is well positioned to meet this challenge. ... Full text Link to item Cite

Cancer control after low-dose-rate prostate brachytherapy performed by a multidisciplinary team with no previous prostate brachytherapy experience.

Journal article Urology · June 2004 Featured Work OBJECTIVES: To describe the biochemical disease-free survival observed in the first cohort men treated by a multidisciplinary team of clinicians with no previous experience in low-dose-rate prostate brachytherapy (LDRPB). METHODS: The information in this r ... Full text Link to item Cite

Medical malpractice and prostate brachytherapy.

Journal article Brachytherapy · 2004 Featured Work Full text Link to item Cite

Permanent prostate brachytherapy: the significance of postimplant dosimetry.

Journal article Rev Urol · 2004 Featured Work Recent developments in imaging science and treatment-planning software allow for accurate postimplant dosimetric assessment in all patients after prostate brachytherapy. This article reviews the available data correlating cancer control and morbidity with ... Link to item Cite

In regard to Ghaly et al., IJROBP 2003;55:1288-1293.

Journal article Int J Radiat Oncol Biol Phys · November 15, 2003 Featured Work Full text Link to item Cite

The 1999 patterns of care study of radiotherapy in localized prostate carcinoma: a comprehensive survey of prostate brachytherapy in the United States.

Journal article Cancer · November 1, 2003 Featured Work BACKGROUND: The objective of the current study was to provide descriptive information on a representative national sample of patients with prostate carcinoma who were treated with prostate brachytherapy (PB) in calendar year 1999. METHODS: A random survey ... Full text Link to item Cite

A structured literature review to determine the use of the American Society for Therapeutic Radiology and Oncology consensus definition of biochemical failure.

Journal article Urology · February 2003 Featured Work OBJECTIVES: The American Society for Therapeutic Radiology and Oncology consensus definition (ACD) of biochemical failure after radiotherapy for prostate cancer requires three consecutive prostate-specific antigen increases from a nadir value. The members ... Full text Link to item Cite

Radioactive sources embedded in suture are associated with improved postimplant dosimetry in men treated with prostate brachytherapy.

Journal article Radiother Oncol · November 2002 Featured Work BACKGROUND AND PURPOSE: Reports using the retropubic and transperineal technique of prostate brachytherapy suggest that adequate radiation doses are required for good clinical results with I-125. After 3 years of using loose sources (LS), radioactive sourc ... Full text Link to item Cite

Interobserver variability leads to significant differences in quantifiers of prostate implant adequacy.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2002 Featured Work PURPOSE: To compare the prostate gland volumes and subsequent quantifiers of implant adequacy determined by five separate brachytherapists on postimplant CT images performed 1 day after prostate brachytherapy. METHODS AND MATERIALS: Ten consecutive patient ... Full text Link to item Cite

The role of androgen deprivation therapy combined with prostate brachytherapy.

Journal article Urology · September 2002 Featured Work Several prospective randomized clinical trials have demonstrated improved outcomes in men receiving androgen deprivation therapy (ADT) in combination with definitive local therapy (external-beam radiotherapy or surgery). ADT is commonly combined with prost ... Full text Link to item Cite

Quality of life after prostate cancer treatment.

Journal article J Clin Oncol · July 1, 2002 Featured Work Full text Link to item Cite

Radiation dose to the neurovascular bundles or penile bulb does not predict erectile dysfunction after prostate brachytherapy.

Journal article Brachytherapy · 2002 Featured Work PURPOSE: To examine the relationship between calculated doses to the neurovascular bundles (NVBs) and the penile bulb (PB) and the development of erectile dysfunction (ED) after low-dose-rate prostate brachytherapy (LDRPB) alone. METHODS AND MATERIALS: Bet ... Full text Link to item Cite