Xiaofei Wang | Scholars@Duke

Xiaofei Wang
Associate Professor of Biostatistics and Bioinformatics

Design and Analysis of Clinical Trials
Nonparametric and Semiparametric Methods
Survival Analysis
Statistical Methods for Diagnostic and Predictive Medicine
Biomarker Discovery and Validation
Health Outcomes Research

Current Appointments & Affiliations

Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015

Contact Information

2424 Erwin Road Suite 1102, 11080 Hock Plaza, Duke Box 272, Durham, NC 27705
Duke Box 2721, Durham, NC 27710
xiaofei.wang@duke.edu (919) 681-5406

Background
Education, Training, & Certifications
- Graduate Research Assistant, Biostatistics, University of North Carolina at Chapel Hill 1996 - 2003
- Ph.D., University of North Carolina at Chapel Hill 2003
- Graduate Research Assistant, Computer Sciences, University of North Carolina at Chapel Hill 1994 - 1996
Duke Appointment History
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2007 - 2012
- Assistant Research Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2004 - 2007
- Instructor, Temporary of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2003
Expertise
Global Scholarship
- Expertise
  - China (Country)
Research
Selected Grants
- Alliance for Clinical Trials in Oncology awarded by Brigham and Women's Hospital 2014 - 2019
- Administrative Core awarded by University of North Carolina - Chapel Hill 2015 - 2018
- Alliance for Clinical Trials in Oncology awarded by Mayo Clinic 2017 - 2018
- National Clinical Trials Network - Network Group Statistics and DMCs awarded by Mayo Clinic 2014 - 2017
- Translational meta-analysis for elderly lung cancer patients awarded by National Institutes of Health 2013 - 2016
- Cancer and Leukemia Group B Statistical Center awarded by National Institutes of Health 1982 - 2010
- Semiparametric ROC Curve Regression for Cancer Screening Studies awarded by National Institutes of Health 2007 - 2010
Publications & Artistic Works
Selected Publications
- Books
  - George, SL, Wang, X, and Pang, H. Cancer Clinical Trials Current and Controversial Issues in Design and Analysis. CRC Press, August 3, 2016.
- Book Sections
  - George, SL, and Wang, X. "Targeted clinical trials." In Designs for Clinical Trials: Perspectives on Current Issues, 157-177. January 1, 2012. Full Text
  - George, SL, and Wang, X. "Targeted clinical trials." In Designs for Clinical Trials: Perspectives on Current Issues, 157-177. January 1, 2012. Full Text
  - George, , Wang, , and Pang, . "Endpoints for cancer clinical trials." In Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis, edited by George, 3-36. Chapman & Hall/CRC. (Chapter)
  - George, , Wang, , and Pang, . "Endpoints for cancer clinical trials." In Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis, edited by George, 3-36. Chapman & Hall/CRC. (Chapter)
- Conference Papers
  - Wang, T, Wang, X, Zhou, H, Cai, J, and George, SL. "Biomarker stratified design enriched by auxiliary variables." May 8, 2017. Link to Item
  - Pang, H, Yan, K, Kratzke, R, Stinchcombe, T, Crawford, J, Kindler, H, Vokes, E, and Wang, X. "Prognostic Model for Mesothelioma Based on Cancer and Leukemia Group B (CALGB) Trials (Alliance)." January 2017. Link to Item
  - Stinchcombe, T, Zhang, Y, Vokes, E, Schiller, J, Bradley, J, Kelly, K, Curran, W, Schild, S, Movsas, B, Clamon, G, Govindan, R, Blumenschein, G, Socinski, M, Ready, N, Akerley, W, Cohen, H, Pang, H, and Wang, X. "A Pooled Analysis Comparing the Outcomes of Elderly to Younger Patients on NCTN Trials of Concurrent CCRT for Stage 3 NSCLC." January 2017. Link to Item
  - Wang, X, Cao, X, Stinchcombe, T, Bradley, J, Adjei, A, Gandara, DR, Ramalingam, S, Pang, H, Vokes, E, and Crawford, J. "Predicting Risk of Chemotherapy-Induced Severe Neutropenia in Lung Patients: A Pooled Analysis of US Cooperative Group Trials." January 2017. Link to Item
  - Stinchcombe, T, Zhang, YJ, Vokes, EE, Schiller, JH, Bradley, JD, Curran, WJ, Movsas, B, Schild, SE, Clamon, GH, Govindan, R, Blumenschein, GR, Socinski, MA, Ready, N, Akerley, WL, Cohen, HJ, Pang, H, and Wang, XF. "A pooled analysis of concurrent chemoradiotherapy (CCRT) for patients with stage III non-small cell lung cancer (NSCLC) who participated in US cooperative group trials: Comparing the outcomes of elderly to younger patients (pts)." May 20, 2016. Full Text Link to Item
  - Yang, C-FJ, Chan, DY, Yerokun, B, Wang, XF, Tong, BC, D'Amico, TA, Onaitis, MW, Hartwig, MG, Berry, MF, and Harpole, D. "Surgery versus optimal medical management of early-stage small cell lung cancer." May 20, 2016. Full Text Link to Item
  - Edelman, MJ, Wang, X, Hodgson, L, Cheney, RT, Baggstrom, M, Sachdev, T, Gajra, A, Bertino, E, Reckamp, K, Molina, J, Schiller, J, Mitchell-Richards, K, Friedman, P, Ritter, J, and Vokes, E. "Abstract CT238: Phase III randomized, placebo controlled trial of COX-2 inhibition in addition to standard chemotherapy for advanced non-small cell lung cancer (NSCLC):CALGB 30801 (Alliance)." October 1, 2014. Full Text
