Xiaoping Zhong | Scholars@Duke

Xiaoping Zhong
Professor of Pediatrics

The immune system protects the host from microbial infection but can cause diseases if not properly controlled. My lab is interested in the receptor signaling mediated regulation of immune cell development and function as well as the pathogenesis and treatment of autoimmune diseases and allergies.

We are currently investigating the roles diacylglycerol kinases (DGKs) and TSC1/2-mTOR play in the immune system. DGKs are a family of ten enzymes that catalyze the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), Both DAG and PA are important second messengers involved signaling from numerous receptors. While we expect DGKs to perform important roles in development and cellular function by modulating DAG and PA levels, the physiologic functions of DGKs have been poorly understood. Using cell line models and genetically manipulated mice, we have demonstrated that DGKα and ζ isoforms play critical roles in: T cell development, activation, and anergy by regulating T cell receptor signaling; FcεRI signaling and mast cell function; and Toll-like receptor signaling and innate immune responses.

Research areas that we are actively pursuing include:
1. The mechanisms that control T cell maturation, activation
and self-tolerance.
2. NKT cell development and function.
3. Thymic epithelial cells and thymic development, function, and involution.
4. Regulation of Toll-like receptor signaling and innate immunity.
5. The pathogenesis and treatment of autoimmune hepatitis.
6. Mast cell development and function.
7. The pathogenesis and immunotherapy for peanut allergy.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2016
Professor of Immunology, Immunology, Basic Science Departments 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2004

Contact Information

Box 2644 Med Ctr, Div. Pediatric Allergy & Immunology, Durham, NC 27710
Rm 133 MSRB, Research Drive, Durham, NC 27710
xiaoping.zhong@duke.edu (919) 681-9450

Background
Education, Training, & Certifications
- Ph.D., Duke University 1997
- M.D., First Medical College in Guangzhou (China) 1985
Duke Appointment History
- Associate Professor of Immunology, Immunology, Basic Science Departments 2012 - 2017
- Associate Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2012 - 2016
- Assistant Professor of Immunology, Immunology, Basic Science Departments 2005 - 2012
- Associate Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2009 - 2012
- Assistant Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2004 - 2009
- Instructor, Temporary of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2004
Expertise
Subject Headings
Research
Selected Grants
- Targeting ATM to boost systemic effects of radiotherapy and immunotherapy awarded by National Institutes of Health 2021 - 2026
- Strawberry notch homologues in T cell homeostasis and function awarded by National Institutes of Health 2021 - 2025
- Basic Immunology Training Program awarded by National Institutes of Health 2002 - 2025
- Targeting apoptotic caspases to enhance cancer radiotherapy awarded by National Institutes of Health 2017 - 2022
- Regulating peripheral T cell tolerance awarded by National Institutes of Health 2020 - 2022
- TSC1 in Alveolar Macrophages Development and Function awarded by National Institutes of Health 2020 - 2022
- Research Training in Allergy and Clinical Immunology awarded by National Institutes of Health 2000 - 2022
- Role of mTOR in thymic epithelial cells in regulating age-associated thymic involution and function awarded by National Institutes of Health 2019 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Regulating peripheral T cell tolerance awarded by National Institutes of Health 2008 - 2019
- Duke Research Training Program for Pediatricians awarded by National Institutes of Health 2002 - 2018
- TSC1-mTOR signaling and T cell tolerance awarded by National Institutes of Health 2012 - 2018
- A Murine Model of Chronic Autoimmune Hepatitis and Liver Fibrosis awarded by National Institutes of Health 2008 - 2014
- Understanding the Mechanism of Mucosal Immunotherapy awarded by National Institutes of Health 2007 - 2012
- Prevention and Treatment of Cashew Allergy via Pepsinized Allergens awarded by National Institutes of Health 2009 - 2011
- Immunotherapy for Peanut Allergy awarded by National Institutes of Health 2008 - 2010
- Immunotherapy for Peanut Allergy awarded by National Institutes of Health 2005 - 2008
External Relationships
- Southern Medical University
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wang, Wei, Ran Li, Wanying Miao, Cody Evans, Liping Lu, Jingjun Lyu, Xuan Li, et al. “Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.” J Am Heart Assoc 10, no. 11 (June 2021): e019142. https://doi.org/10.1161/JAHA.120.019142.
