Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Endocrinology, Medicine, Duke University 1977 - 1979
  • Fellow in Endocrinology, Medicine, Duke University 1974 - 1975
  • Medical Resident, Medicine, Duke University 1972 - 1974
  • Rotating Intern, Medicine, Charlotte Memorial Hospital & Medical Center 1971 - 1972
  • M.D., Wake Forest University 1971
• 

  Duke Appointment History

  • Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2001 - 2013
  • Associate Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 1987 - 2001
  • Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 1995
  • Assistant Professor of Medicine, Medicine, Clinical Science Departments 1981 - 1987
  • Associate in the Department of Medicine, Medicine, Clinical Science Departments 1977 - 1981
• Research
• 

  Selected Grants

  • Hormonal Effects On Cartilage Growth awarded by National Institutes of Health 1986 - 1987
  • Hormonal Effects On Cartilage Growth And Metabolism awarded by National Institutes of Health 1984 - 1985
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Manoli, I, Kwan, JY, Wang, Q, Rushing, EJ, Tsokos, M, Arai, AE, Burch, WM, Dispenzieri, A, McPherron, AC, and Gahl, WA. "Chronic myopathy due to immunoglobulin light chain amyloidosis." Molecular Genetics and Metabolism 108, no. 4 (April 2013): 249-254.  Full Text
    • Burch, W. "Using Bedtime (PM) and Early Morning (AM) Urine Cortisol/Creatinine Ratios to Evaluate Pituitary-Adrenal Function in an Office Practice." Endocrine Practice 17, no. 4 (July 2011): 591-597.  Full Text
    • Jayaraj, K, and Burch, W. "Visual vignette. Hyperparathyroidism due to a parathyroid adenoma." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 6, no. 1 (2000): 116--.
    • Bruch, J, and Burch, W. "Approach to the patient with Graves' disease and an anterior mediastinal mass." Endocrinologist 5, no. 2 (1995): 97-99.
    • "Effect of fatty acids on insulin release: Role of chain length and degree of unsaturation." American Journal of Physiology Endocrinology and Metabolism 266, no. 4 29-4 (January 1, 1994).
    • Opara, EC, Garfinkel, M, Hubbard, VS, Burch, WM, and Akwari, OE. "Effect of fatty acids on insulin release: Role of chain length and degree of unsaturation." AM.J.PHYSIOL. 266, no. 4 part 1 (1994): E635-E639.
    • Opara, EC, Hubbard, VS, Burch, WM, and Akwari, OE. "Addition of L-glutamine to a linoleic acid perifusate prevents the fatty acid-induced desensitization of pancreatic islet response to glucose." The Journal of Nutritional Biochemistry 4, no. 6 (June 1993): 357-361.  Full Text
    • Opara, EC, Hubbard, VS, Burch, WM, and Akwari, OE. "Characterization of the insulinotropic potency of polyunsaturated fatty acids." Endocrinology 130, no. 2 (February 1992): 657-662.  Full Text
    • Jr, WMB. "A response to: "A woman with too much facial hair"." North Carolina medical journal 53, no. 10 (1992): 521--.
    • OPARA, E, HUBBARD, V, BURCH, W, and AKWARI, O. "Homologous desensitization of pancreatic beta cells to glucose response by polyunsaturated fatty acids." The Journal of Nutritional Biochemistry 2, no. 8 (August 1991): 424-429.  Full Text
    • Opara, EC, Burch, WM, Taylor, IL, and Akwari, OE. "Pancreatic hormone response to neuropeptide Y (NPY) perifusion in vitro." Regul Pept 34, no. 3 (July 9, 1991): 225-233.  Link to Item
    • "Characterization of glutamine-regulated pancreatic islet hormone release." Surgical Forum 41 (December 1, 1990): 16-19.
    • Opara, EC, Burch, WM, Hubbard, VS, and Akwari, OE. "Enhancement of endocrine pancreatic secretions by essential fatty acids." The Journal of Surgical Research 48, no. 4 (April 1990): 329-332.  Full Text
    • Burch, WM, Correa, J, Shively, JE, and Powell, DR. "The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro." J Clin Endocrinol Metab 70, no. 1 (January 1990): 173-180.  Full Text  Link to Item
    • Canalis, E, Centrella, M, Burch, W, and McCarthy, TL. "Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures." Journal of Clinical Investigation 83, no. 1 (January 1, 1989): 60-65.  Full Text
    • Jr, JBH, and Burch, WM. "Rapid tests of adrenocortical function. Intravenous versus intramuscular administration of synthetic ACTH." North Carolina medical journal 50, no. 6 (1989): 306-308.
