Yi-Ju Li | Scholars@Duke

Yi-Ju Li
Professor of Biostatistics & Bioinformatics

My research interest is in statistical genetics, primarily in statistical method development and its application for genetic research of human complex diseases. Here is the list of research topics:

Statistical genetics: I have involved in the development of several family-based association methods for quantitative traits with or without censoring, and for detecting X-linked genes. With the availability of next generation sequencing data, we have ongoing projects to develop the association methods for testing rare variants in terms of censored phenotype and multiple traits.
Genetics of Fuchs dystrophy, myopia, Alzheimer, and Parkinson diseases.
Genetic basis of age-at-onset of Alzheimer disease.
Perioperative genomic studies. Investigate the genetic risk factors for postoperative outcomes of patients underwent non-emergent coronary artery bypass grafting with cardiopulmonary bypass.

Current Appointments & Affiliations

Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2021
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2014

Contact Information

300 North Duke Street, 47-122 Carmichael Warehouse, Durham, NC 27701
Duke Box 104775, Durham, NC 27708
yiju.li@duke.edu (919) 684-0604
Li webpage

Background
Education, Training, & Certifications
- Ph.D., North Carolina State University 1996
Duke Appointment History
- Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2020 - 2021
- Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2020
- Associate Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2010 - 2020
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2019 - 2020
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2010 - 2019
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2008 - 2010
- Assistant Professor of Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2008 - 2010
- Assistant Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2006 - 2008
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2007 - 2008
- Assistant Research Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2002 - 2006
- Instructor, Temporary in the Department of Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2002
Expertise
Subject Headings
Research
Selected Grants
- Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF) awarded by National Institutes of Health 2021 - 2026
- Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers awarded by National Institutes of Health 2021 - 2025
- Mast cell activation as a determinant of neurologic injury after cardiac arrest awarded by National Institutes of Health 2020 - 2022
- Genetic basis of age-at-onset of Alzheimer disease awarded by University of Miami 2018 - 2022
- Coordinating Center for the Drug Induced Liver Injury Network (DILIN) awarded by National Institutes of Health 2003 - 2022
- Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health 2016 - 2022
- OPTIMIZING OUTPATIENT ANESTHESIA: IMPROVING ANALGESIA AND REDUCING OPIOID MISADVENTURE awarded by National Institutes of Health 2018 - 2021
- Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke awarded by BioMimetix JV LLC 2019 - 2021
- Qualification of Prognostic and Diagnostic Biomarkers of Knee Osteoarthritis awarded by National Institutes of Health 2017 - 2021
- The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research 2019 - 2021
- Extracellular Vesicles and Their Role in Hallmarks of Aging awarded by National Institutes of Health 2018 - 2020
- A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2020
- Platelets as regulators of inflammation and tissue injury after cardiac surgery awarded by American Heart Association 2015 - 2019
External Relationships
- Anesthesiology; journal for the research field in Anesthesiology.
- Hong Kong Grant Research Council
- Kidney International
- North Carolina-Taiwan Professional and Scholar Society (NCT-PASS)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Vuppalanchi, Raj, Herbert L. Bonkovsky, Jawad Ahmad, Huiman Barnhart, Francisco Durazo, Robert J. Fontana, Jiezhun Gu, et al. “Garcinia Cambogia, Either Alone or in Combination with Green Tea Causes Moderate to Severe Liver Injury.” Clin Gastroenterol Hepatol, August 13, 2021. https://doi.org/10.1016/j.cgh.2021.08.015.
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  - Fontana, Robert J., Yi-Ju Li, Elizabeth Phillips, Naba Saeed, Huiman Barnhart, David Kleiner, Jay Hoofnagle, and Jay Drug Induced Liver Injury Network. “Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles.” Liver Int 41, no. 8 (August 2021): 1884–93. https://doi.org/10.1111/liv.14903.
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  - Hoofnagle, Jay H., Herbert L. Bonkovsky, Elizabeth J. Phillips, Yi-Ju Li, Jawad Ahmad, Huiman Barnhart, Francisco Durazo, et al. “HLA-B*35:01 and Green Tea-Induced Liver Injury.” Hepatology (Baltimore, Md.) 73, no. 6 (June 2021): 2484–93. https://doi.org/10.1002/hep.31538.
