Warren M. Grill
Edmund T. Pratt, Jr. School Distinguished Professor of Biomedical Engineering
Our research employs engineering approaches to understand and control neural function. We work on fundamental questions and applied development in electrical stimulation of the nervous system to restore function to individuals with neurological impairment or injury.
Current projects include:
• understanding the mechanisms of and developing advanced approaches to deep brain stimulation to treat movement disorders,
• developing novel approaches to peripheral nerve electrical stimulation for restoration of bladder function,
• understanding the mechanisms of and developing advanced approaches to spinal cord stimulation to treat chronic pain,
• understanding and controlling the cellular effects of transcranial magnetic stimulation, and
• design of novel electrodes and waveforms for selective stimulation of the nervous system.
Current Research Interests
Neural engineering and neural prostheses and include design and testing of electrodes and stimulation techniques, the electrical properties of tissues and cells, and computational neuroscience with applications in restoration of bladder function, treatment of movement disorders with deep brain stimulation, and treatment of chronic pain.
Current Appointments & Affiliations
- Edmund T. Pratt, Jr. School Distinguished Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016
- Bass Fellow, Biomedical Engineering, Pratt School of Engineering 2014
- Professor in Neurobiology, Neurobiology, Basic Science Departments 2010
- Professor in Neurosurgery, Neurosurgery, Neurosurgery 2017
- Professor in the Department of Electrical and Computer Engineering, Electrical and Computer Engineering, Pratt School of Engineering 2013
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2008
- Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2018
- Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2008
Contact Information
- Box 90281, Dept Biomedical Engineering, Durham, NC 27708-0281
- CIEMAS 1139, Durham, NC 27708
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warren.grill@duke.edu
(919) 660-5276
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Google Scholar
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Lab Webpage
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LinkedIn Profile
- Background
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Education, Training, & Certifications
- Ph.D., Case Western Reserve University 1995
- M.S., Case Western Reserve University 1992
- B.S., Boston University 1989
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Previous Appointments & Affiliations
- Affiliate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2014 - 2018
- Addy Professor, Biomedical Engineering, Pratt School of Engineering 2009 - 2014
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2004 - 2008
- Recognition
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In the News
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APR 28, 2020 Pratt School of Engineering -
MAY 5, 2016 -
NOV 10, 2015 Duke Research Blog -
NOV 1, 2015 -
JUL 8, 2015 -
JUN 26, 2015 -
JUN 26, 2015 The News & Observer -
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JUN 15, 2015 Science Magazine -
MAY 5, 2015 Bio Edge
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Awards & Honors
- Capers & Marion McDonald Award for Excellence in Teaching and Research. Pratt School of Engineering. 2018
- Javits Neuroscience Investigator Award. NIH-NINDS . 2015
- Scholar / Teacher of the Year Award. Duke University. 2014
- Outstanding Postdoc Mentor. Duke University. 2013
- Fellow. Biomedical Engineering Society. 2011
- Fellow. American Institute for Medical and Biological Engineering. 2007
- Research
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Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- NeuroSimNIBS: Integrated electric field and neuronal response modeling for transcranial electric and magnetic stimulation awarded by National Institutes of Health 2022 - 2027
- Deep Brain Stimulation Evoked Potentials (SRA2) awarded by Boston Scientific Corporation 2021 - 2026
- Rational Design of TMS for Neuromodulation awarded by National Institutes of Health 2020 - 2025
- Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health 2020 - 2025
- NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health 2009 - 2025
- MPS-TMS: Modular Pulse Synthesizer for Transcranial Magnetic Stimulation with Fully Adjustable Pulse Shape and Sequence awarded by National Institutes of Health 2020 - 2024
- SC200190 - "Chronic Studies of Spinal Cord Stimulation for Restoration of Bladder Function" awarded by United States Army Medical Research Acquisition Activity 2021 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Computational Tools for Improving Stereo-EEG Implantation and Resection Surgery awarded by National Institutes of Health 2022 - 2023
- Predicting Urinary Continence Status with Sacral Neuromodulation and Botulinum Toxin Treatments awarded by National Institutes of Health 2020 - 2023
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Developing a comprehensive model for peripheral nerve stimulation of gastrointestinal function awarded by National Institutes of Health 2019 - 2023
- Underactive Bladder: Mechanisms and Recovery of Sensation and Function awarded by National Institutes of Health 2019 - 2023
- COMPUTATIONAL MODELING OF VAGUS NERVE STIMULATION awarded by Alfred E Mann Foundation 2022 - 2023
- Temporal Patterns of Spinal Cord Stimulation awarded by National Institutes of Health 2019 - 2022
- Neural Electrodes with Enhanced Charge Injection and Reduced Interfacial Impedance Using Graphenated Carbon Nanotubes Coated With Atomic Layer-Deposited Platinum Nanoparticles awarded by National Institutes of Health 2020 - 2022
- Spinal Cord Stimulation for Restoration of Bladder Function awarded by Paralyzed Veterans of America 2020 - 2022
- Realistic Measurements of tDCS-Modulated Activity and Electric Fields in the Human Brain In Vivo awarded by National Institutes of Health 2019 - 2022
- Temporal Patterns of Deep Brain Stimulation awarded by National Institutes of Health 2004 - 2022
- Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials awarded by National Institutes of Health 2017 - 2022
- Biomimetic somatosensory feedback through intracortical microstimulation awarded by Northwestern University 2016 - 2022
- Analysis and Design of µECoG Array Characteristics for Optimized Signal Acquisition awarded by National Institutes of Health 2020 - 2022
- Sacral Nerve Stimulation to Treat Detrusor Underactivity: Parameters & Pathways awarded by Medtronic, Inc. 2019 - 2022
- Pudendal neuromodlation for incontinence and sphincter dyssynergia after spinal injury awarded by Dignify Therapeutics, LLC 2020 - 2021
- Rational Design of TMS for Neuromodulation awarded by National Institutes of Health 2014 - 2021
- Functional dissection of therapeutic deep brain stimulation circuitry awarded by University of North Carolina - Chapel Hill 2015 - 2021
- Bioelectronic rescue of cognitive impairment after surgery awarded by National Institutes of Health 2018 - 2021
- Pudendal Neuromodulation for urinary and fecal incontinance and sphincter dyssynergia awarded by Dignify Therapeutics, LLC 2019 - 2020
- IPA - Warren Grill awarded by Durham Veterans Affairs Medical Center 2019 - 2020
- Closed-Loop Neural Sensing and Stimulation System for Small Animals awarded by Micro-Leads, Inc. 2017 - 2019
- Targeted electrical stimulation of the urethra to treat urgency urinary incontinence awarded by Urology Care Foundation 2017 - 2019
- Nerve Stimulation for Restoration of Bladder Function awarded by Dignify Therapeutics, LLC 2018 - 2019
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Functional mapping of efferent gut neuroepithelial circuits awarded by National Institutes of Health 2016 - 2018
- Computational modeling of peripheral nerve stimulation awarded by SPR Therapeutics, LLC 2017
- Recording Evoked Potentials for Closed-Loop DBS awarded by National Institutes of Health 2012 - 2017
- Neural Prosthetic Control of Continence and Micturition awarded by National Institutes of Health 2005 - 2017
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- SNr DBS for the treatment of gait and postural disturbances in Parkinsons disease awarded by National Institutes of Health 2014 - 2015
- Stimulation mediated sensory enhancement of the urethral afferents awarded by National Institutes of Health 2013 - 2015
- Novel High Density Interconnects for Flexible Neural Prosthesis awarded by Premitec, Inc. 2011 - 2015
- Optimal Electrode Geometries for Efficient and Selective Deep Brain Stimulation awarded by National Institutes of Health 2012 - 2015
- Effects of Transcranial Magnetic Stimulation on Neurons in Behaving Primates awarded by National Institutes of Health 2012 - 2014
- Evaluation of Carbon Nanotube Electrodes for Neural Stimulation awarded by National Institutes of Health 2011 - 2014
- Characterization of Evoked Potentials During Deep Brain Stimulation awarded by National Institutes of Health 2010 - 2013
- Realistic Human Perception of Spatio-Temporal Thalamic Microstimulation awarded by National Institutes of Health 2010 - 2013
- Time Course of Parkinson's Symptoms in Response to Deep Brain Stimulation awarded by National Institutes of Health 2009 - 2012
- Low Impedance Electrodes for Neural Stimulation awarded by National Institutes of Health 2007 - 2011
- Biomimetic Stimulation of the Sacral DRG to Control Continence and Micturition awarded by National Institutes of Health 2009 - 2010
- Career Development in the Mechanisms of Deep Brain Stimulation awarded by National Institutes of Health 2006 - 2010
- Neural Prosthetic Control of Continence and Micturition awarded by National Institutes of Health 2005 - 2009
- In Situ Polymerized Interfaces for Peripheral Nerve Recording and Stimulation awarded by National Academy of Sciences 2007 - 2009
- Non-Regular Stimulation Patterns for Deep Brain Stimulation awarded by National Institutes of Health 2006 - 2009
- Selective Electrical Stimulation of Thalamic Neurons (supplement) awarded by National Institutes of Health 2005 - 2008
- Neural Signal Acquisition System awarded by Lord Foundation of North Carolina 2006 - 2007
- Neural Prosthetic Control of Continence and Micturition awarded by National Institutes of Health 2001 - 2006
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External Relationships
- AE Mann Founadtion
- Blackfynn
- Boston Scientific Corporation
- Cala Health, LLC
- Deep Brain Innovations
- Diagnostic Biochips
- Dignify Therapeutics
- GLG Consultants
- GSK/Galvani
- Hatteras Investment Partners, LLC
- NDI Healthcare Fund, LLC
- Neilsen Foundation
- Precision Neuroscience Inc
- SPR Therapeutics
- Triangle Angel Partners, LLC
- Vensana Ventures
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Mitchell, K. T., Schmidt, S. L., Cooney, J. W., Grill, W. M., Peters, J., Rahimpour, S., … Turner, D. A. (2022). Initial Clinical Outcome With Bilateral, Dual-Target Deep Brain Stimulation Trial in Parkinson Disease Using Summit RC + S. Neurosurgery, 91(1), 132–138. https://doi.org/10.1227/neu.0000000000001957Full Text Open Access Copy Link to Item
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Goetz, S. M., Howell, B., Wang, B., Li, Z., Sommer, M. A., Peterchev, A. V., & Grill, W. M. (2022). Isolating two sources of variability of subcortical stimulation to quantify fluctuations of corticospinal tract excitability. Clin Neurophysiol, 138, 134–142. https://doi.org/10.1016/j.clinph.2022.02.009Full Text Link to Item
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Cassar, I. R., & Grill, W. M. (2022). The cortical evoked potential corresponds with deep brain stimulation efficacy in rats. Journal of Neurophysiology, 127(5), 1253–1268. https://doi.org/10.1152/jn.00353.2021Full Text
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Sombeck, J. T., Heye, J., Kumaravelu, K., Goetz, S. M., Peterchev, A. V., Grill, W. M., … Miller, L. E. (2022). Characterizing the short-latency evoked response to intracortical microstimulation across a multi-electrode array. J Neural Eng, 19(2). https://doi.org/10.1088/1741-2552/ac63e8Full Text Link to Item
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Kumaravelu, K., Sombeck, J., Miller, L. E., Bensmaia, S. J., & Grill, W. M. (2022). Stoney vs. Histed: Quantifying the spatial effects of intracortical microstimulation. Brain Stimulation, 15(1), 141–151. https://doi.org/10.1016/j.brs.2021.11.015Full Text
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Gonzalez, E. J., Odom, M. R., Hannan, J. L., & Grill, W. M. (2021). Dysfunctional voiding behavior and impaired muscle contractility in a rat model of detrusor underactivity. Neurourology and Urodynamics, 40(8), 1889–1899. https://doi.org/10.1002/nau.24777Full Text
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Musselman, E. D., Cariello, J. E., Grill, W. M., & Pelot, N. A. (2021). ASCENT (Automated Simulations to Characterize Electrical Nerve Thresholds): A pipeline for sample-specific computational modeling of electrical stimulation of peripheral nerves. Plos Computational Biology, 17(9), e1009285. https://doi.org/10.1371/journal.pcbi.1009285Full Text
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Langdale, C. L., Degoski, D., Milliken, P. H., & Grill, W. M. (2021). Voiding behavior in awake unrestrained untethered spontaneously hypertensive and Wistar control rats. American Journal of Physiology. Renal Physiology, 321(2), F195–F206. https://doi.org/10.1152/ajprenal.00564.2020Full Text
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Settell, M. L., Pelot, N. A., Knudsen, B. E., Dingle, A. M., McConico, A. L., Nicolai, E. N., … Ludwig, K. A. (2021). Corrigendum: Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation (2020J. Neural Eng.17 026022). Journal of Neural Engineering, 18(4). https://doi.org/10.1088/1741-2552/ac01ffFull Text