    • Burch, WM, Lopez-Claros, M, Uskokovic, MR, and Drezner, MK. "1,25-Dihydroxyvitamin D3 stimulates avian and mammalian cartilage growth in vitro." J Bone Miner Res 3, no. 1 (February 1988): 87-91.  Full Text  Link to Item
    • Zola, BE, Miller, B, Stiles, GL, Rao, PS, Sonnenblick, EH, and Fein, FS. "Heart rate control in diabetic rabbits: blunted response to isoproterenol." American Journal of Physiology - Endocrinology and Metabolism 255, no. 5 (1988): 18/5-.
    • Levine, PA, Gillespie, CA, Walker, JS, Burch, WM, Kenan, PD, and Kramer, RS. "Cushing's Syndrome Secondary to Ectopic Pituitary Adenoma in the Sphenoid Sinus." Otolaryngology Head and Neck Surgery 96, no. 6 (June 1987): 569-572.  Full Text
    • Itani, KM, Akwari, OE, Burch, W, Watters, CR, and Coleman, RE. "Gastric emptying, glucose tolerance, and insulin response after duodenojejunostomy." J Surg Res 42, no. 5 (May 1987): 521-527.  Link to Item
    • Burch, WM. "Growth of Fetal Porcine Scapular Cartilage In Vitro." The American Journal of the Medical Sciences 293, no. 4 (April 1987): 209-215.  Full Text
    • "Triiodothyronine stimulates cartilage growth and maturation by different mechanisms." American Journal of Physiology Endocrinology and Metabolism 252, no. 2 (January 1, 1987).
    • Burch, WM. "Hashimoto's thyroiditis presenting as a retropharyngeal mass." North Carolina medical journal 48, no. 11 (1987): 561-563.
    • Buckley, NJ, Burch, WM, and Leight, GS. "Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature." Surgery 100, no. 5 (November 1986): 932-937.  Link to Item
    • Burch, WM, Ch'ng, JL, and McPherson, HT. "Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure." North Carolina medical journal 47, no. 11 (1986): 517--.
    • Burch, WM, Weir, S, and Wyk, JJV. "Embryonic chick cartilage produces its own somatomedin-like peptide to stimulate cartilage growth in vitro." Endocrinology 119, no. 3 (1986): 1370-1376.
    • Burch, WM, Corda, G, Kopchick, JJ, and Leung, FC. "Homologous and heterologous growth hormones fail to stimulate avian cartilage growth in vitro." Journal of Clinical Endocrinology and Metabolism 60, no. 4 (1985): 747-750.
    • Burch, WM, Hamner, G, and Wuthier, RE. "Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage." Metabolism 34, no. 2 (1985): 169-175.
    • Burch, WM, Kramer, RS, Kenan, PD, and Hammond, CB. "Cushing's disease caused by an ectopic pituitary adenoma within the sphenoid sinus." New England Journal of Medicine 312, no. 9 (1985): 587-588.
    • Burch, WM, and Corda, G. "Calcitonin stimulates maturation of mammalian growth plate cartilage." Endocrinology 116, no. 5 (1985): 1724-1728.
    • Burch, WM. "Cushing's disease. A review." Archives of Internal Medicine 145, no. 6 (1985): 1106-1111.  Full Text
    • Kier, R, Silverman, PM, Korobkin, M, Wain, S, Leight, G, and Jr, WB. "Malignant teratoma of the thyroid in an adult: CT appearance." Journal of Computer Assisted Tomography 9, no. 1 (1985): 174-176.
    • Burch, W. "Transsphenoidal microadenomectomy for Cushing's disease in children." New England Journal of Medicine 311, no. 7 (1984): 471--.
    • Burch, WM, and Jr, KSM. "Hormonal stimulation of avian embryonic cartilage growth in vitro: Histologic and ultrastructural features." In Vitro 20, no. 4 (1984): 329-338.  Full Text
    • Burch, WM. "Thyroid malignancy masquerading as thyroiditis." North Carolina medical journal 45, no. 9 (1984): 560-562.
    • Burch, WM. "Calcitonin stimulates growth and maturation of embryonic chick pelvic cartilage in vitro." Endocrinology 114, no. 4 (1984): 1196-1202.
    • Jackson, RA, Haynes, BF, Burch, WM, Shimizu, K, Bowring, MA, and Eisenbarth, GS. "Ia⁺ T cells in new onset Graves' disease." Journal of Clinical Endocrinology and Metabolism 59, no. 2 (1984): 187-190.
    • Burch, W. "A survey of results with transsphenoidal surgery in Cushing's disease." New England Journal of Medicine 308, no. 2 (1983): 103-104.
    • Burch, W. "Fine needle aspiration biopsy of the thyroid gland." Annals of Internal Medicine 98, no. 6 (1983): 1023-1024.
    • Burch, WM, and Lebovitz, HE. "Parathyroid hormone stimulates growth of embryonic chick pelvic cartilage in vitro." Calcified Tissue International 35, no. 1 (1983): 526-532.  Full Text
