Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Cytopathology Fellowship, Pathology, Harvard Medical School 2012 - 2013
  • Anatomic and Clinical Pathology, Pathology, Duke University School of Medicine 2008 - 2012
  • M.D., Duke University School of Medicine 2008
• 

  Previous Appointments & Affiliations

  • Associate Professor of Pathology, Pathology, Clinical Science Departments 2019 - 2020
  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 2013 - 2019
• Research
• 

  Selected Grants

  • Race-Related Alternative Splicing: Novel Targets in Prostate Cancer awarded by National Institutes of Health 2017 - 2023
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Arcot, Rohith, Sitharthan Sekar, Srinath Kotamarti, Madison Krischak, Zoe D. Michael, Wen-Chi Foo, Jiaoti Huang, Thomas J. Polascik, and Rajan T. Gupta. “Structured approach to resolving discordance between PI-RADS v2.1 score and targeted prostate biopsy results: an opportunity for quality improvement.” Abdom Radiol (Ny) 47, no. 8 (August 2022): 2917–27. https://doi.org/10.1007/s00261-022-03562-w.
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    • Dov, David, Serge Assaad, Ameer Syedibrahim, Jonathan Bell, Jiaoti Huang, John Madden, Rex Bentley, et al. “A Hybrid Human-Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy.” Arch Pathol Lab Med 146, no. 6 (June 1, 2022): 727–34. https://doi.org/10.5858/arpa.2020-0850-OA.
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    • Jiang, X. S., and W. C. Foo. “Teaching interventional cytopathology.” Seminars in Diagnostic Pathology, January 1, 2022. https://doi.org/10.1053/j.semdp.2022.01.002.
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    • Morris, D Cody, Derek Y. Chan, Mark L. Palmeri, Thomas J. Polascik, Wen-Chi Foo, and Kathryn R. Nightingale. “Prostate Cancer Detection Using 3-D Shear Wave Elasticity Imaging.” Ultrasound Med Biol 47, no. 7 (July 2021): 1670–80. https://doi.org/10.1016/j.ultrasmedbio.2021.02.006.
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    • Xu, Yuemei, Zhiwen Li, Jiong Shi, Yao Fu, Li Zhu, Xiangshan Fan, and Wen-Chi Foo. “Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors.” Virchows Arch 478, no. 4 (April 2021): 619–26. https://doi.org/10.1007/s00428-020-02909-2.
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    • Brown, Landon C., Jason Zhu, Matthew K. Labriola, Yuan Wu, Sachica Cheris, Xin Liu, Kathryn Perkinson, et al. “PD-L1 Assay Concordance in Metastatic Renal Cell Carcinoma and Metastatic Urothelial Carcinoma.” Clin Genitourin Cancer 18, no. 6 (December 2020): 509–13. https://doi.org/10.1016/j.clgc.2020.03.020.
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    • Morris, D Cody, Derek Y. Chan, Theresa H. Lye, Hong Chen, Mark L. Palmeri, Thomas J. Polascik, Wen-Chi Foo, Jiaoti Huang, Jonathan Mamou, and Kathryn R. Nightingale. “Multiparametric Ultrasound for Targeting Prostate Cancer: Combining ARFI, SWEI, QUS and B-Mode.” Ultrasound Med Biol 46, no. 12 (December 2020): 3426–39. https://doi.org/10.1016/j.ultrasmedbio.2020.08.022.
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    • Gupta, Santosh, Daniel H. Hovelson, Gabor Kemeny, Susan Halabi, Wen-Chi Foo, Monika Anand, Jason A. Somarelli, et al. “Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer.” Genes Chromosomes Cancer 59, no. 4 (April 2020): 225–39. https://doi.org/10.1002/gcc.22824.
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    • Yin, Yu, Lingfan Xu, Yan Chang, Tao Zeng, Xufeng Chen, Aifen Wang, Jeff Groth, et al. “Correction to: N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ ATM pathway.” Mol Cancer 18, no. 1 (June 19, 2019): 107. https://doi.org/10.1186/s12943-019-1034-y.
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    • Yin, Yu, Lingfan Xu, Yan Chang, Tao Zeng, Xufeng Chen, Aifeng Wang, Jeff Groth, et al. “N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.” Mol Cancer 18, no. 1 (January 18, 2019): 11. https://doi.org/10.1186/s12943-019-0941-2.
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    • Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.” Plos One 14, no. 5 (2019): e0216934. https://doi.org/10.1371/journal.pone.0216934.
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    • Labriola, Matthew, Wen-Chi Foo, Daniel J. George, and Tian Zhang. “Pazopanib in the Treatment of Bilateral Multifocal Renal Oncocytomas: A Case Report.” Clin Genitourin Cancer 16, no. 3 (June 2018): e509–12. https://doi.org/10.1016/j.clgc.2018.02.017.
