Current Appointments & Affiliations
Assistant Professor of Neurology
·
2020 - Present
Neurology, Neuromuscular Disease,
Neurology
Recent Publications
ALSUntangled #81: Pyridostigmine (mestinon®).
Journal Article Amyotroph Lateral Scler Frontotemporal Degener · November 6, 2025 Pyridostigmine (Mestinon®, Bausch Health, Canada Inc.) increases acetylcholine availability at the neuromuscular junction, enhancing transmission. Preclinical studies suggest that neuromuscular junction dysfunction develops early in ALS, and pyridostigmine ... Full text Link to item CiteOperational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings From the First Four Regimens of the HEALEY ALS Platform Trial.
Journal Article Muscle Nerve · August 2025 INTRODUCTION/AIMS: Platform trials present several advantages over traditional interventional clinical trials. Here, we provide a detailed description of the operational framework of the HEALEY ALS Platform Trial. METHODS: Platform-level procedures for reg ... Full text Link to item CiteSafety and efficacy of trehalose in amyotrophic lateral sclerosis (HEALEY ALS Platform Trial): an adaptive, phase 2/3, double-blind, randomised, placebo-controlled trial.
Journal Article Lancet Neurol · June 2025 BACKGROUND: Trehalose is a disaccharide that activates autophagy pathways in animal models of neurodegenerative diseases, with the potential to catalyse clearance of toxic, misfolded proteins in motor neurons and slow disease progression in amyotrophic lat ... Full text Link to item CiteRecent Grants
A randomized, double-blind, placebo-controlled parallel group study of VHB937 in Amyotrophic Lateral Sclerosis (ALS) over 40 weeks followed by an Open-label Extension (ASTRALS)
Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2024 - 2028ALL ALS Consortium - ASSESS Task Order
ResearchPrincipal Investigator · Awarded by MGH Institute of Health Professionals · 2024 - 2027ALL ALS Consortium - PREVENT Task Order
ResearchPrincipal Investigator · Awarded by MGH Institute of Health Professionals · 2024 - 2027View All Grants
Education, Training & Certifications
Peking Union Medical College (China) ·
2002
Ph.D.
Shandong Medical University (China) ·
1999
M.S.
Taishan Medical University (China) ·
1996
M.D.