William Dean Matthew

Journal article Exp Neurol · May 2001 Featured Publication Apolipoprotein E (apoE) is well characterized as a plasma lipoprotein involved in lipid and cholesterol metabolism. Recent studies implicating apoE in Alzheimer's disease and successful recovery from neurological injury have stimulated much interest in the ... Full text Link to item Cite

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

Journal article J Neuroimmunol · March 1, 2001 Featured Publication Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endog ... Full text Link to item Cite

Peripheral sensory nerve defects in apolipoprotein E knockout mice.

Journal article Exp Neurol · September 1998 Featured Publication Apolipoprotein E (apoE), a plasma lipoprotein involved in lipid metabolism, is also proposed to have important functions within the central and peripheral nervous systems. To investigate the function of apoE in the peripheral nervous system, we examined th ... Full text Link to item Cite

Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.

Journal article Neuroreport · March 9, 1998 Featured Publication The human apolipoprotein (apo) E4 isoform is associated with an increased risk for Alzheimer's disease (AD) and poor prognosis after acute CNS injury. Addition of human apoE inhibits murine microglial activation in culture, suggesting that microglia might ... Full text Link to item Cite

Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor.

Journal article J Neurosci · August 15, 1997 Featured Publication Expression of apolipoprotein E (apoE) and ciliary neurotrophic factor (CNTF), a pleiotropic neuron survival factor, increases in the CNS in response to injury. Although CNTF is believed to act as a survival factor after injury in the CNS, the functions of ... Full text Link to item Cite

Apolipoprotein E suppresses glial cell secretion of TNF alpha.

Journal article J Neuroimmunol · June 1997 Featured Publication Apolipoprotein E (apoE) is a 299 amino acid protein with multiple biological functions. Initially described in the context of cholesterol metabolism, apoE also has immunomodulatory properties and recent evidence has implicated a role for apoE in neurologic ... Full text Link to item Cite

Neurite outgrowth is enhanced by anti-idiotypic monoclonal antibodies to the ganglioside GM1.

Journal article Exp Neurol · May 1997 Featured Publication Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a membrane protein or when a ganglioside intercalates into the plasma membrane. To test whether bin ... Full text Link to item Cite