  - Socinski, MA, Wang, XF, Baggstrom, MQ, Gu, L, Stinchcombe, TE, Edelman, MJ, Jr, BS, Mannuel, HD, Crawford, J, and Vokes, EE. "Sunitinib (S) switch maintenance in advanced non-small cell lung cancer (NSCLC): An ALLIANCE (CALGB 30607), randomized, placebo-controlled phase III trial." May 20, 2014. Link to Item
  - Stinchcombe, T, Sholl, LM, Wang, XF, Gu, L, Socinski, MA, Rodig, SJ, Capelletti, M, Crawford, J, Edelman, MJ, Villalona-Calero, MA, Kratzke, RA, Vokes, EE, Miller, VA, and Janne, PA. "An analysis of the prevalence of HER2 and KRAS mutations, and ALK rearrangements and clinical outcomes in Cancer and Leukemia Group B [CALGB (Alliance)] trial 30406 in advanced non-small cell lung cancer (NSCLC)." May 20, 2013. Link to Item
  - Pang, H, Gu, L, Richards, W, Crawford, J, Green, M, Vokes, E, and Wang, X. "Abstract 4707: Validation of survival prognostic models for non-small-cell lung cancer instage- and age-specific groups." April 15, 2013. Full Text
  - Heist, RS, Wang, XF, Hodgson, L, Otterson, GA, Stinchcombe, T, Vokes, EE, and Socinski, MA. "CALGB 30704: A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small cell lung cancer (NSCLC)." May 20, 2012. Link to Item
  - Janne, PA, Wang, XF, Krug, LM, Hodgson, L, Vokes, EE, and Kindler, HL. "Phase II trial of sorafenib (bay 43-9006) in malignant mesothelioma: CALGB 30307." 2006. Link to Item
- Journal Articles
  - Urbanic, JJ, Wang, X, Bogart, JA, Stinchcombe, TE, Hodgson, L, Schild, SE, Bazhenova, L, Hahn, O, Salgia, R, and Vokes, EE. "Phase 1 Study of Accelerated Hypofractionated Radiation Therapy With Concurrent Chemotherapy for Stage III Non-Small Cell Lung Cancer: CALGB 31102 (Alliance)." International journal of radiation oncology, biology, physics (January 31, 2018). Full Text
  - Wang, X, Zhou, J, Wang, T, and George, SL. "On Enrichment Strategies for Biomarker Stratified Clinical Trials." Journal of biopharmaceutical statistics 28, no. 2 (January 2018): 292-308. Full Text Open Access Copy
  - Yang, C-FJ, McSherry, F, Mayne, NR, Wang, X, Berry, MF, Tong, B, Harpole, DH, D'Amico, TA, Christensen, JD, Ready, NE, and Klapper, JA. "Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small-Cell Lung Cancer." The Annals of thoracic surgery (December 16, 2017). Full Text
  - Yang, C-FJ, Wang, H, Kumar, A, Wang, X, Hartwig, MG, D'Amico, TA, and Berry, MF. "Impact of Timing of Lobectomy on Survival for Clinical Stage IA Lung Squamous Cell Carcinoma." Chest 152, no. 6 (December 2017): 1239-1250. Full Text
  - Yi, JS, Ready, N, Healy, P, Dumbauld, C, Osborne, R, Berry, M, Shoemaker, D, Clarke, J, Crawford, J, Tong, B, Harpole, D, D'Amico, TA, McSherry, F, Dunphy, F, McCall, SJ, Christensen, JD, Wang, X, and Weinhold, KJ. "Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab." Clinical cancer research : an official journal of the American Association for Cancer Research 23, no. 24 (December 2017): 7474-7482. Full Text
  - Stinchcombe, TE, Zhang, Y, Vokes, EE, Schiller, JH, Bradley, JD, Kelly, K, Curran, WJ, Schild, SE, Movsas, B, Clamon, G, Govindan, R, Blumenschein, GR, Socinski, MA, Ready, NE, Akerley, WL, Cohen, HJ, Pang, HH, and Wang, X. "Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 35, no. 25 (September 2017): 2885-2892. Full Text
  - Yao, XI, Wang, X, Speicher, PJ, Hwang, ES, Cheng, P, Harpole, DH, Berry, MF, Schrag, D, and Pang, HH. "Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies." JNCI Journal of the National Cancer Institute 109, no. 8 (August 2017). (Review) Full Text
  - Yerokun, BA, Yang, C-FJ, Gulack, BC, Li, X, Mulvihill, MS, Gu, L, Wang, X, Harpole, DH, D'Amico, TA, Berry, MF, and Hartwig, MG. "A national analysis of wedge resection versus stereotactic body radiation therapy for stage IA non-small cell lung cancer." The Journal of thoracic and cardiovascular surgery 154, no. 2 (August 2017): 675-686.e4. Full Text
  - Edelman, MJ, Wang, X, Hodgson, L, Cheney, RT, Baggstrom, MQ, Thomas, SP, Gajra, A, Bertino, E, Reckamp, KL, Molina, J, Schiller, JH, Mitchell-Richards, K, Friedman, PN, Ritter, J, Milne, G, Hahn, OM, Stinchcombe, TE, Vokes, EE, and Alliance for Clinical Trials in Oncology, . "Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 35, no. 19 (July 2017): 2184-2192. Full Text
  - Kohman, LJ, Gu, L, Altorki, N, Scalzetti, E, Veit, LJ, Wallen, JM, and Wang, X. "Biopsy first: Lessons learned from Cancer and Leukemia Group B (CALGB) 140503." The Journal of thoracic and cardiovascular surgery 153, no. 6 (June 2017): 1592-1597. Full Text
  - Baggstrom, MQ, Socinski, MA, Wang, XF, Gu, L, Stinchcombe, TE, Edelman, MJ, Baker, S, Feliciano, J, Novotny, P, Hahn, O, Crawford, JA, and Vokes, EE. "Maintenance Sunitinib following Initial Platinum-Based Combination Chemotherapy in Advanced-Stage IIIB/IV Non–Small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study—CALGB 30607 (Alliance)." Journal of Thoracic Oncology 12, no. 5 (May 2017): 843-849. Full Text
