Xiaoping Zhong | Scholars@Duke

Xiaoping Zhong
Professor of Pediatrics

The immune system protects the host from microbial infection but can cause diseases if not properly controlled. My lab is interested in the receptor signaling mediated regulation of immune cell development and function as well as the pathogenesis and treatment of autoimmune diseases and allergies.

We are currently investigating the roles diacylglycerol kinases (DGKs) and TSC1/2-mTOR play in the immune system. DGKs are a family of ten enzymes that catalyze the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), Both DAG and PA are important second messengers involved signaling from numerous receptors. While we expect DGKs to perform important roles in development and cellular function by modulating DAG and PA levels, the physiologic functions of DGKs have been poorly understood. Using cell line models and genetically manipulated mice, we have demonstrated that DGKα and ζ isoforms play critical roles in: T cell development, activation, and anergy by regulating T cell receptor signaling; FcεRI signaling and mast cell function; and Toll-like receptor signaling and innate immune responses.

Research areas that we are actively pursuing include:
1. The mechanisms that control T cell maturation, activation
and self-tolerance.
2. NKT cell development and function.
3. Thymic epithelial cells and thymic development, function, and involution.
4. Regulation of Toll-like receptor signaling and innate immunity.
5. The pathogenesis and treatment of autoimmune hepatitis.
6. Mast cell development and function.
7. The pathogenesis and immunotherapy for peanut allergy.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2016
Professor of Immunology, Immunology, Basic Science Departments 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2004

Contact Information

Box 2644 Med Ctr, Div. Pediatric Allergy & Immunology, Durham, NC 27710
Rm 133 MSRB, Research Drive, Durham, NC 27710
xiaoping.zhong@duke.edu (919) 681-9450

Background
Education, Training, & Certifications
- Ph.D., Duke University 1997
- M.D., First Medical College in Guangzhou (China) 1985
Duke Appointment History
- Associate Professor of Immunology, Immunology, Basic Science Departments 2012 - 2017
- Associate Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2012 - 2016
- Assistant Professor of Immunology, Immunology, Basic Science Departments 2005 - 2012
- Associate Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2009 - 2012
- Assistant Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2004 - 2009
- Instructor, Temporary of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2004
Expertise
Subject Headings
Research
Selected Grants
- Targeting apoptotic caspases to enhance cancer radiotherapy awarded by National Institutes of Health 2017 - 2022
- Research Training in Allergy and Clinical Immunology awarded by National Institutes of Health 2000 - 2021
- Regulating peripheral T cell tolerance awarded by National Institutes of Health 2008 - 2019
- Basic Immunology Training Program awarded by National Institutes of Health 2014 - 2019
- Duke Research Training Program for Pediatricians awarded by National Institutes of Health 2002 - 2018
- TSC1-mTOR signaling and T cell tolerance awarded by National Institutes of Health 2012 - 2018
