Current Appointments & Affiliations
Associate Professor in Pathology
·
2021 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2013 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Targeting glutamine dependence with DRP-104 inhibits proliferation and tumor growth of castration-resistant prostate cancer.
Journal Article Prostate · March 2024 BACKGROUND: Prostate cancer (PCa) continues to be one of the leading causes of cancer deaths in men. While androgen deprivation therapy is initially effective, castration-resistant PCa (CRPC) often recurs and has limited treatment options. Our previous stu ... Full text Link to item CiteInterplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.
Journal Article Nat Commun · January 25, 2024 Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional immune signaling. ... Full text Link to item CiteHeat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival.
Journal Article Commun Biol · January 3, 2024 There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this manuscript, we identify that HSF1 regulates the ... Full text Open Access Link to item CiteRecent Grants
The role of focal adhesion kinase in therapy resistant prostate tumors
ResearchResearch Associate · Awarded by National Cancer Institute · 2023 - 2028ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027Glutaminase I isoforms as personalized biomarkers of prostate cancer
ResearchAssociate Research Professor · Awarded by National Cancer Institute · 2022 - 2026View All Grants
Education, Training & Certifications
University of Pennsylvania ·
2002
Ph.D.