Overview
My research interest is in statistical genetics, including statistical method development and its application for understanding the genetic predisposition of human complex diseases. Here is the list of research topics:
- Statistical genetics: development of family-based association methods for quantitative traits with or without censoring and for detecting X-linked genes for disease risk. With the availability of next generation sequencing data, we have ongoing projects to develop the association methods for testing rare variants for different phenotypic measures.
- Genetics of Alzheimer's disease (AD) and Fuchs endothelial corneal dystrophy (FECD).
- Genetic basis of age-at-onset of Alzheimer disease.
- Peri-operative genomic studies. Investigate the genetic risk factors for postoperative outcomes of patients underwent non-emergent coronary artery bypass grafting with cardiopulmonary bypass.
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
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2021 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Member of Duke Molecular Physiology Institute
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2014 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Liver Injury due to Intravenous Methylprednisolone in the Drug-Induced Liver Injury Network.
Journal Article Liver Int · February 2025 BACKGROUND AND AIMS: Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network (DI ... Full text Link to item CiteZim4rv: an R package to modeling zero-inflated count phenotype on regional-based rare variants.
Journal Article BMC Bioinformatics · January 16, 2025 BACKGROUND: With the advance of next-generation sequencing, various gene-based rare variant association tests have been developed, particularly for binary and continuous phenotypes. In contrast, fewer methods are available for traits not following binomial ... Full text Link to item CiteDrug-induced Liver Injury Due to Medications for Alcohol Use Disorder: Results From the DILIN Prospective Study.
Journal Article J Addict Med · December 9, 2024 OBJECTIVES: Concerns about drug-induced liver injury (DILI) may deter physicians from prescribing medications for alcohol use disorder (MAUD). We aim to explore DILI due to MAUD in Drug-Induced Liver Injury Network (DILIN) prospective study. METHODS: High- ... Full text Link to item CiteRecent Grants
Predictors of Pain Severity and Pain-Related Outcomes in Individuals with Sickle Cell Disease
ResearchCo-Mentor · Awarded by National Heart, Lung, and Blood Institute · 2023 - 2028Drug Induced Liver Injury Network Data Coordinating Center
ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2028Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)
Clinical TrialBiostatistician · Awarded by National Institute on Aging · 2021 - 2026View All Grants