Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Shanghai Jiao Tong University (China) 2015
  • Fellowship, Pain Management, Shanghai Jiao Tong University (China) 2007 - 2008
  • Resident, Pain Management, Shanghai Jiao Tong University (China) 2002 - 2007
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  Previous Appointments & Affiliations

  • Assistant Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2020 - 2021
• Research
• 

  Selected Grants

  • A novel clinically- relevant mouse model of chronic overlapping pain conditions for screening analgesics awarded by National Institutes of Health 2022 - 2023
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Wang, Yaomin, Scott A. Scarneo, Shin Hyung Kim, Xin Zhang, Jiegen Chen, Kelly W. Yang, Philip Hughes, Timothy Haystead, and Andrea G. Nackley. “Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain.” Pain 163, no. 6 (June 1, 2022): 1091–1101. https://doi.org/10.1097/j.pain.0000000000002511.
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    • Wang, Yi-Wei, Liang Wang, Sheng-Jie Yuan, Yuan Zhang, Xin Zhang, and Le-Ting Zhou. “Postoperative Cognitive Dysfunction and Alzheimer's Disease: A Transcriptome-Based Comparison of Animal Models.” Front Aging Neurosci 14 (2022): 900350. https://doi.org/10.3389/fnagi.2022.900350.
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    • Zhang, X., L. Xu, X. Chen, X. Zhou, and L. Cao. “Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury.” Translational Neuroscience 13, no. 1 (January 1, 2022): 483–94. https://doi.org/10.1515/tnsci-2022-0266.
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    • Zhang, Xin, Katie Kanter, Jiegen Chen, Seungtae Kim, Yaomin Wang, Clementine Adeyemi, Sandra C. O’Buckley, and Andrea G. Nackley. “Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice.” Pain 161, no. 2 (February 2020): 446–58. https://doi.org/10.1097/j.pain.0000000000001734.
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    • Pu, Shaofeng, Junzhen Wu, Qingjian Han, Xin Zhang, Yingying Lv, Yongming Xu, Chen Li, and Dongping Du. “Ultrasonography-Guided Radiofrequency Ablation for Painful Stump Neuromas to Relieve Postamputation Pain: A Pilot Study.” J Pain Res 13 (2020): 3437–45. https://doi.org/10.2147/JPR.S283986.
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    • Zhang, Xin, Haifeng Shi, Jin Zhou, Yongming Xu, Shaofeng Pu, Yingying Lv, Junzhen Wu, Yueping Cheng, and Dongping Du. “The effectiveness of ultrasound-guided cervical transforaminal epidural steroid injections in cervical radiculopathy: a prospective pilot study.” J Pain Res 12 (2019): 171–77. https://doi.org/10.2147/JPR.S181915.
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    • Han, Qingjian, Di Liu, Marino Convertino, Zilong Wang, Changyu Jiang, Yong Ho Kim, Xin Luo, et al. “miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.” Neuron 99, no. 3 (August 8, 2018): 449-463.e6. https://doi.org/10.1016/j.neuron.2018.06.039.
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    • Guo, Yong, Yinan Zhang, Peiyu Jia, Wenying Wang, Quanhong Zhou, Lulu Sun, Aihua Zhao, et al. “Preoperative Serum Metabolites Are Associated With Postoperative Delirium in Elderly Hip-Fracture Patients.” J Gerontol a Biol Sci Med Sci 72, no. 12 (November 9, 2017): 1689–96. https://doi.org/10.1093/gerona/glx001.
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    • Zhang, X., Y. Xu, J. Zhou, S. Pu, Y. Lv, Y. Chen, and D. Du. “Ultrasound-guided alcohol neurolysis and radiofrequency ablation of painful stump neuroma: Effective treatments for post-amputation pain.” Journal of Pain Research 10 (February 3, 2017): 295–302. https://doi.org/10.2147/JPR.S127157.
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    • Tian, J. G., T. T. Yu, X. Zhang, and D. P. Du. “Construction of a rat tibial neuroma transposition model and changes of neurotrophin expressions in the nervous system.” Journal of Shanghai Jiaotong University (Medical Science) 37, no. 1 (January 28, 2017): 1–6. https://doi.org/10.3969/j.issn.1674-8115.2017.01.001.
