Overview
My research interest is in statistical genetics, including statistical method development and its application for understanding the genetic predisposition of human complex diseases. Here is the list of research topics:
- Statistical genetics: development of family-based association methods for quantitative traits with or without censoring and for detecting X-linked genes for disease risk. With the availability of next generation sequencing data, we have ongoing projects to develop the association methods for testing rare variants for different phenotypic measures.
- Genetics of Alzheimer's disease (AD) and Fuchs endothelial corneal dystrophy (FECD).
- Genetic basis of age-at-onset of Alzheimer disease.
- Peri-operative genomic studies. Investigate the genetic risk factors for postoperative outcomes of patients underwent non-emergent coronary artery bypass grafting with cardiopulmonary bypass.
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
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2021 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Member of Duke Molecular Physiology Institute
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2014 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
DRESS syndrome in patients with drug-induced liver injury: Characteristics and HLA risk factors.
Journal Article Am J Gastroenterol · June 12, 2025 INTRODUCTION: Drug reaction with eosinophilia and systemic symptoms (DRESS) can sometimes occur in patients with drug-induced liver injury (DILI). However, detailed studies of DRESS in patients with DILI from the US are lacking. We investigated the charact ... Full text Link to item CiteDrug-induced Liver Injury Due to Medications for Alcohol Use Disorder: Results From the DILIN Prospective Study.
Journal Article J Addict Med · May 2025 OBJECTIVES: Concerns about drug-induced liver injury (DILI) may deter physicians from prescribing medications for alcohol use disorder (MAUD). We aim to explore DILI due to MAUD in Drug-Induced Liver Injury Network (DILIN) prospective study. METHODS: High- ... Full text Link to item CiteTreating malignant hypertension with a low-sodium, low-protein, low-fat diet
Preprint · April 3, 2025 Full text CiteRecent Grants
Drug Induced Liver Injury Network Data Coordinating Center
ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2028Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)
Clinical TrialBiostatistician · Awarded by National Institute on Aging · 2021 - 2026Duke Testing Site for Stroke Preclinical Assessment Network
ResearchBiostatistician · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2025View All Grants