Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Associate, Pathology, Johns Hopkins University 2008 - 2010
  • Howard Hughes Researcher, Pathology, Johns Hopkins University 2003 - 2008
  • Post-doctoral Fellow, Pathology, Johns Hopkins University 2003
  • Ph.D., University of Pennsylvania 2002
• 

  Duke Appointment History

  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 2010 - 2018
  • Instructor Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2010
• Research
• 

  Selected Grants

  • Exploiting MTAP deletion for GBM therapeutics awarded by National Institutes of Health 2017 - 2022
  • Exploiting MTAP for more effective treatment of glioblastoma with temozolomide awarded by Southeastern Brain Tumor Foundation 2016 - 2017
  • Developing novel mouse models for medulloblastoma awarded by Circle of Service Foundation 2013 - 2017
  • Automated Library Preparation System for Next-Generation Sequencing awarded by North Carolina Biotechnology Center 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Baig, SM, Fatima, A, Tariq, M, Khan, TN, Ali, Z, Faheem, M, Mahmood, H, Killela, P, Waitkus, M, He, Y, Zhao, F, Wang, S, Jiao, Y, and Yan, H. "Hereditary brain tumor with a homozygous germline mutation in PMS2: pedigree analysis and prenatal screening in a family with constitutional mismatch repair deficiency (CMMRD) syndrome." Familial Cancer (November 26, 2018).  Full Text
    • Diplas, BH, Liu, H, Yang, R, Hansen, LJ, Zachem, AL, Zhao, F, Bigner, DD, McLendon, RE, Jiao, Y, He, Y, Waitkus, MS, and Yan, H. "Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas." Neuro Oncology (October 22, 2018).  Full Text
    • Lei, K, Sun, R, Chen, LH, Diplas, BH, Moure, CJ, Wang, W, Hansen, LJ, Tao, Y, Chen, X, Chen, C-PJ, Greer, PK, Zhao, F, Yan, H, Bigner, DD, Huang, J, and He, Y. "Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells." Scientific Reports 8, no. 1 (August 21, 2018): 12507-null.  Full Text
    • Diplas, BH, He, X, Brosnan-Cashman, JA, Liu, H, Chen, LH, Wang, Z, Moure, CJ, Killela, PJ, Loriaux, DB, Lipp, ES, Greer, PK, Yang, R, Rizzo, AJ, Rodriguez, FJ, Friedman, AH, Friedman, HS, Wang, S, He, Y, McLendon, RE, Bigner, DD, Jiao, Y, Waitkus, MS, Meeker, AK, and Yan, H. "The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma." Nature Communications 9, no. 1 (May 25, 2018): 2087-null.  Full Text
    • Waitkus, MS, Pirozzi, CJ, Moure, CJ, Diplas, BH, Hansen, LJ, Carpenter, AB, Yang, R, Wang, Z, Ingram, BO, Karoly, ED, Mohney, RP, Spasojevic, I, McLendon, RE, Friedman, HS, He, Y, Bigner, DD, and Yan, H. "Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities." Cancer Research 78, no. 1 (January 2018): 36-50.  Full Text
    • Yang, R, Chen, LH, Hansen, LJ, Carpenter, AB, Moure, CJ, Liu, H, Pirozzi, CJ, Diplas, BH, Waitkus, MS, Greer, PK, Zhu, H, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation." Cancer Research 77, no. 22 (November 2017): 6097-6108.  Full Text
    • Xu, C, Liu, X, Geng, Y, Bai, Q, Pan, C, Sun, Y, Chen, X, Yu, H, Wu, Y, Zhang, P, Wu, W, Wang, Y, Wu, Z, Zhang, J, Wang, Z, Yang, R, Lewis, J, Bigner, D, Zhao, F, He, Y, Yan, H, Shen, Q, and Zhang, L. "Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors." Oncotarget 8, no. 44 (September 2017): 76644-76655.  Full Text
    • Xu, C, Liu, X, Geng, Y, Bai, Q, Pan, C, Sun, Y, Chen, X, Yu, H, Wu, Y, Zhang, P, Wu, W, Wang, Y, Wu, Z, Zhang, J, Wang, Z, Yang, R, Lewis, J, Bigner, D, Zhao, F, He, Y, Yan, H, Shen, Q, and Zhang, L. "Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors." Oncotarget (July 28, 2017).  Full Text
