Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Endocrinology, Medicine, Duke University 1977 - 1979
  • Fellow in Endocrinology, Medicine, Duke University 1974 - 1975
  • Medical Resident, Medicine, Duke University 1972 - 1974
  • Rotating Intern, Medicine, Charlotte Memorial Hospital & Medical Center 1971 - 1972
  • M.D., Wake Forest University 1971
• 

  Duke Appointment History

  • Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2001 - 2013
  • Associate Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 1987 - 2001
  • Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 1995
  • Assistant Professor of Medicine, Medicine, Clinical Science Departments 1981 - 1987
  • Associate in the Department of Medicine, Medicine, Clinical Science Departments 1977 - 1981
• Research
• 

  Selected Grants

  • Hormonal Effects On Cartilage Growth awarded by National Institutes of Health 1986 - 1987
  • Hormonal Effects On Cartilage Growth And Metabolism awarded by National Institutes of Health 1984 - 1985
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Manoli, Irini, Justin Y. Kwan, Qian Wang, Elisabeth J. Rushing, Maria Tsokos, Andrew E. Arai, Warner M. Burch, Angela Dispenzieri, Alexandra C. McPherron, and William A. Gahl. “Chronic myopathy due to immunoglobulin light chain amyloidosis..” Mol Genet Metab 108, no. 4 (April 2013): 249–54. https://doi.org/10.1016/j.ymgme.2013.01.015.
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    • Burch, W. “Using bedtime (PM) and early morning (AM) urine cortisol/creatinine ratios to evaluate pituitary-adrenal function in an office practice.” Endocrine Practice 17, no. 4 (2011): 591–97. https://doi.org/10.4158/EP10177.OR.
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    • Jayaraj, K., and W. Burch. “Visual vignette. Hyperparathyroidism due to a parathyroid adenoma..” Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 6, no. 1 (2000).
    • Bruch, J., and W. Burch. “Approach to the patient with Graves' disease and an anterior mediastinal mass.” Endocrinologist 5, no. 2 (1995): 97–99.
    • Opara, E. C., M. Garfinkel, V. S. Hubbard, W. M. Burch, and O. E. Akwari. “Effect of fatty acids on insulin release: Role of chain length and degree of unsaturation.” American Journal of Physiology  Endocrinology and Metabolism 266, no. 4 29-4 (January 1, 1994).
    • Opara, E. C., M. Garfinkel, V. S. Hubbard, W. M. Burch, and O. E. Akwari. “Effect of fatty acids on insulin release: Role of chain length and degree of unsaturation.” Am.J.Physiol. 266, no. 4 part 1 (January 1, 1994).
    • Opara, E. C., V. S. Hubbard, W. M. Burch, and O. E. Akwari. “Addition of L-glutamine to a linoleic acid perifusate prevents the fatty acid-induced desensitization of pancreatic islet response to glucose.” The Journal of Nutritional Biochemistry 4, no. 6 (January 1, 1993): 357–61. https://doi.org/10.1016/0955-2863(93)90082-8.
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    • Opara, E. C., V. S. Hubbard, W. M. Burch, and O. E. Akwari. “Characterization of the insulinotropic potency of polyunsaturated fatty acids..” Endocrinology 130, no. 2 (February 1992): 657–62. https://doi.org/10.1210/endo.130.2.1733714.
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    • Jr, W. M. B. “A response to: "A woman with too much facial hair"..” North Carolina Medical Journal 53, no. 10 (1992).
    • Opara, E. C., W. M. Burch, I. L. Taylor, and O. E. Akwari. “Pancreatic hormone response to neuropeptide Y (NPY) perifusion in vitro..” Regul Pept 34, no. 3 (July 9, 1991): 225–33. https://doi.org/10.1016/0167-0115(91)90181-f.
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    • Opara, E. C., V. S. Hubbard, W. M. Burch, and O. E. Akwari. “Homologous desensitization of pancreatic beta cells to glucose response by polyunsaturated fatty acids.” The Journal of Nutritional Biochemistry 2, no. 8 (January 1, 1991): 424–29. https://doi.org/10.1016/0955-2863(91)90111-H.