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Barth, B. B., Travis, L., Spencer, N. J., & Grill, W. M. (2021). Control of colonic motility using electrical stimulation to modulate enteric neural activity. American Journal of Physiology. Gastrointestinal and Liver Physiology, 320(4), G675–G687. https://doi.org/10.1152/ajpgi.00463.2020Full Text
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Schmidt, S. L., & Grill, W. M. (2021). Levodopa-Induced Dyskinesia Is Mediated by Cortical Gamma Oscillations in Experimental Parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society, 36(4), 1044–1045. https://doi.org/10.1002/mds.28578Full Text
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Peña, E., Pelot, N. A., & Grill, W. M. (2021). Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance. Scientific Reports, 11(1), 5077. https://doi.org/10.1038/s41598-021-84503-3Full Text
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Hokanson, J. A., Langdale, C. L., Milliken, P. H., Sridhar, A., & Grill, W. M. (2021). Effects of intravesical prostaglandin E2 on bladder function are preserved in capsaicin-desensitized rats. American Journal of Physiology. Renal Physiology, 320(2), F212–F223. https://doi.org/10.1152/ajprenal.00302.2020Full Text
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Krauss, J. K., Lipsman, N., Aziz, T., Boutet, A., Brown, P., Chang, J. W., … Lozano, A. M. (2021). Technology of deep brain stimulation: current status and future directions. Nature Reviews. Neurology, 17(2), 75–87. https://doi.org/10.1038/s41582-020-00426-zFull Text
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Hokanson, J. A., Langdale, C. L., Sridhar, A., Milliken, P., & Grill, W. M. (2021). State-dependent bioelectronic interface to control bladder function. Scientific Reports, 11(1), 314. https://doi.org/10.1038/s41598-020-79493-7Full Text
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Pelot, N. A., Catherall, D. C., Thio, B. J., Titus, N. D., Liang, E. D., Henriquez, C. S., & Grill, W. M. (2021). Excitation properties of computational models of unmyelinated peripheral axons. Journal of Neurophysiology, 125(1), 86–104. https://doi.org/10.1152/jn.00315.2020Full Text
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Quigley, K. S., Kanoski, S., Grill, W. M., Barrett, L. F., & Tsakiris, M. (2021). Functions of Interoception: From Energy Regulation to Experience of the Self. Trends in Neurosciences, 44(1), 29–38. https://doi.org/10.1016/j.tins.2020.09.008Full Text
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Settell, M. L., Skubal, A. C., Chen, R. C. H., Kasole, M., Knudsen, B. E., Nicolai, E. N., … Ludwig, K. A. (2021). In vivo Visualization of Pig Vagus Nerve "Vagotopy" Using Ultrasound. Frontiers in Neuroscience, 15, 676680. https://doi.org/10.3389/fnins.2021.676680Full Text
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Zhu, Y., Wang, J., Li, H., Liu, C., & Grill, W. M. (2021). Adaptive Parameter Modulation of Deep Brain Stimulation Based on Improved Supervisory Algorithm. Frontiers in Neuroscience, 15, 750806. https://doi.org/10.3389/fnins.2021.750806Full Text
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Bourbeau, D., Creasey, G., French, J., Grill, W. M., Howley, S., Krassioukov, A., … Wheeler, T. (2020). A roadmap for advancing neurostimulation approaches for bladder and bowel function after spinal cord injury. Spinal Cord, 58(11), 1227–1232. https://doi.org/10.1038/s41393-020-00544-xFull Text
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Schmidt, S. L., Brocker, D. T., Swan, B. D., Turner, D. A., & Grill, W. M. (2020). Evoked potentials reveal neural circuits engaged by human deep brain stimulation. Brain Stimul, 13(6), 1706–1718. https://doi.org/10.1016/j.brs.2020.09.028Full Text Link to Item
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Peña, E., Pelot, N. A., & Grill, W. M. (2020). Quantitative comparisons of block thresholds and onset responses for charge-balanced kilohertz frequency waveforms. Journal of Neural Engineering, 17(4), 046048. https://doi.org/10.1088/1741-2552/abadb5Full Text
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Kumaravelu, K., Tomlinson, T., Callier, T., Sombeck, J., Bensmaia, S. J., Miller, L. E., & Grill, W. M. (2020). A comprehensive model-based framework for optimal design of biomimetic patterns of electrical stimulation for prosthetic sensation. Journal of Neural Engineering, 17(4), 046045. https://doi.org/10.1088/1741-2552/abacd8Full Text
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Nicolai, E. N., Settell, M. L., Knudsen, B. E., McConico, A. L., Gosink, B. A., Trevathan, J. K., … Ludwig, K. A. (2020). Sources of off-target effects of vagus nerve stimulation using the helical clinical lead in domestic pigs. Journal of Neural Engineering, 17(4), 046017. https://doi.org/10.1088/1741-2552/ab9db8Full Text
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Steadman, C. J., & Grill, W. M. (2020). Spinal cord stimulation for the restoration of bladder function after spinal cord injury. Healthcare Technology Letters, 7(3), 87–92. https://doi.org/10.1049/htl.2020.0026Full Text
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Yi, G., & Grill, W. M. (2020). Kilohertz waveforms optimized to produce closed-state Na+ channel inactivation eliminate onset response in nerve conduction block. Plos Computational Biology, 16(6), e1007766. https://doi.org/10.1371/journal.pcbi.1007766Full Text
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Langdale, C. L., Hokanson, J. A., Milliken, P. H., Sridhar, A., & Grill, W. M. (2020). Stimulation of the pelvic nerve increases bladder capacity in the PGE2 cat model of overactive bladder. American Journal of Physiology. Renal Physiology, 318(6), F1357–F1368. https://doi.org/10.1152/ajprenal.00068.2020Full Text
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Yu, C., Cassar, I. R., Sambangi, J., & Grill, W. M. (2020). Frequency-Specific Optogenetic Deep Brain Stimulation of Subthalamic Nucleus Improves Parkinsonian Motor Behaviors. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 40(22), 4323–4334. https://doi.org/10.1523/jneurosci.3071-19.2020Full Text
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Settell, M. L., Pelot, N. A., Knudsen, B. E., Dingle, A. M., McConico, A. L., Nicolai, E. N., … Ludwig, K. A. (2020). Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation. Journal of Neural Engineering, 17(2), 026022. https://doi.org/10.1088/1741-2552/ab7ad4Full Text
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Grill, W. M., & Wongsarnpigoon, A. (2020). Energy Optimal Stimulation Waveforms, Or Not: Comments on "An Investigation of Neural Stimulation Efficiency With Gaussian Waveforms". Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society. https://doi.org/10.1109/tnsre.2020.2984402Full Text
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Pelot, N. A., & Grill, W. M. (2020). In vivo quantification of excitation and kilohertz frequency block of the rat vagus nerve. Journal of Neural Engineering, 17(2), 026005. https://doi.org/10.1088/1741-2552/ab6cb6Full Text
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Schmidt, S. L., Peters, J. J., Turner, D. A., & Grill, W. M. (2020). Continuous deep brain stimulation of the subthalamic nucleus may not modulate beta bursts in patients with Parkinson's disease. Brain Stimul, 13(2), 433–443. https://doi.org/10.1016/j.brs.2019.12.008Full Text Link to Item
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Swan, B. D., Brocker, D. T., Gross, R. E., Turner, D. A., & Grill, W. M. (2020). Effects of ramped-frequency thalamic deep brain stimulation on tremor and activity of modeled neurons. Clin Neurophysiol, 131(3), 625–634. https://doi.org/10.1016/j.clinph.2019.11.060Full Text Link to Item
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Ramirez-Zamora, A., Giordano, J., Gunduz, A., Alcantara, J., Cagle, J. N., Cernera, S., … Okun, M. S. (2020). Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. Frontiers in Human Neuroscience, 14, 54. https://doi.org/10.3389/fnhum.2020.00054Full Text
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Aberra, A. S., Wang, B., Grill, W. M., & Peterchev, A. V. (2020). Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons. Brain Stimul, 13(1), 175–189. https://doi.org/10.1016/j.brs.2019.10.002Full Text Link to Item
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Pelot, N. A., Goldhagen, G. B., Cariello, J. E., Musselman, E. D., Clissold, K. A., Ezzell, J. A., & Grill, W. M. (2020). Quantified Morphology of the Cervical and Subdiaphragmatic Vagus Nerves of Human, Pig, and Rat. Frontiers in Neuroscience, 14, 601479. https://doi.org/10.3389/fnins.2020.601479Full Text
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McKee, D. C., Gonzalez, E. J., Amundsen, C. L., & Grill, W. M. (2019). Randomized Controlled Trial to Assess the Impact of High Concentration Intraurethral Lidocaine on Urodynamic Voiding Parameters. Urology, 133, 72–77. https://doi.org/10.1016/j.urology.2019.08.020Full Text Link to Item
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Goetz, S. M., Kozyrkov, I. C., Luber, B., Lisanby, S. H., Murphy, D. L. K., Grill, W. M., & Peterchev, A. V. (2019). Accuracy of robotic coil positioning during transcranial magnetic stimulation. J Neural Eng, 16(5), 054003. https://doi.org/10.1088/1741-2552/ab2953Full Text Link to Item
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Cartmell, S. C., Tian, Q., Thio, B. J., Leuze, C., Ye, L., Williams, N. R., … Halpern, C. H. (2019). Multimodal characterization of the human nucleus accumbens. Neuroimage, 198, 137–149. https://doi.org/10.1016/j.neuroimage.2019.05.019Full Text
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Swan, C. B., Schulte, D. J., Brocker, D. T., & Grill, W. M. (2019). Beta Frequency Oscillations in the Subthalamic Nucleus Are Not Sufficient for the Development of Symptoms of Parkinsonian Bradykinesia/Akinesia in Rats. Eneuro, 6(5), ENEURO.0089-ENEU19.2019. https://doi.org/10.1523/eneuro.0089-19.2019Full Text
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Musselman, E. D., Pelot, N. A., & Grill, W. M. (2019). Empirically Based Guidelines for Selecting Vagus Nerve Stimulation Parameters in Epilepsy and Heart Failure. Cold Spring Harbor Perspectives in Medicine, 9(7), a034264. https://doi.org/10.1101/cshperspect.a034264Full Text
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Cassar, I. R., Yu, C., Sambangi, J., Lee, C. D., Whalen, J. J., Petrossians, A., & Grill, W. M. (2019). Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays. Biomaterials, 205, 120–132. https://doi.org/10.1016/j.biomaterials.2019.03.017Full Text
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Yi, G., & Grill, W. M. (2019). Average firing rate rather than temporal pattern determines metabolic cost of activity in thalamocortical relay neurons. Scientific Reports, 9(1), 6940. https://doi.org/10.1038/s41598-019-43460-8Full Text
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Grill, W. M., & DeBerry, J. J. (2019). Innovative device illuminates the horizon of bioelectronic medicines. Nature Reviews. Urology, 16(4), 209–210. https://doi.org/10.1038/s41585-019-0155-9Full Text
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Pelot, N. A., Behrend, C. E., & Grill, W. M. (2019). On the parameters used in finite element modeling of compound peripheral nerves. Journal of Neural Engineering, 16(1), 016007. https://doi.org/10.1088/1741-2552/aaeb0cFull Text
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Gonzalez, E. J., & Grill, W. M. (2019). Sensory pudendal nerve stimulation increases bladder capacity through sympathetic mechanisms in cyclophosphamide-induced cystitis rats. Neurourology and Urodynamics, 38(1), 135–143. https://doi.org/10.1002/nau.23860Full Text
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Su, F., Kumaravelu, K., Wang, J., & Grill, W. M. (2019). Model-Based Evaluation of Closed-Loop Deep Brain Stimulation Controller to Adapt to Dynamic Changes in Reference Signal. Frontiers in Neuroscience, 13, 956. https://doi.org/10.3389/fnins.2019.00956Full Text
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Huffman, W. J., Subramaniyan, S., Rodriguiz, R. M., Wetsel, W. C., Grill, W. M., & Terrando, N. (2019). Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice. Brain Stimul, 12(1), 19–29. https://doi.org/10.1016/j.brs.2018.10.005Full Text Link to Item
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Aberra, A. S., Peterchev, A. V., & Grill, W. M. (2018). Biophysically realistic neuron models for simulation of cortical stimulation. J Neural Eng, 15(6), 066023. https://doi.org/10.1088/1741-2552/aadbb1Full Text Link to Item
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Grill, W. M. (2018). Temporal Pattern of Electrical Stimulation is a New Dimension of Therapeutic Innovation. Current Opinion in Biomedical Engineering, 8, 1–6. https://doi.org/10.1016/j.cobme.2018.08.007Full Text
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Oza, C. S., Brocker, D. T., Behrend, C. E., & Grill, W. M. (2018). Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats. Journal of Neurophysiology, 120(5), 2410–2422. https://doi.org/10.1152/jn.00929.2017Full Text
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Yi, G., & Grill, W. M. (2018). Frequency-dependent antidromic activation in thalamocortical relay neurons: effects of synaptic inputs. Journal of Neural Engineering, 15(5), 056001. https://doi.org/10.1088/1741-2552/aacbffFull Text
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Kumaravelu, K., Oza, C. S., Behrend, C. E., & Grill, W. M. (2018). Model-based deconstruction of cortical evoked potentials generated by subthalamic nucleus deep brain stimulation. Journal of Neurophysiology, 120(2), 662–680. https://doi.org/10.1152/jn.00862.2017Full Text