    • Pirozzi, CJ, Carpenter, AB, Waitkus, MS, Wang, CY, Zhu, H, Hansen, LJ, Chen, LH, Greer, PK, Feng, J, Wang, Y, Bock, CB, Fan, P, Spasojevic, I, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression." Molecular Cancer Research : Mcr 15, no. 5 (May 2017): 507-520.  Full Text
    • Feng, N, Yin, Y, He, Y, and Huang, J. "Alternative Splicing Provides a Novel Molecular Mechanism for Prostatic Small-cell Neuroendocrine Carcinoma." European urology 71, no. 1 (January 2017): 79-80.  Full Text
    • Yin, Y, Zhang, Q, Zhang, H, He, Y, and Huang, J. "Molecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 1 (January 2017): 6-8. (Letter)  Full Text  Open Access Copy
    • Huang, D-S, Tao, H-Q, He, X-J, Long, M, Yu, S, Xia, Y-J, Wei, Z, Xiong, Z, Jones, S, He, Y, Yan, H, and Wang, X. "Prevalence of deleterious ATM germline mutations in gastric cancer patients." Oncotarget 6, no. 38 (December 2015): 40953-40958.  Full Text
    • Zhang, L, Chen, LH, Wan, H, Yang, R, Wang, Z, Feng, J, Yang, S, Jones, S, Wang, S, Zhou, W, Zhu, H, Killela, PJ, Zhang, J, Wu, Z, Li, G, Hao, S, Wang, Y, Webb, JB, Friedman, HS, Friedman, AH, McLendon, RE, He, Y, Reitman, ZJ, Bigner, DD, and Yan, H. "Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas." Nature genetics 46, no. 7 (July 2014): 726-730.  Full Text
    • Killela, PJ, Pirozzi, CJ, Healy, P, Reitman, ZJ, Lipp, E, Rasheed, BA, Yang, R, Diplas, BH, Wang, Z, Greer, PK, Zhu, H, Wang, CY, Carpenter, AB, Friedman, H, Friedman, AH, Keir, ST, He, J, He, Y, McLendon, RE, Herndon, JE, Yan, H, and Bigner, DD. "Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas." Oncotarget 5, no. 6 (March 2014): 1515-1525.  Full Text  Open Access Copy
    • Killela, PJ, Pirozzi, CJ, Reitman, ZJ, Jones, S, Rasheed, BA, Lipp, E, Friedman, H, Friedman, AH, He, Y, McLendon, RE, Bigner, DD, and Yan, H. "The genetic landscape of anaplastic astrocytoma." Oncotarget 5, no. 6 (March 2014): 1452-1457.  Full Text
    • López, GY, Grant, GA, Fuchs, HE, Leithe, LG, Gururangan, S, Bigner, DD, Yan, H, McLendon, RE, and He, Y. "Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations." Neuropathology and Applied Neurobiology 40, no. 2 (February 2014): 217-220. (Letter)  Full Text
    • Wortham, M, Guo, C, Zhang, M, Song, L, Lee, B-K, Iyer, VR, Furey, TS, Crawford, GE, Yan, H, and He, Y. "Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma." PloS one 9, no. 9 (January 2014): e107156-.  Full Text  Open Access Copy
    • Zhang, L, Chen, LH, Wan, H, Yang, R, Wang, Z, Feng, J, Yang, S, Jones, S, Wang, S, Zhou, W, Zhu, H, Killela, PJ, Zhang, J, Wu, Z, Li, G, Hao, S, Wang, Y, Webb, JB, Friedman, HS, Friedman, AH, McLendon, RE, He, Y, Reitman, ZJ, Bigner, DD, and Yan, H. "Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas." Nature Genetics 46, no. 7 (January 1, 2014): 726-730.  Full Text
    • Guo, C, Chen, LH, Huang, Y, Chang, C-C, Wang, P, Pirozzi, CJ, Qin, X, Bao, X, Greer, PK, McLendon, RE, Yan, H, Keir, ST, Bigner, DD, and He, Y. "KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation." Oncotarget 4, no. 11 (November 2013): 2144-2153.  Full Text
    • Killela, PJ, Reitman, ZJ, Jiao, Y, Bettegowda, C, Agrawal, N, Diaz, LA, Friedman, AH, Friedman, H, Gallia, GL, Giovanella, BC, Grollman, AP, He, T-C, He, Y, Hruban, RH, Jallo, GI, Mandahl, N, Meeker, AK, Mertens, F, Netto, GJ, Rasheed, BA, Riggins, GJ, Rosenquist, TA, Schiffman, M, Shih, I-M, Theodorescu, D, Torbenson, MS, Velculescu, VE, Wang, T-L, Wentzensen, N, Wood, LD, Zhang, M, McLendon, RE, Bigner, DD, Kinzler, KW, Vogelstein, B, Papadopoulos, N, and Yan, H. "TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal." Proceedings of the National Academy of Sciences of the United States of America 110, no. 15 (April 2013): 6021-6026.  Full Text
