Current Duke Appointments & Affiliations
Medical Instructor in the Department of Medicine
·
2023 - Present
Medicine, Nephrology,
Medicine
Recent Scholarly Works
The myeloid IL-1 receptor limits IL-27-mediated endothelial type I IFN during nephrotoxic serum nephritis.
Journal article JCI Insight · September 1, 2026 Autoimmune kidney diseases can cause glomerulonephritis and tubulointerstitial nephritis, which if unresolved, lead to progressive glomerulosclerosis and tubulointerstitial fibrosis. The IL-1 receptor (IL-1R1) is known to have divergent and cell-specific e ... Full text Link to item CiteTranscription factor Twist1 drives fibroblast activation to promote kidney fibrosis via signaling proteins Prrx1/TNC.
Journal article Kidney Int · November 2024 The transcription factor Twist1 plays a vital role in normal development in many tissue systems and continues to be important throughout life. However, inappropriate Twist1 activity has been associated with kidney injury and fibrosis, though the underlying ... Full text Link to item CiteTNF- α from the Proximal Nephron Exacerbates Aristolochic Acid Nephropathy.
Journal article Kidney360 · January 1, 2024 KEY POINTS: Proximal tubular TNF aggravates kidney injury and fibrogenesis in aristolochic acid nephropathy. Tubular TNF disrupts the cell cycle in injured tubular epithelial cells. TNF-mediated toxic renal injury is independent of systemic immune response ... Full text Link to item CiteRecent Grants
The Role of RelA and TWIST1 in Mitigating Immune-Mediated Hypertension
FellowshipCo-Mentor · Awarded by American Heart Association · 2026 - 2028Porcupine protects the kidney by suppressing tubular inflammation and preserving mitochondrial integrity
ResearchPrincipal Investigator · Awarded by American Heart Association · 2023 - 2026The interleukin-1 receptor regulates crosstalk between myeloid and renal tubular cells in hypertension
ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2019 - 2023View All Grants
Education
Sun Yat Sen University (China) ·
2017
Ph.D.
Southern Medical University (China) ·
2012
B.M.