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Pelot, N. A., & Grill, W. M. (2018). Effects of vagal neuromodulation on feeding behavior. Brain Research, 1693(Pt B), 180–187. https://doi.org/10.1016/j.brainres.2018.02.003Full Text
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Rutter, E. M., Langdale, C. L., Hokanson, J. A., Hamilton, F., Tran, H., Grill, W. M., & Flores, K. B. (2018). Detection of Bladder Contractions From the Activity of the External Urethral Sphincter in Rats Using Sparse Regression. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 26(8), 1636–1644. https://doi.org/10.1109/tnsre.2018.2854675Full Text
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Wheeler, T. L., Bowel and Bladder Workshop Participants, ., de Groat, W., Eisner, K., Emmanuel, A., French, J., … Kleitman, N. (2018). Translating promising strategies for bowel and bladder management in spinal cord injury. Experimental Neurology, 306, 169–176. https://doi.org/10.1016/j.expneurol.2018.05.006Full Text
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Wang, B., Grill, W. M., & Peterchev, A. V. (2018). Coupling Magnetically Induced Electric Fields to Neurons: Longitudinal and Transverse Activation. Biophys J, 115(1), 95–107. https://doi.org/10.1016/j.bpj.2018.06.004Full Text Link to Item
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Lee, H.-M., Howell, B., Grill, W. M., & Ghovanloo, M. (2018). Stimulation Efficiency With Decaying Exponential Waveforms in a Wirelessly Powered Switched-Capacitor Discharge Stimulation System. Ieee Transactions on Bio Medical Engineering, 65(5), 1095–1106. https://doi.org/10.1109/tbme.2017.2741107Full Text Open Access Copy
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Hokanson, J. A., Langdale, C. L., Sridhar, A., & Grill, W. M. (2018). Stimulation of the sensory pudendal nerve increases bladder capacity in the rat. American Journal of Physiology. Renal Physiology, 314(4), F543–F550. https://doi.org/10.1152/ajprenal.00373.2017Full Text
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Wang, B., Aberra, A. S., Grill, W. M., & Peterchev, A. V. (2018). Modified cable equation incorporating transverse polarization of neuronal membranes for accurate coupling of electric fields. J Neural Eng, 15(2), 026003. https://doi.org/10.1088/1741-2552/aa8b7cFull Text Link to Item
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Swan, B. D., Gasperson, L. B., Krucoff, M. O., Grill, W. M., & Turner, D. A. (2018). Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus. Brain Stimul, 11(2), 416–422. https://doi.org/10.1016/j.brs.2017.10.017Full Text Link to Item
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Pelot, N. A., Thio, B. J., & Grill, W. M. (2018). Modeling Current Sources for Neural Stimulation in COMSOL. Frontiers in Computational Neuroscience, 12, 40. https://doi.org/10.3389/fncom.2018.00040Full Text
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Barth, B. B., Henriquez, C. S., Grill, W. M., & Shen, X. (2017). Electrical stimulation of gut motility guided by an in silico model. Journal of Neural Engineering, 14(6), 066010. https://doi.org/10.1088/1741-2552/aa86c8Full Text
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Cassar, I. R., Titus, N. D., & Grill, W. M. (2017). An improved genetic algorithm for designing optimal temporal patterns of neural stimulation. Journal of Neural Engineering, 14(6), 066013. https://doi.org/10.1088/1741-2552/aa8270Full Text
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Hokanson, J. A., Langdale, C. L., Sridhar, A., & Grill, W. M. (2017). OAB without an overactive bladder in the acute prostaglandin E2 rat model. American Journal of Physiology. Renal Physiology, 313(5), F1169–F1177. https://doi.org/10.1152/ajprenal.00270.2017Full Text
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McGee, M. J., Swan, B. D., Danziger, Z. C., Amundsen, C. L., & Grill, W. M. (2017). Multiple Reflex Pathways Contribute to Bladder Activation by Intraurethral Stimulation in Persons With Spinal Cord Injury. Urology, 109, 210–215. https://doi.org/10.1016/j.urology.2017.07.041Full Text Link to Item
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Gonzalez, E. J., & Grill, W. M. (2017). The effects of neuromodulation in a novel obese-prone rat model of detrusor underactivity. American Journal of Physiology. Renal Physiology, 313(3), F815–F825. https://doi.org/10.1152/ajprenal.00242.2017Full Text
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Langdale, C. L., Hokanson, J. A., Sridhar, A., & Grill, W. M. (2017). Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder. American Journal of Physiology. Renal Physiology, 313(3), F657–F665. https://doi.org/10.1152/ajprenal.00116.2017Full Text
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Danziger, Z. C., & Grill, W. M. (2017). Sensory feedback from the urethra evokes state-dependent lower urinary tract reflexes in rat. The Journal of Physiology, 595(16), 5687–5698. https://doi.org/10.1113/jp274191Full Text
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Pelot, N. A., Behrend, C. E., & Grill, W. M. (2017). Modeling the response of small myelinated axons in a compound nerve to kilohertz frequency signals. Journal of Neural Engineering, 14(4), 046022. https://doi.org/10.1088/1741-2552/aa6a5fFull Text
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Cho, K.-I., Yoon, D., Qiu, S., Danziger, Z., Grill, W. M., Wetsel, W. C., & Ferreira, P. A. (2017). Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. Dis Model Mech, 10(5), 559–579. https://doi.org/10.1242/dmm.027730Full Text Link to Item
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So, R. Q., McConnell, G. C., & Grill, W. M. (2017). Frequency-dependent, transient effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling and neuronal activity in the hemiparkinsonian rat. Behavioural Brain Research, 320, 119–127. https://doi.org/10.1016/j.bbr.2016.12.003Full Text
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Brocker, D. T., Swan, B. D., So, R. Q., Turner, D. A., Gross, R. E., & Grill, W. M. (2017). Optimized temporal pattern of brain stimulation designed by computational evolution. Sci Transl Med, 9(371). https://doi.org/10.1126/scitranslmed.aah3532Full Text Link to Item
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Crosby, N. D., Janik, J. J., & Grill, W. M. (2017). Modulation of activity and conduction in single dorsal column axons by kilohertz-frequency spinal cord stimulation. Journal of Neurophysiology, 117(1), 136–147. https://doi.org/10.1152/jn.00701.2016Full Text
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Ramirez-Zamora, A., Giordano, J. J., Gunduz, A., Brown, P., Sanchez, J. C., Foote, K. D., … Okun, M. S. (2017). Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank. Frontiers in Neuroscience, 11, 734. https://doi.org/10.3389/fnins.2017.00734Full Text
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Hoang, K. B., Cassar, I. R., Grill, W. M., & Turner, D. A. (2017). Biomarkers and Stimulation Algorithms for Adaptive Brain Stimulation. Front Neurosci, 11, 564. https://doi.org/10.3389/fnins.2017.00564Full Text Link to Item
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Langdale, C. L., & Grill, W. M. (2016). Phasic activation of the external urethral sphincter increases voiding efficiency in the rat and the cat. Experimental Neurology, 285(Pt B), 173–181. https://doi.org/10.1016/j.expneurol.2016.05.030Full Text
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McGee, M. J., & Grill, W. M. (2016). Temporal pattern of stimulation modulates reflex bladder activation by pudendal nerve stimulation. Neurourology and Urodynamics, 35(8), 882–887. https://doi.org/10.1002/nau.22822Full Text
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Danziger, Z. C., & Grill, W. M. (2016). Sensory and circuit mechanisms mediating lower urinary tract reflexes. Autonomic Neuroscience : Basic & Clinical, 200, 21–28. https://doi.org/10.1016/j.autneu.2015.06.004Full Text
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Danziger, Z. C., & Grill, W. M. (2016). Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms. American Journal of Physiology. Renal Physiology, 311(2), F459–F468. https://doi.org/10.1152/ajprenal.00516.2015Full Text
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Medina, L. E., & Grill, W. M. (2016). Nerve excitation using an amplitude-modulated signal with kilohertz-frequency carrier and non-zero offset. Journal of Neuroengineering and Rehabilitation, 13(1), 63. https://doi.org/10.1186/s12984-016-0171-4Full Text
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McConnell, G. C., So, R. Q., & Grill, W. M. (2016). Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation. Journal of Neurophysiology, 115(6), 2791–2802. https://doi.org/10.1152/jn.00822.2015Full Text
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McGee, M. J., & Grill, W. M. (2016). Modeling the spinal pudendo-vesical reflex for bladder control by pudendal afferent stimulation. Journal of Computational Neuroscience, 40(3), 283–296. https://doi.org/10.1007/s10827-016-0597-5Full Text
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Pages, D. S., Ross, D. A., Puñal, V. M., Agashe, S., Dweck, I., Mueller, J., … Groh, J. M. (2016). Effects of Electrical Stimulation in the Inferior Colliculus on Frequency Discrimination by Rhesus Monkeys and Implications for the Auditory Midbrain Implant. J Neurosci, 36(18), 5071–5083. https://doi.org/10.1523/JNEUROSCI.3540-15.2016Full Text Open Access Copy Link to Item
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Kumaravelu, K., Brocker, D. T., & Grill, W. M. (2016). A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease. Journal of Computational Neuroscience, 40(2), 207–229. https://doi.org/10.1007/s10827-016-0593-9Full Text
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Swan, B. D., Brocker, D. T., Hilliard, J. D., Tatter, S. B., Gross, R. E., Turner, D. A., & Grill, W. M. (2016). Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting. Clin Neurophysiol, 127(2), 1551–1559. https://doi.org/10.1016/j.clinph.2015.07.034Full Text Link to Item
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Yoo, P. B., Liu, H., Hincapie, J. G., Ruble, S. B., Hamann, J. J., & Grill, W. M. (2016). Modulation of heart rate by temporally patterned vagus nerve stimulation in the anesthetized dog. Physiological Reports, 4(2), e12689. https://doi.org/10.14814/phy2.12689Full Text
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Couto, J., & Grill, W. M. (2016). Kilohertz Frequency Deep Brain Stimulation Is Ineffective at Regularizing the Firing of Model Thalamic Neurons. Frontiers in Computational Neuroscience, 10, 22. https://doi.org/10.3389/fncom.2016.00022Full Text
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Deeb, W., Giordano, J. J., Rossi, P. J., Mogilner, A. Y., Gunduz, A., Judy, J. W., … Okun, M. S. (2016). Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. Frontiers in Integrative Neuroscience, 10, 38. https://doi.org/10.3389/fnint.2016.00038Full Text
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Rossi, P. J., Gunduz, A., Judy, J., Wilson, L., Machado, A., Giordano, J. J., … Okun, M. S. (2016). Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. Frontiers in Neuroscience, 10, 119. https://doi.org/10.3389/fnins.2016.00119Full Text
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Goetz, S. M., Luber, B., Lisanby, S. H., Murphy, D. L. K., Kozyrkov, I. C., Grill, W. M., & Peterchev, A. V. (2016). Enhancement of Neuromodulation with Novel Pulse Shapes Generated by Controllable Pulse Parameter Transcranial Magnetic Stimulation. Brain Stimul, 9(1), 39–47. https://doi.org/10.1016/j.brs.2015.08.013Full Text Link to Item
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Howell, B., Medina, L. E., & Grill, W. M. (2015). Effects of frequency-dependent membrane capacitance on neural excitability. Journal of Neural Engineering, 12(5), 56015–56015. https://doi.org/10.1088/1741-2560/12/5/056015Full Text Open Access Copy
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Grigsby, E. M., Koval, M. J., Smith, M. V., Mueller, J. K., Deng, Z. D., Peterchev, A., … Sommer, M. A. (2015). Neural Effects of rTMS: Single Neuron Recordings From a Rhesus Macaque. Journal of Ect, 31(3), E33–E33.Open Access Copy Link to Item
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Danziger, Z. C., & Grill, W. M. (2015). Dynamics of the sensory response to urethral flow over multiple time scales in rat. The Journal of Physiology, 593(15), 3351–3371. https://doi.org/10.1113/jp270911Full Text
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Howell, B., Huynh, B., & Grill, W. M. (2015). Design and in vivo evaluation of more efficient and selective deep brain stimulation electrodes. Journal of Neural Engineering, 12(4), 046030. https://doi.org/10.1088/1741-2560/12/4/046030Full Text Open Access Copy
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Zhang, T. C., Janik, J. J., Peters, R. V., Chen, G., Ji, R.-R., & Grill, W. M. (2015). Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control. J Neurophysiol, 114(1), 284–300. https://doi.org/10.1152/jn.00147.2015Full Text Link to Item
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Lee, H. M., Kwon, K. Y., Li, W., Howell, B., Grill, W. M., & Ghovanloo, M. (2015). Corrections to “A Power-Efficient Switched-Capacitor Stimulating System for Electrical/Optical Deep-Brain Stimulation”. Ieee Journal of Solid State Circuits. https://doi.org/10.1109/JSSC.2015.2443431Full Text Open Access Copy
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Howell, B., Lad, S. P., & Grill, W. M. (2015). Correction: Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation. Plos One, 10(4). https://doi.org/10.1371/journal.pone.0123485Full Text Open Access Copy
