Current Appointments & Affiliations
Medical Instructor in the Department of Medicine
·
2023 - Present
Medicine, Nephrology,
Medicine
Recent Publications
Transcription factor Twist1 drives fibroblast activation to promote kidney fibrosis via signaling proteins Prrx1/TNC.
Journal Article Kidney Int · November 2024 The transcription factor Twist1 plays a vital role in normal development in many tissue systems and continues to be important throughout life. However, inappropriate Twist1 activity has been associated with kidney injury and fibrosis, though the underlying ... Full text Link to item CiteTNF- α from the Proximal Nephron Exacerbates Aristolochic Acid Nephropathy.
Journal Article Kidney360 · January 1, 2024 KEY POINTS: Proximal tubular TNF aggravates kidney injury and fibrogenesis in aristolochic acid nephropathy. Tubular TNF disrupts the cell cycle in injured tubular epithelial cells. TNF-mediated toxic renal injury is independent of systemic immune response ... Full text Link to item CiteNovel anti-inflammatory effects of the IL-1 receptor in kidney myeloid cells following ischemic AKI.
Journal Article Front Mol Biosci · 2024 Introduction: Acute kidney injury (AKI) is one of the most common causes of organ failure in critically ill patients. Following AKI, the canonical pro-inflammatory cytokine interleukin-1β (IL-1β) is released predominantly from activated myeloid cells and b ... Full text Link to item CiteRecent Grants
Porcupine protects the kidney by suppressing tubular inflammation and preserving mitochondrial integrity
ResearchPrincipal Investigator · Awarded by American Heart Association · 2023 - 2026The interleukin-1 receptor regulates crosstalk between myeloid and renal tubular cells in hypertension
ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2019 - 2023Role of Dendritic Cell-mediated T Cell Activation in Salt-sensitive Hypertension
ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2016 - 2021View All Grants
Education, Training & Certifications
Sun Yat Sen University (China) ·
2017
Ph.D.
Southern Medical University (China) ·
2012
B.M.