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  - Bickhaus, J. A., M. S. Bradley, C. L. Amundsen, A. G. Visco, T. Truong, Y. J. Li, and N. Y. Siddiqui. “Does a recent urinary tract infection increase the risk of postprocedure urinary tract infection after onabotulinum toxin a?” Obstetrical and Gynecological Survey 76, no. 5 (May 1, 2021): 267–68. https://doi.org/10.1097/01.ogx.0000751432.28331.65.
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  - Manning, Michael W., Yi-Ju Li, Dean Linder, John C. Haney, Yi-Hung Wu, Mihai V. Podgoreanu, Madhav Swaminathan, et al. “Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.” J Cardiothorac Vasc Anesth 35, no. 5 (May 2021): 1310–18. https://doi.org/10.1053/j.jvca.2020.11.036.
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  - Martin, Eden R., Xiaoyi R. Gao, and Yi-Ju Li. “An exploration of genetic association tests for disease risk and age at onset.” Genet Epidemiol 45, no. 3 (April 2021): 249–79. https://doi.org/10.1002/gepi.22368.
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  - Engel, C., A. L. Faulkner, D. W. Van Wyck, A. R. Zomorodi, N. K. K. King, R. A. Williamson Taylor, C. E. Hailey, et al. “Associations between Features of External Ventricular Drain Management, Disposition, and Shunt Dependence.” Journal of Neuroanaesthesiology and Critical Care 8, no. 1 (March 1, 2021): 28–33. https://doi.org/10.1055/s-0040-1710410.
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  - Bickhaus, Jennifer A., Megan S. Bradley, Cindy L. Amundsen, Anthony G. Visco, Tracy Truong, Yi-Ju Li, and Nazema Y. Siddiqui. “Does a Recent Urinary Tract Infection Increase the Risk of Postprocedure Urinary Tract Infection After Onabotulinum Toxin A?” Female Pelvic Med Reconstr Surg 27, no. 2 (February 1, 2021): 121–25. https://doi.org/10.1097/SPV.0000000000000753.
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  - Xu, Timothy T., Yi-Ju Li, Natalie A. Afshari, Ross A. Aleff, Tommy A. Rinkoski, Sanjay V. Patel, Leo J. Maguire, et al. “Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion.” Invest Ophthalmol Vis Sci 62, no. 1 (January 4, 2021): 17. https://doi.org/10.1167/iovs.62.1.17.
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  - Li, Yi-Ju, Elizabeth J. Phillips, Andrew Dellinger, Paola Nicoletti, Ryan Schutte, Danmeng Li, David A. Ostrov, et al. “Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury.” Hepatology 73, no. 1 (January 2021): 268–81. https://doi.org/10.1002/hep.31258.
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  - Melton, M Stephen, Yi-Ju Li, Richard Pollard, Zhengxi Chen, John Hunting, Thomas Hopkins, William Buhrman, et al. “Unplanned hospital admission after ambulatory surgery: a retrospective, single cohort study.” Can J Anaesth 68, no. 1 (January 2021): 30–41. https://doi.org/10.1007/s12630-020-01822-1.
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  - VanDusen, Keith W., Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J Will Thompson, M Arthur Moseley, et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis 80, no. 3 (2021): 1281–97. https://doi.org/10.3233/JAD-201544.
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  - Privratsky, Jamie R., Yi-Ju Li, Carol Haynes, Mihai Podgoreanu, Joseph Mathew, Svati H. Shah, and Mark Stafford-Smith. “Apolipoprotein L1 (APOL1) Coding Variants Are Associated With Creatinine Rise After Cardiac Surgery.” J Cardiothorac Vasc Anesth 34, no. 12 (December 2020): 3314–20. https://doi.org/10.1053/j.jvca.2020.04.017.
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  - Bickhaus, Jennifer A., Monique Vaughan, Tracy Truong, Yi-Ju Li, and Nazema Y. Siddiqui. “A comparison of antibiotic prophylaxis regimens to decrease the risk of post-procedure urinary tract infection after onabotulinum toxin A injection.” Int Urogynecol J 31, no. 9 (September 2020): 1907–12. https://doi.org/10.1007/s00192-020-04230-7.
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  - Hawkins, Nicole N., Agnes M. Lamon, Yi-Ju Li, Chad Grotegut, and Ashraf S. Habib. “Analgesic use after vaginal delivery in women with perineal lacerations: a retrospective cohort study.” Curr Med Res Opin 36, no. 6 (June 2020): 1009–13. https://doi.org/10.1080/03007995.2020.1754185.
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  - Cherry, Anne D., Jennifer N. Hauck, Benjamin Y. Andrew, Yi-Ju Li, Jamie R. Privratsky, Lakshmi D. Kartha, Alina Nicoara, Annemarie Thompson, Joseph P. Mathew, and Mark Stafford-Smith. “Intraoperative renal resistive index threshold as an acute kidney injury biomarker.” J Clin Anesth 61 (May 2020): 109626. https://doi.org/10.1016/j.jclinane.2019.109626.
