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Yiping He

Associate Professor in Pathology
Pathology

Current Appointments & Affiliations


Associate Professor in Pathology · 2021 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2013 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Targeting glutamine dependence with DRP-104 inhibits proliferation and tumor growth of castration-resistant prostate cancer.

Journal Article Prostate · March 2024 BACKGROUND: Prostate cancer (PCa) continues to be one of the leading causes of cancer deaths in men. While androgen deprivation therapy is initially effective, castration-resistant PCa (CRPC) often recurs and has limited treatment options. Our previous stu ... Full text Link to item Cite

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.

Journal Article Nat Commun · January 25, 2024 Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional immune signaling. ... Full text Link to item Cite

Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival.

Journal Article Commun Biol · January 3, 2024 There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this manuscript, we identify that HSF1 regulates the ... Full text Open Access Link to item Cite
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Recent Grants


The role of focal adhesion kinase in therapy resistant prostate tumors

ResearchResearch Associate · Awarded by National Cancer Institute · 2023 - 2028

ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas

ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027

Glutaminase I isoforms as personalized biomarkers of prostate cancer

ResearchAssociate Research Professor · Awarded by National Cancer Institute · 2022 - 2026

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Education, Training & Certifications


University of Pennsylvania · 2002 Ph.D.