Julia K.L. Walker

Journal article Proceedings of the National Academy of Sciences of the United States of America · October 2012 Featured Publication Proteinase-Activated rreceptor-2 (PAR(2)), a G-protein-coupled Receptor, activated by serine proteinases, is reported to have both protective and proinflammatory effects in the airway. Given these opposing actions, both inhibitors and activators of PAR(2) ... Full text Cite

Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.

Journal article Br J Pharmacol · April 2012 Featured Publication BACKGROUND AND PURPOSE: Inhalation of a β-adrenoceptor agonist (β-agonist) is first-line asthma therapy, used for both prophylaxis against, and acute relief of, bronchoconstriction. However, repeated clinical use of β-agonists leads to impaired bronchoprot ... Full text Link to item Cite

New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.

Journal article British journal of pharmacology · May 2011 Featured Publication In the last two decades several significant changes have been proposed in the receptor theory that describes how ligands can interact with G protein-coupled receptors (GPCRs). Here we briefly summarize the evolution of receptor theory and detail recent pro ... Full text Cite

beta-Adrenoceptor inverse agonists in asthma.

Journal article Current opinion in pharmacology · June 2010 Featured Publication Beta(2)-adrenoceptor (beta(2)-AR) agonists are very effective bronchodilators and play a major role in every stage of asthma management. However, their chronic, regular use is associated with detrimental effects including an increase in asthma-related deat ... Full text Cite

Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease.

Journal article American journal of respiratory cell and molecular biology · October 2009 Featured Publication Allergic asthma, a major cause of morbidity and leading cause of hospitalizations, is an inflammatory disease orchestrated by T helper cells and characterized by lung migration of eosinophils, important asthma effector cells. Lung migration of inflammatory ... Full text Cite

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.

Journal article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · July 2008 Featured Publication Chronic use of inhaled beta-agonists by asthmatics is associated with a loss of bronchoprotective effect and deterioration of asthma control. Beta-agonist-promoted desensitization of airway smooth muscle beta-2-adrenergic receptors, mediated by G protein-c ... Full text Cite

Beta-arrestin-2 regulates the development of allergic asthma.

Journal article J Clin Invest · August 2003 Featured Publication Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function and is regulated in large part ... Full text Open Access Link to item Cite