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McGee, M. J., Amundsen, C. L., & Grill, W. M. (2015). Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury. J Spinal Cord Med, 38(2), 135–146. https://doi.org/10.1179/2045772314Y.0000000299Full Text Link to Item
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Danziger, Z., & Grill, W. M. (2015). A neuron model of stochastic resonance using rectangular pulse trains. Journal of Computational Neuroscience, 38(1), 53–66. https://doi.org/10.1007/s10827-014-0526-4Full Text
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Grill, W. M. (2015). Model-based analysis and design of waveforms for efficient neural stimulation. Progress in Brain Research, 222, 147–162. https://doi.org/10.1016/bs.pbr.2015.07.031Full Text
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Kent, A. R., Swan, B. D., Brocker, D. T., Turner, D. A., Gross, R. E., & Grill, W. M. (2015). Measurement of evoked potentials during thalamic deep brain stimulation. Brain Stimul, 8(1), 42–56. https://doi.org/10.1016/j.brs.2014.09.017Full Text Link to Item
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Medina, L. E., & Grill, W. M. (2014). Volume conductor model of transcutaneous electrical stimulation with kilohertz signals. Journal of Neural Engineering, 11(6), 066012. https://doi.org/10.1088/1741-2560/11/6/066012Full Text
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McGee, M. J., & Grill, W. M. (2014). Selective co-stimulation of pudendal afferents enhances bladder activation and improves voiding efficiency. Neurourology and Urodynamics, 33(8), 1272–1278. https://doi.org/10.1002/nau.22474Full Text
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McGee, M. J., Danziger, Z. C., Bamford, J. A., & Grill, W. M. (2014). A spinal GABAergic mechanism is necessary for bladder inhibition by pudendal afferent stimulation. American Journal of Physiology. Renal Physiology, 307(8), F921–F930. https://doi.org/10.1152/ajprenal.00330.2014Full Text
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Kent, A. R., & Grill, W. M. (2014). Analysis of deep brain stimulation electrode characteristics for neural recording. Journal of Neural Engineering, 11(4), 046010. https://doi.org/10.1088/1741-2560/11/4/046010Full Text
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Zhang, T. C., Janik, J. J., & Grill, W. M. (2014). Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition. Journal of Neurophysiology, 112(3), 552–567. https://doi.org/10.1152/jn.00254.2014Full Text
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Howell, B., & Grill, W. M. (2014). Evaluation of high-perimeter electrode designs for deep brain stimulation. Journal of Neural Engineering, 11(4), 046026. https://doi.org/10.1088/1741-2560/11/4/046026Full Text Open Access Copy
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Mueller, J. K., Grigsby, E. M., Prevosto, V., Petraglia, F. W., Rao, H., Deng, Z.-D., … Grill, W. M. (2014). Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. Nat Neurosci, 17(8), 1130–1136. https://doi.org/10.1038/nn.3751Full Text Open Access Copy Link to Item
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Swan, B. D., Grill, W. M., & Turner, D. A. (2014). Investigation of deep brain stimulation mechanisms during implantable pulse generator replacement surgery. Neuromodulation, 17(5), 419–424. https://doi.org/10.1111/ner.12123Full Text Link to Item
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Zhang, T. C., Janik, J. J., & Grill, W. M. (2014). Mechanisms and models of spinal cord stimulation for the treatment of neuropathic pain. Brain Research, 1569, 19–31. https://doi.org/10.1016/j.brainres.2014.04.039Full Text
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Birmingham, K., Gradinaru, V., Anikeeva, P., Grill, W. M., Pikov, V., McLaughlin, B., … Famm, K. (2014). Bioelectronic medicines: a research roadmap. Nature Reviews. Drug Discovery, 13(6), 399–400. https://doi.org/10.1038/nrd4351Full Text
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Dorval, A. D., & Grill, W. M. (2014). Deep brain stimulation of the subthalamic nucleus reestablishes neuronal information transmission in the 6-OHDA rat model of parkinsonism. Journal of Neurophysiology, 111(10), 1949–1959. https://doi.org/10.1152/jn.00713.2013Full Text
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Howell, B., Naik, S., & Grill, W. M. (2014). Influences of interpolation error, electrode geometry, and the electrode-tissue interface on models of electric fields produced by deep brain stimulation. Ieee Transactions on Bio Medical Engineering, 61(2), 297–307. https://doi.org/10.1109/tbme.2013.2292025Full Text Open Access Copy
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Birdno, M. J., Tang, W., Dostrovsky, J. O., Hutchison, W. D., & Grill, W. M. (2014). Response of human thalamic neurons to high-frequency stimulation. Plos One, 9(5), e96026. https://doi.org/10.1371/journal.pone.0096026Full Text
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Mueller, J. K., Grigsby, E. M., Prevosto, V., Petraglia, F. W., Rao, H., Deng, Z. D., … Grill, W. M. (2014). Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. Nature Neuroscience, 17(8), 1130–1136. https://doi.org/10.1038/nn.3751Full Text
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Howell, B., Lad, S. P., & Grill, W. M. (2014). Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation. Plos One, 9(12), e114938. https://doi.org/10.1371/journal.pone.0114938Full Text Open Access Copy Link to Item
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Goetz, S. M., Luber, B., Lisanby, S., Kozyrkov, C. I., Grill, W. M., & Peterchev, A. V. (2013). Enhancement of rTMS Neuromodulatory Effects with Novel Waveforms Demonstrated via Controllable Pulse Parameter TMS (cTMS). Neuropsychopharmacology, 38, S246–S247.Link to Item
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Frahm, K. S., Mørch, C. D., Grill, W. M., Lubock, N. B., Hennings, K., & Andersen, O. K. (2013). Activation of peripheral nerve fibers by electrical stimulation in the sole of the foot. Bmc Neuroscience, 14, 116. https://doi.org/10.1186/1471-2202-14-116Full Text
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Frahm, K. S., Mørch, C. D., Grill, W. M., & Andersen, O. K. (2013). Experimental and model-based analysis of differences in perception of cutaneous electrical stimulation across the sole of the foot. Medical & Biological Engineering & Computing, 51(9), 999–1009. https://doi.org/10.1007/s11517-013-1079-9Full Text
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Kent, A. R., & Grill, W. M. (2013). Neural origin of evoked potentials during thalamic deep brain stimulation. Journal of Neurophysiology, 110(4), 826–843. https://doi.org/10.1152/jn.00074.2013Full Text
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Kent, A. R., & Grill, W. M. (2013). Model-based analysis and design of nerve cuff electrodes for restoring bladder function by selective stimulation of the pudendal nerve. Journal of Neural Engineering, 10(3), 036010. https://doi.org/10.1088/1741-2560/10/3/036010Full Text
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Mueller, J. K., & Grill, W. M. (2013). Model-based analysis of multiple electrode array stimulation for epiretinal visual prostheses. Journal of Neural Engineering, 10(3), 036002. https://doi.org/10.1088/1741-2560/10/3/036002Full Text
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Yoo, P. B., Lubock, N. B., Hincapie, J. G., Ruble, S. B., Hamann, J. J., & Grill, W. M. (2013). High-resolution measurement of electrically-evoked vagus nerve activity in the anesthetized dog. Journal of Neural Engineering, 10(2), 026003. https://doi.org/10.1088/1741-2560/10/2/026003Full Text
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Brocker, D. T., & Grill, W. M. (2013). Principles of electrical stimulation of neural tissue. Handbook of Clinical Neurology, 116, 3–18. https://doi.org/10.1016/b978-0-444-53497-2.00001-2Full Text
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Brocker, D. T., Swan, B. D., Turner, D. A., Gross, R. E., Tatter, S. B., Koop, M. M., … Grill, W. M. (2013). Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease. Exp Neurol, 239, 60–67. https://doi.org/10.1016/j.expneurol.2012.09.008Full Text Link to Item
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McConnell, G. C., So, R. Q., Hilliard, J. D., Lopomo, P., & Grill, W. M. (2012). Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 32(45), 15657–15668. https://doi.org/10.1523/jneurosci.2824-12.2012Full Text
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Brown, B., Parker, C. B., Stoner, B. R., Grill, W. M., & Glass, J. T. (2012). Electrochemical charge storage properties of vertically aligned carbon nanotube films: Effects of thermal oxidation. Journal of Physical Chemistry C, 116(36), 19526–19534. https://doi.org/10.1021/jp304419aFull Text
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So, R. Q., McConnell, G. C., August, A. T., & Grill, W. M. (2012). Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 20(5), 626–635. https://doi.org/10.1109/tnsre.2012.2197761Full Text
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Klein, S. M., Melton, M. S., Grill, W. M., & Nielsen, K. C. (2012). Peripheral nerve stimulation in regional anesthesia. Reg Anesth Pain Med, 37(4), 383–392. https://doi.org/10.1097/AAP.0b013e3182576647Full Text Link to Item
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Snellings, A. E., & Grill, W. M. (2012). Effects of stimulation site and stimulation parameters on bladder inhibition by electrical nerve stimulation. Bju International, 110(1), 136–143. https://doi.org/10.1111/j.1464-410x.2011.10789.xFull Text
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Kent, A. R., & Grill, W. M. (2012). Recording evoked potentials during deep brain stimulation: development and validation of instrumentation to suppress the stimulus artefact. Journal of Neural Engineering, 9(3), 036004. https://doi.org/10.1088/1741-2560/9/3/036004Full Text
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So, R. Q., Kent, A. R., & Grill, W. M. (2012). Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study. Journal of Computational Neuroscience, 32(3), 499–519. https://doi.org/10.1007/s10827-011-0366-4Full Text
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Kuncel, A. M., Birdno, M. J., Swan, B. D., & Grill, W. M. (2012). Tremor reduction and modeled neural activity during cycling thalamic deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 123(5), 1044–1052. https://doi.org/10.1016/j.clinph.2011.07.052Full Text
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Snellings, A. E., Yoo, P. B., & Grill, W. M. (2012). Urethral flow-responsive afferents in the cat sacral dorsal root ganglia. Neuroscience Letters, 516(1), 34–38. https://doi.org/10.1016/j.neulet.2012.03.045Full Text
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Chen, S.-C., Grill, W. M., Fan, W.-J., Kou, Y. R., Lin, Y. S., Lai, C.-H., & Peng, C.-W. (2012). Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention. Bju International, 109(7), 1051–1058. https://doi.org/10.1111/j.1464-410x.2011.10526.xFull Text
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Birdno, M. J., Kuncel, A. M., Dorval, A. D., Turner, D. A., Gross, R. E., & Grill, W. M. (2012). Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. J Neurophysiol, 107(1), 364–383. https://doi.org/10.1152/jn.00906.2010Full Text Link to Item
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Kent, A. R., & Grill, W. M. (2012). Recording evoked potentials during deep brain stimulation: development and evaluation of instrumentation to suppress the stimulation artifact. Journal of Neural Engineering, 9(036004).
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Wongsarnpigoon, A., & Grill, W. M. (2012). Computer-based model of epidural motor cortex stimulation: effects of electrode position and geometry on activation of cortical neurons. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 123(1), 160–172. https://doi.org/10.1016/j.clinph.2011.06.005Full Text
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Wongsarnpigoon, A., & Grill, W. M. (2011). Effects of stimulation parameters and electrode location on thresholds for epidural stimulation of cat motor cortex. Journal of Neural Engineering, 8(6), 066016. https://doi.org/10.1088/1741-2560/8/6/066016Full Text
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So, R. Q., McConnell, G. C., Hilliard, J. D., & Grill, W. M. (2011). Irregular high frequency patterns decrease the effectiveness of deep brain stimulation in a rat model of Parkinson's disease. 2011 5th International Ieee/Embs Conference on Neural Engineering, Ner 2011, 322–325. https://doi.org/10.1109/NER.2011.5910552Full Text
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Santaniello, S., Fiengo, G., Glielmo, L., & Grill, W. M. (2011). Closed-loop control of deep brain stimulation: a simulation study. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 19(1), 15–24. https://doi.org/10.1109/tnsre.2010.2081377Full Text
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Woock, J. P., Yoo, P. B., & Grill, W. M. (2011). Mechanisms of reflex bladder activation by pudendal afferents. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 300(2), R398–R407. https://doi.org/10.1152/ajpregu.00154.2010Full Text
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Yoo, P. B., Horvath, E. E., Amundsen, C. L., Webster, G. D., & Grill, W. M. (2011). Multiple pudendal sensory pathways reflexly modulate bladder and urethral activity in patients with spinal cord injury. J Urol, 185(2), 737–743. https://doi.org/10.1016/j.juro.2010.09.079Full Text Link to Item
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Brown, B., Parker, C. B., Stoner, B. R., Grill, W. M., & Glass, J. T. (2011). Electrochemical charge storage properties of vertically aligned carbon nanotube films: the activation-enhanced length effect. Journal of the Electrochemical Society, 158, K217–K224.