  - Edelman, MJ, Wang, X, Hodgson, L, Cheney, RT, Baggstrom, MQ, Sachdev, T, Gajra, A, Bertino, EM, Reckamp, KL, Molina, J, Schiller, J, Mitchell-Edwards, K, Friedman, P, Ritter, J, Milne, G, Stinchcombe, TE, Hahn, O, and Vokes, EE. "Final Results of a Phase 3 Trial of Celecoxib (C) in Addition to Standard Chemotherapy for Advanced Non-Small Cell Lung Cancer With COX- 2 Overexpression: CALGB 30801 (Alliance)." International journal of radiation oncology, biology, physics 98, no. 1 (May 2017): 220-221. Full Text
  - Augert, A, Zhang, Q, Bates, B, Cui, M, Wang, X, Wildey, G, Dowlati, A, and MacPherson, D. "Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance)." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 12, no. 4 (April 2017): 704-713. Full Text
  - Cox, ML, Yang, C-FJ, Speicher, PJ, Anderson, KL, Fitch, ZW, Gu, L, Davis, RP, Wang, X, D'Amico, TA, Hartwig, MG, Harpole, DH, and Berry, MF. "The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 12, no. 4 (April 2017): 689-696. Full Text
  - Hwang, ES, and Wang, X. "Value of Propensity Score Matching to Study Surgical Outcomes." Annals of surgery 265, no. 3 (March 2017): 457-458. Full Text
  - Wang, X, Wang, X, Hodgson, L, George, SL, Sargent, DJ, Foster, NR, Ganti, AK, Stinchcombe, TE, Crawford, J, Kratzke, R, Adjei, AA, Kindler, HL, Vokes, EE, and Pang, H. "Validation of Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Malignant Mesothelioma: Analysis of Cancer and Leukemia Group B and North Central Cancer Treatment Group (Alliance) Trials." The oncologist 22, no. 2 (February 10, 2017): 189-198. Full Text
  - Torok, JA, Gu, L, Tandberg, DJ, Wang, X, Harpole, DH, Kelsey, CR, and Salama, JK. "Patterns of Distant Metastases After Surgical Management of Non-Small-cell Lung Cancer." Clinical lung cancer 18, no. 1 (January 2017): e57-e70. Full Text
  - Yang, C-FJ, Chan, DY, Wang, X, D'Amico, TA, Harpole, DH, and Berry, MF. "Reply to T.-H. Wang et al." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 35, no. 1 (January 2017): 118-120. Full Text
  - Pang, HH, Wang, X, Stinchcombe, TE, Wong, ML, Cheng, P, Ganti, AK, Sargent, DJ, Zhang, Y, Hu, C, Mandrekar, SJ, Redman, MW, Manola, JB, Schilsky, RL, Cohen, HJ, Bradley, JD, Adjei, AA, Gandara, D, Ramalingam, SS, and Vokes, EE. "Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 33 (November 2016): 3992-3999. Full Text
  - De Ruysscher, D, Lueza, B, Le Péchoux, C, Johnson, DH, O'Brien, M, Murray, N, Spiro, S, Wang, X, Takada, M, Lebeau, B, Blackstock, W, Skarlos, D, Baas, P, Choy, H, Price, A, Seymour, L, Arriagada, R, Pignon, J-P, and RTT-SCLC Collaborative Group, . "Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis." Annals of oncology : official journal of the European Society for Medical Oncology 27, no. 10 (October 2016): 1818-1828. (Review) Full Text
  - Huang, A, Li, R, Zhao, J, Wang, X, Jin, B, Niu, Y, Zhang, J, Jiang, L, and Han, B. "Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors combined with chemotherapy in first-line treatment in an advanced non-small cell lung cancer patient with EGFR sensitive mutation." Thoracic cancer 7, no. 5 (September 2016): 614-618. Full Text
  - Wang, L, Wang, B, Chen, SR, Hou, X, Wang, XF, Zhao, SH, Song, JQ, and Wang, YG. "Effect of Selenium Supplementation on Recurrent Hyperthyroidism Caused by Graves' Disease: A Prospective Pilot Study." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 48, no. 9 (September 2016): 559-564. Full Text
  - Boyer, MJ, Gu, L, Wang, X, Kelsey, CR, Yoo, DS, Onaitis, MW, Dunphy, FR, Crawford, J, Ready, NE, and Salama, JK. "Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer." Lung cancer (Amsterdam, Netherlands) 98 (August 2016): 76-78. Full Text
  - Zhu, Z, Wang, X, Saha-Chaudhuri, P, Kosinski, AS, and George, SL. "Time-dependent classification accuracy curve under marker-dependent sampling." Biometrical journal. Biometrische Zeitschrift 58, no. 4 (July 2016): 974-992. Full Text
  - Martin, LW, D'Cunha, J, Wang, X, Herzan, D, Gu, L, Abraham, N, Demmy, TL, Detterbeck, FC, Groth, SS, Harpole, DH, Krasna, MJ, Kernstine, K, Kohman, LJ, Patterson, GA, Sugarbaker, DJ, Vollmer, RT, Maddaus, MA, and Kratzke, RA. "Detection of Occult Micrometastases in Patients With Clinical Stage I Non-Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 13 (May 2016): 1484-1491. Full Text
  - Yang, C-FJ, Kumar, A, Gulack, BC, Mulvihill, MS, Hartwig, MG, Wang, X, D'Amico, TA, and Berry, MF. "Long-term outcomes after lobectomy for non-small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis." The Journal of thoracic and cardiovascular surgery 151, no. 5 (May 2016): 1380-1388. Full Text
  - Yang, C-FJ, Chan, DY, Speicher, PJ, Gulack, BC, Wang, X, Hartwig, MG, Onaitis, MW, Tong, BC, D'Amico, TA, Berry, MF, and Harpole, DH. "Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 10 (April 2016): 1057-1064. Full Text
  - Speicher, PJ, Englum, BR, Ganapathi, AM, Wang, X, Hartwig, MG, D'Amico, TA, and Berry, MF. "Traveling to a High-volume Center is Associated With Improved Survival for Patients With Esophageal Cancer." Annals of surgery (March 15, 2016).