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  - Haraden, Collin A., Janet L. Huebner, Ming-Feng Hsueh, Yi-Ju Li, and Virginia Byers Kraus. “Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation.” Arthritis Res Ther 21, no. 1 (June 13, 2019): 146. https://doi.org/10.1186/s13075-019-1923-x.
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  - Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.
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  - Cirulli, Elizabeth T., Paola Nicoletti, Karen Abramson, Raul J. Andrade, Einar S. Bjornsson, Naga Chalasani, Robert J. Fontana, et al. “A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.” Gastroenterology 156, no. 6 (May 2019): 1707-1716.e2. https://doi.org/10.1053/j.gastro.2019.01.034.
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  - Hashmi, Nazish K., Kamrouz Ghadimi, Amudan J. Srinivasan, Yi-Ju Li, Robert D. Raiff, Jeffrey G. Gaca, Adam G. Root, et al. “Three-factor prothrombin complex concentrates for refractory bleeding after cardiovascular surgery within an algorithmic approach to haemostasis.” Vox Sang 114, no. 4 (May 2019): 374–85. https://doi.org/10.1111/vox.12774.
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  - Xie, Yongqiu, Yi-Ju Li, Beilei Lei, Dawn Kernagis, Wen-Wei Liu, Ellen R. Bennett, Talagnair Venkatraman, et al. “Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.” Transl Stroke Res 10, no. 2 (April 2019): 231–39. https://doi.org/10.1007/s12975-018-0633-z.
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  - Qi, Wenjing, Andrew S. Allen, and Yi-Ju Li. “Family-based association tests for rare variants with censored traits.” Plos One 14, no. 1 (2019): e0210870. https://doi.org/10.1371/journal.pone.0210870.
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  - Huang, Z. Y., E. Perry, J. L. Huebner, B. Katz, Y. -. J. Li, and V. B. Kraus. “Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial.” Osteoarthritis Cartilage 26, no. 12 (December 2018): 1658–65. https://doi.org/10.1016/j.joca.2018.08.005.
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  - Peyser, Bruce, Emily P. Perry, Kavisha Singh, Rosalynn D. Gill, Michael R. Mehan, Susanne B. Haga, Michael D. Musty, et al. “Effects of Delivering SLCO1B1 Pharmacogenetic Information in Randomized Trial and Observational Settings.” Circ Genom Precis Med 11, no. 9 (September 2018): e002228. https://doi.org/10.1161/CIRCGEN.118.002228.
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  - Newcomb, Laura K., Megan S. Bradley, Tracy Truong, Michelle Tang, Bryan Comstock, Yi-Ju Li, Anthony G. Visco, and Nazema Y. Siddiqui. “Correlation of Virtual Reality Simulation and Dry Lab Robotic Technical Skills.” J Minim Invasive Gynecol 25, no. 4 (May 2018): 689–96. https://doi.org/10.1016/j.jmig.2017.11.006.
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  - Klinger, Rebecca Y., Olga G. James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.” Anesthesiology 128, no. 4 (April 2018): 728–44. https://doi.org/10.1097/ALN.0000000000002103.
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  - Keyhan, Sanaz, Tracy Truong, Yi-Ju Li, Tia Jackson-Bey, and Jennifer L. Eaton. “Preterm Delivery and Low Birth Weight Among Neonates Conceived With Intracytoplasmic Sperm Injection Compared With Conventional In Vitro Fertilization.” Obstet Gynecol 131, no. 2 (February 2018): 262–68. https://doi.org/10.1097/AOG.0000000000002423.
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  - El Husseini, Nada, Benjamin M. Hoffman, Ellen R. Bennett, Yen-Wei Li, Rachel A. Williamson Taylor, Claire E. Hailey, Kara Richardson, Yi-Ju Li, Daniel T. Laskowitz, and Michael L. James. “Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.” J Stroke Cerebrovasc Dis 27, no. 1 (January 2018): 125–31. https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.08.017.
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  - Sibley, Alexander, Zhiguo Li, Yu Jiang, Yi-Ju Li, Cliburn Chan, Andrew Allen, and Kouros Owzar. “Facilitating the Calculation of the Efficient Score Using Symbolic Computing.” Am Stat 72, no. 2 (2018): 199–205. https://doi.org/10.1080/00031305.2017.1392361.
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  - Afshari, Natalie A., Robert P. Igo, Nathan J. Morris, Dwight Stambolian, Shiwani Sharma, V Lakshmi Pulagam, Steven Dunn, et al. “Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.” Nat Commun 8 (March 30, 2017): 14898. https://doi.org/10.1038/ncomms14898.
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  - Jiang, Yu, Yunqi Ji, Alexander B. Sibley, Yi-Ju Li, and Andrew S. Allen. “Leveraging population information in family-based rare variant association analyses of quantitative traits.” Genet Epidemiol 41, no. 2 (February 2017): 98–107. https://doi.org/10.1002/gepi.22022.
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  - Chou, Ying-Hui, Mark Sundman, Heather E. Whitson, Pooja Gaur, Mei-Lan Chu, Carol P. Weingarten, David J. Madden, et al. “Maintenance and Representation of Mind Wandering during Resting-State fMRI.” Sci Rep 7 (January 12, 2017): 40722. https://doi.org/10.1038/srep40722.