    • Jin, G, Reitman, ZJ, Duncan, CG, Spasojevic, I, Gooden, DM, Rasheed, BA, Yang, R, Lopez, GY, He, Y, McLendon, RE, Bigner, DD, and Yan, H. "Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas." Cancer Research 73, no. 2 (January 2013): 496-501.  Full Text  Open Access Copy
    • Guo, C, Chang, C-C, Wortham, M, Chen, LH, Kernagis, DN, Qin, X, Cho, Y-W, Chi, J-T, Grant, GA, McLendon, RE, Yan, H, Ge, K, Papadopoulos, N, Bigner, DD, and He, Y. "Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways." Proc Natl Acad Sci U S A 109, no. 43 (October 23, 2012): 17603-17608.  Full Text  Link to Item
    • Jin, G, Pirozzi, CJ, Chen, LH, Lopez, GY, Duncan, CG, Feng, J, Spasojevic, I, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 is required for IDH1 mutated tumor cell growth." Oncotarget 3, no. 8 (August 2012): 774-782.  Full Text  Open Access Copy
    • Jiao, Y, Killela, PJ, Reitman, ZJ, Rasheed, AB, Heaphy, CM, de Wilde, RF, Rodriguez, FJ, Rosemberg, S, Oba-Shinjo, SM, Nagahashi Marie, SK, Bettegowda, C, Agrawal, N, Lipp, E, Pirozzi, C, Lopez, G, He, Y, Friedman, H, Friedman, AH, Riggins, GJ, Holdhoff, M, Burger, P, McLendon, R, Bigner, DD, Vogelstein, B, Meeker, AK, Kinzler, KW, Papadopoulos, N, Diaz, LA, and Yan, H. "Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas." Oncotarget 3, no. 7 (July 2012): 709-722.  Full Text  Open Access Copy
    • Wortham, M, Jin, G, Sun, JL, Bigner, DD, He, Y, and Yan, H. "Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells." Plos One 7, no. 4 (January 2012): e36211-null.  Full Text
    • Heaphy, CM, de Wilde, RF, Jiao, Y, Klein, AP, Edil, BH, Shi, C, Bettegowda, C, Rodriguez, FJ, Eberhart, CG, Hebbar, S, Offerhaus, GJ, McLendon, R, Rasheed, BA, He, Y, Yan, H, Bigner, DD, Oba-Shinjo, SM, Marie, SKN, Riggins, GJ, Kinzler, KW, Vogelstein, B, Hruban, RH, Maitra, A, Papadopoulos, N, and Meeker, AK. "Altered telomeres in tumors with ATRX and DAXX mutations." Science (New York, N.Y.) 333, no. 6041 (July 2011): 425-null.  Full Text
    • Reitman, ZJ, Jin, G, Karoly, ED, Spasojevic, I, Yang, J, Kinzler, KW, He, Y, Bigner, DD, Vogelstein, B, and Yan, H. "Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome." Proceedings of the National Academy of Sciences of the United States of America 108, no. 8 (February 2, 2011): 3270-3275.  Full Text
    • Parsons, DW, Li, M, Zhang, X, Jones, S, Leary, RJ, Lin, JC-H, Boca, SM, Carter, H, Samayoa, J, Bettegowda, C, Gallia, GL, Jallo, GI, Binder, ZA, Nikolsky, Y, Hartigan, J, Smith, DR, Gerhard, DS, Fults, DW, VandenBerg, S, Berger, MS, Marie, SKN, Shinjo, SMO, Clara, C, Phillips, PC, Minturn, JE, Biegel, JA, Judkins, AR, Resnick, AC, Storm, PB, Curran, T, He, Y, Rasheed, BA, Friedman, HS, Keir, ST, McLendon, R, Northcott, PA, Taylor, MD, Burger, PC, Riggins, GJ, Karchin, R, Parmigiani, G, Bigner, DD, Yan, H, Papadopoulos, N, Vogelstein, B, Kinzler, KW, and Velculescu, VE. "The genetic landscape of the childhood cancer medulloblastoma." Science (New York, N.Y.) 331, no. 6016 (January 2011): 435-439.  Full Text
    • He, Y, Wu, J, Dressman, DC, Iacobuzio-Donahue, C, Markowitz, SD, Velculescu, VE, Diaz, LA, Kinzler, KW, Vogelstein, B, and Papadopoulos, N. "Heteroplasmic mitochondrial DNA mutations in normal and tumour cells." Nature 464, no. 7288 (March 3, 2010): 610-614.  Full Text
    • Li, M, Chen, W-D, Papadopoulos, N, Goodman, SN, Bjerregaard, NC, Laurberg, S, Levin, B, Juhl, H, Arber, N, Moinova, H, Durkee, K, Schmidt, K, He, Y, Diehl, F, Velculescu, VE, Zhou, S, Diaz, LA, Kinzler, KW, Markowitz, SD, and Vogelstein, B. "Sensitive digital quantification of DNA methylation in clinical samples." Nature Biotechnology 27, no. 9 (September 2009): 858-863.  Full Text