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    • Opara, E. C., W. M. Burch, and O. E. Akwari. “Characterization of glutamine-regulated pancreatic islet hormone release.” Surgical Forum 41 (December 1, 1990): 16–19.
    • Opara, E. C., W. M. Burch, V. S. Hubbard, and O. E. Akwari. “Enhancement of endocrine pancreatic secretions by essential fatty acids..” J Surg Res 48, no. 4 (April 1990): 329–32. https://doi.org/10.1016/0022-4804(90)90068-d.
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    • Burch, W. M., J. Correa, J. E. Shively, and D. R. Powell. “The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro..” J Clin Endocrinol Metab 70, no. 1 (January 1990): 173–80. https://doi.org/10.1210/jcem-70-1-173.
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    • Canalis, E., M. Centrella, W. Burch, and T. L. McCarthy. “Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.” Journal of Clinical Investigation 83, no. 1 (1989): 60–65. https://doi.org/10.1172/JCI113885.
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    • Jr, J. B. H., and W. M. Burch. “Rapid tests of adrenocortical function. Intravenous versus intramuscular administration of synthetic ACTH..” North Carolina Medical Journal 50, no. 6 (1989): 306–8.
    • Burch, W. M., M. Lopez-Claros, M. R. Uskokovic, and M. K. Drezner. “1,25-Dihydroxyvitamin D3 stimulates avian and mammalian cartilage growth in vitro..” J Bone Miner Res 3, no. 1 (February 1988): 87–91. https://doi.org/10.1002/jbmr.5650030113.
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    • Zola, B. E., B. Miller, G. L. Stiles, P. S. Rao, E. H. Sonnenblick, and F. S. Fein. “Heart rate control in diabetic rabbits: blunted response to isoproterenol.” American Journal of Physiology  Endocrinology and Metabolism 255, no. 5 (1988).
    • Itani, K. M., O. E. Akwari, W. Burch, C. R. Watters, and R. E. Coleman. “Gastric emptying, glucose tolerance, and insulin response after duodenojejunostomy..” J Surg Res 42, no. 5 (May 1987): 521–27. https://doi.org/10.1016/0022-4804(87)90027-8.
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    • Burch, W. M. “Hashimoto's thyroiditis presenting as a retropharyngeal mass..” North Carolina Medical Journal 48, no. 11 (1987): 561–63.
    • Burch, W. M. “Growth of fetal porcine scapular cartilage in vitro.” American Journal of the Medical Sciences 293, no. 4 (January 1, 1987): 209–15. https://doi.org/10.1097/00000441-198704000-00001.
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    • Burch, W. M., and J. J. Van Wyk. “Triiodothyronine stimulates cartilage growth and maturation by different mechanisms.” American Journal of Physiology  Endocrinology and Metabolism 252, no. 2 (January 1, 1987).
    • Gillespie, C. A., J. S. Walker, W. M. Burch, P. D. Kenan, and R. S. Kramer. “Cushing's syndrome secondary to ectopic pituitary adenoma in the sphenoid sinus.” Otolaryngology Head and Neck Surgery 96, no. 6 (January 1, 1987): 569–72. https://doi.org/10.1177/019459988709600610.
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    • Buckley, N. J., W. M. Burch, and G. S. Leight. “Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature..” Surgery 100, no. 5 (November 1986): 932–37.
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    • Burch, W. M., J. L. Ch’ng, and H. T. McPherson. “Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure..” N C Med J 47, no. 11 (November 1986).
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    • Burch, W. M., S. Weir, and J. J. Van Wyk. “Embryonic chick cartilage produces its own somatomedin-like peptide to stimulate cartilage growth in vitro..” Endocrinology 119, no. 3 (September 1986): 1370–76. https://doi.org/10.1210/endo-119-3-1370.
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    • Burch, W. M. “Cushing's disease. A review..” Arch Intern Med 145, no. 6 (June 1985): 1106–11.
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    • Burch, W. M., and G. Corda. “Calcitonin stimulates maturation of mammalian growth plate cartilage..” Endocrinology 116, no. 5 (May 1985): 1724–28. https://doi.org/10.1210/endo-116-5-1724.