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  - Kertai, Miklos D., Sreekanth Cheruku, Wenjing Qi, Yi-Ju Li, G Chad Hughes, Joseph P. Mathew, and Jörn A. Karhausen. “Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 153, no. 1 (January 2017): 68-76.e2. https://doi.org/10.1016/j.jtcvs.2016.05.063.
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  - Oprea, Adriana D., Frederick W. Lombard, Wen-Wei Liu, William D. White, Jörn A. Karhausen, Yi-Ju Li, Timothy E. Miller, et al. “Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery.” Anesth Analg 123, no. 6 (December 2016): 1480–89. https://doi.org/10.1213/ANE.0000000000001557.
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  - Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “In Reply.” Anesthesiology 125, no. 2 (August 2016): 438–39. https://doi.org/10.1097/ALN.0000000000001190.
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  - Berger, Miles, Jacob W. Nadler, Allan Friedman, David L. McDonagh, Ellen R. Bennett, Mary Cooter, Wenjing Qi, et al. “The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.” J Alzheimers Dis 52, no. 4 (April 15, 2016): 1299–1310. https://doi.org/10.3233/JAD-151190.
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  - Kertai, Miklos D., Yunqi Ji, Yi-Ju Li, Joseph P. Mathew, James P. Daubert, Mihai V. Podgoreanu, and Mihai V. PEGASUS Investigative Team. “Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.” Can J Anaesth 63, no. 4 (April 2016): 397–410. https://doi.org/10.1007/s12630-015-0576-8.
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  - Kertai, Miklos D., Wenjing Qi, Yi-Ju Li, Frederick W. Lombard, Yutao Liu, Michael P. Smith, Mark Stafford-Smith, et al. “Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers.” J Mol Cell Cardiol 92 (March 2016): 109–15. https://doi.org/10.1016/j.yjmcc.2016.02.006.
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  - Sandoval, J. S., R. G. Steward, C. Chen, Y. J. Li, T. M. Price, and S. J. Muasher. “High peak estradiol/mature oocyte ratio predicts lower clinical pregnancy, ongoing pregnancy, and live birth rates in GnRH antagonist intracytoplasmic sperm injection cycles.” Journal of Reproductive Medicine 61, no. 1 (February 1, 2016): 11–16.
  - Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.” Anesthesiology 124, no. 2 (February 2016): 339–52. https://doi.org/10.1097/ALN.0000000000000959.
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  - Feng, Liping, Carla E. Ransom, Matthew K. Nazzal, Terrence K. Allen, Yi-Ju Li, Tracy Truong, Lauren C. Potts, Patrick C. Seed, and Amy P. Murtha. “The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection.” Plos One 11, no. 12 (2016): e0168102. https://doi.org/10.1371/journal.pone.0168102.
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  - Feng, Liping, Fengxiu Ouyang, Liangpo Liu, Xu Wang, Xia Wang, Yi-Ju Li, Amy Murtha, Heqing Shen, Junfeng Zhang, and Jun Jim Zhang. “Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai.” J Environ Public Health 2016 (2016): 9416054. https://doi.org/10.1155/2016/9416054.
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  - Sandoval, Juan S., Ryan G. Steward, Chen Chen, Yi-Ju Li, Thomas M. Price, and Suheil J. Muasher. “High Peak Estradiol/Mature Oocyte Ratio Predicts Lower Clinical Pregnancy, Ongoing Pregnancy, and Live Birth Rates in GnRH Antagonist Intracytoplasmic Sperm Injection Cycles.” J Reprod Med 61, no. 1–2 (January 2016): 11–16.
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  - Steward, R. G., C. E. Zhang, A. A. Shah, J. S. Yeh, C. Chen, Y. J. Li, T. M. Price, and S. J. Muasher. “High peak estradiol predicts higher miscarriage and lower live birth rates in high responders triggered with a gnrh agonist in IVF/ICSI cycles.” Journal of Reproductive Medicine 60, no. 6 (December 1, 2015): 463–70.
  - Steward, Ryan G., Cindy E. Zhang, Anish A. Shah, Jason S. Yeh, Chen Chen, Yi-Ju Li, Thomas M. Price, and Suheil J. Muasher. “High Peak Estradiol Predicts Higher Miscarriage and Lower Live Birth Rates in High Responders Triggered with a GnRH Agonist in IVF/ICSI Cycles.” J Reprod Med 60, no. 11–12 (November 2015): 463–70.
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  - Stafford-Smith, Mark, Yi-Ju Li, Joseph P. Mathew, Yen-Wei Li, Yunqi Ji, Barbara G. Phillips-Bute, Carmelo A. Milano, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.” Kidney Int 88, no. 4 (October 2015): 823–32. https://doi.org/10.1038/ki.2015.161.
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  - Kertai, Miklos D., Yi-Ju Li, Yunqi Ji, Wenjing Qi, Frederick W. Lombard, Svati H. Shah, William E. Kraus, et al. “Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.” Am Heart J 170, no. 3 (September 2015): 580-90.e28. https://doi.org/10.1016/j.ahj.2015.06.009.