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Castoro, M. A., Yoo, P. B., Hincapie, J. G., Hamann, J. J., Ruble, S. B., Wolf, P. D., & Grill, W. M. (2011). Excitation properties of the right cervical vagus nerve in adult dogs. Experimental Neurology, 227(1), 62–68. https://doi.org/10.1016/j.expneurol.2010.09.011Full Text
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Kennelly, M. J., Bennett, M. E., Grill, W. M., Grill, J. H., & Boggs, J. W. (2011). Electrical stimulation of the urethra evokes bladder contractions and emptying in spinal cord injury men: case studies. The Journal of Spinal Cord Medicine, 34(3), 315–321. https://doi.org/10.1179/2045772311y.0000000012Full Text
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Kent, A. R., & Grill, W. M. (2011). Instrumentation to record evoked potentials for closed-loop control of deep brain stimulation. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2011, 6777–6780. https://doi.org/10.1109/iembs.2011.6091671Full Text
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McGee, M. J., Yoo, P. B., & Grill, W. M. (2011). Selective co-stimulation of pudendal afferents enhances reflex bladder activation. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2011, 1057–1060. https://doi.org/10.1109/iembs.2011.6090246Full Text
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Yoo, P. B., Hincapie, J. G., Hamann, J. J., Ruble, S. B., Wolf, P. D., & Grill, W. M. (2011). Selective control of physiological responses by temporally-patterned electrical stimulation of the canine vagus nerve. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2011, 3107–3110. https://doi.org/10.1109/iembs.2011.6090848Full Text
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Zhang, T. C., & Grill, W. M. (2010). Modeling deep brain stimulation: point source approximation versus realistic representation of the electrode. Journal of Neural Engineering, 7(6), 066009. https://doi.org/10.1088/1741-2560/7/6/066009Full Text
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Zhang, J. Y., & Grill, W. M. (2010). Optimizing the geometry of deep brain stimulating electrodes. Ifmbe Proceedings, 32 IFMBE, 389–392. https://doi.org/10.1007/978-3-642-14998-6_99Full Text
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Dorval, A. D., Kuncel, A. M., Birdno, M. J., Turner, D. A., & Grill, W. M. (2010). Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity. J Neurophysiol, 104(2), 911–921. https://doi.org/10.1152/jn.00103.2010Full Text Link to Item
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Wongsarnpigoon, A., & Grill, W. M. (2010). Energy-efficient waveform shapes for neural stimulation revealed with a genetic algorithm. Journal of Neural Engineering, 7(4), 046009. https://doi.org/10.1088/1741-2560/7/4/046009Full Text
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Wongsarnpigoon, A., Woock, J. P., & Grill, W. M. (2010). Efficiency analysis of waveform shape for electrical excitation of nerve fibers. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 18(3), 319–328. https://doi.org/10.1109/tnsre.2010.2047610Full Text
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Woock, J. P., Yoo, P. B., & Grill, W. M. (2010). Finite element modeling and in vivo analysis of electrode configurations for selective stimulation of pudendal afferent fibers. Bmc Urology, 10, 11. https://doi.org/10.1186/1471-2490-10-11Full Text
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Becker, D., Gary, D. S., Rosenzweig, E. S., Grill, W. M., & McDonald, J. W. (2010). Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. Experimental Neurology, 222(2), 211–218. https://doi.org/10.1016/j.expneurol.2009.12.029Full Text
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Horvath, E. E., Yoo, P. B., Amundsen, C. L., Webster, G. D., & Grill, W. M. (2010). Conditional and continuous electrical stimulation increase cystometric capacity in persons with spinal cord injury. Neurourol Urodyn, 29(3), 401–407. https://doi.org/10.1002/nau.20766Full Text Link to Item
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Grill, W. M. (2010). Neural interfaces. American Scientist, 98(1), 48–57. https://doi.org/10.1511/2010.82.48Full Text
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Grill, W. M. (2010). Neural Interfaces Communicating with the nervous system through implanted devices requires engineering solutions to biomedical problems. American Scientist, 98(1), 48–57.Link to Item
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Kennelly, M. J., Arena, K. C., Shaffer, N., Bennett, M. E., Grill, W. M., Grill, J. H., & Boggs, J. W. (2010). Electrical stimulation of the urethra evokes bladder contractions in a woman with spinal cord injury. The Journal of Spinal Cord Medicine, 33(3), 261–265. https://doi.org/10.1080/10790268.2010.11689704Full Text
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Dorval, A. D., Panjwani, N., Qi, R. Y., & Grill, W. M. (2009). Deep brain stimulation that abolishes Parkinsonian activity in basal ganglia improves thalamic relay fidelity in a computational circuit. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 4230–4233.
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Grill, W. M. (2009). Electrical stimulation for control of bladder function. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 2009, 2369–2370.
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Grill, W. M. (2009). Principles of Electric Field Generation for Stimulation of the Central Nervous System, 1, 145–155. https://doi.org/10.1016/B978-0-12-374248-3.00015-XFull Text
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Grill, W. M., & Wei, X. F. (2009). High efficiency electrodes for deep brain stimulation. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 3298–3301.
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Wongsarnpigoon, A., & Grill, W. M. (2009). Genetic algorithm reveals energy-efficient waveforms for neural stimulation. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 634–637.
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Yoo, P. B., Horvath, E. E., Amundsen, C. L., Webster, G. D., & Grill, W. M. (2009). Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 6781–6784.
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Zhang, T., & Grill, W. M. (2009). Effect of electrode geometry on deep brain stimulation: Monopolar point source vs. medtronic 3389 lead. Ifmbe Proceedings, 24, 167–170. https://doi.org/10.1007/978-3-642-01697-4_61Full Text
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Lemay, M. A., Grasse, D., & Grill, W. M. (2009). Hindlimb endpoint forces predict movement direction evoked by intraspinal microstimulation in cats. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 17(4), 379–389. https://doi.org/10.1109/tnsre.2009.2023295Full Text
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Wei, X. F., & Grill, W. M. (2009). Impedance characteristics of deep brain stimulation electrodes in vitro and in vivo. Journal of Neural Engineering, 6(4), 046008. https://doi.org/10.1088/1741-2560/6/4/046008Full Text
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Woock, J. P., Yoo, P. B., & Grill, W. M. (2009). Intraurethral stimulation evokes bladder responses via 2 distinct reflex pathways. The Journal of Urology, 182(1), 366–373. https://doi.org/10.1016/j.juro.2009.02.110Full Text
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Cantrell, M. B., Grill, W. M., & Klein, S. M. (2009). Computer-based finite element modeling of insulated Tuohy needles used in regional anesthesia. Anesthesiology, 110(6), 1229–1234. https://doi.org/10.1097/ALN.0b013e3181a16275Full Text Link to Item
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Mahnam, A., Hashemi, S. M. R., & Grill, W. M. (2009). Measurement of the current-distance relationship using a novel refractory interaction technique. Journal of Neural Engineering, 6(3), 036005. https://doi.org/10.1088/1741-2560/6/3/036005Full Text
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Kuncel, A. M., Turner, D. A., Ozelius, L. J., Greene, P. E., Grill, W. M., & Stacy, M. A. (2009). Myoclonus and tremor response to thalamic deep brain stimulation parameters in a patient with inherited myoclonus-dystonia syndrome. Clin Neurol Neurosurg, 111(3), 303–306. https://doi.org/10.1016/j.clineuro.2008.10.015Full Text Link to Item
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Dorval, A. D., Panjwani, N., Qi, R. Y., & Grill, W. M. (2009). Deep brain stimulation that abolishes Parkinsonian activity in basal ganglia improves thalamic relay fidelity in a computational circuit. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2009, 4230–4233. https://doi.org/10.1109/iembs.2009.5333611Full Text
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Grill, W. M. (2009). Electrical stimulation for control of bladder function. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2009, 2369–2370. https://doi.org/10.1109/iembs.2009.5335001Full Text
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Grill, W. M., & Wei, X. F. (2009). High efficiency electrodes for deep brain stimulation. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2009, 3298–3301. https://doi.org/10.1109/iembs.2009.5333774Full Text
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Grill, W. M., & Wei, X. F. (2009). High efficiency electrodes for deep brain stimulation. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 2009, 3298–3301.
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Grill, W. M., Norman, S. E., & Bellamkonda, R. V. (2009). Implanted neural interfaces: biochallenges and engineered solutions. Annual Review of Biomedical Engineering, 11, 1–24. https://doi.org/10.1146/annurev-bioeng-061008-124927Full Text
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Wei, X. F., & Grill, W. M. (2009). Analysis of high-perimeter planar electrodes for efficient neural stimulation. Frontiers in Neuroengineering, 2, 15. https://doi.org/10.3389/neuro.16.015.2009Full Text
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Wongsarnpigoon, A., & Grill, W. M. (2009). Genetic algorithm reveals energy-efficient waveforms for neural stimulation. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference, 2009, 634–637. https://doi.org/10.1109/iembs.2009.5333722Full Text
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Wongsarnpigoon, A., & Grill, W. M. (2009). Genetic algorithm reveals energy-efficient waveforms for neural stimulation. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 2009, 634–637.
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Yoo, P. B., Horvath, E. E., Amundsen, C. L., Webster, G. D., & Grill, W. M. (2009). Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury. Annu Int Conf Ieee Eng Med Biol Soc, 2009, 6781–6784. https://doi.org/10.1109/IEMBS.2009.5333982Full Text Link to Item
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Wongsarnpigoon, A., & Grill, W. M. (2008). Computational modeling of epidural cortical stimulation. Journal of Neural Engineering, 5(4), 443–454. https://doi.org/10.1088/1741-2560/5/4/009Full Text
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Yoo, P. B., Woock, J. P., & Grill, W. M. (2008). Somatic innervation of the feline lower urinary tract. Brain Research, 1246, 80–87. https://doi.org/10.1016/j.brainres.2008.09.053Full Text
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Dorval, A. D., Russo, G. S., Hashimoto, T., Xu, W., Grill, W. M., & Vitek, J. L. (2008). Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of Parkinson's disease. Journal of Neurophysiology, 100(5), 2807–2818. https://doi.org/10.1152/jn.90763.2008Full Text
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Cooper, S. E., Kuncel, A. M., Wolgamuth, B. R., Rezai, A. R., & Grill, W. M. (2008). A model predicting optimal parameters for deep brain stimulation in essential tremor. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society, 25(5), 265–273. https://doi.org/10.1097/wnp.0b013e318182ed44Full Text
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Kuncel, A. M., Cooper, S. E., & Grill, W. M. (2008). A method to estimate the spatial extent of activation in thalamic deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 119(9), 2148–2158. https://doi.org/10.1016/j.clinph.2008.02.025Full Text
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Mahnam, A., Hashemi, S. M. R., & Grill, W. M. (2008). Computational evaluation of methods for measuring the spatial extent of neural activation. Journal of Neuroscience Methods, 173(1), 153–164. https://doi.org/10.1016/j.jneumeth.2008.05.019Full Text
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Yoo, P. B., Woock, J. P., & Grill, W. M. (2008). Bladder activation by selective stimulation of pudendal nerve afferents in the cat. Experimental Neurology, 212(1), 218–225. https://doi.org/10.1016/j.expneurol.2008.04.010Full Text
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Woock, J. P., Yoo, P. B., & Grill, W. M. (2008). Activation and inhibition of the micturition reflex by penile afferents in the cat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 294(6), R1880–R1889. https://doi.org/10.1152/ajpregu.00029.2008Full Text
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Peng, C. W., Chen, J. J. J., Cheng, C. L., & Grill, W. M. (2008). Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents. Journal of Neural Engineering, 5(2), 144–154.