  - Salama, JK, Gu, L, Wang, X, Pang, HH, Bogart, JA, Crawford, J, Schild, SE, Vokes, EE, and Ready, NE. "Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE)." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 11, no. 3 (March 2016): 361-369. Full Text
  - Wang, X, and Berry, MF. "Risk calculators are useful but.." The Journal of thoracic and cardiovascular surgery 151, no. 3 (March 2016): 706-707. Full Text
  - Pang, H, and Wang, X. "Statistical aspect of translational and correlative studies in clinical trials." Chinese clinical oncology 5, no. 1 (February 2016): 11-. Full Text
  - Speicher, PJ, Gu, L, Gulack, BC, Wang, X, D'Amico, TA, Hartwig, MG, and Berry, MF. "Sublobar Resection for Clinical Stage IA Non-small-cell Lung Cancer in the United States." Clinical lung cancer 17, no. 1 (January 2016): 47-55. Full Text
  - Wang, X, Jiao, W, Zhao, Y, Zhang, L, Yao, R, Wang, Y, Wang, M, Luo, Y, and Zhao, J. "CUG-binding protein 1 (CUGBP1) expression and prognosis of brain metastases from non-small cell lung cancer." Thoracic Cancer 7, no. 1 (January 2016): 32-38. Full Text
  - Xia, F, George, SL, and Wang, X. "A Multi-state Model for Designing Clinical Trials for Testing Overall Survival Allowing for Crossover after Progression." Statistics in biopharmaceutical research 8, no. 1 (January 2016): 12-21. Full Text
  - Clarke, JM, Wang, X, and Ready, NE. "Surrogate clinical endpoints to predict overall survival in non-small cell lung cancer trials-are we in a new era?." Translational lung cancer research 4, no. 6 (December 2015): 804-808. Full Text
  - Gulack, BC, Yang, C-FJ, Speicher, PJ, Meza, JM, Gu, L, Wang, X, D'Amico, TA, Hartwig, MG, and Berry, MF. "The impact of tumor size on the association of the extent of lymph node resection and survival in clinical stage I non-small cell lung cancer." Lung cancer (Amsterdam, Netherlands) 90, no. 3 (December 2015): 554-560. Full Text
  - Yang, C-FJ, Gulack, BC, Gu, L, Speicher, PJ, Wang, X, Harpole, DH, Onaitis, MW, D'Amico, TA, Berry, MF, and Hartwig, MG. "Adding radiation to induction chemotherapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer." The Journal of thoracic and cardiovascular surgery 150, no. 6 (December 2015): 1484-1492. Full Text
  - Zhao, J, Zhao, Y, Qiu, T, Jiao, W, Xuan, Y, Wang, X, Wang, Y, and Luo, Y. "Quality of life and survival after II stage nonsmall cell carcinoma surgery: Video-assisted thoracic surgery versus thoracotomy lobectomy." Indian journal of cancer 52 Suppl 2 (December 2015): e130-e133. Full Text
  - Speicher, PJ, Wang, X, Englum, BR, Ganapathi, AM, Yerokun, B, Hartwig, MG, D'Amico, TA, and Berry, MF. "Induction chemoradiation therapy prior to esophagectomy is associated with superior long-term survival for esophageal cancer." Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 28, no. 8 (November 2015): 788-796. Full Text
  - Wang, X, Gu, L, Zhang, Y, Sargent, DJ, Richards, W, Ganti, AK, Crawford, J, Cohen, HJ, Stinchcombe, T, Vokes, E, and Pang, H. "Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups." Lung cancer (Amsterdam, Netherlands) 90, no. 2 (November 2015): 281-287. Full Text
  - Zhang, T, Chen, X, Chu, X, Shen, Y, Jiao, W, Wei, Y, Qiu, T, Yan, G, Wang, X, and Xu, L. "Slug overexpression is associated with poor prognosis in thymoma patients." Oncology Letters (October 30, 2015). Full Text
  - Salama, JK, Gu, L, Wang, X, Bogart, J, Crawford, J, Schild, S, Ready, N, and Vokes, E. "PCI Survival Improvement for Extensive Stage SCLC Limited to Patients on Maintenance Systemic Therapy: A Secondary Analysis of CALGB 30504." JOURNAL OF THORACIC ONCOLOGY 10, no. 9 (September 2015): S401-S401. Link to Item
  - Foster, NR, Renfro, LA, Schild, SE, Redman, MW, Wang, XF, Dahlberg, SE, Ding, K, Bradbury, PA, Ramalingam, SS, Gandara, DR, Shibata, T, Saijo, N, Vokes, EE, Adjei, AA, and Mandrekar, SJ. "Multitrial Evaluation of Progression-Free Survival as a Surrogate End Point for Overall Survival in First-Line Extensive-Stage Small-Cell Lung Cancer." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 10, no. 7 (July 2015): 1099-1106. Full Text
  - Speicher, PJ, Gu, L, Wang, X, Hartwig, MG, D'Amico, TA, and Berry, MF. "Adjuvant Chemotherapy After Lobectomy for T1-2N0 Non-Small Cell Lung Cancer: Are the Guidelines Supported?." Journal of the National Comprehensive Cancer Network : JNCCN 13, no. 6 (June 2015): 755-761. Full Text
