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Yang Sheng

Assistant Professor of Radiation Oncology
Radiation Oncology

Overview


My research interest focuses on machine learning and AI application in radiation oncology treatment planning, including prostate cancer, head-and-neck cancer and pancreatic cancer etc.

Current Appointments & Affiliations


Assistant Professor of Radiation Oncology · 2022 - Present Radiation Oncology, Clinical Science Departments

Recent Publications


Foresight planning: Radiotherapy plan optimization via self-supervised model predictive control.

Journal Article Med Phys · November 2025 BACKGROUND: Treatment planning for intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) relies on meticulous operation of the inverse optimization, a complex and iterative process of adjusting dose-volume objectives to a ... Full text Link to item Cite

A technique for achieving arbitrary machine dose rates via MLC leaf motion modulation using fixed-gantry IMRT delivery mode.

Journal Article Med Phys · June 2025 BACKGROUND: The medical linear accelerator (Linac) typically operates at a constant but discrete dose rate for both 3D conformal fields and intensity modulation radiotherapy (IMRT) fields. However, in certain clinical and radiobiological scenarios, such as ... Full text Link to item Cite

A machine learning toolkit assisted approach for IMRT fluence map optimization: feasibility and advantages.

Journal Article Biomed Phys Eng Express · April 22, 2025 Purpose. Traditional machine learning (ML) and deep learning (DL) applications in treatment planning rely on complex model architectures and large, high-quality training datasets. However, they cannot fully replace the conventional optimization process. Th ... Full text Link to item Cite
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Recent Grants


Strategizing Beam-Arc Placement and Dominance Choice for RapidArc Dynamic Delivery

ResearchPrincipal Investigator · Awarded by Varian Medical Systems, Inc. · 2025 - 2027

Understanding Human-Robot Interaction of Artificial Intelligence (AI) Tool in Radiation Oncology: An application of Breast Cancer Treatment Planning Agent

ResearchPrincipal Investigator · Awarded by American Association of Physicists in Medicine · 2021 - 2023

Clinical Experience Guided Reinforcement Learning for Pancreas SBRT

ResearchCollaborating Investigator · Awarded by Varian Medical Systems, Inc. · 2019 - 2022

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Education, Training & Certifications


Duke University · 2017 Ph.D.
Duke University · 2014 M.S.