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  - Tao, Huishan, Yun Pan, Shuai Chu, Lei Li, Jinhai Xie, Peng Wang, Shimeng Zhang, Srija Reddy, John W. Sleasman, and Xiao-Ping Zhong. “Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.” Nat Commun 12, no. 1 (April 1, 2021): 2029. https://doi.org/10.1038/s41467-021-22162-8.
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  - Zhang, Shimeng, Lei Li, Danli Xie, Srija Reddy, John W. Sleasman, Li Ma, and Xiao-Ping Zhong. “Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1.” Front Immunol 12 (2021): 620437. https://doi.org/10.3389/fimmu.2021.620437.
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  - Tao, Huishan, Lei Li, Nan-Shih Liao, Kimberly S. Schluns, Shirley Luckhart, John W. Sleasman, and Xiao-Ping Zhong. “Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.” Front Immunol 12 (2021): 623280. https://doi.org/10.3389/fimmu.2021.623280.
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  - Xie, Danli, Shimeng Zhang, Pengcheng Chen, Wenhai Deng, Yun Pan, Jinhai Xie, Jinli Wang, Bryce Liao, John W. Sleasman, and Xiao-Ping Zhong. “Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice.” Eur J Immunol 50, no. 11 (November 2020): 1729–45. https://doi.org/10.1002/eji.201948442.
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  - Zhou, Xinying, Lijie Zhang, Linmiao Lie, Zelin Zhang, Bo Zhu, Jiahui Yang, Yuchi Gao, et al. “MxA suppresses TAK1-IKKα/β-NF-κB mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection.” J Infect 81, no. 2 (August 2020): 231–41. https://doi.org/10.1016/j.jinf.2020.05.030.
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  - Pan, Yun, Wenhai Deng, Jinhai Xie, Shimeng Zhang, Edwin C. K. Wan, Lei Li, Huishan Tao, et al. “Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice.” Eur J Immunol 50, no. 2 (February 2020): 192–204. https://doi.org/10.1002/eji.201948289.
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  - Chen, Pengcheng, Shang Wang, Kyathanahalli S. Janardhan, Rachel L. Zemans, Wenhai Deng, Peer Karmaus, Shudan Shen, et al. “Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis.” J Immunol 203, no. 5 (September 1, 2019): 1208–17. https://doi.org/10.4049/jimmunol.1900566.
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  - Fu, Yuling, Xiaoxia Zhan, Yichong Wang, Xiaobing Jiang, Min Liu, Yalong Yang, Yulan Huang, et al. “NLRC3 expression in dendritic cells attenuates CD4+ T cell response and autoimmunity.” Embo J 38, no. 16 (August 15, 2019): e101397. https://doi.org/10.15252/embj.2018101397.
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  - Xie, Jinhai, Yun Pan, Huishan Tao, Peng Wang, Yongping Chen, Jimin Gao, and Xiao-Ping Zhong. “Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice.” Immunohorizons 3, no. 6 (June 11, 2019): 203–7. https://doi.org/10.4049/immunohorizons.1900035.
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  - Chen, Pengcheng, Wenhai Deng, Dandan Li, Tai Zeng, Ling Huang, Qun Wang, Jinli Wang, et al. “Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly.” Front Immunol 10 (2019): 260. https://doi.org/10.3389/fimmu.2019.00260.
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  - Tao, Huishan, Lei Li, Ying Gao, Zehua Wang, and Xiao-Ping Zhong. “Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor.” Front Immunol 10 (2019): 2710. https://doi.org/10.3389/fimmu.2019.02710.
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  - Wang, Hong-Xia, Wenrong Pan, Lei Zheng, Xiao-Ping Zhong, Liang Tan, Zhanfeng Liang, Jing He, Pingfeng Feng, Yong Zhao, and Yu-Rong Qiu. “Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development.” Front Immunol 10 (2019): 3099. https://doi.org/10.3389/fimmu.2019.03099.
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  - Yang, Jialong, Hong-Xia Wang, Jinhai Xie, Lei Li, Jinli Wang, Edwin C. K. Wan, and Xiao-Ping Zhong. “DGK α and ζ Activities Control TH1 and TH17 Cell Differentiation.” Front Immunol 10 (2019): 3048. https://doi.org/10.3389/fimmu.2019.03048.
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  - Hu, Shengfeng, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Xiaoxia Zhan, Wenting He, et al. “NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection.” Plos Pathog 14, no. 8 (August 2018): e1007266. https://doi.org/10.1371/journal.ppat.1007266.