  - Nwogu, CE, D'Cunha, J, Pang, H, Gu, L, Wang, X, Richards, WG, Veit, LJ, Demmy, TL, Sugarbaker, DJ, Kohman, LJ, Swanson, SJ, and Alliance for Clinical Trials in Oncology, . "VATS lobectomy has better perioperative outcomes than open lobectomy: CALGB 31001, an ancillary analysis of CALGB 140202 (Alliance)." The Annals of thoracic surgery 99, no. 2 (February 2015): 399-405. Full Text
  - Wang, X, Jiao, W, Zhao, Y, Xuan, Y, and Wang, Z. "Two-incision approach for video-assisted thoracoscopic sleeve lobectomy treating the central lung cancer." Indian journal of cancer 51 Suppl 2 (February 2015): e18-e20. Full Text
  - Zhao, Y, Jiao, W, Zhao, J, Wang, X, Luo, Y, and Wang, Y. "Anastomosis in minimally invasive Ivor Lewis esophagectomy via two ports provides equivalent perioperative outcomes to open." Indian journal of cancer 51 Suppl 2 (February 2015): e25-e28. Full Text
  - Lilenbaum, R, Samuels, M, Wang, X, Kong, FM, Jänne, PA, Masters, G, Katragadda, S, Hodgson, L, Bogart, J, Bradley, J, and Vokes, E. "A phase II study of induction chemotherapy followed by thoracic radiotherapy and erlotinib in poor-risk stage III non-small-cell lung cancer: results of CALGB 30605 (Alliance)/RTOG 0972 (NRG)." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 10, no. 1 (January 2015): 143-147. Full Text
  - Nwogu, CE, D'Cunha, J, Pang, H, Gu, L, Wang, X, Richards, WG, Veit, LJ, Demmy, TL, Sugarbaker, DJ, Kohman, LJ, and Swanson, SJ. "VATS lobectomy has better perioperative outcomes than open lobectomy: CALGB 31001, an ancillary analysis of CALGB 140202 (Alliance)." Annals of Thoracic Surgery 99, no. 2 (January 1, 2015): 399-405. Full Text
  - Heist, RS, Wang, X, Hodgson, L, Otterson, GA, Stinchcombe, TE, Gandhi, L, Villalona-Calero, MA, Watson, P, Vokes, EE, Socinski, MA, and Alliance for Clinical Trials in Oncology, . "CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer." J Thorac Oncol 9, no. 2 (February 2014): 214-221. Full Text Link to Item
  - Berry, MF, Worni, M, Wang, X, Harpole, DH, D'Amico, TA, and Onaitis, MW. "Sleeve lobectomy for non-small cell lung cancer with N1 nodal disease does not compromise survival." Annals of Thoracic Surgery 97, no. 1 (January 1, 2014): 230-235. Full Text
  - Berry, MF, Worni, M, Wang, X, Harpole, DH, D'Amico, TA, and Onaitis, MW. "Sleeve lobectomy for non-small cell lung cancer with N1 nodal disease does not compromise survival." Ann Thorac Surg 97, no. 1 (January 2014): 230-235. Full Text Link to Item
  - Jiao, W, Zhao, Y, Wang, X, and Zhao, J. "Video-assisted thoracoscopic left upper lobe sleeve lobectomy combined with pulmonary arterioplasty via two-port approach." Journal of Thoracic Disease 6, no. 12 (January 1, 2014): 1813-1815. Full Text
  - Ma, Q, Liu, D, Guo, Y, Shi, B, Tian, Y, Song, Z, Zhang, Z, Ge, B, Wang, X, and D'Amico, TA. "Surgical techniques and results of the pulmonary artery reconstruction for patients with central non-small cell lung cancer." Journal of Cardiothoracic Surgery 8, no. 1 (December 1, 2013). Full Text
  - Ma, Q, Liu, D, Guo, Y, Shi, B, Song, Z, Tian, Y-C, Ge, B, Wang, X, and Amico, TAD. "SURGICAL TECHNIQUES AND RESULTS OF RECONSTRUCTION OF THE PULMONARY ARTERY FOR PATIENTS WITH CENTRAL NON-SMALL CELL LUNG CANCER." JOURNAL OF THORACIC ONCOLOGY 8 (November 2013): S217-S217. Link to Item
  - Pang, H, Hodgson, L, Kratzke, R, Crawford, J, Kindler, H, Vokes, E, and Wang, X. "VALIDATION OF THE CALGB AND EORTC PROGNOSTIC MODELS FOR MESOTHELIOMA BASED ON MULTIPLE CALGB TRIALS (ALLIANCE)." JOURNAL OF THORACIC ONCOLOGY 8 (November 2013): S934-S935. Link to Item
  - Jaklitsch, MT, Gu, L, Demmy, T, Harpole, DH, D'Amico, TA, McKenna, RJ, Krasna, MJ, Kohman, LJ, Swanson, SJ, DeCamp, MM, Wang, X, Barry, S, Sugarbaker, DJ, and CALGB Thoracic Surgeons, . "Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol 39803." J Thorac Cardiovasc Surg 146, no. 1 (July 2013): 9-16. Full Text Link to Item
  - Boylan, AM, Wang, XF, Ko, R, Watson, PM, Gu, L, Harpole, D, Bueno, R, Kelly, R, Kohman, L, and Kratzke, R. "Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non-small cell lung cancer: Results from Cancer and Leukemia Group B 159902." Journal of Thoracic and Cardiovascular Surgery 146, no. 1 (2013): 206-211. Full Text
