Xiaoyan Li

Journal Article Amyotroph Lateral Scler Frontotemporal Degener · May 2026 Pyridostigmine (Mestinon®, Bausch Health, Canada Inc.) increases acetylcholine availability at the neuromuscular junction, enhancing transmission. Preclinical studies suggest that neuromuscular junction dysfunction develops early in ALS, and pyridostigmine ... Full text Link to item Cite

ALSUntangled #82: N-acetylcysteine.

Journal Article Amyotroph Lateral Scler Frontotemporal Degener · March 4, 2026 N-acetylcysteine is a thiol-containing compound and a precursor of glutathione, with mechanistic plausibility for ALS, including reducing oxidative stress, regulating neuroinflammation, and mitigating mitochondrial dysfunction. Preclinical studies have yie ... Full text Link to item Cite

ALSUntangled #79: alpha-lipoic acid.

Journal Article Amyotroph Lateral Scler Frontotemporal Degener · February 2026 Alpha-lipoic acid (ALA) is a naturally occurring fatty acid. It serves as an essential cofactor for enzymatic reactions in mitochondrial energy production, is a potent antioxidant and has anti-inflammatory effects, which are plausible mechanisms in slowing ... Full text Link to item Cite

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Recent Grants

Clinical Research in ALS & related disorders for Therapeutic Development (CReATe)

ResearchPrincipal Investigator · Awarded by University of Miami · 2025 - 2030

A randomized, double-blind, placebo-controlled parallel group study of VHB937 in Amyotrophic Lateral Sclerosis (ALS) over 40 weeks followed by an Open-label Extension (ASTRALS)

Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2024 - 2028

ALL ALS Consortium - ASSESS Task Order

ResearchPrincipal Investigator · Awarded by MGH Institute of Health Professionals · 2024 - 2027

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Education

Peking Union Medical College (China) · 2002 Ph.D.

Shandong Medical University (China) · 1999 M.S.

Taishan Medical University (China) · 1996 M.D.