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Birdno, M. J., Kuncel, A. M., Dorval, A. D., Turner, D. A., & Grill, W. M. (2008). Tremor varies as a function of the temporal regularity of deep brain stimulation. Neuroreport, 19(5), 599–602. https://doi.org/10.1097/WNR.0b013e3282f9e45eFull Text Link to Item
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Bossetti, C. A., Birdno, M. J., & Grill, W. M. (2008). Analysis of the quasi-static approximation for calculating potentials generated by neural stimulation. Journal of Neural Engineering, 5(1), 44–53. https://doi.org/10.1088/1741-2560/5/1/005Full Text
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Grill, W. M., Cantrell, M. B., & Robertson, M. S. (2008). Antidromic propagation of action potentials in branched axons: implications for the mechanisms of action of deep brain stimulation. Journal of Computational Neuroscience, 24(1), 81–93. https://doi.org/10.1007/s10827-007-0043-9Full Text
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Kayagil, T. A., Grimes, J. P., & Grill, W. M. (2008). Mechanisms underlying reversal of motor unit activation order in electrically evoked contractions after spinal cord injury. Muscle & Nerve, 37(2), 210–218. https://doi.org/10.1002/mus.20914Full Text
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Birdno, M. J., & Grill, W. M. (2008). Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency. Neurotherapeutics : The Journal of the American Society for Experimental Neurotherapeutics, 5(1), 14–25. https://doi.org/10.1016/j.nurt.2007.10.067Full Text
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Goldman, H. B., Amundsen, C. L., Mangel, J., Grill, J., Bennett, M., Gustafson, K. J., & Grill, W. M. (2008). Dorsal genital nerve stimulation for the treatment of overactive bladder symptoms. Neurourol Urodyn, 27(6), 499–503. https://doi.org/10.1002/nau.20544Full Text Link to Item
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Peng, C. W., Chen, J. J., Cheng, C. L., & Grill, W. M. (2008). Role of pudendal afferents in voiding efficiency in the rat. American Journal of Physiology Regulatory, Integrative, and Comparative Physiology, 294, 660–672.
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Santaniello, S., Fiengo, G., Glielmo, L., & Grill, W. M. (2007). Basal ganglia modeling in healthy and Parkinson's disease state. II. network-based multi-units simulation. Proceedings of the American Control Conference, 4095–4100. https://doi.org/10.1109/ACC.2007.4282742Full Text
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Santaniello, S., Fiengo, G., Glielmo, L., & Grill, W. M. (2007). Basal ganglia modeling in healthy and Parkinson's disease state. I. isolated neurons activity. Proceedings of the American Control Conference, 4089–4094. https://doi.org/10.1109/ACC.2007.4282741Full Text
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Birdno, M. J., Cooper, S. E., Rezai, A. R., & Grill, W. M. (2007). Pulse-to-pulse changes in the frequency of deep brain stimulation affect tremor and modeled neuronal activity. Journal of Neurophysiology, 98(3), 1675–1684. https://doi.org/10.1152/jn.00547.2007Full Text
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Kuncel, A. M., Cooper, S. E., Wolgamuth, B. R., & Grill, W. M. (2007). How does deep brain stimulation work? Expert Review of Medical Devices, 4(4), 428–429.Link to Item
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Kuncel, A. M., Cooper, S. E., Wolgamuth, B. R., & Grill, W. M. (2007). Amplitude- and frequency-dependent changes in neuronal regularity parallel changes in tremor With thalamic deep brain stimulation. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 15(2), 190–197. https://doi.org/10.1109/tnsre.2007.897004Full Text
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Grill, W. M. (2007). NAKFI smart prosthetics: exploring assistive devices for the body and mind. Expert Review of Medical Devices, 4(2), 107–108. https://doi.org/10.1586/17434440.4.2.107Full Text
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Grill, W. M., Dostrovsky, J. O., & Turner, D. A. (2007). Guest editorial: Special theme on deep brain stimulation. Ieee Transactions on Neural Systems and Rehabilitation Engineering, 15(1), 153–154. https://doi.org/10.1109/TNSRE.2007.896988Full Text
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Keohan, F., Wei, X. F., Wongsarnpigoon, A., Lazaro, E., Darga, J. E., & Grill, W. M. (2007). Fabrication and evaluation of conductive elastomer electrodes for neural stimulation. Journal of Biomaterials Science. Polymer Edition, 18(8), 1057–1073. https://doi.org/10.1163/156856207781494395Full Text
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Lemay, M. A., Bhowmik-Stoker, M., McConnell, G. C., & Grill, W. M. (2007). Role of biomechanics and muscle activation strategy in the production of endpoint force patterns in the cat hindlimb. Journal of Biomechanics, 40(16), 3679–3687. https://doi.org/10.1016/j.jbiomech.2007.06.021Full Text
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Nabutovsky, Y., Florio, J., Morgan, K., Grill, W. M., & Farazi, T. G. (2007). Lead design and initial applications of a new lead for long-term endovascular vagal stimulation. Pacing and Clinical Electrophysiology : Pace, 30 Suppl 1, S215–S218. https://doi.org/10.1111/j.1540-8159.2007.00641.xFull Text
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Yoo, P. B., & Grill, W. M. (2007). Minimally-invasive electrical stimulation of the pudendal nerve: a pre-clinical study for neural control of the lower urinary tract. Neurourology and Urodynamics, 26(4), 562–569. https://doi.org/10.1002/nau.20376Full Text
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Yoo, P. B., Klein, S. M., Grafstein, N. H., Horvath, E. E., Amundsen, C. L., Webster, G. D., & Grill, W. M. (2007). Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury. Neurourol Urodyn, 26(7), 1020–1023. https://doi.org/10.1002/nau.20441Full Text Link to Item
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Boggs, J. W., Wenzel, B. J., Gustafson, K. J., & Grill, W. M. (2006). Frequency-dependent selection of reflexes by pudendal afferents in the cat. The Journal of Physiology, 577(Pt 1), 115–126. https://doi.org/10.1113/jphysiol.2006.111815Full Text
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Kuncel, A. M., & Grill, W. M. (2006). NIH Neural Interfaces Workshop: August 21-23, 2006, Bethesda, MD, USA. Expert Review of Medical Devices, 3(6), 695–697. https://doi.org/10.1586/17434440.3.6.695Full Text
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Kuncel, A. M., Cooper, S. E., Wolgamuth, B. R., Clyde, M. A., Snyder, S. A., Montgomery, E. B., … Grill, W. M. (2006). Clinical response to varying the stimulus parameters in deep brain stimulation for essential tremor. Movement Disorders : Official Journal of the Movement Disorder Society, 21(11), 1920–1928. https://doi.org/10.1002/mds.21087Full Text
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Gustafson, K. J., Moffitt, M. A., Wang, X., Sun, J., Snyder, S., & Grill, W. M. (2006). Topography of spinal neurons active during hindlimb withdrawal reflexes in the decerebrate cat. Neuroscience, 141(4), 1983–1994. https://doi.org/10.1016/j.neuroscience.2006.05.018Full Text
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Wenzel, B. J., Boggs, J. W., Gustafson, K. J., & Grill, W. M. (2006). Closed loop electrical control of urinary continence. The Journal of Urology, 175(4), 1559–1563. https://doi.org/10.1016/s0022-5347(05)00657-9Full Text
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Boggs, J. W., Wenzel, B. J., Gustafson, K. J., & Grill, W. M. (2006). Bladder emptying by intermittent electrical stimulation of the pudendal nerve. Journal of Neural Engineering, 3(1), 43–51. https://doi.org/10.1088/1741-2560/3/1/005Full Text
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Schiefer, M. A., & Grill, W. M. (2006). Sites of neuronal excitation by epiretinal electrical stimulation. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 14(1), 5–13. https://doi.org/10.1109/tnsre.2006.870488Full Text
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Wenzel, B. J., Boggs, J. W., Gustafson, K. J., Creasey, G. H., & Grill, W. M. (2006). Detection of neurogenic detrusor contractions from the activity of the external anal sphincter in cat and human. Neurourology and Urodynamics, 25(2), 140–147. https://doi.org/10.1002/nau.20204Full Text
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Gustafson, K. J., Zelkovic, P. F., Feng, A. H., Draper, C. E., Bodner, D. R., & Grill, W. M. (2005). Fascicular anatomy and surgical access of the human pudendal nerve. World Journal of Urology, 23(6), 411–418. https://doi.org/10.1007/s00345-005-0032-4Full Text
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Grill, W. M., & Robertson, M. W. (2005). Antidromic action potential propagation in branched axons. 2nd International Ieee Embs Conference on Neural Engineering, 2005, 183–185. https://doi.org/10.1109/CNE.2005.1419585Full Text
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Wei, X. F., & Grill, W. M. (2005). Current density distributions, field distributions and impedance analysis of segmented deep brain stimulation electrodes. Journal of Neural Engineering, 2(4), 139–147. https://doi.org/10.1088/1741-2560/2/4/010Full Text
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Wenzel, B. J., Grill, W. M., Boggs, J. W., & Gustafson, K. J. (2005). Event-triggered electrical control of urinary continence. 2nd International Ieee Embs Conference on Neural Engineering, 2005, 687–689. https://doi.org/10.1109/CNE.2005.1419718Full Text
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Wenzel, B. J., Boggs, J. W., Gustafson, K. J., & Grill, W. M. (2005). Detecting the onset of hyper-reflexive bladder contractions from the electrical activity of the pudendal nerve. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 13(3), 428–435. https://doi.org/10.1109/tnsre.2005.848355Full Text
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Grill, W. M. (2005). Safety considerations for deep brain stimulation: review and analysis. Expert Review of Medical Devices, 2(4), 409–420. https://doi.org/10.1586/17434440.2.4.409Full Text
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Boggs, J. W., Wenzel, B. J., Gustafson, K. J., & Grill, W. M. (2005). Spinal micturition reflex mediated by afferents in the deep perineal nerve. Journal of Neurophysiology, 93(5), 2688–2697. https://doi.org/10.1152/jn.00978.2004Full Text
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Grill, W. M., Simmons, A. M., Cooper, S. E., Miocinovic, S., Montgomery, E. B., Baker, K. B., & Rezai, A. R. (2005). Temporal excitation properties of paresthesias evoked by thalamic microstimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 116(5), 1227–1234. https://doi.org/10.1016/j.clinph.2004.12.020Full Text
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Lee, D. C., & Grill, W. M. (2005). Polarization of a spherical cell in a nonuniform extracellular electric field. Annals of Biomedical Engineering, 33(5), 603–615. https://doi.org/10.1007/s10439-005-2397-3Full Text
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Moffitt, M. A., Dale, B. M., Duerk, J. L., & Grill, W. M. (2005). Functional magnetic resonance imaging of the human lumbar spinal cord. Journal of Magnetic Resonance Imaging : Jmri, 21(5), 527–535. https://doi.org/10.1002/jmri.20314Full Text
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Lee, D. C., Jensen, A. L., Schiefer, M. A., Morgan, C. W., & Grill, W. M. (2005). Structural mechanisms to produce differential dendritic gains. Brain Research, 1033(2), 117–127. https://doi.org/10.1016/j.brainres.2004.11.034Full Text
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Swift, M. J., Crago, P. E., & Grill, W. M. (2005). Applied electric fields accelerate the diffusion rate and increase the diffusion distance of DiI in fixed tissue. Journal of Neuroscience Methods, 141(1), 155–163. https://doi.org/10.1016/j.jneumeth.2004.06.011Full Text
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Moffitt, M. A., & Grill, W. M. (2004). Electrical localization of neural activity in the dorsal horn of the spinal cord: a modeling study. Annals of Biomedical Engineering, 32(12), 1694–1709. https://doi.org/10.1007/s10439-004-7822-5Full Text
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Kuncel, A. M., & Grill, W. M. (2004). Selection of stimulus parameters for deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 115(11), 2431–2441. https://doi.org/10.1016/j.clinph.2004.05.031Full Text
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Grill, W. M., Snyder, A. N., & Miocinovic, S. (2004). Deep brain stimulation creates an informational lesion of the stimulated nucleus. Neuroreport, 15(7), 1137–1140. https://doi.org/10.1097/00001756-200405190-00011Full Text
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Gustafson, K. J., Creasey, G. H., & Grill, W. M. (2004). A urethral afferent mediated excitatory bladder reflex exists in humans. Neuroscience Letters, 360(1–2), 9–12. https://doi.org/10.1016/j.neulet.2004.01.001Full Text
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McIntyre, C. C., Grill, W. M., Sherman, D. L., & Thakor, N. V. (2004). Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. Journal of Neurophysiology, 91(4), 1457–1469. https://doi.org/10.1152/jn.00989.2003Full Text
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Moffitt, M. A., McIntyre, C. C., & Grill, W. M. (2004). Prediction of myelinated nerve fiber stimulation thresholds: limitations of linear models. Ieee Transactions on Bio Medical Engineering, 51(2), 229–236. https://doi.org/10.1109/tbme.2003.820382Full Text
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Lemay, M. A., & Grill, W. M. (2004). Modularity of motor output evoked by intraspinal microstimulation in cats. Journal of Neurophysiology, 91(1), 502–514. https://doi.org/10.1152/jn.00235.2003Full Text
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Miocinovic, S., & Grill, W. M. (2004). Sensitivity of temporal excitation properties to the neuronal element activated by extracellular stimulation. Journal of Neuroscience Methods, 132(1), 91–99. https://doi.org/10.1016/j.jneumeth.2003.09.004Full Text
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Wenzel, B. J., Grill, W. M., Boggs, J. W., & Gustafson, K. J. (2004). Detecting the onset of hyper-reflexive bladder contractions from pudendal nerve electrical activity. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference, 2004, 4213–4216. https://doi.org/10.1109/iembs.2004.1404175Full Text
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Boggs, J. W., Grill, W. M., Wenzel, B. J., & Gustafson, K. J. (2003). Stimulation of the Deep Perineal Nerve Elicits Bladder Contractions. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 2031–2034.