- A Murine Model of Chronic Autoimmune Hepatitis and Liver Fibrosis awarded by National Institutes of Health 2008 - 2014
- Understanding the Mechanism of Mucosal Immunotherapy awarded by National Institutes of Health 2007 - 2012
- Prevention and Treatment of Cashew Allergy via Pepsinized Allergens awarded by National Institutes of Health 2009 - 2011
- Immunotherapy for Peanut Allergy awarded by National Institutes of Health 2008 - 2010
- Immunotherapy for Peanut Allergy awarded by National Institutes of Health 2005 - 2008
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Deng, W, Yang, J, Lin, X, Shin, J, Gao, J, and Zhong, X-P. "The role of mTORC1 on regulating tissue resident macrophage homeostasis." International Congress of Immunology (ICI). Melbourne, AUSTRALIA. August 21, 2016 - August 26, 2016.: WILEY-BLACKWELL, August 1, 2016. Link to Item
  - Zhong, X, and Wu, J. "TSC1 is critical for iNKT-cell terminal maturation and controls iNKT-1/17 balance." : AMER ASSOC IMMUNOLOGISTS, May 1, 2014. Link to Item
  - Mousallem, T, Yang, J, Urban, TJ, Wang, H, Parrott, RE, Roberts, JL, Buckley, RH, Zhong, X, and Goldstein, DB. "Whole-Exome Sequencing Reveals IKBKB As a Cause of Combined Immunodeficiency." February 2014. Full Text
  - Zhong, X, Wu, J, Wang, S, and Shin, J. "Signal control of iNKT development and effector lineage differentiation." May 1, 2013. Link to Item
  - Zhong, X, Wan, C-K, and Guo, R. "Synergistic role of idacylglycerol kinases alpha and zeta in T cell development and self-tolerance." : AMER ASSOC IMMUNOLOGISTS, April 1, 2009. Link to Item
  - Liu, C-H, Machado, FS, Guo, R, Nichols, KE, Burks, AW, Aliberti, JC, and Zhong, X-P. "Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii." : AMER ASSOC IMMUNOLOGISTS, April 1, 2007. Link to Item
  - Zhong, X-P, Guo, R, and Carpenter, JH. "Synergistic control of T cell activation, regulatory T cell function, and autoimmunity by Diacylglycerol Kinases alpha and zeta." : AMER ASSOC IMMUNOLOGISTS, April 1, 2007. Link to Item
  - Zhong, X-P, and Guo, R. "Synergistic control of T cell development by Diacylglycerol kinase alpha and zeta." : AMER ASSOC IMMUNOLOGISTS, April 1, 2007. Link to Item
- Journal Articles
  - Hu, S, Du, X, Huang, Y, Fu, Y, Yang, Y, Zhan, X, He, W, Wen, Q, Zhou, X, Zhou, C, Zhong, X-P, Yang, J, Xiong, W, Wang, R, Gao, Y, and Ma, L. "NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection." Plos Pathogens 14, no. 8 (August 22, 2018): e1007266-null. Full Text
  - He, W, Hu, S, Du, X, Wen, Q, Zhong, X-P, Zhou, X, Zhou, C, Xiong, W, Gao, Y, Zhang, S, Wang, R, Yang, J, and Ma, L. "Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis." Frontiers in Immunology 9 (January 2018): 365-null. Full Text
  - Hu, S, He, W, Du, X, Huang, Y, Fu, Y, Yang, Y, Hu, C, Li, S, Wang, Q, Wen, Q, Zhou, X, Zhou, C, Zhong, X-P, and Ma, L. "Vitamin B1 Helps to Limit Mycobacterium tuberculosis Growth via Regulating Innate Immunity in a Peroxisome Proliferator-Activated Receptor-γ-Dependent Manner." Frontiers in Immunology 9 (January 2018): 1778-null. Full Text
  - Hu, S, He, W, Du, X, Yang, J, Wen, Q, Zhong, X-P, and Ma, L. "IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection." Ebiomedicine 23 (September 2017): 88-99. Full Text
  - Deng, W, Yang, J, Lin, X, Shin, J, Gao, J, and Zhong, X-P. "Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages." Journal of immunology (Baltimore, Md. : 1950) 198, no. 1 (January 2017): 492-504. Full Text