  - Wang, X, Ma, J, and George, SL. "ROC curve estimation under test-result-dependent sampling." Biostatistics 14, no. 1 (January 2013): 160-172. Full Text Link to Item
  - Demmy, TL, Gu, L, Burkhalter, JE, Toloza, EM, D'Amico, TA, Sutherland, S, Wang, X, Archer, L, Veit, LJ, Kohman, L, and Cancer and Leukemia Group B, . "Optimal management of malignant pleural effusions (results of CALGB 30102)." J Natl Compr Canc Netw 10, no. 8 (August 2012): 975-982. Link to Item
  - Boylan, AM, Wang, XF, Ko, R, Watson, PM, Gu, L, Harpole, D, Bueno, R, Kelly, R, Kohman, L, and Kratzke, R. "Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non-small cell lung cancer: Results from Cancer and Leukemia Group B 159902." Journal of Thoracic and Cardiovascular Surgery (2012). Full Text
  - Chen, J, Wang, X, Yang, D, and Fan, B. "Nonparametric modeling auxiliary covariates in random coefficient models." Communications in Statistics: Simulation and Computation 41, no. 8 (2012): 1271-1281. Full Text
  - Edelman, MJ, Hodgson, L, Rosenblatt, PY, Christenson, RH, Vokes, EE, Wang, X, and Kratzke, R. "CYFRA 21-1 as a prognostic and predictive marker in advanced non-small-cell lung cancer in a prospective trial: CALGB 150304." Journal of Thoracic Oncology 7, no. 4 (2012): 649-654. Full Text
  - Edelman, MJ, Hodgson, L, Wang, X, Kratzke, RA, and Vokes, EE. "Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced non-small-cell lung cancer." Journal of Clinical Oncology 30, no. 16 (2012): 2019-2020. Full Text
  - Jahan, T, Gu, L, Kratzke, R, Dudek, A, Otterson, GA, Wang, X, Green, M, Vokes, EE, and Kindler, HL. "Vatalanib in malignant mesothelioma: A phase II trial by the Cancer and Leukemia Group B (CALGB 30107)." Lung Cancer 76, no. 3 (2012): 393-396. Full Text
  - Jänne, PA, Wang, X, Socinski, MA, Crawford, J, Stinchcombe, TE, Gu, L, Capelletti, M, Edelman, MJ, Villalona-Calero, MA, Kratzke, R, Vokes, EE, and Miller, VA. "Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial." Journal of Clinical Oncology 30, no. 17 (2012): 2063-2069. Full Text
  - Schroen, AT, Petroni, GR, Wang, H, Thielen, MJ, Gray, R, Benedetti, J, Wang, XF, Sargent, DJ, Wickerham, DL, Cronin, W, Djulbegovic, B, and Jr, CLS. "Achieving sufficient accrual to address the primary endpoint in phase III clinical trials from U.S. Cooperative Oncology Groups." Clinical Cancer Research 18, no. 1 (2012): 256-262. Full Text
  - Wang, X, Ma, J, George, S, and Zhou, H. "Estimation of AUC or Partial AUC under Test-Result-Dependent Sampling." Stat Biopharm Res 4, no. 4 (January 1, 2012): 313-323. Full Text Link to Item
  - Salama, JK, Stinchcombe, TE, Gu, L, Wang, X, Morano, K, Bogart, JA, Crawford, JC, Socinski, MA, Blackstock, AW, Vokes, EE, and Cancer and Leukemia Group B, . "Pulmonary toxicity in Stage III non-small cell lung cancer patients treated with high-dose (74 Gy) 3-dimensional conformal thoracic radiotherapy and concurrent chemotherapy following induction chemotherapy: a secondary analysis of Cancer and Leukemia Group B (CALGB) trial 30105." Int J Radiat Oncol Biol Phys 81, no. 4 (November 15, 2011): e269-e274. Full Text Link to Item
  - Janne, PA, Wang, X, Socinski, MA, Crawford, J, Gu, L, Capelletti, M, Edelman, MJ, Villalona-Calero, MA, Kratzke, RA, Vokes, E, and Miller, VA. "OUTCOME OF ADVANCED NSCLC PATIENTS WITH EGFR EXON 19 AND 21 MUTATIONS TREATED WITH ERLOTINIB (E) ALONE OR IN COMBINATION WITH CARBOPLATIN/PACLITAXEL (CP) IN CALGB 30406." JOURNAL OF THORACIC ONCOLOGY 6, no. 6 (June 2011): S447-S448. Link to Item
  - Li, J, Chen, X, Yang, H, Wang, X, Yuan, D, Zeng, Y, Wen, T, Yan, L, and Li, B. "Tumour cryoablation combined with palliative bypass surgery in the treatment of unresectable pancreatic cancer: a retrospective study of 142 patients." Postgraduate medical journal 87, no. 1024 (February 2011): 89-95. Full Text
  - Edelman, MJ, Hodgson, L, Wang, X, Christenson, R, Jewell, S, Vokes, E, and Kratzke, R. "Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and leukemia group B 150304." Journal of Thoracic Oncology 6, no. 11 (2011): 1902-1906. Full Text
  - Govindan, R, Bogart, J, Stinchcombe, T, Wang, X, Hodgson, L, Kratzke, R, Garst, J, Brotherton, T, and Vokes, EE. "Randomized phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and leukemia group B trial 30407." Journal of Clinical Oncology 29, no. 23 (2011): 3120-3125. Full Text
