Scholars@Duke
Yarui Diao

Yarui Diao

Associate Professor of Cell Biology
Cell Biology
406 Sands Building, Durham, NC 27710

Scholarly Works - Conferences

Abstract We0039: Integration of Genome-Wide Association Studies with Single Cell Chromatin Accessibility Data Identifies a Fibro-Adipogenic Progenitor (FAP) Enhancer and Mmp1 and Mmp3 as Novel Targets for PAD.

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · April 2025 Introduction: Peripheral arterial disease (PAD), which affects more than 200 million individuals worldwide, is a complex disease caused by a myriad of environmental and poorly understood genetic facto ... Full text Cite

Abstract We0086: Transcriptomic Profiling Links Senescent Fibro-Adipogenic Progenitors to Amputation and Mortality in Human Chronic Limb Threatening Ischemia Patients

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · April 2025 Introduction: Chronic limb threatening ischemia (CLTI), the most advanced stage of peripheral arterial disease (PAD), is associated with high rates of amputation and mortality. Despite significant imp ... Full text Cite

Abstract We0085: Senescent Cells Accumulate in the Ischemic Limb

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · April 2025 Introduction: Skeletal muscle health and function are critical determinants of clinical outcomes in peripheral arterial disease (PAD). Unfortunately, the mechanism that governs failed muscle regenerat ... Full text Cite

Abstract 142: Nr3c1-Sfrp1 Axis Regulates The Adipogenic Differentiation Of Vcam1+ Fibro-adipogenic Progenitors In Chronic Limb Threatening Ischemia

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · May 2024 Introduction: Skeletal muscle health and function is a critical determinant of clinical outcomes in peripheral arterial disease (PAD). Fatty infiltration, the ectopic deposition of adipose tissue with ... Full text Cite

Abstract 18426: Secreted Frizzled-Related Protein 1 Mediates Adipogenic Differentiation of Vascular Cell Adhesion Protein 1 Fibroadipogenic Progenitors in the Ischemic Limb

Conference Circulation · November 7, 2023 Introduction: Chronic limb threatening ischemia (CLTI) patients display a skeletal muscle myopathy that is hallmarked by fatty infiltration. The replacement of functional muscle fibers with adipocytes ... Full text Cite

Abstract 604: Distinct Fibroadipogenic Progenitor Populations And Trajectories Characterize Regenerative And Non-regenerative Responses In The Ischemic Limb

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · May 2023 Introduction: Skeletal muscle possesses the capacity for self-repair. This ability is impaired in chronic limb threatening ischemia (CLTI) patients. Myopathy in CLTI patients is associated with advers ... Full text Cite

Abstract 134: A Single-cell Atlas Of Human Skeletal Muscle Tissue In Chronic Limb-threatening Ischemia

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · May 2023 Introduction: Chronic limb-threatening ischemia (CLTI) represents end-stage peripheral arterial disease (PAD) and is a significant cause of limb amputation and mortality. Evidence supports the importa ... Full text Cite

Abstract 267: Altered Macrophage Response Associated With Impaired Skeletal Muscle Regeneration In Murine Model Of Limb Ischemia

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · May 2022 Introduction: Skeletal muscle regeneration in the ischemic limb is a complex complex process dependent on coordinated intercellular communication involving an array of cell types. These interactions a ... Full text Cite

Abstract 266: Distinct Satellite Cell Trajectories Characterize Regenerative And Non-regenerative Responses In The Ischemic Limb

Conference Arteriosclerosis, Thrombosis, and Vascular Biology · May 2022 Introduction: Skeletal muscle regeneration is a critical determinant of outcomes in the ischemic limb. The precise mechanisms of skeletal muscle recovery in the ischemic limb remain unknown. A major h ... Full text Cite