  - Xie, D-L, Zheng, M-M, Zheng, Y, Gao, H, Zhang, J, Zhang, T, Guo, J-C, Yang, XF, Zhong, X-P, and Lou, Y-L. "Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages." PloS one 12, no. 7 (January 2017): e0181454-. Full Text
  - Lin, X, Yang, J, Wang, J, Huang, H, Wang, H-X, Chen, P, Wang, S, Pan, Y, Qiu, Y-R, Taylor, GA, Vallance, BA, Gao, J, and Zhong, X-P. "mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium." Scientific reports 6 (October 12, 2016): 34939-. Full Text
  - Yang, J, Lin, X, Pan, Y, Wang, J, Chen, P, Huang, H, Xue, H-H, Gao, J, and Zhong, X-P. "Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses." Elife 5 (September 30, 2016). Full Text
  - Pan, H, Zhong, X-P, and Lee, S. "Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis." BMC biochemistry 17, no. 1 (July 7, 2016): 14-. Full Text
  - Petrovski, S, Parrott, RE, Roberts, JL, Huang, H, Yang, J, Gorentla, B, Mousallem, T, Wang, E, Armstrong, M, McHale, D, MacIver, NJ, Goldstein, DB, Zhong, X-P, and Buckley, RH. "Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature." Journal of clinical immunology 36, no. 5 (July 2016): 462-471. Full Text Open Access Copy
  - Wang, H-X, Cheng, JS, Chu, S, Qiu, Y-R, and Zhong, X-P. "mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development." Journal of immunology (Baltimore, Md. : 1950) 197, no. 1 (July 2016): 141-150. Full Text
  - Yang, J, Zhang, P, Krishna, S, Wang, J, Lin, X, Huang, H, Xie, D, Gorentla, B, Huang, R, Gao, J, Li, Q-J, and Zhong, X-P. "Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation." Oncotarget 7, no. 23 (June 2016): 33744-33764. Full Text
  - Wang, H-X, Shin, J, Wang, S, Gorentla, B, Lin, X, Gao, J, Qiu, Y-R, and Zhong, X-P. "mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination." PLoS biology 14, no. 2 (February 18, 2016): e1002370-. Full Text
  - Chen, SS, Hu, Z, and Zhong, X-P. "Diacylglycerol Kinases in T Cell Tolerance and Effector Function." Frontiers in Cell and Developmental Biology 4 (January 2016): 130-null. (Review) Full Text
  - Wang, H-X, Qiu, Y-R, and Zhong, X-P. "Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells." PloS one 11, no. 3 (January 2016): e0152641-. Full Text Open Access Copy
  - Yang, W, Gorentla, B, Zhong, X-P, and Shin, J. "mTOR and its tight regulation for iNKT cell development and effector function." Molecular immunology 68, no. 2 Pt C (December 2015): 536-545. (Review) Full Text
  - Ci, X, Kuraoka, M, Wang, H, Carico, Z, Hopper, K, Shin, J, Deng, X, Qiu, Y, Unniraman, S, Kelsoe, G, and Zhong, X-P. "TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation." PloS one 10, no. 5 (January 2015): e0127527-. Full Text Open Access Copy
  - Martin, BN, Wang, C, Willette-Brown, J, Herjan, T, Gulen, MF, Zhou, H, Bulek, K, Franchi, L, Sato, T, Alnemri, ES, Narla, G, Zhong, X-P, Thomas, J, Klinman, D, Fitzgerald, KA, Karin, M, Nuñez, G, Dubyak, G, Hu, Y, and Li, X. "IKKα negatively regulates ASC-dependent inflammasome activation." Nature Communications 5 (September 30, 2014): 4977-null. Full Text
  - Mousallem, T, Yang, J, Urban, TJ, Wang, H, Adeli, M, Parrott, RE, Roberts, JL, Goldstein, DB, Buckley, RH, and Zhong, X-P. "A nonsense mutation in IKBKB causes combined immunodeficiency." Blood 124, no. 13 (September 2014): 2046-2050. Full Text