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    • Sun, L., P. Jia, J. Zhang, X. Zhang, Y. Zhang, H. Jiang, W. Jiang, and Y. Guo. “Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium.” Neuropsychiatric Disease and Treatment 12 (October 27, 2016): 2789–95. https://doi.org/10.2147/NDT.S113077.
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    • Wu, Xiao-Bo, De-Li Cao, Xin Zhang, Bao-Chun Jiang, Lin-Xia Zhao, Bin Qian, and Yong-Jing Gao. “CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain.” Sci Rep 6 (October 6, 2016): 34836. https://doi.org/10.1038/srep34836.
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    • Xu, Yongming, Guangxia Cheng, Yanrong Zhu, Xin Zhang, Shaofeng Pu, Junzhen Wu, Yingying Lv, and Dongping Du. “Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain.” Acta Biochim Biophys Sin (Shanghai) 48, no. 10 (October 2016): 902–8. https://doi.org/10.1093/abbs/gmw083.
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    • Zhang, Xin, Jing Wang, Tingting Yu, Dongping Du, and Wei Jiang. “Minocycline can delay the development of morphine tolerance, but cannot reverse existing tolerance in the maintenance period of neuropathic pain in rats.” Clin Exp Pharmacol Physiol 42, no. 1 (January 2015): 94–101. https://doi.org/10.1111/1440-1681.12316.
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    • Xu, Yongming, Xin Zhang, Shaofeng Pu, Junzhen Wu, Yingying Lv, and Dongping Du. “Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions.” Acta Biochimica Et Biophysica Sinica 46, no. 11 (November 2014): 942–49. https://doi.org/10.1093/abbs/gmu090.
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    • Bao, Yu-Hua, Quan-Hong Zhou, Rui Chen, Hao Xu, Lu-Lu Zeng, Xin Zhang, Wei Jiang, and Dong-Ping Du. “Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats.” J Mol Neurosci 54, no. 1 (September 2014): 137–46. https://doi.org/10.1007/s12031-014-0262-2.
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    • Zhou, Quanhong, Yuhua Bao, Xin Zhang, Lulu Zeng, Li Wang, Jing Wang, and Wei Jiang. “Optimal interval for hot water immersion tail-flick test in rats.” Acta Neuropsychiatr 26, no. 4 (August 2014): 218–22. https://doi.org/10.1017/neu.2013.57.
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    • Xu, Jie, Ming-Di Zhu, Xin Zhang, Hao Tian, Jin-Hua Zhang, Xiao-Bo Wu, and Yong-Jing Gao. “NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice.” J Neuroinflammation 11 (March 1, 2014): 38. https://doi.org/10.1186/1742-2094-11-38.
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    • Bao, Yu-Hua, Quan-Hong Zhou, Rui Chen, Hao Xu, Lulu Zeng, Xin Zhang, Wei Jiang, and Dongping Du. “Gabapentin attenuates morphine tolerance through interleukin-10.” Neuroreport 25, no. 2 (January 22, 2014): 71–76. https://doi.org/10.1097/WNR.0b013e328363fde8.
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    • Zhang, Xin, Lulu Zeng, Tingting Yu, Yongming Xu, Shaofeng Pu, Dongping Du, and Wei Jiang. “Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation.” Cell Physiol Biochem 34, no. 3 (2014): 715–23. https://doi.org/10.1159/000363036.
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    • Zhou, Quanhong, Jing Wang, Xin Zhang, Lulu Zeng, Li Wang, and Wei Jiang. “Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain.” Eur J Pharmacol 718, no. 1–3 (October 15, 2013): 17–23. https://doi.org/10.1016/j.ejphar.2013.09.009.
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    • Pu, Shaofeng, Yongming Xu, Dongping Du, Meirong Yang, Xin Zhang, Junzhen Wu, and Wei Jiang. “Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model.” J Physiol Biochem 69, no. 3 (September 2013): 349–57. https://doi.org/10.1007/s13105-012-0217-4.