    • Burch, WM, and Posillico, JT. "Hypoparathyroidism after I-131 therapy with subsequent return of parathyroid function." Journal of Clinical Endocrinology and Metabolism 57, no. 2 (1983): 398-401.
    • Burch, WM. "Diagnosis and treatment of Cushing's disease at Duke University (1977-1982)." North Carolina medical journal 44, no. 5 (1983): 293-296.
    • Burch, WM. "Propranolol-induced hyperthyroxinemia." North Carolina medical journal 44, no. 4 (1983): 215-216.
    • Burch, WM. "Normal menstruation and pregnancy in a patient with Nelson's syndrome." Southern Medical Journal 76, no. 10 (1983): 1319-1320.
    • DOWNS, RW, LEVINE, MA, DREZNER, MK, BURCH, WM, and SPIEGEL, AM. "DEFICIENT ADENYLATE-CYCLASE REGULATORY PROTEIN IN RENAL MEMBRANES FROM A PATIENT WITH PSEUDOHYPOPARATHYROIDISM." JOURNAL OF CLINICAL INVESTIGATION 71, no. 2 (1983): 231-235.  Full Text  Link to Item
    • Dolinar, R, and Burch, WM. "Testosterone-producing adrenal adenoma in a woman with normal urinary 17-ketosteroid levels." Journal of the American Medical Association 250, no. 18 (1983): 2504-2507.  Full Text
    • Burch, WM, and Snyderman, R. "Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene." Ann Intern Med 96, no. 3 (March 1982): 329-331.  Link to Item
    • "Parathyroid hormone stimulates embryonic cartilage growth." Clinical Research 30, no. 2 (January 1, 1982).
    • Burch, WM, and Lebovitz, HE. "Triiodothyronine stimulation of in vitro growth and maturation of embryonic chick cartilage." Endocrinology 111, no. 2 (1982): 462-468.
    • Burch, WM, and Lebovitz, HE. "In vitro stimulation of alkaline phosphatase activity in immature embryonic chick pelvic cartilage by adenosine 3',5'-monophosphate." Journal of Cell Biology 93, no. 2 (1982): 338-342.
    • Burch, WM, and Lebovitz, HE. "In vitro stimulation of mammalian cartilage maturation by triiodothyronine." Clinical Research 30, no. 2 (1982): 268A-.
    • Burch, WM, and Lebovitz, HE. "Triiodothyronine stimulates maturation of porcine growth-plate cartilage in vitro." Journal of Clinical Investigation 70, no. 3 (1982): 496-504.  Full Text
    • Burch, WM. "Urine free-cortisol determination. A useful tool in the management of chronic hypoadrenal states." Journal of the American Medical Association 247, no. 14 (1982): 2002-2004.  Full Text
    • Burch, WM, and Lebovitz, HE. "Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage." The American Journal of Physiology 241, no. 6 (December 1981): E454-E459.  Full Text
    • "Urinary free cortisol: A useful tool in treatment of chronic hypoadrenal states." Clinical Research 29, no. 5 (January 1, 1981).
    • "Parathyroid hormone stimulates embryonic cartilage growth." Clinical Research 29, no. 5 (January 1, 1981).
    • Burch, WM, and Lebovitz, HE. "Adenosine 3',5'-monophosphate. A modulator of embryonic chick cartilage growth." Journal of Clinical Investigation 68, no. 6 (1981): 1496-1502.  Full Text
    • Burch, WM, and Lebovitz, HE. "Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage." American Journal of Physiology - Endocrinology and Metabolism 4, no. 6 (1981): 454-459.
    • Jr, WMB. "Thyroid nodules: 1981." North Carolina medical journal 42, no. 10 (1981): 713-714.
    • Jr, WMB, and Lebovitz, HE. "Specific nuclear binding of adenosine 3',5'-monophosphate-binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage." Journal of Clinical Investigation 66, no. 3 (1980): 532-542.  Full Text
    • Jr, WMB. "Pseudothyrotoxic myopathy: A complication of thionamide therapy in hyperthyroidism." Southern Medical Journal 72, no. 11 (1979): 1494-1495.
    • Jr, WMB. "A method of aspirating thyroid cysts." Surgery Gynecology and Obstetrics 148, no. 1 (1979): 95-96.
    • Drezner, MK, and Jr, WMB. "Altered activity of the nucleotide regulatory site in the parathyroid hormone sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism." Journal of Clinical Investigation 62, no. 6 (1978): 1222-1227.  Full Text
    • Lafferty, KJ, Bootes, A, Killby, VAA, and Burch, W. "Mechanism of thyroid allograft rejection." Australian Journal of Experimental Biology and Medical Science 54, no. 6 (1976): 573-586.
    • "Induction of cellular immunity to Coccidioides immitis following sensitization with dinitrochlorobenzene (DNCB)." Clinical Research 22, no. 1 (January 1, 1974).

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