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  - Law, Lawrence Siu-Chun, Mingjuan Tan, Yaowu Bai, Timothy E. Miller, Yi-Ju Li, and Tong-Joo Gan. “Paravertebral Block for Inguinal Herniorrhaphy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Anesth Analg 121, no. 2 (August 2015): 556–69. https://doi.org/10.1213/ANE.0000000000000835.
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  - Bartels, Karsten, Yi-Ju Li, Yen-Wei Li, William D. White, Daniel T. Laskowitz, Miklos D. Kertai, Mark Stafford-Smith, Mihai V. Podgoreanu, Mark F. Newman, and Joseph P. Mathew. “Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study.” Can J Anaesth 62, no. 6 (June 2015): 618–26. https://doi.org/10.1007/s12630-015-0337-8.
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  - Kertai, Miklos D., Yi-Ju Li, Yen-Wei Li, Yunqi Ji, John Alexander, Mark F. Newman, Peter K. Smith, et al. “Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.” Bmj Open 5, no. 5 (May 6, 2015): e006920. https://doi.org/10.1136/bmjopen-2014-006920.
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  - Welsby, Ian J., and Yi-Ju Li. “Invited commentary.” Ann Thorac Surg 99, no. 3 (March 2015): 768–69. https://doi.org/10.1016/j.athoracsur.2014.11.006.
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  - Li, Yi-Ju, Mollie A. Minear, Xuejun Qin, Jacqueline Rimmler, Michael A. Hauser, R Rand Allingham, Robert P. Igo, et al. “Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.” Invest Ophthalmol Vis Sci 55, no. 7 (June 10, 2014): 4577–84. https://doi.org/10.1167/iovs.13-13517.
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  - Zhu, Li, Xiaoming Wang, Xin-Lei Li, Aaron Towers, Xinyu Cao, Ping Wang, Rachel Bowman, et al. “Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders.” Hum Mol Genet 23, no. 6 (March 15, 2014): 1563–78. https://doi.org/10.1093/hmg/ddt547.
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  - Mathew, Joseph P., William D. White, David B. Schinderle, Mihai V. Podgoreanu, Miles Berger, Carmelo A. Milano, Daniel T. Laskowitz, et al. “Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.” Stroke 44, no. 12 (December 2013): 3407–13. https://doi.org/10.1161/STROKEAHA.113.002703.
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  - Tran-Viet, Khanh-Nhat, Caldwell Powell, Veluchamy A. Barathi, Thomas Klemm, Sebastian Maurer-Stroh, Vachiranee Limviphuvadh, Vincent Soler, et al. “Mutations in SCO2 are associated with autosomal-dominant high-grade myopia.” Am J Hum Genet 92, no. 5 (May 2, 2013): 820–26. https://doi.org/10.1016/j.ajhg.2013.04.005.
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  - Hawthorne, Felicia, Sheng Feng, Ravikanth Metlapally, Yi-Ju Li, Khanh-Nhat Tran-Viet, Jeremy A. Guggenheim, Francois Malecaze, et al. “Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.” Invest Ophthalmol Vis Sci 54, no. 3 (March 21, 2013): 2076–86. https://doi.org/10.1167/iovs.12-11102.
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  - Minear, Mollie A., Yi-Ju Li, Jacqueline Rimmler, Elmer Balajonda, Shera Watson, R Rand Allingham, Michael A. Hauser, Gordon K. Klintworth, Natalie A. Afshari, and Simon G. Gregory. “Genetic screen of African Americans with Fuchs endothelial corneal dystrophy.” Mol Vis 19 (2013): 2508–16.
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  - Nolan, Daniel, William E. Kraus, Elizabeth Hauser, Yi-Ju Li, Dana K. Thompson, Jessica Johnson, Hsiang-Cheng Chen, et al. “Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.” Plos One 8, no. 8 (2013): e71779. https://doi.org/10.1371/journal.pone.0071779.
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  - Verhoeven, Virginie J. M., Pirro G. Hysi, Seang-Mei Saw, Veronique Vitart, Alireza Mirshahi, Jeremy A. Guggenheim, Mary Frances Cotch, et al. “Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.” Hum Genet 131, no. 9 (September 2012): 1467–80. https://doi.org/10.1007/s00439-012-1176-0.
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  - Rubio, D. M., D. J. del Junco, R. Bhore, C. J. Lindsell, R. A. Oster, K. M. Wittkowski, L. J. Welty, and Y. J. Li. “Correction: Evaluation metrics for biostatistical and epidemiological collaborations.” Statistics in Medicine 31, no. 6 (March 15, 2012): 600. https://doi.org/10.1002/sim.4436.
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  - Abbott, Diana, Yi-Ju Li, Jeremy A. Guggenheim, Ravikanth Metlapally, Francois Malecaze, Patrick Calvas, Thomas Rosenberg, et al. “An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error.” Mol Vis 18 (2012): 720–29.
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  - Dellinger, Andrew E., Seang-Mei Saw, Liang K. Goh, Mark Seielstad, Terri L. Young, and Yi-Ju Li. “Comparative analyses of seven algorithms for copy number variant identification from single nucleotide polymorphism arrays.” Nucleic Acids Res 38, no. 9 (May 2010): e105. https://doi.org/10.1093/nar/gkq040.