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    • Hui, Jie, Zhi-Jun Zhang, Xin Zhang, Yan Shen, and Yong-Jing Gao. “Repetitive hyperbaric oxygen treatment attenuates complete Freund's adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord.” J Pain 14, no. 7 (July 2013): 747–58. https://doi.org/10.1016/j.jpain.2013.02.003.
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    • Wang, Jing, Lulu Zeng, Quanhong Zhou, Yongming Xu, Shaofeng Pu, Wei Jiang, Xin Zhang, and Dongping Du. “L6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of GFAP on ipsilateral dorsal horn.” Acta Neurochir (Wien) 155, no. 5 (May 2013): 935–40. https://doi.org/10.1007/s00701-012-1616-6.
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    • Quanhong, Zhou, Xue Ying, Chen Moxi, Xu Tao, Wang Jing, Zhang Xin, Wang Li, Cui Derong, Zhang Xiaoli, and Jiang Wei. “Intrathecal PLC(β3) oligodeoxynucleotides antisense potentiates acute morphine efficacy and attenuates chronic morphine tolerance.” Brain Res 1472 (September 7, 2012): 38–44. https://doi.org/10.1016/j.brainres.2012.06.030.
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    • Zeng, L. L., J. Wang, X. Zhang, W. Jiang, and D. P. Du. “Neuregulin1/erbB and neuropathic pain.” Journal of Shanghai Jiaotong University (Medical Science) 32, no. 8 (August 1, 2012): 1097–1100. https://doi.org/10.3969/j.issn.1674-8115.2012.08.029.
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    • Zhang, Zhi-Jun, Lin-Xia Zhao, De-Li Cao, Xin Zhang, Yong-Jing Gao, and Chunlin Xia. “Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.” Cell Mol Neurobiol 32, no. 6 (August 2012): 1003–10. https://doi.org/10.1007/s10571-012-9816-4.
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    • Zeng, L. L., J. Wang, X. Zhang, Q. H. Zhou, W. Jiang, and D. P. Du. “Effects of intrathecal injection of exogenous BDNF-activated astrocytes on pain sensation of normal rats.” Journal of Shanghai Jiaotong University (Medical Science) 32, no. 7 (July 1, 2012): 881–85. https://doi.org/10.3969/j.issn.1674-8115.2012.07.013.
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    • Wang, J., X. Zhang, W. Jiang, and D. P. Du. “Contribution of BDNF/TrkB pathway to development of neuropathic pain by activation of astrocytes in rats.” Journal of Shanghai Jiaotong University (Medical Science) 32, no. 3 (March 1, 2012): 279–82.
    • Zhang, Xin, Yongming Xu, Jing Wang, Quanhong Zhou, Shaofeng Pu, Wei Jiang, and Dongping Du. “The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats.” J Neural Transm (Vienna) 119, no. 3 (March 2012): 329–36. https://doi.org/10.1007/s00702-011-0713-7.
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    • Zhang, X., J. Wang, Q. Zhou, Y. Xu, S. Pu, J. Wu, Y. Xue, et al. “Brain-derived neurotrophic factor-activated astrocytes produce mechanical allodynia in neuropathic pain.” Neuroscience 199 (December 29, 2011): 452–60. https://doi.org/10.1016/j.neuroscience.2011.10.017.
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    • Wang, J., X. Zhang, D. P. Du, and W. Jiang. “Effects of BDNF on activation of spinal dorsal horn astrocytes in rats with spinal nerve ligation.” Journal of Shanghai Jiaotong University (Medical Science) 31, no. 11 (December 14, 2011): 1578–82. https://doi.org/10.3969/j.issn.1674-8115.2011.11.016.
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    • Wang, L., B. Wu, Y. Sun, T. Xu, X. Zhang, M. Zhou, and W. Jiang. “Translocation of protein kinase C isoforms is involved in propofol-induced endothelial nitric oxide synthase activation.” British Journal of Anaesthesia 104, no. 5 (January 1, 2010): 606–12. https://doi.org/10.1093/bja/aeq064.
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