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    • Inouye, Brian M., Francis M. Hughes, Huixia Jin, Robin Lütolf, Kunal C. Potnis, Jonathan C. Routh, Douglas C. Rouse, Wen-Chi Foo, and J Todd Purves. “Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria.” Res Rep Urol 10 (2018): 219–25. https://doi.org/10.2147/RRU.S177633.
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    • Foo, Wen-Chi, Grant Harrison, and Xuefeng Zhang. “Immunocytochemistry for SOX-11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies.” Cancer Cytopathol 125, no. 11 (November 2017): 831–37. https://doi.org/10.1002/cncy.21931.
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    • Qi, Robert, Wen-Chi Foo, Michael N. Ferrandino, Leah G. Davis, Sitharthan Sekar, Thomas A. Longo, Ghalib Jibara, Tracy Han, Ilhan Gokhan, and Judd W. Moul. “Over half of contemporary clinical Gleason 8 on prostate biopsy are downgraded at radical prostatectomy.” Can J Urol 24, no. 5 (October 2017): 8982–89.
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    • Gopalakrishna, Ajay, Joseph J. Fantony, Thomas A. Longo, Richmond Owusu, Wen-Chi Foo, Rajesh Dash, Brian T. Denton, and Brant A. Inman. “Anticipatory Positive Urine Tests for Bladder Cancer.” Ann Surg Oncol 24, no. 6 (June 2017): 1747–53. https://doi.org/10.1245/s10434-016-5763-5.
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    • Fantony, Joseph J., Thomas A. Longo, Ajay Gopalakrishna, Richmond Owusu, Raymond S. Lance, Wen-Chi Foo, Brant A. Inman, and Michael R. Abern. “Urinary NID2 and TWIST1 methylation to augment conventional urine cytology for the detection of bladder cancer.” Cancer Biomark 18, no. 4 (2017): 381–87. https://doi.org/10.3233/CBM-160261.
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    • Ramalingam, Sundhar, Adva Eisenberg, Wen Chi Foo, Jennifer Freedman, Andrew J. Armstrong, Larry G. Moss, and Michael R. Harrison. “Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome.” Int J Urol 23, no. 12 (December 2016): 1038–41. https://doi.org/10.1111/iju.13225.
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    • Ware, Kathryn E., Jason A. Somarelli, Daneen Schaeffer, Jing Li, Tian Zhang, Sally Park, Steven R. Patierno, et al. “Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.” Oncotarget 7, no. 31 (August 2, 2016): 50507–21. https://doi.org/10.18632/oncotarget.10476.
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    • Gopalakrishna, Ajay, Thomas A. Longo, Joseph J. Fantony, Richmond Owusu, Wen-Chi Foo, Rajesh Dash, and Brant A. Inman. “The diagnostic accuracy of urine-based tests for bladder cancer varies greatly by patient.” Bmc Urol 16, no. 1 (June 13, 2016): 30. https://doi.org/10.1186/s12894-016-0147-5.
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    • Foo, Wen-Chi, Vickie Y. Jo, and Jeffrey F. Krane. “Usefulness of translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms.” Cancer Cytopathol 124, no. 6 (June 2016): 397–405. https://doi.org/10.1002/cncy.21693.
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    • Hughes, Francis M., Hayden M. Hill, Case M. Wood, Andrew T. Edmondson, Aliya Dumas, Wen-Chi Foo, James M. Oelsen, Goran Rac, and J Todd Purves. “The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction.” J Urol 195, no. 5 (May 2016): 1598–1605. https://doi.org/10.1016/j.juro.2015.12.068.
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    • Foo, W. C., K. E. Youens, P. S. Jowell, and S. M. Bean. “Image-guided fine-needle aspiration of secondary pancreatic neoplasms: A case series and review of the literature.” Pathology Case Reviews 20, no. 4 (July 10, 2015): 175–81. https://doi.org/10.1097/PCR.0000000000000096.
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    • Lew, Madelyn, Wen-Chi Foo, and Michael H. Roh. “Diagnosis of metastatic renal cell carcinoma on fine-needle aspiration cytology.” Arch Pathol Lab Med 138, no. 10 (October 2014): 1278–85. https://doi.org/10.5858/arpa.2014-0283-CC.
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    • Bhargava, Puneet, Ramesh S. Iyer, Mariam Moshiri, Matthew M. Yeh, Melissa P. Upton, Wen-Chi Foo, Lorenzo Mannelli, and Rajan T. Gupta. “Radiologic-pathologic correlation of uncommon mesenchymal liver tumors.” Curr Probl Diagn Radiol 42, no. 5 (September 2013): 183–90. https://doi.org/10.1067/j.cpradiol.2013.05.002.
