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William Christopher Wetsel

Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
Box 103203 Med Ctr, Durham, NC 27710
354 Sands Bldg, Durham, NC 27710

Scholarly Works - Conferences


Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.

Conference ACS Pharmacol Transl Sci · January 13, 2023 We have developed and characterized a novel D2R antagonist with exceptional GPCR selectivity - ML321. In functional profiling screens of 168 different GPCRs, ML321 showed little activity beyond potent inhibition of the D2R and to a lesser extent the D3R, d ... Full text Link to item Cite