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  - He, Wenting, Shengfeng Hu, Xialin Du, Qian Wen, Xiao-Ping Zhong, Xinying Zhou, Chaoying Zhou, et al. “Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis.” Front Immunol 9 (2018): 365. https://doi.org/10.3389/fimmu.2018.00365.
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  - Hu, Shengfeng, Wenting He, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Chuxuan Hu, et al. “Vitamin B1 Helps to Limit Mycobacterium tuberculosis Growth via Regulating Innate Immunity in a Peroxisome Proliferator-Activated Receptor-γ-Dependent Manner.” Front Immunol 9 (2018): 1778. https://doi.org/10.3389/fimmu.2018.01778.
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  - Hu, Shengfeng, Wenting He, Xialin Du, Jiahui Yang, Qian Wen, Xiao-Ping Zhong, and Li Ma. “IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection.” Ebiomedicine 23 (September 2017): 88–99. https://doi.org/10.1016/j.ebiom.2017.08.001.
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  - Xie, Dan-Li, Meng-Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian-Chun Guo, X Frank Yang, Xiao-Ping Zhong, and Yong-Liang Lou. “Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.” Plos One 12, no. 7 (2017): e0181454. https://doi.org/10.1371/journal.pone.0181454.
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  - Deng, Wenhai, Jialong Yang, Xingguang Lin, Jinwook Shin, Jimin Gao, and Xiao-Ping Zhong. “Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.” J Immunol 198, no. 1 (January 1, 2017): 492–504. https://doi.org/10.4049/jimmunol.1501845.
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  - Lin, Xingguang, Jialong Yang, Jinli Wang, Hongxiang Huang, Hong-Xia Wang, Pengcheng Chen, Shang Wang, et al. “mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.” Sci Rep 6 (October 12, 2016): 34939. https://doi.org/10.1038/srep34939.
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  - Yang, Jialong, Xingguang Lin, Yun Pan, Jinli Wang, Pengcheng Chen, Hongxiang Huang, Hai-Hui Xue, Jimin Gao, and Xiao-Ping Zhong. “Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.” Elife 5 (September 30, 2016). https://doi.org/10.7554/eLife.17936.
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  - Pan, Hongjie, Xiao-Ping Zhong, and Sunhee Lee. “Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.” Bmc Biochem 17, no. 1 (July 7, 2016): 14. https://doi.org/10.1186/s12858-016-0069-6.
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  - Petrovski, Slavé, Roberta E. Parrott, Joseph L. Roberts, Hongxiang Huang, Jialong Yang, Balachandra Gorentla, Talal Mousallem, et al. “Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature.” J Clin Immunol 36, no. 5 (July 2016): 462–71. https://doi.org/10.1007/s10875-016-0281-6.
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  - Wang, Hong-Xia, Joyce S. Cheng, Shuai Chu, Yu-Rong Qiu, and Xiao-Ping Zhong. “mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.” J Immunol 197, no. 1 (July 1, 2016): 141–50. https://doi.org/10.4049/jimmunol.1502698.
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  - Yang, Jialong, Ping Zhang, Sruti Krishna, Jinli Wang, Xingguang Lin, Hongxiang Huang, Danli Xie, et al. “Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.” Oncotarget 7, no. 23 (June 7, 2016): 33744–64. https://doi.org/10.18632/oncotarget.8164.
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  - Wang, Hong-Xia, Jinwook Shin, Shang Wang, Balachandra Gorentla, Xingguang Lin, Jimin Gao, Yu-Rong Qiu, and Xiao-Ping Zhong. “mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.” Plos Biol 14, no. 2 (February 2016): e1002370. https://doi.org/10.1371/journal.pbio.1002370.
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  - Chen, Shelley S., Zhiming Hu, and Xiao-Ping Zhong. “Diacylglycerol Kinases in T Cell Tolerance and Effector Function.” Front Cell Dev Biol 4 (2016): 130. https://doi.org/10.3389/fcell.2016.00130.
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  - Wang, Hong-Xia, Yu-Rong Qiu, and Xiao-Ping Zhong. “Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells.” Plos One 11, no. 3 (2016): e0152641. https://doi.org/10.1371/journal.pone.0152641.
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  - Yang, Wei, Balachandra Gorentla, Xiao-Ping Zhong, and Jinwook Shin. “mTOR and its tight regulation for iNKT cell development and effector function.” Mol Immunol 68, no. 2 Pt C (December 2015): 536–45. https://doi.org/10.1016/j.molimm.2015.07.022.