    • Yashiro-Ohtani, Y, He, Y, Ohtani, T, Jones, ME, Shestova, O, Xu, L, Fang, TC, Chiang, MY, Intlekofer, AM, Blacklow, SC, Zhuang, Y, and Pear, WS. "Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A." Genes & Development 23, no. 14 (July 2009): 1665-1676.  Full Text
    • He, Y, Vogelstein, B, Velculescu, VE, Papadopoulos, N, and Kinzler, KW. "The antisense transcriptomes of human cells." Science (New York, N.Y.) 322, no. 5909 (December 4, 2008): 1855-1857.  Full Text
    • Michie, AM, Chan, AC, Ciofani, M, Carleton, M, Lefebvre, JM, He, Y, Allman, DM, Wiest, DL, Zúñiga-Pflücker, JC, and Izon, DJ. "Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals." International Immunology 19, no. 12 (December 2007): 1421-1430.  Full Text
    • Wouters, BJ, Jordà, MA, Keeshan, K, Louwers, I, Erpelinck-Verschueren, CAJ, Tielemans, D, Langerak, AW, He, Y, Yashiro-Ohtani, Y, Zhang, P, Hetherington, CJ, Verhaak, RGW, Valk, PJM, Löwenberg, B, Tenen, DG, Pear, WS, and Delwel, R. "Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1." Blood 110, no. 10 (November 2007): 3706-3714.  Full Text
    • Keeshan, K, He, Y, Wouters, BJ, Shestova, O, Xu, L, Sai, H, Rodriguez, CG, Maillard, I, Tobias, JW, Valk, P, Carroll, M, Aster, JC, Delwel, R, and Pear, WS. "Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia." Cancer cell 10, no. 5 (November 2006): 401-411.  Full Text
    • Diehl, F, Li, M, He, Y, Kinzler, KW, Vogelstein, B, and Dressman, D. "BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions." Nature Methods 3, no. 7 (July 2006): 551-559.  Full Text
    • Cummins, JM, He, Y, Leary, RJ, Pagliarini, R, Diaz, LA, Sjoblom, T, Barad, O, Bentwich, Z, Szafranska, AE, Labourier, E, Raymond, CK, Roberts, BS, Juhl, H, Kinzler, KW, Vogelstein, B, and Velculescu, VE. "The colorectal microRNAome." Proceedings of the National Academy of Sciences of the United States of America 103, no. 10 (March 2006): 3687-3692.  Full Text
    • Zweidler-McKay, PA, He, Y, Xu, L, Rodriguez, CG, Karnell, FG, Carpenter, AC, Aster, JC, Allman, D, and Pear, WS. "Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies." Blood 106, no. 12 (December 2005): 3898-3906.  Full Text
    • Diehl, F, Li, M, Dressman, D, He, Y, Shen, D, Szabo, S, Diaz, LA, Goodman, SN, David, KA, Juhl, H, Kinzler, KW, and Vogelstein, B. "Detection and quantification of mutations in the plasma of patients with colorectal tumors." Proceedings of the National Academy of Sciences of the United States of America 102, no. 45 (November 2005): 16368-16373.  Full Text
    • Eagar, TN, Tang, Q, Wolfe, M, He, Y, Pear, WS, and Bluestone, JA. "Notch 1 signaling regulates peripheral T cell activation." Immunity 20, no. 4 (April 2004): 407-415.  Full Text
    • Maillard, I, He, Y, and Pear, WS. "From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis." Immunity 18, no. 5 (May 2003): 587-589.  Full Text
    • He, Y, and Pear, WS. "Notch signalling in B cells." Seminars in cell & developmental biology 14, no. 2 (April 2003): 135-142. (Review)  Full Text
    • Wertheim, JA, Miller, JP, Xu, L, He, Y, and Pear, WS. "The biology of chronic myelogenous leukemia:mouse models and cell adhesion." Oncogene 21, no. 56 (December 2002): 8612-8628. (Review)  Full Text
    • He, Y, Wertheim, JA, Xu, L, Miller, JP, Karnell, FG, Choi, JK, Ren, R, and Pear, WS. "The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl." Blood 99, no. 8 (April 2002): 2957-2968.  Full Text
    • Izon, DJ, Aster, JC, He, Y, Weng, A, Karnell, FG, Patriub, V, Xu, L, Bakkour, S, Rodriguez, C, Allman, D, and Pear, WS. "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1." Immunity 16, no. 2 (February 2002): 231-243.  Full Text