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  - Chen, Hsiang-Cheng, Virginia Byers Kraus, Yi-Ju Li, Sarah Nelson, Carol Haynes, Jessica Johnson, Thomas Stabler, et al. “Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.” Arthritis Rheum 62, no. 3 (March 2010): 781–90. https://doi.org/10.1002/art.27288.
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  - Lin, Pao-Hwa, Saki Miwa, Yi-Ju Li, Yanfang Wang, Erma Levy, Katherine Lastor, and Catherine Champagne. “Factors influencing dietary protein sources in the PREMIER trial population.” J Am Diet Assoc 110, no. 2 (February 2010): 291–95. https://doi.org/10.1016/j.jada.2009.10.041.
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  - Lu, Y., D. P. Dimasi, P. G. Hysi, A. W. Hewitt, K. P. Burdon, T. Toh, J. B. Ruddle, et al. “Common genetic variants near the Brittle Cornea Syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness.” Plos Genetics 6, no. 5 (2010): e1000947. https://doi.org/10.1371/journal.pgen.1000947.
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  - Liu, Youfang, Yi-Ju Li, Glen A. Satten, Andrew S. Allen, and Jung-Ying Tzeng. “A regression-based association test for case-control studies that uses inferred ancestral haplotype similarity.” Ann Hum Genet 73, no. Pt 5 (September 2009): 520–26. https://doi.org/10.1111/j.1469-1809.2009.00536.x.
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  - Samanta, Suvajit, Yi-Ju Li, and Bruce S. Weir. “Drawing inferences about the coancestry coefficient.” Theor Popul Biol 75, no. 4 (June 2009): 312–19. https://doi.org/10.1016/j.tpb.2009.03.005.
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  - Yanovitch, Tammy, Yi-Ju Li, Ravikanth Metlapally, Diana Abbott, Khanh-Nhat Tran Viet, and Terri L. Young. “Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population.” Mol Vis 15 (May 20, 2009): 1028–35.
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  - Zhang, Li, Eden R. Martin, Richard W. Morris, and Yi-Ju Li. “Association test for X-linked QTL in family-based designs.” Am J Hum Genet 84, no. 4 (April 2009): 431–44. https://doi.org/10.1016/j.ajhg.2009.02.010.
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  - Afshari, Natalie A., Yi-Ju Li, Margaret A. Pericak-Vance, Simon Gregory, and Gordon K. Klintworth. “Genome-wide linkage scan in fuchs endothelial corneal dystrophy.” Invest Ophthalmol Vis Sci 50, no. 3 (March 2009): 1093–97. https://doi.org/10.1167/iovs.08-1839.
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  - Beecham, Gary W., Eden R. Martin, Yi-Ju Li, Michael A. Slifer, John R. Gilbert, Jonathan L. Haines, and Margaret A. Pericak-Vance. “Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.” Am J Hum Genet 84, no. 1 (January 2009): 35–43. https://doi.org/10.1016/j.ajhg.2008.12.008.
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  - Li, Bin, Jie Li, Chia-San Hsieh, Laura P. Hale, Yi-Ju Li, Blythe H. Devlin, and M Louise Markert. “Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes.” Immunol Res 44, no. 1–3 (2009): 71–83. https://doi.org/10.1007/s12026-008-8083-4.
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  - Zayats, Tetyana, Tammy Yanovitch, Rosalind C. Creer, George McMahon, Yi-Ju Li, Terri L. Young, and Jeremy A. Guggenheim. “Myocilin polymorphisms and high myopia in subjects of European origin.” Mol Vis 15 (2009): 213–22.
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  - Chen, Hsiang-Cheng, Svati H. Shah, Yi-Ju Li, Thomas V. Stabler, Joanne M. Jordan, and Virginia Byers Kraus. “Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels.” Arthritis Rheum 58, no. 12 (December 2008): 3854–64. https://doi.org/10.1002/art.24319.
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  - Chen, H. -. C., S. Shah, T. V. Stabler, Y. -. J. Li, and V. B. Kraus. “Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.” Osteoarthritis Cartilage 16, no. 9 (September 2008): 1054–59. https://doi.org/10.1016/j.joca.2007.12.010.
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  - Markert, M. L., B. H. Devlin, I. K. Chinn, E. A. McCarthy, and Y. J. Li. “Factors affecting success of thymus transplantation for complete DiGeorge anomaly.” Am J Transplant 8, no. 8 (August 2008): 1729–36. https://doi.org/10.1111/j.1600-6143.2008.02301.x.
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  - Stafford-Smith, Mark, Uptal D. Patel, Barbara G. Phillips-Bute, Andrew D. Shaw, and Madhav Swaminathan. “Acute kidney injury and chronic kidney disease after cardiac surgery.” Adv Chronic Kidney Dis 15, no. 3 (July 2008): 257–77. https://doi.org/10.1053/j.ackd.2008.04.006.