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Wenzel, B. J., Grill, W. M., Boggs, J. W., & Gustafson, K. J. (2003). Using External Anal Sphincter Activity to Detect the Onset of Hyper-Reflexive Bladder Contractions. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 2, 1579–1582.
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Bhowmik, M., Boyce, V., McConnell, G., Joyce, D. M., Grill, W. M., & Lemay, M. A. (2003). Experimental and biomechanical model force fields produced by intraspinal microstimulation of the cat lumbar spinal cord. Bioengineering, Proceedings of the Northeast Conference, 37–38.
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Gustafson, K. J., Creasey, G. H., & Grill, W. M. (2003). A catheter based method to activate urethral sensory nerve fibers. The Journal of Urology, 170(1), 126–129. https://doi.org/10.1097/01.ju.0000070821.87785.14Full Text
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Grill, W. M., Gustafson, K. J., & Creasey, G. H. (2002). Control of bladder function by electrical activation of spinal neural circuits. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 2043–2044.
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Gustafson, K. J., Boggs, J. W., Wenzel, B. J., & Grill, W. M. (2002). Generation of bladder contractions via electrical stimulation of urethral afferent nerves and intra-urethral stimulation. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 2084–2085.
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Lee, D. C., & Grill, W. M. (2002). Polarization of a spherical cell in a non-uniform electric field: Transient response and comparison with polarization in a uniform field. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 1980–1981.
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McIntyre, C. C., Grill, W. M., Sherman, D. L., & Thakor, N. V. (2002). Model-based analysis of deep brain stimulation of the thalamus. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 2047–2048.
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Moffitt, M. A., & Grill, W. M. (2002). Source localization in the spinal cord: A modeling study. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 1977–1978.
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McIntyre, C. C., & Grill, W. M. (2002). Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. Journal of Neurophysiology, 88(4), 1592–1604. https://doi.org/10.1152/jn.2002.88.4.1592Full Text
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Jezernik, S., Craggs, M., Grill, W. M., Creasey, G., & Rijkhoff, N. J. M. (2002). Electrical stimulation for the treatment of bladder dysfunction: current status and future possibilities. Neurological Research, 24(5), 413–430. https://doi.org/10.1179/016164102101200294Full Text
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Humbert, S. D., Snyder, S. A., & Grill, W. M. (2002). Evaluation of command algorithms for control of upper-extremity neural prostheses. Ieee Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 10(2), 94–101. https://doi.org/10.1109/tnsre.2002.1031977Full Text
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Mino, H., & Grill, W. M. (2002). Effects of stochastic sodium channels on extracellular excitation of myelinated nerve fibers. Ieee Transactions on Bio Medical Engineering, 49(6), 527–532. https://doi.org/10.1109/tbme.2002.1001966Full Text
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McIntyre, C. C., Richardson, A. G., & Grill, W. M. (2002). Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. Journal of Neurophysiology, 87(2), 995–1006. https://doi.org/10.1152/jn.00353.2001Full Text
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Lemay, M. A., McConnell, G. C., Kao, T., Joyce, D. M., & Grill, W. M. (2002). Endpoint forces obtained during intraspinal microstimulation of the cat lumbar spinal cord - Experimental and biomechanical model results. Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec, 113–114.
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Grill, W. M. (2001). Neural modeling in neuromuscular and rehabilitation research. Annual Reports of the Research Reactor Institute, Kyoto University, 4, 4065–4068.
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McIntyre, C. C., & Grill, W. M. (2001). Model-based design of stimulus trains for selective microstimulation of targeted neuronal populations. Annual Reports of the Research Reactor Institute, Kyoto University, 1, 806–809.
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Grill, W. M., & McIntyre, C. C. (2001). Extracellular excitation of central neurons: Implications for the mechanisms of deep brain stimulation. Thalamus and Related Systems, 1(3), 269–277. https://doi.org/10.1016/S1472-9288(01)00025-5Full Text
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Grill, W. M., Craggs, M. D., Foreman, R. D., Ludlow, C. L., & Buller, J. L. (2001). Emerging clinical applications of electrical stimulation: opportunities for restoration of function. Journal of Rehabilitation Research and Development, 38(6), 641–653.
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Grill, W. M., McDonald, J. W., Peckham, P. H., Heetderks, W., Kocsis, J., & Weinrich, M. (2001). At the interface: convergence of neural regeneration and neural prostheses for restoration of function. Journal of Rehabilitation Research and Development, 38(6), 633–639.
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Jezernik, S., Grill, W. M., & Sinkjaer, T. (2001). Neural network classification of nerve activity recorded in a mixed nerve. Neurological Research, 23(5), 429–434. https://doi.org/10.1179/016164101101198811Full Text
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Jezernik, S., & Grill, W. M. (2001). Optimal filtering of whole nerve signals. Journal of Neuroscience Methods, 106(1), 101–110. https://doi.org/10.1016/s0165-0270(01)00334-xFull Text
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McIntyre, C. C., & Grill, W. M. (2001). Finite element analysis of the current-density and electric field generated by metal microelectrodes. Annals of Biomedical Engineering, 29(3), 227–235. https://doi.org/10.1114/1.1352640Full Text
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Grill, W. M. (2001). Functional electrical stimulation for control of internal organ function: Commentary. Neuromodulation, 4(4), 161–162.
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Jezernik, S., Grill, W. M., & Sinkjaer, T. (2001). Detection and inhibition of hyperreflexia-like bladder contractions in the cat by sacral nerve root recording and electrical stimulation. Neurourology and Urodynamics, 20(2), 215–230. https://doi.org/10.1002/1520-6777(2001)20:2<215::aid-nau23>3.0.co;2-0Full Text
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Grill, W., & McIntyre, C. (2000). What neural elements are excited by extracellular stimulation in the central nervous system? Annals of Biomedical Engineering, 28(SUPPL. 1).
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Lemay, M. A., & Grill, W. M. (2000). Endpoint force patterns evoked by intraspinal stimulation - Ipsilateral and contralateral responses. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 2, 918–920.
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McIntyre, C. C., & Grill, W. M. (2000). Current density and electric field analysis of microelectrodes using finite element modeling. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 2010–2011.
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Mino, H., & Grill, W. M. (2000). Modeling of mammalian myelinated nerve with stochastic sodium ionic channels. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 2, 915–917.
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Moffitt, M., & Grill, W. (2000). Effect of source location and tissue properties on surface potentials in a cylindrical volume conductor model. Annals of Biomedical Engineering, 28(SUPPL. 1).
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Richardson, A. G., McIntyre, C. C., & Grill, W. M. (2000). Modelling the effects of electric fields on nerve fibres: influence of the myelin sheath. Medical & Biological Engineering & Computing, 38(4), 438–446. https://doi.org/10.1007/bf02345014Full Text
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Grill, W. M. (2000). Electrical activation of spinal neural circuits: application to motor-system neural prostheses. Neuromodulation : Journal of the International Neuromodulation Society, 3(2), 97–106. https://doi.org/10.1046/j.1525-1403.2000.00097.xFull Text
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McIntyre, C. C., & Grill, W. M. (2000). Selective microstimulation of central nervous system neurons. Annals of Biomedical Engineering, 28(3), 219–233. https://doi.org/10.1114/1.262Full Text
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Grill, W. M., & Kirsch, R. F. (2000). Neuroprosthetic applications of electrical stimulation. Assistive Technology : The Official Journal of Resna, 12(1), 6–20. https://doi.org/10.1080/10400435.2000.10132006Full Text
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Grill, W. M., Richardson, A. G., & McIntyre, C. C. (2000). Influence of the myelin sheath on excitation properties of nerve fibers. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 3, 1605–1607. https://doi.org/10.1109/IEMBS.2000.900380Full Text
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Humbert, S. D., & Grill, W. M. (2000). Performance evaluation of command control algorithms for upper-extremity neuroprostheses. Assistive Technology, 12(2), 154–154.Link to Item
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Grill, W. M., & Mortimer, J. T. (2000). Neural and connective tissue response to long-term implantation of multiple contact nerve cuff electrodes. Journal of Biomedical Materials Research, 50(2), 215–226. https://doi.org/10.1002/(SICI)1097-4636(200005)50:23.0.CO;2-AFull Text Link to Item
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Lemay, M. A., & Grill, W. M. (1999). Endpoint forces evoked by microstimulation of the cat spinal cord. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 1, 481.
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McIntyre, C. C., & Grill, W. M. (1999). Model-based design of stimulus waveforms for selective microstimulation in the central nervous system. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 1, 384.
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Barbeau, H., McCrea, D. A., O’Donovan, M. J., Rossignol, S., Grill, W. M., & Lemay, M. A. (1999). Tapping into spinal circuits to restore motor function. Brain Research. Brain Research Reviews, 30(1), 27–51. https://doi.org/10.1016/s0165-0173(99)00008-9Full Text
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Grill, W. M., Bhadra, N., & Wang, B. (1999). Bladder and urethral pressures evoked by microstimulation of the sacral spinal cord in cats. Brain Research, 836(1–2), 19–30. https://doi.org/10.1016/s0006-8993(99)01581-4Full Text
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Grill, W. M., Erokwu, B. O., Hadziefendic, S., & Haxhiu, M. A. (1999). Extended survival time following pseudorabies virus injection labels the suprapontine neural network controlling the bladder and urethra in the rat. Neuroscience Letters, 270(2), 63–66. https://doi.org/10.1016/s0304-3940(99)00462-0Full Text
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McIntyre, C. C., & Grill, W. M. (1999). Excitation of central nervous system neurons by nonuniform electric fields. Biophysical Journal, 76(2), 878–888. https://doi.org/10.1016/s0006-3495(99)77251-6Full Text
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Wang, B., Bhadra, N., & Grill, W. M. (1999). Functional anatomy of the male feline urethra: morphological and physiological correlations. The Journal of Urology, 161(2), 654–659. https://doi.org/10.1016/s0022-5347(01)61989-xFull Text
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Jr, W. M. G. (1999). Modeling the effects of electric fields on nerve fibers: Influence of tissue electrical properties. Ieee Transactions on Biomedical Engineering, 46(8), 918–928. https://doi.org/10.1109/10.775401Full Text
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Grill, W. M., & Mortimer, J. T. (1998). Stability of the input-output properties of chronically implanted multiple contact nerve cuff stimulating electrodes. Ieee Transactions on Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 6(4), 364–373. https://doi.org/10.1109/86.736150Full Text
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McIntyre, C. C., & Grill, W. M. (1998). Sensitivity analysis of a model of mammalian neural membrane. Biological Cybernetics, 79(1), 29–37. https://doi.org/10.1007/s004220050455Full Text
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Grill, W. M., Wang, B., Hadziefendic, S., & Haxhiu, M. A. (1998). Identification of the spinal neural network involved in coordination of micturition in the male cat. Brain Research, 796(1–2), 150–160. https://doi.org/10.1016/s0006-8993(98)00340-0Full Text
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Grill, W. M., & Van Doren, C. L. (1997). Detection of object contact during grasp using nail-mounted strain sensors. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 5, 1952–1953.
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Grill, W. M., & Wang, B. (1997). Mapping knee torques evoked by intraspinal microstimulation. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 5, 1950–1951.
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McIntyre, C. C., & Grill, W. M. (1997). Microstimulation of spinal motoneurons: a model study. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 5, 2032–2034.
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Grill, W. M., & Mortimer, J. T. (1997). Inversion of the current-distance relationship by transient depolarization. Ieee Transactions on Bio Medical Engineering, 44(1), 1–9. https://doi.org/10.1109/10.553708Full Text
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Grill, W. M. (1996). Effects of tissue electrical properties on neural excitation. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, (1), 349–350.