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  - Ci, Xinxin, Masayuki Kuraoka, Hongxia Wang, Zachary Carico, Kristen Hopper, Jinwook Shin, Xuming Deng, et al. “TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.” Plos One 10, no. 5 (2015): e0127527. https://doi.org/10.1371/journal.pone.0127527.
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  - Martin, Bradley N., Chenhui Wang, Jami Willette-Brown, Tomasz Herjan, Muhammet F. Gulen, Hao Zhou, Katarzyna Bulek, et al. “IKKα negatively regulates ASC-dependent inflammasome activation.” Nat Commun 5 (September 30, 2014): 4977. https://doi.org/10.1038/ncomms5977.
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  - Mousallem, Talal, Jialong Yang, Thomas J. Urban, Hongxia Wang, Mehdi Adeli, Roberta E. Parrott, Joseph L. Roberts, David B. Goldstein, Rebecca H. Buckley, and Xiao-Ping Zhong. “A nonsense mutation in IKBKB causes combined immunodeficiency.” Blood 124, no. 13 (September 2014): 2046–50. https://doi.org/10.1182/blood-2014-04-571265.
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  - Krishna, Sruti, Jialong Yang, Hongxia Wang, Yurong Qiu, and Xiao-Ping Zhong. “Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection.” Infect Immun 82, no. 7 (July 2014): 3045–57. https://doi.org/10.1128/IAI.01816-14.
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  - Hamilton, Kristia S., Binh Phong, Catherine Corey, Jing Cheng, Balachandra Gorentla, Xiaoping Zhong, Sruti Shiva, and Lawrence P. Kane. “T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.” Sci Signal 7, no. 329 (June 10, 2014): ra55. https://doi.org/10.1126/scisignal.2005169.
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  - Wu, Jinhong, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, et al. “iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.” J Clin Invest 124, no. 4 (April 2014): 1685–98. https://doi.org/10.1172/JCI69780.
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  - Wu, Jinhong, Jinwook Shin, Danli Xie, Hongxia Wang, Jimin Gao, and Xiao-Ping Zhong. “Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity.” J Immunol 192, no. 6 (March 15, 2014): 2643–50. https://doi.org/10.4049/jimmunol.1302076.
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  - Shin, Jinwook, Shang Wang, Wenhai Deng, Jinhong Wu, Jimin Gao, and Xiao-Ping Zhong. “Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.” Proc Natl Acad Sci U S A 111, no. 8 (February 25, 2014): E776–83. https://doi.org/10.1073/pnas.1315435111.
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  - You, Jae-Sung, Hannah C. Lincoln, Chan-Ran Kim, John W. Frey, Craig A. Goodman, Xiao-Ping Zhong, and Troy A. Hornberger. “The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy.” J Biol Chem 289, no. 3 (January 17, 2014): 1551–63. https://doi.org/10.1074/jbc.M113.531392.
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  - Wheeler, Matthew L., Matthew B. Dong, Robert Brink, Xiao-Ping Zhong, and Anthony L. DeFranco. “Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.” Sci Signal 6, no. 297 (October 15, 2013): ra91. https://doi.org/10.1126/scisignal.2004189.
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  - Pan, Hongjie, Thomas F. O’Brien, Gabriela Wright, Jialong Yang, Jinwook Shin, Kenneth L. Wright, and Xiao-Ping Zhong. “Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.” J Immunol 191, no. 2 (July 15, 2013): 699–707. https://doi.org/10.4049/jimmunol.1201443.
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  - Kulis, Mike, Balachandra Gorentla, A Wesley Burks, and Xiao-Ping Zhong. “Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice.” Mol Nutr Food Res 57, no. 5 (May 2013): 906–15. https://doi.org/10.1002/mnfr.201200410.
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  - Gorentla, Balachandra K., Sruti Krishna, Jinwook Shin, Makoto Inoue, Mari L. Shinohara, Jason M. Grayson, Rikiro Fukunaga, and Xiao-Ping Zhong. “Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.” J Immunol 190, no. 3 (February 1, 2013): 1026–37. https://doi.org/10.4049/jimmunol.1200026.
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  - Krishna, Sruti, and Xiao-Ping Zhong. “Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function.” Front Immunol 4 (2013): 178. https://doi.org/10.3389/fimmu.2013.00178.
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  - Krishna, Sruti, and Xiaoping Zhong. “Role of diacylglycerol kinases in T cell development and function.” Crit Rev Immunol 33, no. 2 (2013): 97–118. https://doi.org/10.1615/critrevimmunol.2013006696.