  - Kawaguchi, A, Koch, GG, and Wang, X. "Stratified multivariate Mann-Whitney estimators for the comparison of two treatments with randomization based covariance adjustment." Statistics in Biopharmaceutical Research 3, no. 2 (2011): 217-231. Full Text
  - Masters, GA, Wang, X, Hodgson, L, Shea, T, Vokes, E, and Green, M. "A phase II trial of high dose carboplatin and paclitaxel with G-CSF and peripheral blood stem cell support followed by surgery and/or chest radiation in patients with stage III non-small cell lung cancer: CALGB 9531." Lung Cancer 74, no. 2 (2011): 258-263. Full Text
  - Schroen, AT, Petroni, GR, Wang, H, Thielen, MJ, Sargent, D, Benedetti, JK, Cronin, WM, Wickerham, DL, Wang, XF, Gray, R, Cohn, WF, Slingluff, CL, and Djulbegovic, B. "Challenges to accrual predictions to phase III cancer clinical trials: A survey of study chairs and lead statisticians of 248 NCI-sponsored trials." Clinical Trials 8, no. 5 (2011): 591-600. Full Text
  - Wu, Y, and Wang, X. "Optimal weight in estimating and comparing areas under the receiver operating characteristic curve using longitudinal data." Biometrical Journal 53, no. 5 (2011): 764-778. Full Text
  - Dubey, S, Jänne, PA, Krug, L, Pang, H, Wang, X, Heinze, R, Watt, C, Crawford, J, Kratzke, R, Vokes, E, and Kindler, HL. "A phase II study of sorafenib in malignant mesothelioma: results of Cancer and Leukemia Group B 30307." J Thorac Oncol 5, no. 10 (October 2010): 1655-1661. Full Text Link to Item
  - Ready, N, Jänne, PA, Bogart, J, Dipetrillo, T, Garst, J, Graziano, S, Gu, L, Wang, X, Green, MR, Vokes, EE, Cancer, Leukemia Group B, Chicago, and IL, . "Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: cancer and leukemia group B (CALEB) 30106, a CALGB-stratified phase II trial." J Thorac Oncol 5, no. 9 (September 2010): 1382-1390. Full Text Link to Item
  - Schroen, AT, Petroni, GR, Wang, H, Gray, R, Wang, XF, Cronin, W, Sargent, DJ, Benedetti, J, Wickerham, DL, Djulbegovic, B, and Jr, SCL. "Preliminary evaluation of factors associated with premature trial closure and feasibility of accrual benchmarks in phase III oncology trials." CLINICAL TRIALS 7, no. 4 (August 2010): 312-321. Full Text Link to Item
  - Wang, X, and Zhou, H. "Design and inference for cancer biomarker study with an outcome and auxiliary-dependent subsampling." Biometrics 66, no. 2 (June 2010): 502-511. Full Text Link to Item
  - Aupérin, A, Le Péchoux, C, Rolland, E, Curran, WJ, Furuse, K, Fournel, P, Belderbos, J, Clamon, G, Ulutin, HC, Paulus, R, Yamanaka, T, Bozonnat, M-C, Uitterhoeve, A, Wang, X, Stewart, L, Arriagada, R, Burdett, S, and Pignon, J-P. "Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 28, no. 13 (May 2010): 2181-2190. (Review) Full Text
  - Bogart, JA, Hodgson, L, Seagren, SL, Blackstock, AW, Wang, X, Lenox, R, III, ATT, Reilly, J, Gajra, A, Vokes, EE, and Green, MR. "Phase I study of accelerated conformal radiotherapy for stage I non-small-cell lung cancer in patients with pulmonary dysfunction: CALGB 39904." Journal of Clinical Oncology 28, no. 2 (2010): 202-206. Full Text
  - Graziano, SL, Gu, L, Wang, X, Tatum, AH, Vollmer, RT, Strauss, GM, Kratzke, R, Dudek, AZ, Vokes, EE, and Green, MR. "Prognostic significance of mucin and P53 expression in stage ib non-small cell lung cancer: A laboratory companion study to CALGB 9633." Journal of Thoracic Oncology 5, no. 6 (2010): 810-817. Full Text
  - Partridge, AH, Archer, L, Kornblith, AB, Gralow, J, Grenier, D, Perez, E, Wolff, AC, Wang, X, Kastrissios, H, Berry, D, Hudis, C, Winer, E, and Muss, H. "Adherence and persistence with oral adjuvant chemotherapy in older women with early-stage breast cancer in CALGB 49907: Adherence companion study 60104." Journal of Clinical Oncology 28, no. 14 (2010): 2418-2422. Full Text
  - Wang, X, Wu, Y, and Zhou, H. "Outcome- and auxiliary-dependent subsampling and its statistical inference." J Biopharm Stat 19, no. 6 (November 2009): 1132-1150. Full Text Link to Item
  - D'Cunha, J, Xiaofei, W, Groth, SS, Vollmer, RT, Abraham, NZ, Herzan, DL, Lin, G, Patterson, GA, Kohman, LJ, Green, MR, Kratzke, RA, Maddaus, MA, and Leukemia, GBC. "The impact of occult micrometastases on survival following resection of stage I non-small cell lung cancer: final analysis of CALGB 9761." JOURNAL OF THORACIC ONCOLOGY 4, no. 9 (September 2009): S576-S576. Link to Item