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Grill, W. M., & Mortimer, J. T. (1996). Quantification of recruitment properties of multiple contact cuff electrodes. Ieee Transactions on Rehabilitation Engineering : A Publication of the Ieee Engineering in Medicine and Biology Society, 4(2), 49–62. https://doi.org/10.1109/86.506402Full Text
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Grill, W. M., & Mortimer, J. T. (1996). Non-invasive measurement of the input-output properties of peripheral nerve stimulating electrodes. Journal of Neuroscience Methods, 65(1), 43–50. https://doi.org/10.1016/0165-0270(95)00143-3Full Text
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Grill, W. M., & Mortimer, J. T. (1996). The effect of stimulus pulse duration on selectivity of neural stimulation. Ieee Transactions on Bio Medical Engineering, 43(2), 161–166. https://doi.org/10.1109/10.481985Full Text
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Grill, W. M., & Mortimer, J. T. (1995). Temporal stability of nerve cuff electrode recruitment properties. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 17(2), 1089–1090.
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Tarler, M., Grill, W. M., & Mortimer, J. T. (1995). Comparison between monopolar and tripolar configurations in chronically implanted nerve cuff electrodes. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 17(2), 1093–1094.
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Grill, W. M., & Mortimer, J. T. (1995). Stimulus Waveforms for Selective Neural Stimulation. Ieee Engineering in Medicine and Biology Magazine, 14(4), 375–385. https://doi.org/10.1109/51.395310Full Text
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Grill, W. M., & Mortimer, J. T. (1994). Effect of stimulus pulsewidth on spatial selectivity of neural stimulation. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 16(pt 1), 363–364.
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Grill, W. M., & Mortimer, J. T. (1994). Electrical properties of implant encapsulation tissue. Annals of Biomedical Engineering, 22(1), 23–33. https://doi.org/10.1007/bf02368219Full Text
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Grill, W. M., & Mortimer, J. T. (1993). Functional control of joint torque with a cuff electrode. Proceedings of the Annual Conference on Engineering in Medicine and Biology, 15(pt 3), 1328–1329.
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Grill, W. M., & Mortimer, J. T. (1993). Selective activation of distant nerve fibers. Proceedings of the Annual Conference on Engineering in Medicine and Biology, 15(pt 3), 1249–1250.
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Veraart, C., Grill, W. M., & Mortimer, J. T. (1993). Selective control of muscle activation with a multipolar nerve cuff electrode. Ieee Transactions on Bio Medical Engineering, 40(7), 640–653. https://doi.org/10.1109/10.237694Full Text
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Warman, E. N., Grill, W. M., & Durand, D. (1992). Modeling the effects of electric fields on nerve fibers: determination of excitation thresholds. Ieee Transactions on Bio Medical Engineering, 39(12), 1244–1254. https://doi.org/10.1109/10.184700Full Text
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Grill, W. M., Veraart, C., & Mortimer, J. T. (1991). Selective activation of peripheral nerve fascicles: Use of field steering currents. Proceedings of the Annual Conference on Engineering in Medicine and Biology, 13(pt 2), 904–905.
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Warman, E. N., Grill, W. M., Durand, D., & Mortimer, J. T. (1991). A new formulation of the activating function for estimation of neural excitation thresholds. Proceedings of the Annual Conference on Engineering in Medicine and Biology, 13(pt 2), 916–917.
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Kisby, C. K., Gonzalez, E. J., Visco, A. G., Amundsen, C. L., & Grill, W. M. (n.d.). Randomized Controlled Trial to Assess the Impact of Intraurethral Lidocaine on Urodynamic Voiding Parameters. Female Pelvic Med Reconstr Surg, 25(4), 265–270. https://doi.org/10.1097/SPV.0000000000000544Full Text Link to Item
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Book Sections
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Hokanson, J. A., Amundsen, C. L., & Grill, W. M. (2017). Neuroprosthetic control of lower urinary tract function. In Neuroprosthetics: Theory and Practice: Second Edition (pp. 537–565). https://doi.org/10.1142/9789813207158_0017Full Text
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Howell, B., & Grill, W. M. (2015). Design of electrodes for stimulation and recording. In Implantable Neuroprostheses for Restoring Function (pp. 59–93). https://doi.org/10.1016/B978-1-78242-101-6.00004-5Full Text
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Howell, B., & Grill, W. M. (2014). Computational Models to Optimize the Electrodes and Waveforms for Deep Brain Stimulation. In Encyclopedia of Computational Neuroscience (pp. 1–5). Springer New York. https://doi.org/10.1007/978-1-4614-7320-6_366-1Full Text
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Medina, L. E., & Grill, W. M. (2014). Mammalian Motor Nerve Fibers, Models of. In Encyclopedia of Computational Neuroscience (pp. 1–4). Springer New York. https://doi.org/10.1007/978-1-4614-7320-6_369-2Full Text
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McGee, M., & Grill, W. M. (2013). Methodologies for the Restoration of Bladder and Bowel Functions. In Encyclopedia of Computational Neuroscience (pp. 1–6). Springer New York. https://doi.org/10.1007/978-1-4614-7320-6_589-5Full Text
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Grill, W. M. (2007). Signal considerations for chronically implanted electrodes for brain interfacing. In Indwelling Neural Implants: Strategies for Contending with the in Vivo Environment (pp. 41–61).
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Lee, D. C., McIntyre, C. C., & Grill, W. M. (2002). Extracellular electrical stimulation of central neurons: Quantitative studies. In Handbook of Neuroprosthetic Methods (pp. 95–125).
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Conference Papers
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Gao, Q., Naumann, M., Jovanov, I., Lesi, V., Kamaravelu, K., Grill, W. M., & Pajic, M. (2020). Model-based design of closed loop deep brain stimulation controller using reinforcement learning. In Proceedings 2020 Acm/Ieee 11th International Conference on Cyber Physical Systems, Iccps 2020 (pp. 108–118). https://doi.org/10.1109/ICCPS48487.2020.00018Full Text
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Jovanov, I., Nauman, M., Kumaravelu, K., Lesi, V., Zutshi, A., Grill, W. M., & Pajic, M. (2018). Learning-Based Control Design for Deep Brain Stimulation. In Proceedings 9th Acm/Ieee International Conference on Cyber Physical Systems, Iccps 2018 (pp. 349–350). https://doi.org/10.1109/ICCPS.2018.00048Full Text
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Jovanov, I., Naumann, M., Kumaravelu, K., Grill, W. M., & Pajic, M. (2018). Platform for Model-Based Design and Testing for Deep Brain Stimulation. In Proceedings 9th Acm/Ieee International Conference on Cyber Physical Systems, Iccps 2018 (pp. 263–274). https://doi.org/10.1109/ICCPS.2018.00033Full Text
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Lubba, C., Mitrani, E., Hokanson, J., Grill, W. M., & Schultz, S. R. (2017). Real-time decoding of bladder pressure from pelvic nerve activity CP. In International Ieee/Embs Conference on Neural Engineering, Ner (pp. 617–620). https://doi.org/10.1109/NER.2017.8008427Full Text
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Medina, L. E., & Grill, W. M. (2015). Phantom model of transcutaneous electrical stimulation with kilohertz signals. In International Ieee/Embs Conference on Neural Engineering, Ner (Vol. 2015-July, pp. 430–433). https://doi.org/10.1109/NER.2015.7146651Full Text
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Pelot, N. A., Behrend, C. E., & Grill, W. M. (2015). Modeling the response of small myelinated and unmyelinated axons to kilohertz frequency signals. In International Ieee/Embs Conference on Neural Engineering, Ner (Vol. 2015-July, pp. 406–409). https://doi.org/10.1109/NER.2015.7146645Full Text
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Behrend, C. E., Mace, B. E., Gauger, L., Kolls, B. J., & Grill, W. M. (2015). Quantification of beta activity with disease progression in EEG recordings in Parkinson's disease patients. In Movement Disorders (Vol. 30, pp. S31–S31). San Diego, CA: WILEY-BLACKWELL.Link to Item
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McConnell, G. C., & Grill, W. M. (2013). Stimulation location within the substantia nigra pars reticulata differentially modulates gait in hemiparkinsonian rats. In International Ieee/Embs Conference on Neural Engineering, Ner (pp. 1210–1213). https://doi.org/10.1109/NER.2013.6696157Full Text
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McGee, M. J., & Grill, W. M. (2013). Temporal patterns of pudendal afferent stimulation modulate reflex bladder activation. In International Ieee/Embs Conference on Neural Engineering, Ner (pp. 843–846). https://doi.org/10.1109/NER.2013.6696066Full Text
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Medina, L. E., & Grill, W. M. (2013). Circuit and volume conductor models of transcutaneous electrical stimulation. In International Ieee/Embs Conference on Neural Engineering, Ner (pp. 1473–1476). https://doi.org/10.1109/NER.2013.6696223Full Text
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Zhang, T. C., Janik, J. J., & Grill, W. M. (2013). Network model of the effects of spinal cord stimulation. In International Ieee/Embs Conference on Neural Engineering, Ner (pp. 1123–1126). https://doi.org/10.1109/NER.2013.6696135Full Text
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Howell, B., & Grill, W. M. (2013). Model-based optimization of electrode designs for deep brain stimulation. In International Ieee/Embs Conference on Neural Engineering, Ner (pp. 154–157). https://doi.org/10.1109/NER.2013.6695895Full Text
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Santaniello, S., Fiengo, G., Glielmo, L., & Grill, W. M. (2007). Basal ganglia modeling in healthy and Parkinson's disease state. II. Network-based multi-units simulation. In 2007 American Control Conference, Vols 1 13 (pp. 3627-+). New York, NY: IEEE.Link to Item
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Santaniello, S., Fiengo, G., Glielmo, L., & Grill, W. M. (2007). Basal ganglia modeling in healthy and Parkinson's disease state. I. Isolated neurons activity. In 2007 American Control Conference, Vols 1 13 (pp. 3621-+). New York, NY: IEEE.Link to Item
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Cooper, S. E., Kuncel, A. M., Henderson, J., Rezai, A. R., Montgomery, E. B., & Grill, W. M. (2005). Predicting optimal stimulation parameters for DBS of the thalamus in essential tremor. In Neurology (Vol. 64, pp. A254–A254). Miami Beach, FL: LIPPINCOTT WILLIAMS & WILKINS.Link to Item
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Cooper, S. E., Kuncel, A. M., Henderson, J., Rezai, A., Montgomery, E. B., & Grill, W. M. (2004). Stimulation parameters' relationship to stimulation effect in deep brain stimulation of the thalamus. In Movement Disorders (Vol. 19, pp. S309–S309). Rome, ITALY: WILEY-LISS.Link to Item
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Gustafson, K. J., Creasey, G. H., & Grill, W. M. (2003). An excitatory urethra-to-bladder reflex in humans. In Journal of Urology (Vol. 169, pp. 373–373). CHICAGO, ILLINOIS: LIPPINCOTT WILLIAMS & WILKINS.Link to Item
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Bhowmik, M., Boyce, V., McConnell, G., Joyce, D. M., Grill, W. M., & Lemay, M. A. (2003). Experimental and biomechanical model force fields produced by intraspinal microstimulation of the cat lumbar spinal cord. In Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec (pp. 37–38).
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Grill, W. M., & Mortimer, J. T. (1992). Electrical impedance of electrode encapsulation tissue. In Proceedings of the Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Embs (Vol. 4, pp. 1376–1377). https://doi.org/10.1109/IEMBS.1992.5761837Full Text
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Grill, W. M., Durand, D., & Warman, E. N. (1992). A new method to predict neural excitation thresholds for applied electric fields. In Proceedings of the Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Embs (Vol. 4, pp. 1384–1385). https://doi.org/10.1109/IEMBS.1992.5761841Full Text
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Datasets
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Grill, W., & Yi, G. (2020). Data and code from: Waveforms optimized to produce closed-state Na+ inactivation eliminate onset response in nerve conduction block. https://doi.org/10.7924/r4z31t79kData Access
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- Teaching & Mentoring
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Recent Courses
- BME 493: Projects in Biomedical Engineering (GE) 2022
- BME 494: Projects in Biomedical Engineering (GE) 2022
- BME 515: Neural Prosthetic Systems (GE, EL, IM) 2022
- BME 804: Developments in Neural Engineering 2022
- NEUROSCI 515: Neural Prosthetic Systems (GE, EL, IM) 2022
- BME 301L: Bioelectricity (AC or GE) 2021
- BME 394: Projects in Biomedical Engineering (GE) 2021
- BME 493: Projects in Biomedical Engineering (GE) 2021
- BME 494: Projects in Biomedical Engineering (GE) 2021
- BME 504: Fundamentals of Electrical Stimulation of the Nervous System (EL, GE) 2021
- BME 791: Graduate Independent Study 2021
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021
- NEUROSCI 301L: Bioelectricity (AC or GE) 2021
- NEUROSCI 504: Fundamentals of Electrical Stimulation of the Nervous System (EL, GE) 2021
- BME 504: Fundamentals of Electrical Stimulation of the Nervous System (EL, GE) 2020
- BME 515: Neural Prosthetic Systems (GE, EL, IM) 2020
- NEUROSCI 504: Fundamentals of Electrical Stimulation of the Nervous System (EL, GE) 2020
- NEUROSCI 515: Neural Prosthetic Systems (GE, EL, IM) 2020
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