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  - Shin, Jinwook, Danli Xie, and Xiao-Ping Zhong. “MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ.” Plos One 8, no. 10 (2013): e77983. https://doi.org/10.1371/journal.pone.0077983.
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  - Shin, Jinwook, Ping Zhang, Shang Wang, Jinhong Wu, Ziqiang Guan, and Xiao-Ping Zhong. “Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.” Eur J Immunol 43, no. 1 (January 2013): 240–48. https://doi.org/10.1002/eji.201242571.
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  - Wu, Jinhong, Shudan Shen, Jialong Yang, Zhenwei Xia, and Xiao-Ping Zhong. “Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells.” Plos One 8, no. 9 (2013): e75202. https://doi.org/10.1371/journal.pone.0075202.
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  - Zhong, Xiao-Ping. “An expanded role of the tumor suppressor TSC1 in T cell tolerance.” Cell Cycle 11, no. 21 (November 1, 2012): 3909–10. https://doi.org/10.4161/cc.22235.
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  - Martínez-Moreno, Mónica, Job García-Liévana, Denise Soutar, Pedro Torres-Ayuso, Elena Andrada, Xiao-Ping Zhong, Gary A. Koretzky, Isabel Mérida, and Antonia Ávila-Flores. “FoxO-dependent regulation of diacylglycerol kinase α gene expression.” Mol Cell Biol 32, no. 20 (October 2012): 4168–80. https://doi.org/10.1128/MCB.00654-12.
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  - Kulis, Mike, Ian Macqueen, Yifan Li, Rishu Guo, Xiao-Ping Zhong, and A Wesley Burks. “Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy.” J Allergy Clin Immunol 130, no. 3 (September 2012): 716–23. https://doi.org/10.1016/j.jaci.2012.05.044.
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  - Xie, Dan-Li, Jinhong Wu, Yong-Liang Lou, and Xiao-Ping Zhong. “Tumor suppressor TSC1 is critical for T-cell anergy.” Proc Natl Acad Sci U S A 109, no. 35 (August 28, 2012): 14152–57. https://doi.org/10.1073/pnas.1119744109.
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  - Krishna, Sruti, Danli Xie, Balachandra Gorentla, Jinwook Shin, Jimin Gao, and Xiao-Ping Zhong. “Chronic activation of the kinase IKKβ impairs T cell function and survival.” Journal of Immunology (Baltimore, Md. : 1950) 189, no. 3 (August 2012): 1209–19. https://doi.org/10.4049/jimmunol.1102429.
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  - Chen, Yong, Xinxin Ci, Balachandra Gorentla, Sarah A. Sullivan, James C. Stone, Weiguo Zhang, Pablo Pereira, Jianxin Lu, and Xiao-Ping Zhong. “Differential requirement of RasGRP1 for γδ T cell development and activation.” J Immunol 189, no. 1 (July 1, 2012): 61–71. https://doi.org/10.4049/jimmunol.1103272.
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  - Roberts, Joseph L., Rebecca H. Buckley, Biao Luo, Jianming Pei, Alla Lapidus, Suraj Peri, Qiong Wei, et al. “CD45-deficient severe combined immunodeficiency caused by uniparental disomy.” Proc Natl Acad Sci U S A 109, no. 26 (June 26, 2012): 10456–61. https://doi.org/10.1073/pnas.1202249109.
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  - O’Brien, Thomas F., and Xiao-Ping Zhong. “The role and regulation of mTOR in T-lymphocyte function.” Arch Immunol Ther Exp (Warsz) 60, no. 3 (June 2012): 173–81. https://doi.org/10.1007/s00005-012-0171-4.
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  - Shin, Jinwook, Hongjie Pan, and Xiao-Ping Zhong. “Regulation of mast cell survival and function by tuberous sclerosis complex 1.” Blood 119, no. 14 (April 5, 2012): 3306–14. https://doi.org/10.1182/blood-2011-05-353342.
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  - Pan, Hongjie, Thomas F. O’Brien, Ping Zhang, and Xiao-Ping Zhong. “The role of tuberous sclerosis complex 1 in regulating innate immunity.” Journal of Immunology (Baltimore, Md. : 1950) 188, no. 8 (April 2012): 3658–66. https://doi.org/10.4049/jimmunol.1102187.