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  - Markert, M Louise, Jie Li, Blythe H. Devlin, Jeffrey C. Hoehner, Henry E. Rice, Michael A. Skinner, Yi-Ju Li, and Laura P. Hale. “Use of allograft biopsies to assess thymopoiesis after thymus transplantation.” J Immunol 180, no. 9 (May 1, 2008): 6354–64. https://doi.org/10.4049/jimmunol.180.9.6354.
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  - Zhang, Li, Eden R. Martin, Ren-Hua Chung, Yi-Ju Li, and Richard W. Morris. “X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design.” Genet Epidemiol 32, no. 4 (May 2008): 370–80. https://doi.org/10.1002/gepi.20311.
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  - Metlapally, Ravikanth, Yi-Ju Li, Khanh-Nhat Tran-Viet, Anuradha Bulusu, Tristan R. White, Jaclyn Ellis, Daniel Kao, and Terri L. Young. “Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia.” Mol Vis 14 (March 4, 2008): 387–93.
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  - Chinn, Ivan K., Blythe H. Devlin, Yi-Ju Li, and M Louise Markert. “Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly.” Clin Immunol 126, no. 3 (March 2008): 277–81. https://doi.org/10.1016/j.clim.2007.11.009.
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  - Gao, X., W. K. Scott, G. Wang, G. Mayhew, Y. J. Li, J. M. Vance, and E. R. Martin. “Gene-gene interaction between FGF20 and MAOB in Parkinson disease.” Ann Hum Genet 72, no. Pt 2 (March 2008): 157–62. https://doi.org/10.1111/j.1469-1809.2007.00418.x.
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  - Wang, Gaofeng, Joelle M. van der Walt, Gregory Mayhew, Yi-Ju Li, Stephan Züchner, William K. Scott, Eden R. Martin, and Jeffery M. Vance. “Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.” Am J Hum Genet 82, no. 2 (February 2008): 283–89. https://doi.org/10.1016/j.ajhg.2007.09.021.
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  - Hancock, Dana B., Eden R. Martin, Yi-Ju Li, and William K. Scott. “Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations.” Genet Epidemiol 31, no. 8 (December 2007): 883–93. https://doi.org/10.1002/gepi.20249.
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  - Chung, Ren-Hua, Richard W. Morris, Li Zhang, Yi-Ju Li, and Eden R. Martin. “X-APL: an improved family-based test of association in the presence of linkage for the X chromosome.” Am J Hum Genet 80, no. 1 (January 2007): 59–68. https://doi.org/10.1086/510630.
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  - Jadico, Suzanne K., David A. Young, Alexandra Huebner, Jane C. Edmond, Avrum N. Pollock, Donna M. McDonald-McGinn, Yi-Ju Li, Elaine H. Zackai, and Terri L. Young. “Ocular abnormalities in Apert syndrome: genotype/phenotype correlations with fibroblast growth factor receptor type 2 mutations.” J Aapos 10, no. 6 (December 2006): 521–27. https://doi.org/10.1016/j.jaapos.2006.07.012.
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  - Allen, Andrew S., Eden R. Martin, Xuejun Qin, and Yi-Ju Li. “Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring.” Genet Epidemiol 30, no. 3 (April 2006): 248–58. https://doi.org/10.1002/gepi.20141.
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  - Li, Yi-Ju, Eden R. Martin, Ling Zhang, and Andrew S. Allen. “Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study.” Bmc Genet 6 Suppl 1 (December 30, 2005): S53. https://doi.org/10.1186/1471-2156-6-S1-S53.
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  - Oliveira, Sofia A., Yi-Ju Li, Maher A. Noureddine, Stephan Zuchner, Xuejun Qin, Margaret A. Pericak-Vance, and Jeffery M. Vance. “Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.” Am J Hum Genet 77, no. 2 (August 2005): 252–64. https://doi.org/10.1086/432588.
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  - Hauser, Michael A., Yi-Ju Li, Hong Xu, Maher A. Noureddine, Yujun S. Shao, Steven R. Gullans, Clemens R. Scherzer, et al. “Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism.” Arch Neurol 62, no. 6 (June 2005): 917–21. https://doi.org/10.1001/archneur.62.6.917.
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  - Li, Y. J., M. A. Hauser, W. K. Scott, E. R. Martin, M. W. Booze, X. J. Qin, J. W. Walter, et al. “Apolipoprotein E controls the risk and age at onset of Parkinson disease.” Neurology 62, no. 11 (June 8, 2004): 2005–9. https://doi.org/10.1212/01.wnl.0000128089.53030.ac.
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  - Li, Y. J., S. C. M. Tsoi, H. Mannen, and S. S. L. Li. “Erratum: Phylogenetic Analysis of Vertebrate Lactate Dehydrogenase (LDH) Multigene Families (Journal of Molecular Evolution (2002) 54 (614-624)).” Journal of Molecular Evolution 57, no. 6 (December 1, 2003): 745. https://doi.org/10.1007/s00239-003-5761-7.
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- Book Sections
  - Li, Y. J., and Q. Fan. “Statistical analysis of genome-wide association studies for myopia.” In Myopia: Animal Models to Clinical Trials, 244–67, 2010. https://doi.org/10.1142/9789812832986_0013.