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    • Dash, Rajesh C., James A. Robb, David L. Booker, Wen-Chi Foo, David L. Witte, and Lynn Bry. “Biospecimens and biorepositories for the community pathologist.” Arch Pathol Lab Med 136, no. 6 (June 2012): 668–78. https://doi.org/10.5858/arpa.2011-0274-SO.
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    • Zhai, Liang, Thomas J. Polascik, Wen-Chi Foo, Stephen Rosenzweig, Mark L. Palmeri, John Madden, and Kathryn R. Nightingale. “Acoustic radiation force impulse imaging of human prostates: initial in vivo demonstration.” Ultrasound Med Biol 38, no. 1 (January 2012): 50–61. https://doi.org/10.1016/j.ultrasmedbio.2011.10.002.
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    • Foo, Wen-Chi, John A. Papalas, Stanley J. Robboy, and Maria A. Selim. “Vulvar manifestations of Crohn's disease.” Am J Dermatopathol 33, no. 6 (August 2011): 588–93. https://doi.org/10.1097/DAD.0b013e31820a2635.
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    • Foo, W. -. C., A. Desjardins, and T. J. Cummings. “Primary intracerebral Hodgkin lymphoma with recurrence.” Clin Neuropathol 30, no. 2 (March 2011): 75–79. https://doi.org/10.5414/npp30075.
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    • Foo, Wen-Chi, Qin Huang, Siby Sebastian, Charles B. Hutchinson, Jim Burchette, and Endi Wang. “Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with fludarabine: a dimorphic presentation of iatrogenic immunodeficiency-associated lymphoproliferative disorder with evidence suggestive of multiclonal transformability of B cells by Epstein-Barr virus.” Hum Pathol 41, no. 12 (December 2010): 1802–8. https://doi.org/10.1016/j.humpath.2010.04.019.
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    • Zhai, Liang, John Madden, Wen-Chi Foo, Vladimir Mouraviev, Thomas J. Polascik, Mark L. Palmeri, and Kathryn R. Nightingale. “Characterizing stiffness of human prostates using acoustic radiation force.” Ultrason Imaging 32, no. 4 (October 2010): 201–13. https://doi.org/10.1177/016173461003200401.
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    • Papalas, John A., Stanley J. Robboy, James L. Burchette, Wen-Chi Foo, and M Angelica Selim. “Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors.” J Cutan Pathol 37, no. 9 (September 2010): 958–65. https://doi.org/10.1111/j.1600-0560.2010.01569.x.
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    • Wang, Endi, Wen-Chi Foo, and Qin Huang. “A sinusoidal large cell lymphoma with expression of CD30, CD15, and multiple B-cell antigens: a classical Hodgkin lymphoma with sinusoidal infiltrating pattern or a sinusoidal CD30 positive large B-cell lymphoma with CD15?” Leuk Lymphoma 51, no. 6 (June 2010): 1148–51. https://doi.org/10.3109/10428194.2010.480820.
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    • Zhai, Liang, John Madden, Wen-Chi Foo, Mark L. Palmeri, Vladimir Mouraviev, Thomas J. Polascik, and Kathryn R. Nightingale. “Acoustic radiation force impulse imaging of human prostates ex vivo.” Ultrasound Med Biol 36, no. 4 (April 2010): 576–88. https://doi.org/10.1016/j.ultrasmedbio.2009.12.006.
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    • Eyler, Christine E., Wen-Chi Foo, Katherine M. LaFiura, Roger E. McLendon, Anita B. Hjelmeland, and Jeremy N. Rich. “Brain cancer stem cells display preferential sensitivity to Akt inhibition.” Stem Cells 26, no. 12 (December 2008): 3027–36. https://doi.org/10.1634/stemcells.2007-1073.
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  • Conference Papers

    • Patierno, Brendon M., Wen-Chi Foo, Tyler Allen, Jason A. Somarelli, Kathryn E. Ware, Santosh Gupta, Sandra Wise, et al. “Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.” In Prostate Cancer Prostatic Dis, 25:513–23, 2022. https://doi.org/10.1038/s41391-021-00460-y.
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    • Morris, D. C., D. Y. Chan, H. Chen, M. L. Palmeri, T. J. Polascik, W. C. Foo, J. Huang, J. Mamou, and K. R. Nightingale. “Multiparametric Ultrasound for the Targeting of Prostate Cancer using ARFI, SWEI, B-mode, and QUS.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:880–83, 2019. https://doi.org/10.1109/ULTSYM.2019.8926035.
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