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  - Shin, Jinwook, Thomas F. O’Brien, Jason M. Grayson, and Xiao-Ping Zhong. “Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.” J Immunol 188, no. 5 (March 1, 2012): 2111–17. https://doi.org/10.4049/jimmunol.1102265.
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  - Chen, Yong, Shudan Shen, Balachandra K. Gorentla, Jimin Gao, and Xiao-Ping Zhong. “Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.” J Immunol 188, no. 4 (February 15, 2012): 1698–1707. https://doi.org/10.4049/jimmunol.1102448.
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  - Baldanzi, Gianluca, Andrea Pighini, Valentina Bettio, Elena Rainero, Sara Traini, Federica Chianale, Paolo E. Porporato, et al. “SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.” J Immunol 187, no. 11 (December 1, 2011): 5941–51. https://doi.org/10.4049/jimmunol.1002476.
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  - Li, Y., M. Kulis, L. Pons, X. P. Zhong, and A. W. Burks. “Peanut allergen Ara h 2-specific T cells are activated via Ras-Erk MAP kinase pathway signalling and identified by CD154 expression.” Food and Agricultural Immunology 22, no. 4 (December 1, 2011): 335–44. https://doi.org/10.1080/09540105.2011.579591.
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  - O’Brien, Thomas F., Balachandra K. Gorentla, Danli Xie, Sruti Srivatsan, Ian X. McLeod, You-Wen He, and Xiao-Ping Zhong. “Regulation of T-cell survival and mitochondrial homeostasis by TSC1.” Eur J Immunol 41, no. 11 (November 2011): 3361–70. https://doi.org/10.1002/eji.201141411.
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  - Shen, Shudan, Yong Chen, Balachandra K. Gorentla, Jianxin Lu, James C. Stone, and Xiao-Ping Zhong. “Critical roles of RasGRP1 for invariant NKT cell development.” J Immunol 187, no. 9 (November 1, 2011): 4467–73. https://doi.org/10.4049/jimmunol.1003798.
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  - Shen, Shudan, Jinhong Wu, Sruti Srivatsan, Balachandra K. Gorentla, Jinwook Shin, Li Xu, and Xiao-Ping Zhong. “Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development.” J Immunol 187, no. 5 (September 1, 2011): 2122–29. https://doi.org/10.4049/jimmunol.1100495.
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  - Kulis, Mike, Chi-Keung Wan, Balachandra K. Gorentla, A Wesley Burks, and Xiao-Ping Zhong. “Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity.” J Allergy Clin Immunol 128, no. 1 (July 2011): 212–14. https://doi.org/10.1016/j.jaci.2011.02.035.
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  - Gorentla, Balachandra K., Chi-Keung Wan, and Xiao-Ping Zhong. “Negative regulation of mTOR activation by diacylglycerol kinases.” Blood 117, no. 15 (April 14, 2011): 4022–31. https://doi.org/10.1182/blood-2010-08-300731.
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  - Zhong, Xiao-Ping, Jinwook Shin, Balachandra K. Gorentla, Tommy O’Brien, Sruti Srivatsan, Li Xu, Yong Chen, Danli Xie, and Hongjie Pan. “Receptor signaling in immune cell development and function.” Immunol Res 49, no. 1–3 (April 2011): 109–23. https://doi.org/10.1007/s12026-010-8175-9.
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  - Jones, Stacie M., Laurent Pons, Joseph L. Roberts, Amy M. Scurlock, Tamara T. Perry, Mike Kulis, Wayne G. Shreffler, et al. “Clinical efficacy and immune regulation with peanut oral immunotherapy.” J Allergy Clin Immunol 124, no. 2 (August 2009): 292-300.97. https://doi.org/10.1016/j.jaci.2009.05.022.
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  - Kim, Karam, Jinhee Yang, Xiao-Ping Zhong, Myoung-Hwan Kim, Yun Sook Kim, Hyun Woo Lee, Seungnam Han, et al. “Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.” Embo J 28, no. 8 (April 22, 2009): 1170–79. https://doi.org/10.1038/emboj.2009.44.
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  - Abramovici, Hanan, Parmiss Mojtabaie, Robin J. Parks, Xiao-Ping Zhong, Gary A. Koretzky, Matthew K. Topham, and Stephen H. Gee. “Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.” Mol Biol Cell 20, no. 7 (April 2009): 2049–59. https://doi.org/10.1091/mbc.e07-12-1248.