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    • Burch, W. M., G. Corda, J. J. Kopchick, and F. C. Leung. “Homologous and heterologous growth hormones fail to stimulate avian cartilage growth in vitro..” J Clin Endocrinol Metab 60, no. 4 (April 1985): 747–50. https://doi.org/10.1210/jcem-60-4-747.
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    • Burch, W. M., R. S. Kramer, P. D. Kenan, and C. B. Hammond. “Cushing's disease caused by an ectopic pituitary adenoma within the sphenoid sinus..” N Engl J Med 312, no. 9 (February 28, 1985): 587–88. https://doi.org/10.1056/nejm198502283120921.
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    • Burch, W. M., G. Hamner, and R. E. Wuthier. “Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage..” Metabolism 34, no. 2 (February 1985): 169–75. https://doi.org/10.1016/0026-0495(85)90128-3.
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    • Kier, R., P. M. Silverman, M. Korobkin, S. Wain, G. Leight, and W. Burch. “Malignant teratoma of the thyroid in an adult: CT appearance..” J Comput Assist Tomogr 9, no. 1 (January 1985): 174–76. https://doi.org/10.1097/00004728-198501000-00030.
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    • Burch, W. M. “Thyroid malignancy masquerading as thyroiditis..” N C Med J 45, no. 9 (September 1984): 560–62.
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    • Burch, W. M. “Calcitonin stimulates growth and maturation of embryonic chick pelvic cartilage in vitro..” Endocrinology 114, no. 4 (April 1984): 1196–1202. https://doi.org/10.1210/endo-114-4-1196.
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    • Burch, W. M., and K. S. McCarty. “Hormonal stimulation of avian embryonic cartilage growth in vitro: histologic and ultrastructural features..” In Vitro 20, no. 4 (April 1984): 329–38. https://doi.org/10.1007/bf02618596.
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    • Burch, W. “Transsphenoidal microadenomectomy for Cushing's disease in children..” New England Journal of Medicine 311, no. 7 (1984).
    • Jackson, R. A., B. F. Haynes, W. M. Burch, K. Shimizu, M. A. Bowring, and G. S. Eisenbarth. “Ia⁺ T cells in new onset Graves' disease.” Journal of Clinical Endocrinology and Metabolism 59, no. 2 (1984): 187–90.
    • Dolinar, R., and W. M. Burch. “Testosterone-producing adrenal adenoma in a woman with normal urinary 17-ketosteroid levels..” Jama 250, no. 18 (November 11, 1983): 2504–5.
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    • Burch, W. M. “Normal menstruation and pregnancy in a patient with Nelson's syndrome..” South Med J 76, no. 10 (October 1983): 1319–20. https://doi.org/10.1097/00007611-198310000-00034.
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    • Burch, W. M., and J. T. Posillico. “Hypoparathyroidism after I-131 therapy with subsequent return of parathyroid function..” J Clin Endocrinol Metab 57, no. 2 (August 1983): 398–401. https://doi.org/10.1210/jcem-57-2-398.
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    • Burch, W. M., and H. E. Lebovitz. “Parathyroid hormone stimulates growth of embryonic chick pelvic cartilage in vitro..” Calcif Tissue Int 35, no. 4–5 (July 1983): 526–32. https://doi.org/10.1007/bf02405088.
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    • Burch, W. M. “Diagnosis and treatment of Cushing's disease at Duke University (1977-1982)..” N C Med J 44, no. 5 (May 1983): 293–96.
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    • Burch, W. M. “Propranolol-induced hyperthyroxinemia..” N C Med J 44, no. 4 (April 1983): 215–16.
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    • Downs, R. W., M. A. Levine, M. K. Drezner, W. M. Burch, and A. M. Spiegel. “Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism..” J Clin Invest 71, no. 2 (February 1983): 231–35. https://doi.org/10.1172/jci110763.
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    • Burch, W. “A survey of results with transsphenoidal surgery in Cushing's disease..” New England Journal of Medicine 308, no. 2 (1983): 103–4.
    • Burch, W. “Fine needle aspiration biopsy of the thyroid gland.” Annals of Internal Medicine 98, no. 6 (1983): 1023–24.
