Wiley Alexander Schell

Journal article JAMA Intern Med · April 2014 Featured Publication IMPORTANCE Many health care facilities compound medications on site to fulfill local demands when customized formulations are needed, national supply is critically low, or costs for manufactured pharmaceuticals are excessive. Small, institutional compoundi ... Full text Link to item Cite

Quantitative models of the dose-response and time course of inhalational anthrax in humans.

Journal article PLoS Pathog · August 2013 Featured Publication Anthrax poses a community health risk due to accidental or intentional aerosol release. Reliable quantitative dose-response analyses are required to estimate the magnitude and timeline of potential consequences and the effect of public health intervention ... Full text Link to item Cite

Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.

Journal article Antimicrob Agents Chemother · November 2012 Featured Publication Epidemiological cutoff values (ECVs) for the Cryptococcus neoformans-Cryptococcus gattii species complex versus fluconazole, itraconazole, posaconazole, and voriconazole are not available. We established ECVs for these species and agents based on wild-type ... Full text Link to item Cite

Heterothallic mating in Mucor irregularis and first isolate of the species outside of Asia.

Journal article Med Mycol · October 2011 Featured Publication This study reports on the discovery of heterothallic mating in Mucor irregularis (formerly Rhizomucor variabilis var. variabilis) and it extends the range of this species from Asia to the United States. We report on a case of primary cutaneous mucormycosis ... Full text Link to item Cite

A new lineage in Pucciniomycotina: class Tritirachiomycetes, order Tritirachiales, family Tritirachiaceae.

Journal article Mycologia · 2011 Featured Publication Based on multiple gene analyses (nuclear large subunit, nuclear small subunit, internal transcribed spacer region including the 5.8 s subunit rDNA, and translation elongation factor 1α) and septal pore ultrastructure we describe a new lineage of Pucciniomy ... Full text Link to item Cite

Multiplexed real-time polymerase chain reaction on a digital microfluidic platform.

Journal article Anal Chem · March 15, 2010 Featured Publication This paper details the development of a digital microfluidic platform for multiplexed real-time polymerase chain reactions (PCR). Liquid samples in discrete droplet format are programmably manipulated upon an electrode array by the use of electrowetting. R ... Full text Open Access Link to item Cite

Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Journal article PLoS Pathog · July 2009 Featured Publication Candida albicans is the leading fungal pathogen of humans, causing life-threatening disease in immunocompromised individuals. Treatment of candidiasis is hampered by the limited number of antifungal drugs whose efficacy is compromised by host toxicity, fun ... Full text Link to item Cite

Preserving accuracy in GenBank.

Journal article Science · March 21, 2008 Featured Publication Full text Link to item Cite

Quality control and reference guidelines for CLSI broth microdilution method (M38-A document) for susceptibility testing of anidulafungin against molds.

Journal article J Clin Microbiol · July 2007 Featured Publication The CLSI (formerly NCCLS) M38-A document for antifungal susceptibility testing of filamentous fungi does not describe guidelines for echinocandins. A multicenter study (eight centers) evaluated inter- and intralaboratory reproducibilities of two reading ti ... Full text Link to item Cite

Sinusitis caused by the fungus Xylaria enteroleuca in a lung transplant recipient.

Journal article Diagn Microbiol Infect Dis · October 2006 Featured Publication We report the 1st case of sinusitis and human infection by Xylaria enteroleuca (anamorph Nodulisporium sp.), a rare fungal endophyte of rain forest trees. The patient was a Brazilian woman who had her lung transplanted. Diagnosis was established by direct ... Full text Link to item Cite

Novel use of a swimming pool biocide in the treatment of a rare fungal mastoiditis.

Journal article Laryngoscope · June 2005 Featured Publication OBJECTIVE: To describe an extremely rare fungal mastoiditis caused by Lecythophora hoffmannii, its recalcitrant behavior to therapy, and eventual successful treatment with adjunctive therapy using polyhexamethylene biguanide (a common swimming pool biocide ... Full text Link to item Cite

Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.

Journal article Eukaryot Cell · August 2004 Featured Publication In response to various extracellular signals, the morphology of the human fungal pathogen Candida albicans switches from yeast to hypha form. Here, we report that GPR1 encoding a putative G-protein-coupled receptor and GPA2 encoding a Galpha subunit are re ... Full text Link to item Cite

In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.

Journal article Antimicrob Agents Chemother · May 2004 Featured Publication The optimal treatment for invasive aspergillosis remains elusive, despite the increased efficacy of newer agents. The immunosuppressants cyclosporine (CY), tacrolimus (FK506), and sirolimus (formerly called rapamycin) exhibit in vitro and in vivo activity ... Full text Link to item Cite

Calcineurin is essential for Candida albicans survival in serum and virulence.

Journal article Eukaryot Cell · June 2003 Featured Publication Calcineurin is a calcium-activated protein phosphatase that is the target of the immunosuppressants cyclosporin A and FK506. In T cells, calcineurin controls nuclear import of the NF-AT transcription factor and gene activation. In plants and fungi, calcine ... Full text Link to item Cite

Histopathology of fungal rhinosinusitis.

Journal article Otolaryngol Clin North Am · April 2000 Featured Publication Treatments for the various kinds of fungal rhinosinusitis are fundamentally different, and it is essential to obtain an accurate diagnosis of the particular syndrome in a given case. Microscopic examination of specimens is the most definite and rapid means ... Full text Link to item Cite

Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology.

Journal article Am J Clin Pathol · January 1998 Featured Publication Nontraditional human pathogenic fungi, including Fusarium, Paecilomyces, and Acremonium species, have been increasingly documented as agents of infection in immunocompromised patients and, occasionally, in normal hosts. Although definitive identification o ... Full text Link to item Cite