  • Book Sections

    • Chandramohan, V, Sanchez-Perez, L, He, Y, Pirozzi, CJ, Congdon, KL, and Bigner, DD. "Preclinical Immunotherapeutic Animal Models for Brain Tumors." In Translational Immunotherapy of Brain Tumors, 111-147. March 2, 2017.  Full Text

  • Conference Papers

    • Guo, C, Chen, LH, Huang, Y, Chang, C-C, Wang, P, Pirozzi, CJ, Qin, X, Bao, X, Greer, PK, McLendon, RE, Yan, H, Keir, ST, Bigner, DD, and He, Y. "Abstract LB-82: MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation." October 1, 2014.  Full Text
    • Pirozzi, CJ, Wang, CY, Carpenter, AB, Zhu, H, Greer, PK, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma." October 1, 2014.  Full Text
    • Guo, C, Chang, C-C, Wortham, M, Chen, L, Kernagis, D, Qin, X, Cho, Y-W, Chi, J-T, Grant, G, McLendon, R, Yan, H, Ge, K, Papadopoulos, N, Bigner, D, and He, Y. "GLOBAL IDENTIFICATION OF MLL2-TARGETED LOCI REVEALS MLL2'S ROLE IN DIVERSE SIGNALING PATHWAYS." April 2013.  Link to Item
    • Wortham, M, Reitman, Z, He, Y, Bigner, D, and Yan, H. "ABERRANT Otx2 EXPRESSION ENHANCES MIGRATION AND INDUCES ECTOPIC PROLIFERATION OF HINDBRAIN NEURONAL PROGENITOR CELLS." April 2013.  Link to Item
    • Reitman, ZJ, Jin, G, Karoly, ED, Spasojevic, I, Yang, J, Kinzler, KW, He, Y, Bigner, DD, Vogelstein, B, and Yan, H. "METABOLOMIC PROFILING OF A GLIOMA CELL LINE EXPRESSING IDH1 AND IDH2 MUTANTS." May 2011.  Link to Item
    • Yan, H, Reitman, ZJ, Jin, G, Spasojevic, I, He, Y, Bigner, DD, Karoly, ED, Yang, J, Kinzler, KW, and Vogelstein, B. "Abstract LB-257: Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome." : American Association for Cancer Research (AACR), April 15, 2011.  Full Text
• Teaching & Mentoring
• 

  Recent Courses

  • PATHOL 293: Research Independent Study 2019
  • PATHOL 785: Molecular Aspects of Disease 2019
  • PATHOL 793: Research Independent Study 2019
  • NEUROSCI 150: Research Practicum 2018

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