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Yang Sheng

Assistant Professor of Radiation Oncology
Radiation Oncology

Overview


My research interest focuses on machine learning and AI application in radiation oncology treatment planning, including prostate cancer, head-and-neck cancer and pancreatic cancer etc.

Current Duke Appointments & Affiliations


Assistant Professor of Radiation Oncology · 2022 - Present Radiation Oncology, Clinical Science Departments

Recent Scholarly Works


Feasibility study of a machine learning inspired approach for VMAT optimization.

Journal article Med Phys · April 2026 BACKGROUND: Despite the widespread clinical adoption of volumetric modulated arc therapy (VMAT), advances in its fundamental optimization methodology have remained relatively limited, particularly with respect to open and researcher-accessible optimization ... Full text Link to item Cite

Prescription tradeoff decision support for pancreas stereotactic body radiation therapy: From templates to artificial intelligence models

Journal article Radiation Medicine and Protection · April 1, 2026 Objective: To develop an artificial intelligence (AI) driven plan tradeoff decision making assistant for radiation oncologists. Methods: A user interface (UI) was developed to integrate the assistant with the treatment planning system to facilitate prescri ... Full text Cite

Accuracy of Photon Dose Calculation on Photon-Counting Computed Tomography-A Comparison Study Based on Virtual Monoenergetic and Electron Density (Rho) Images for Pancreatic Cases.

Journal article Adv Radiat Oncol · February 2026 PURPOSE: Photon-counting computed tomography (PCCT) offers versatile anatomic information because of better energy discrimination and higher spatial resolution than conventional energy-integrating computed tomography (CT). With its rapid applications in di ... Full text Link to item Cite
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Recent Grants


Strategizing Beam-Arc Placement and Dominance Choice for RapidArc Dynamic Delivery

ResearchPrincipal Investigator · Awarded by Varian Medical Systems, Inc. · 2025 - 2027

Understanding Human-Robot Interaction of Artificial Intelligence (AI) Tool in Radiation Oncology: An application of Breast Cancer Treatment Planning Agent

ResearchPrincipal Investigator · Awarded by American Association of Physicists in Medicine · 2021 - 2023

Clinical Experience Guided Reinforcement Learning for Pancreas SBRT

ResearchCollaborating Investigator · Awarded by Varian Medical Systems, Inc. · 2019 - 2022

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Education


Duke University · 2017 Ph.D.
Duke University · 2014 M.S.