  - Govindan, R, Bogart, J, Wang, X, Hodgson, L, Kratzke, RA, and Vokes, EE. "A phase II study of pemetrexed, carboplatin and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small cell lung cancer: CALGB 30407." JOURNAL OF THORACIC ONCOLOGY 4, no. 9 (September 2009): S371-S372. Link to Item
  - Liptay, MJ, D'amico, TA, Nwogu, C, Demmy, TL, Wang, XF, Gu, L, Litle, VR, Swanson, SJ, Kohman, LJ, and Thoracic Surgery Subcommittee of the Cancer and Leukemia Group B, . "Intraoperative sentinel node mapping with technitium-99 in lung cancer: results of CALGB 140203 multicenter phase II trial." J Thorac Oncol 4, no. 2 (February 2009): 198-202. Full Text Link to Item
  - Govindan, R, Wang, X, Baggstrom, MQ, Burdette-Radoux, S, Hodgson, L, Vokes, EE, and Green, MR. "A phase II study of carboplatin, etoposide, and exisulind in patients with extensive small cell lung cancer CALGB 30104." Journal of Thoracic Oncology 4, no. 2 (2009): 220-226. Full Text
  - Lilenbaum, R, Wang, X, Gu, L, Kirshner, J, Lerro, K, and Vokes, E. "Randomized phase II trial of docetaxel plus cetuximab or docetaxel plus bortezomib in patients with advanced non-small-cell lung cancer and a performance status of 2: CALGB 30402." Journal of Clinical Oncology 27, no. 27 (2009): 4487-4491. Full Text
  - Graziano, SL, Herndon, JE, Socinski, MA, Wang, X, Watson, D, Vokes, E, Green, MR, and Cancer and Leukemia Group B, . "Phase II trial of weekly dose-dense paclitaxel in extensive-stage small cell lung cancer: cancer and leukemia group B study 39901." J Thorac Oncol 3, no. 2 (February 2008): 158-162. Full Text Link to Item
  - Edelman, MJ, Watson, D, Wang, X, Morrison, C, Kratzke, RA, Jewell, S, Hodgson, L, Mauer, AM, Gajra, A, Masters, GA, Bedor, M, Vokes, EE, and Green, MJ. "Eicosanoid modulation in advanced lung cancer: Cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy - Cancer and leukemia group B trial 30203." Journal of Clinical Oncology 26, no. 6 (2008): 848-855. Full Text
  - Kratzke, RA, Wang, X, Wong, L, Kratzke, MG, Green, MR, Vokes, EE, Vogelzang, NJ, Kindler, HL, and Kern, JA. "Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16^INK4a: Results of cancer and leukemia group B 159904." Journal of Thoracic Oncology 3, no. 4 (2008): 417-421. Full Text
  - Miller, AA, Wang, XF, Gu, L, Hoffman, P, Khatri, J, Dunphy, F, Edelman, MJ, Bolger, M, Vokes, EE, and Green, MR. "Phase II randomized study of dose-dense docetaxel and cisplatin every 2 weeks with pegfilgrastim and darbepoetin alfa with and without the chemoprotector BNP7787 in patients with advanced non-small cell lung cancer (CALGB 30303)." Journal of Thoracic Oncology 3, no. 10 (2008): 1159-1165. Full Text
  - Rudin, CM, Salgia, R, Wang, X, Hodgson, LD, Masters, GA, Green, M, and Vokes, EE. "Randomized phase II study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103." Journal of Clinical Oncology 26, no. 6 (2008): 870-876. Full Text
  - Socinski, MA, Blackstock, AW, Bogart, JA, Wang, X, Munley, M, Rosenman, J, Gu, L, Masters, GA, Ungaro, P, Sleeper, A, Green, M, Miller, AA, and Vokes, EE. "Randomized phase II trial of induction chemotherapy followed by concurrent chemotherapy and dose-escalated thoracic conformal radiotherapy (74 Gy) in stage III non-small-cell lung cancer: CALGB 30105." Journal of Clinical Oncology 26, no. 15 (2008): 2457-2463. Full Text
  - Graziano, SL, Gu, L, Wang, XF, Tatum, AH, Vollmer, RT, Strauss, GM, Kratzke, RA, Green, MR, and Vokes, EE. "D5-01: Prognostic significance of molecular markers and clinical factors in stage ib non-small cell lung cancer (NSCLC): a laboratory companion study to CALGB 9633." Journal of Thoracic Oncology 2, no. 8 (August 2007): S403-S403. Full Text
  - Miller, AA, Wang, XF, Bogart, JA, Hodgson, LD, Lima, CMSR, Radford, JE, Vokes, EE, and Green, MR. "Phase II trial of paclitaxel-topotecan-etoposide followed by consolidation chemoradiotherapy for limited-stage small cell lung cancer: CALGB 30002." Journal of Thoracic Oncology 2, no. 7 (2007): 645-651. Full Text
  - Perry, MC, Kohman, LJ, Bonner, JA, Gu, L, Wang, X, Vokes, EE, and Green, MR. "A phase III study of surgical resection and paclitaxel/carboplatin chemotherapy with or without adjuvant radiation therapy for resected stage III non-small-cell lung cancer: Cancer and Leukemia Group B 9734." Clinical Lung Cancer 8, no. 4 (2007): 268-272.
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