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  - Li, Y. J., S. Shao, and M. Speer. “Sample Size and Power.” In Genetic Analysis of Complex Diseases: Second Edition, 355–96, 2005. https://doi.org/10.1002/9780471781141.ch13.
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- Other Articles
  - Kertai, Miklos D., Yen-Wei Li, Yi-Ju Li, Svati H. Shah, William E. Kraus, Manuel L. Fontes, Mark Stafford-Smith, et al. “G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.” Circ Cardiovasc Genet, October 2014. https://doi.org/10.1161/CIRCGENETICS.113.000451.
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- Conference Papers
  - Jackson-Bey, T., S. Keyhan, T. Truong, Y. J. Li, and J. L. Eaton. “Peak serum estradiol and neonatal birth weight following in vitro fertilization.” In Journal of Reproductive Medicine, 65:151–56, 2020. https://doi.org/10.1016/j.fertnstert.2016.07.525.
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  - Nicoletti, Paola, Federico Innocenti, Amy Etheridge, Naga P. Chalasani, Robert J. Fontana, Yi-Ju Li, Joseph Odin, et al. “DISCOVERY OF ERAP2 GENE EXPRESSION AS A RISK FACTOR FOR DRUG-INDUCED LIVER INJURY DUE TO AMOXICILLIN-CLAVULANIC ACID.” In Hepatology, 70:137A-138A. WILEY, 2019.
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  - Karhausen, Jörn A., Wenjing Qi, Alan M. Smeltz, Yi-Ju Li, Svati H. Shah, William E. Kraus, Joseph P. Mathew, Mihai V. Podgoreanu, Miklos D. Kertai, and Miklos D. Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team. “Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.” In Thromb Haemost, 118:1572–85, 2018. https://doi.org/10.1055/s-0038-1667199.
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  - Jackson-Bey, Tia, Sanaz Keyhan, Yi Li, tracy Truong, and J. Eaton. “Serum peak estradiol and neonatal birth weight following in vitro fertilization.” In Fertility and Sterility, 106:179–80. Elsevier, 2016.
  - Keyhan, Sanaz, Tracy Truong, Tia Jackson-Bey, Yi Li, and J. Eaton. “Perinatal outcomes following intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilization (IVF).” In Fertility and Sterility, 106:e165–e165. Elsevier, 2016.
  - Iyengar, Sudha K., Yi-Ju Li, Robert P. Igo, Kathryn P. Burdon, John H. Fingert, John Gottsch, Gordon K. Klintworth, Jonathan H. Lass, and Natalie A. Afshari. “Common variants in TCF4 and three novel genes increase susceptibility to Fuchs Dystrophy.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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  - Baratz, Keith, Ross Ale, Yi-Ju Li, Malinda Butz, Simon Gregory, Gordon Klintworth, W Edward Highsmith, Natalie Afshari, and Eric Wieben. “A Family-based Investigation of the Role of TCF4 Trinucleotide Repeat Expansion in Fuchs Endothelial Corneal Dystrophy (FECD).” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
    Link to Item
  - Li, Yi-Ju, Mollie Minear, Jacqueline Rimmler, Elmer Balajonda, Michael Hauser, R Rand Allingham, Gordon Klintworth, Simon Gregory, and Natalie Afshari. “An Investigation of Mitochondrial Haplogroups in Fuchs Endothelial Corneal Dystrophy.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
    Link to Item
  - Li, Y. -. J., and T. Young. “Copy Number Variants Associated With Refractive Error.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Metlapally, R., Y. -. J. Li, K-N Tran Viet, D. Abbott, F. J. Malecaze, P. Calvas, D. A. Mackey, T. Rosenberg, J. A. Guggenheim, and T. L. Young. “Genetic Association of Insulin-Like Growth Factor-1 Polymorphisms With High-Grade Myopia in an International Family Cohort.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Riazuddin, S. A., N. A. Zaghloul, A. Al-Saif, A. O. Eghrari, M. A. Minear, Y. J. Li, G. K. Klintworth, N. Afshari, J. D. Gottsch, and N. Katsanis. “Missense Mutations in TCF8 Cause Late-Onset Fuchs Corneal Dystrophy and Interact With a Novel Locus on 9p.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Young, T. L., R. Metlapally, K. -. N. Tran-Viet, D. Abbott, F. Hawthorne, Y. Liu, R. Allingham, M. Hauser, and Y. -. J. Li. “Association of LOC339766 With High Myopia in Caucasian Family Cohorts.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Merchant, Akeel, ben Andrew, Alina Nicoara, M. A. R. K. Stafford-Smith, Jennifer Hauck, yi Li, and Anne Cherry. “Intraoperative renal resistive index with adjustment for aortic insufficiency for acute kidney injury prediction in cardiac surgery patients,” n.d.
    Open Access Copy
Teaching & Mentoring
Advising & Mentoring
- Former postdoctoral fellows: Andrew Dellinger, Yen-Wei Li, Yunqi Ji, and Wenjing Qi
  Current postdoctoral fellow: Wei-Quan Fang (2020~)

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

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External Relationships

Selected Publications

Academic Articles

Book Sections

Other Articles

Conference Papers

Advising & Mentoring