    • Burch, W. M., and H. E. Lebovitz. “Triiodothyronine stimulates maturation of porcine growth-plate cartilage in vitro..” J Clin Invest 70, no. 3 (September 1982): 496–504. https://doi.org/10.1172/jci110641.
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    • Burch, W. M., and H. E. Lebovitz. “Triiodothyronine stimulation of in vitro growth and maturation of embryonic chick cartilage..” Endocrinology 111, no. 2 (August 1982): 462–68. https://doi.org/10.1210/endo-111-2-462.
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    • Burch, W. M., and H. E. Lebovitz. “In vitro stimulation of alkaline phosphatase activity in immature embryonic chick pelvic cartilage by adenosine 3'5'-monophosphate..” J Cell Biol 93, no. 2 (May 1982): 338–42. https://doi.org/10.1083/jcb.93.2.338.
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    • Burch, W. M. “Urine free-cortisol determination. A useful tool in the management of chronic hypoadrenal states..” Jama 247, no. 14 (April 9, 1982): 2002–4. https://doi.org/10.1001/jama.247.14.2002.
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    • Burch, W. M., and R. Snyderman. “Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene..” Ann Intern Med 96, no. 3 (March 1982): 329–31. https://doi.org/10.7326/0003-4819-96-3-329.
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    • Burch, W. M., and H. E. Lebovitz. “In vitro stimulation of mammalian cartilage maturation by triiodothyronine.” Clinical Research 30, no. 2 (January 1, 1982).
    • Burch, W. M., and H. E. Lebovitz. “Parathyroid hormone stimulates embryonic cartilage growth.” Clinical Research 30, no. 2 (January 1, 1982).
    • Burch, W. M., and H. E. Lebovitz. “Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage..” Am J Physiol 241, no. 6 (December 1981): E454–59. https://doi.org/10.1152/ajpendo.1981.241.6.E454.
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    • Burch, W. M., and H. E. Lebovitz. “Adenosine 3',5'-monophosphate: a modulator of embryonic chick cartilage growth..” J Clin Invest 68, no. 6 (December 1981): 1496–1502. https://doi.org/10.1172/jci110403.
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    • Burch, W. M., and H. E. Lebovitz. “Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage.” American Journal of Physiology  Endocrinology and Metabolism 4, no. 6 (December 1, 1981): 454–59.
    • Burch, W. M. “Urinary free cortisol: A useful tool in treatment of chronic hypoadrenal states.” Clinical Research 29, no. 5 (January 1, 1981).
    • Burch, W. M., and H. E. Lebovitz. “Parathyroid hormone stimulates embryonic cartilage growth.” Clinical Research 29, no. 5 (January 1, 1981).
    • Jr, W. M. B. “Thyroid nodules: 1981..” North Carolina Medical Journal 42, no. 10 (1981): 713–14.
    • Burch, W. M., and H. E. Lebovitz. “Specific nuclear binding of adenosine 3',5'-monophosphate-binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage..” J Clin Invest 66, no. 3 (September 1980): 532–42. https://doi.org/10.1172/JCI109885.
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    • Burch, W. M. “Pseudothyrotoxic myopathy: a complication of thionamide therapy in hyperthyroidism..” South Med J 72, no. 11 (November 1979): 1494–95.
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    • Burch, W. M. “A method of aspirating thyroid cysts..” Surg Gynecol Obstet 148, no. 1 (January 1979): 95–96.
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    • Drezner, M. K., and W. M. Burch. “Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism..” J Clin Invest 62, no. 6 (December 1978): 1222–27. https://doi.org/10.1172/JCI109242.
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    • Lafferty, K. J., A. Bootes, V. A. A. Killby, and W. Burch. “Mechanism of thyroid allograft rejection.” Australian Journal of Experimental Biology and Medical Science 54, no. 6 (1976): 573–86.
    • Snyderman, R., and W. Burch. “Induction of cellular immunity to Coccidioides immitis following sensitization with dinitrochlorobenzene (DNCB).” Clinical Research 22, no. 1 (January 1, 1974).

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