Overview
My research interest is in statistical genetics, including statistical method development and its application for understanding the genetic predisposition of human complex diseases. Here is the list of research topics:
- Statistical genetics: development of family-based association methods for quantitative traits with or without censoring and for detecting X-linked genes for disease risk. With the availability of next generation sequencing data, we have ongoing projects to develop the association methods for testing rare variants for different phenotypic measures.
- Genetics of Alzheimer's disease (AD) and Fuchs endothelial corneal dystrophy (FECD).
- Genetic basis of age-at-onset of Alzheimer disease.
- Peri-operative genomic studies. Investigate the genetic risk factors for postoperative outcomes of patients underwent non-emergent coronary artery bypass grafting with cardiopulmonary bypass.
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
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2021 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Member of Duke Molecular Physiology Institute
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2014 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Editorial: Cephalosporin-Induced Liver Injury-Interesting but Tricky. Authors' Reply.
Journal Article Aliment Pharmacol Ther · November 2025 Full text Link to item CiteTreating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet.
Journal Article Hypertension · October 27, 2025 BACKGROUND: The rice diet (RD), a low-sodium (<150 mg/d), low-protein (20 g/d), and low-fat (<5 g/d) diet was used to treat patients with malignant hypertension beginning in the 1940s, before any effective antihypertensive drugs were available. We retrospe ... Full text Link to item CiteRight Ventricle-Pulmonary Artery Coupling and Major Morbidity and Operative Mortality After Cardiac Surgery.
Journal Article Anesth Analg · October 1, 2025 BACKGROUND: The right ventricle-pulmonary artery (RV-PA) coupling ratio provides an assessment of RV function indexed to PA afterload. A low preoperative RV-PA ratio has been associated with increased mortality after transcatheter procedures. In patients u ... Full text Link to item CiteRecent Grants
Drug Induced Liver Injury Network Data Coordinating Center
ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2028Proteomic Biomarkers Predicting Osteoarthritis Onset and Progression
ResearchCo Investigator · Awarded by Department of Defense · 2025 - 2027Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)
Clinical TrialBiostatistician · Awarded by National Institute on Aging · 2021 - 2026View All Grants