  - Krishna, S, Yang, J, Wang, H, Qiu, Y, and Zhong, X-P. "Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection." Infection and Immunity 82, no. 7 (July 2014): 3045-3057. Full Text
  - Hamilton, KS, Phong, B, Corey, C, Cheng, J, Gorentla, B, Zhong, X, Shiva, S, and Kane, LP. "T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10." Science Signaling 7, no. 329 (June 10, 2014): ra55-null. Full Text
  - Wu, J, Yang, J, Yang, K, Wang, H, Gorentla, B, Shin, J, Qiu, Y, Que, LG, Foster, WM, Xia, Z, Chi, H, and Zhong, X-P. "iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions." The Journal of Clinical Investigation 124, no. 4 (April 2014): 1685-1698. Full Text
  - Wu, J, Shin, J, Xie, D, Wang, H, Gao, J, and Zhong, X-P. "Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity." Journal of immunology (Baltimore, Md. : 1950) 192, no. 6 (March 2014): 2643-2650. Full Text
  - Shin, J, Wang, S, Deng, W, Wu, J, Gao, J, and Zhong, X-P. "Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function." Proceedings of the National Academy of Sciences of the United States of America 111, no. 8 (February 10, 2014): E776-E783. Full Text
  - Shin, J, Wang, S, Deng, W, Wu, J, Gao, J, and Zhong, X-P. "Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function." Proceedings of the National Academy of Sciences of the United States of America 111, no. 8 (2014): E766-E783. Full Text
  - Shin, J, Wang, S, Deng, W, Wu, J, Gao, J, and Zhong, X-P. "Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function." Proceedings of the National Academy of Sciences of the United States of America 111, no. 8 (2014): E776-E783. Full Text
  - You, J-S, Lincoln, HC, Kim, C-R, Frey, JW, Goodman, CA, Zhong, X-P, and Hornberger, TA. "The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy." The Journal of Biological Chemistry 289, no. 3 (January 2014): 1551-1563. Full Text
  - Pan, H, O'Brien, TF, Wright, G, Yang, J, Shin, J, Wright, KL, and Zhong, X-P. "Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA." J Immunol 191, no. 2 (July 15, 2013): 699-707. Full Text Link to Item
  - Kulis, M, Gorentla, B, Burks, AW, and Zhong, X-P. "Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice." Molecular Nutrition & Food Research 57, no. 5 (May 2013): 906-915. Full Text
  - Gorentla, BK, Krishna, S, Shin, J, Inoue, M, Shinohara, ML, Grayson, JM, Fukunaga, R, and Zhong, X-P. "Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis." J Immunol 190, no. 3 (February 1, 2013): 1026-1037. Full Text Link to Item
  - Krishna, S, and Zhong, X. "Role of diacylglycerol kinases in T cell development and function." Crit Rev Immunol 33, no. 2 (2013): 97-118. (Review) Link to Item
  - Shin, J, Xie, D, and Zhong, X-P. "MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ." Plos One 8, no. 10 (January 2013): e77983-null. Full Text
  - Shin, J, Zhang, P, Wang, S, Wu, J, Guan, Z, and Zhong, X-P. "Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1." Eur J Immunol 43, no. 1 (January 2013): 240-248. Full Text Link to Item
  - Shin, J, Zhang, P, Wang, S, Wu, J, Guan, Z, and Zhong, X-P. "Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1." European Journal of Immunology 43, no. 1 (2013): 240-248. Full Text
  - Wu, J, Shen, S, Yang, J, Xia, Z, and Zhong, X-P. "Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. (Published online)" PLoS One 8, no. 9 (2013): e75202-. Full Text Link to Item