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  - Guo, Rishu, Chi-Keung Wan, Jeffery H. Carpenter, Talal Mousallem, Rose-Mary N. Boustany, Chien-Tsun Kuan, A Wesley Burks, and Xiao-Ping Zhong. “Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.” Proc Natl Acad Sci U S A 105, no. 33 (August 19, 2008): 11909–14. https://doi.org/10.1073/pnas.0711856105.
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  - Zhong, Xiao-Ping, Rishu Guo, Houde Zhou, Chenghu Liu, and Chi-Keung Wan. “Diacylglycerol kinases in immune cell function and self-tolerance.” Immunol Rev 224 (August 2008): 249–64. https://doi.org/10.1111/j.1600-065X.2008.00647.x.
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  - Liu, Cheng-Hu, Fabiana S. Machado, Rishu Guo, Kim E. Nichols, A Wesley Burks, Julio C. Aliberti, and Xiao-Ping Zhong. “Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.” J Exp Med 204, no. 4 (April 16, 2007): 781–92. https://doi.org/10.1084/jem.20061856.
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  - Roberts, Joseph L., Jens Peter H. Lauritsen, Myriah Cooney, Roberta E. Parrott, Elisa O. Sajaroff, Chan M. Win, Michael D. Keller, et al. “T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.” Blood 109, no. 8 (April 15, 2007): 3198–3206. https://doi.org/10.1182/blood-2006-08-043166.
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  - Zhong, X. P., B. A. Olenchock, and G. A. Koretzky. “The role of diacylglycerol kinases in T cell anergy.” Ernst Schering Found Symp Proc, no. 3 (2007): 139–49.
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  - Olenchock, Benjamin A., Rishu Guo, Jeffery H. Carpenter, Martha Jordan, Matthew K. Topham, Gary A. Koretzky, and Xiao-Ping Zhong. “Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.” Nat Immunol 7, no. 11 (November 2006): 1174–81. https://doi.org/10.1038/ni1400.
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  - Olenchock, Benjamin A., Rishu Guo, Michael A. Silverman, Jennifer N. Wu, Jeffery H. Carpenter, Gary A. Koretzky, and Xiao-Ping Zhong. “Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.” J Exp Med 203, no. 6 (June 12, 2006): 1471–80. https://doi.org/10.1084/jem.20052424.
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  - Zhong, Xiao-Ping, Jonathan S. Maltzman, Ehmonie A. Hainey, and Gary A. Koretzky. “Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.” J Immunol 171, no. 12 (December 15, 2003): 6621–29. https://doi.org/10.4049/jimmunol.171.12.6621.
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  - Zhong, Xiao-Ping, Ehmonie A. Hainey, Benjamin A. Olenchock, Martha S. Jordan, Jonathan S. Maltzman, Kim E. Nichols, Hao Shen, and Gary A. Koretzky. “Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.” Nat Immunol 4, no. 9 (September 2003): 882–90. https://doi.org/10.1038/ni958.
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  - Koretzky, Gary A., Farhad Abtahian, Geo S. Derimanov, Sally A. Dmowski, Anastasia Guerriero, Martha S. Jordan, Jonathan S. Maltzman, et al. “Regulation of hematopoietic cell development and activation by adapter proteins.” Immunol Res 27, no. 2–3 (2003): 357–66. https://doi.org/10.1385/IR:27:2-3:357.
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  - Zhong, Xiao-Ping, Ehmonie A. Hainey, Benjamin A. Olenchock, Haoran Zhao, Matthew K. Topham, and Gary A. Koretzky. “Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.” J Biol Chem 277, no. 34 (August 23, 2002): 31089–98. https://doi.org/10.1074/jbc.M203818200.
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  - Sleckman, B. P., J. Carabana, X. Zhong, and M. S. Krangel. “Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus.” Immunology 104, no. 1 (September 2001): 11–18. https://doi.org/10.1046/j.1365-2567.2001.01304.x.
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  - Krangel, M. S., M. T. McMurry, C. Hernandez-Munain, X. P. Zhong, and J. Carabana. “Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus.” Immunol Res 22, no. 2–3 (2000): 127–35. https://doi.org/10.1385/IR:22:2-3:127.
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  - Zhong, X. P., J. Carabaña, and M. S. Krangel. “Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.” Proc Natl Acad Sci U S A 96, no. 21 (October 12, 1999): 11970–75. https://doi.org/10.1073/pnas.96.21.11970.
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  - Zhong, X. P., and M. S. Krangel. “Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes.” J Immunol 163, no. 1 (July 1, 1999): 295–300.