  - Zhong, X-P. "An expanded role of the tumor suppressor TSC1 in T cell tolerance." Cell Cycle (Georgetown, Tex.) 11, no. 21 (November 2012): 3909-3910. Full Text
  - Kulis, M, Macqueen, I, Li, Y, Guo, R, Zhong, X-P, and Burks, AW. "Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy." J Allergy Clin Immunol 130, no. 3 (September 2012): 716-723. Full Text Link to Item
  - Xie, D-L, Wu, J, Lou, Y-L, and Zhong, X-P. "Tumor suppressor TSC1 is critical for T-cell anergy." Proceedings of the National Academy of Sciences of the United States of America 109, no. 35 (August 13, 2012): 14152-14157. Full Text
  - Chen, Y, Ci, X, Gorentla, B, Sullivan, SA, Stone, JC, Zhang, W, Pereira, P, Lu, J, and Zhong, X-P. "Differential requirement of RasGRP1 for γδ T cell development and activation." Journal of Immunology (Baltimore, Md. : 1950) 189, no. 1 (July 2012): 61-71. Full Text
  - Roberts, JL, Buckley, RH, Luo, B, Pei, J, Lapidus, A, Peri, S, Wei, Q, Shin, J, Parrott, RE, Dunbrack, RL, Testa, JR, Zhong, X-P, and Wiest, DL. "CD45-deficient severe combined immunodeficiency caused by uniparental disomy." Proc Natl Acad Sci U S A 109, no. 26 (June 26, 2012): 10456-10461. Full Text Link to Item
  - Pan, H, O'Brien, TF, Zhang, P, and Zhong, X-P. "The role of tuberous sclerosis complex 1 in regulating innate immunity." Journal of Immunology (Baltimore, Md. : 1950) 188, no. 8 (April 2012): 3658-3666. Full Text
  - Shin, J, Pan, H, and Zhong, X-P. "Regulation of mast cell survival and function by tuberous sclerosis complex 1." Blood 119, no. 14 (April 2012): 3306-3314. Full Text
  - Shin, J, O'Brien, TF, Grayson, JM, and Zhong, X-P. "Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases." Journal of Immunology (Baltimore, Md. : 1950) 188, no. 5 (March 2012): 2111-2117. Full Text
  - Chen, Y, Shen, S, Gorentla, BK, Gao, J, and Zhong, X-P. "Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression." Journal of Immunology (Baltimore, Md. : 1950) 188, no. 4 (February 2012): 1698-1707. Full Text
  - Krishna, S, Xie, D, Gorentla, B, Shin, J, Gao, J, and Zhong, X-P. "Chronic activation of the kinase IKKβ impairs T cell function and survival." Journal of Immunology 189, no. 3 (2012): 1209-1219. Full Text
  - Martínez-Moreno, M, García-Liévana, J, Soutar, D, Torres-Ayuso, P, Andrada, E, Zhong, X-P, Koretzky, GA, Mérida, I, and Ávila-Flores, A. "FoxO-dependent regulation of diacylglycerol kinase α gene expression." Molecular and Cellular Biology 32, no. 20 (2012): 4168-4180. Full Text
  - O'Brien, TF, and Zhong, X-P. "The role and regulation of mTOR in T-lymphocyte function." Archivum Immunologiae et Therapiae Experimentalis 60, no. 3 (2012): 173-181. Full Text
  - O'Brien, TF, Gorentla, BK, Xie, D, Srivatsan, S, McLeod, IX, He, Y-W, and Zhong, X-P. "Regulation of T-cell survival and mitochondrial homeostasis by TSC1." European Journal of Immunology 41, no. 11 (November 2011): 3361-3370. Full Text
  - Shen, S, Chen, Y, Gorentla, BK, Lu, J, Stone, JC, and Zhong, X-P. "Critical roles of RasGRP1 for invariant NKT cell development." J Immunol 187, no. 9 (November 1, 2011): 4467-4473. Full Text Link to Item
  - Kulis, M, Wan, C-K, Gorentla, BK, Burks, AW, and Zhong, X-P. "Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity." The Journal of Allergy and Clinical Immunology 128, no. 1 (July 2011): 212-214. (Letter) Full Text
  - Zhong, X-P, Shin, J, Gorentla, BK, O'Brien, T, Srivatsan, S, Xu, L, Chen, Y, Xie, D, and Pan, H. "Receptor signaling in immune cell development and function." Immunol Res 49, no. 1-3 (April 2011): 109-123. Full Text Link to Item
  - Baldanzi, G, Pighini, A, Bettio, V, Rainero, E, Traini, S, Chianale, F, Porporato, PE, Filigheddu, N, Mesturini, R, Song, S, Schweighoffer, T, Patrussi, L, Baldari, CT, Zhong, X-P, Blitterswijk, WJV, Sinigaglia, F, Nichols, KE, Rubio, I, Parolini, O, and Graziani, A. "SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling." Journal of Immunology 187, no. 11 (2011): 5941-5951. Full Text
  - Gorentla, BK, Wan, C-K, and Zhong, X-P. "Negative regulation of mTOR activation by diacylglycerol kinases." Blood 117, no. 15 (2011): 4022-4031. Full Text
  - Li, Y, Kulis, M, Pons, L, Zhong, X-P, and Burks, AW. "Peanut allergen Ara h 2-specific T cells are activated via Ras-Erk MAP kinase pathway signalling and identified by CD154 expression." Food and Agricultural Immunology 22, no. 4 (2011): 335-344. Full Text
  - Shen, S, Wu, J, Srivatsan, S, Gorentla, BK, Shin, J, Xu, L, and Zhong, X-P. "Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development." Journal of Immunology 187, no. 5 (2011): 2122-2129. Full Text
  - Jones, SM, Pons, L, Roberts, JL, Scurlock, AM, Perry, TT, Kulis, M, Shreffler, WG, Steele, P, Henry, KA, Adair, M, Francis, JM, Durham, S, Vickery, BP, Zhong, X, and Burks, AW. "Clinical efficacy and immune regulation with peanut oral immunotherapy." The Journal of Allergy and Clinical Immunology 124, no. 2 (August 2009): 292-300.97. Full Text
  - Abramovici, H, Mojtabaie, P, Parks, RJ, Zhong, X-P, Koretzky, GA, Topham, MK, and Gee, SH. "Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI." Molecular Biology of the Cell 20, no. 7 (April 2009): 2049-2059. Full Text
  - Kim, K, Yang, J, Zhong, X-P, Kim, M-H, Kim, YS, Lee, HW, Han, S, Choi, J, Han, K, Seo, J, Prescott, SM, Topham, MK, Bae, YC, Koretzky, G, Choi, S-Y, and Kim, E. "Synaptic removal of diacylglycerol by DGKζ and PSD-95 regulates dendritic spine maintenance." EMBO Journal 28, no. 8 (2009): 1170-1179. Full Text
  - Guo, R, Wan, C-K, Carpenter, JH, Mousallem, T, Boustany, R-MN, Kuan, C-T, Burks, AW, and Zhong, X-P. "Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta." Proceedings of the National Academy of Sciences of the United States of America 105, no. 33 (August 8, 2008): 11909-11914. Full Text
  - Zhong, X-P, Guo, R, Zhou, H, Liu, C, and Wan, C-K. "Diacylglycerol kinases in immune cell function and self-tolerance." Immunol Rev 224 (August 2008): 249-264. (Review) Full Text Link to Item
  - Roberts, JL, Lauritsen, JPH, Cooney, M, Parrott, RE, Sajaroff, EO, Win, CM, Keller, MD, Carpenter, JH, Carabana, J, Krangel, MS, Sarzotti, M, Zhong, X-P, Wiest, DL, and Buckley, RH. "T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex." Blood 109, no. 8 (April 15, 2007): 3198-3206. Full Text Link to Item
  - Liu, C-H, Machado, FS, Guo, R, Nichols, KE, Burks, AW, Aliberti, JC, and Zhong, X-P. "Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii." The Journal of Experimental Medicine 204, no. 4 (April 2007): 781-792. Full Text
  - Zhong, XP, Olenchock, BA, and Koretzky, GA. "The role of diacylglycerol kinases in T cell anergy." Ernst Schering Foundation symposium proceedings , no. 3 (2007): 139-149.