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  - Krangel, M. S., C. Hernandez-Munain, P. Lauzurica, M. McMurry, J. L. Roberts, and X. P. Zhong. “Developmental regulation of V(D)J recombination at the TCR alpha/delta locus.” Immunol Rev 165 (October 1998): 131–47. https://doi.org/10.1111/j.1600-065x.1998.tb01236.x.
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  - Zhong, X. P., and M. S. Krangel. “An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.” Proc Natl Acad Sci U S A 94, no. 10 (May 13, 1997): 5219–24. https://doi.org/10.1073/pnas.94.10.5219.
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  - Lauzurica, P., X. P. Zhong, M. S. Krangel, and J. L. Roberts. “Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2.” J Exp Med 185, no. 7 (April 7, 1997): 1193–1201. https://doi.org/10.1084/jem.185.7.1193.
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  - Gorentla, B. K., and X. P. Zhong. “T cell Receptor Signal Transduction in T lymphocytes.” J Clin Cell Immunol 2012, no. (Suppl 12) (n.d.).
  - Krishna, S., and X. P. Zhong. “Role of diacylglycerol kinases in T cell development and function.” Crit Rev Immunol 33, no. 2 (n.d.): 97–118.
  - Wu, J., S. Shen, J. Yang, Z. Xia, and X. P. Zhong. “Diacylglycerol Kinase Zeta Positively Controls the Development of iNKT-17 Cells.” Plos One 8, no. 9 (n.d.).
- Other Articles
  - Zhong, P., F. Xing, X. Huang, H. Zhu, H. W. Lo, X. Zhong, S. Pruitt, and C. Robertson. “HIFU as a neoadjuvant therapy in cancer treatment.” Aip Conference Proceedings, October 13, 2011. https://doi.org/10.1063/1.3607920.
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- Journal Issues
  - Wu, Jinhong, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, et al. “iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.” J Clin Invest, November 1, 2017. https://doi.org/10.1172/JCI98066.
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- Conference Papers
  - Deng, W., J. Yang, X. Lin, J. Shin, J. Gao, and X. -. P. Zhong. “The role of mTORC1 on regulating tissue resident macrophage homeostasis.” In European Journal of Immunology, 46:856–856. WILEY-BLACKWELL, 2016.
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  - Zhong, Xiaoping, and Jinhong Wu. “TSC1 is critical for iNKT-cell terminal maturation and controls iNKT-1/17 balance.” In Journal of Immunology, Vol. 192. AMER ASSOC IMMUNOLOGISTS, 2014.
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  - Mousallem, Talal, Jialong Yang, Thomas J. Urban, Hongxia Wang, Roberta E. Parrott, Joseph L. Roberts, Rebecca H. Buckley, Xiaoping Zhong, and David B. Goldstein. “Whole-Exome Sequencing Reveals IKBKB As a Cause of Combined Immunodeficiency.” In Journal of Allergy and Clinical Immunology, 133:AB399–AB399. Elsevier BV, 2014. https://doi.org/10.1016/j.jaci.2013.12.1053.
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  - Zhong, Xiaoping, Jinhong Wu, Shang Wang, and Jinwook Shin. “Signal control of iNKT development and effector lineage differentiation.” In Journal of Immunology, Vol. 190. AMER ASSOC IMMUNOLOGISTS, 2013.
    Link to Item
  - Zhong, Xiaoping, Chi-Keung Wan, and Rishu Guo. “Synergistic role of idacylglycerol kinases alpha and zeta in T cell development and self-tolerance.” In Journal of Immunology, Vol. 182. AMER ASSOC IMMUNOLOGISTS, 2009.
    Link to Item
  - Liu, Cheng-hu, Fabiana S. Machado, Rishu Guo, Kim E. Nichols, A Wesley Burks, Julio C. Aliberti, and Xiao-Ping Zhong. “Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.
    Link to Item
  - Zhong, Xiao-Ping, Rishu Guo, and Jeffery H. Carpenter. “Synergistic control of T cell activation, regulatory T cell function, and autoimmunity by Diacylglycerol Kinases alpha and zeta.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.
    Link to Item
  - Zhong, Xiao-Ping, and Rishu Guo. “Synergistic control of T cell development by Diacylglycerol kinase alpha and zeta.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.
    Link to Item
Teaching & Mentoring
Teaching Activities
- PTH785: Molecular Aspects of Disease

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