  - Olenchock, BA, Guo, R, Carpenter, JH, Jordan, M, Topham, MK, Koretzky, GA, and Zhong, X-P. "Disruption of diacylglycerol metabolism impairs the induction of T cell anergy." Nature Immunology 7, no. 11 (November 2006): 1174-1181. Full Text
  - Olenchock, BA, Guo, R, Silverman, MA, Wu, JN, Carpenter, JH, Koretzky, GA, and Zhong, X-P. "Impaired degranulation but enhanced cytokine production after FcεRI stimulation of diacylglycerol kinase ζ-deficient mast cells." Journal of Experimental Medicine 203, no. 6 (2006): 1471-1480. Full Text
  - Zhong, X-P, Hainey, EA, Olenchock, BA, Jordan, MS, Maltzman, JS, Nichols, KE, Shen, H, and Koretzky, GA. "Enhanced T cell responses due to diacylglycerol kinase zeta deficiency." Nature Immunology 4, no. 9 (September 2003): 882-890. Full Text
  - Koretzky, GA, Abtahian, F, Derimanov, GS, Dmowski, SA, Guerriero, A, Jordan, MS, Maltzman, JS, Olenchock, BA, Singer, AL, Wu, JN, and Zhong, X-P. "Regulation of hematopoietic cell development and activation by adapter proteins." Immunologic Research 27, no. 2-3 (2003): 357-366. Full Text
  - Zhong, X-P, Maltzman, JS, Hainey, EA, and Koretzky, GA. "Transcriptional Regulation of Src Homology 2 Domain-Containing Leukocyte Phosphoprotein of 76 kDa: Dissection of Key Promoter Elements." Journal of Immunology 171, no. 12 (2003): 6621-6629.
  - Zhong, X-P, Hainey, EA, Olenchock, BA, Zhao, H, Topham, MK, and Koretzky, GA. "Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase ζ." Journal of Biological Chemistry 277, no. 34 (2002): 31089-31098. Full Text
  - Sleckman, BP, Carabana, J, Zhong, X, and Krangel, MS. "Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus." Immunology 104, no. 1 (September 2001): 11-18. Full Text
  - Krangel, MS, McMurry, MT, Hernandez-Munain, C, Zhong, XP, and Carabana, J. "Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus." Immunol Res 22, no. 2-3 (2000): 127-135. (Review) Full Text Link to Item
  - Zhong, XP, Carabaña, J, and Krangel, MS. "Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination." Proceedings of the National Academy of Sciences of the United States of America 96, no. 21 (October 1999): 11970-11975. Full Text
  - Zhong, XP, and Krangel, MS. "Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes." Journal of Immunology (Baltimore, Md. : 1950) 163, no. 1 (July 1999): 295-300.
  - Krangel, MS, Hernandez-Munain, C, Lauzurica, P, McMurry, M, Roberts, JL, and Zhong, XP. "Developmental regulation of V(D)J recombination at the TCR alpha/delta locus." Immunol Rev 165 (October 1998): 131-147. (Review) Link to Item
  - Zhong, XP, and Krangel, MS. "An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus." Proc Natl Acad Sci U S A 94, no. 10 (May 13, 1997): 5219-5224. Link to Item
  - Lauzurica, P, Zhong, XP, Krangel, MS, and Roberts, JL. "Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2." The Journal of Experimental Medicine 185, no. 7 (April 1997): 1193-1201. Full Text
  - Gorentla, BK, and Zhong, XP. "T cell Receptor Signal Transduction in T lymphocytes." J Clin Cell Immunol 2012, no. (Suppl 12). (Review)
  - Krishna, S, and Zhong, XP. "Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function." Front Immunol 4, no. 178. (Review)
  - Krishna, S, and Zhong, XP. "Role of diacylglycerol kinases in T cell development and function." Crit Rev Immunol 33, no. 2: 97-118. (Review)
  - Wheeler, ML, Dong, MB, Brink, R, Zhong, XP, and Defranco, AL. "Diacylglycerol Kinase ζ Limits B Cell Antigen Receptor-Dependent Activation of ERK Signaling to Inhibit Early Antibody Responses." Sci Signal 6, no. 297. (Academic Article)
  - Wu, J, Shen, S, Yang, J, Xia, Z, and Zhong, XP. "Diacylglycerol Kinase Zeta Positively Controls the Development of iNKT-17 Cells." PLoS One 8, no. 9. (Academic Article)
- Other Articles
  - Zhong, P, Xing, F, Huang, X, Zhu, H, Lo, HW, Zhong, X, Pruitt, S, and Robertson, C. "HIFU as a neoadjuvant therapy in cancer treatment." AIP Conference Proceedings 1359 (2011): 289-294. Full Text

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