Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Associate, Pathology, Johns Hopkins University 2008 - 2010
  • Howard Hughes Researcher, Pathology, Johns Hopkins University 2003 - 2008
  • Post-doctoral Fellow, Pathology, Johns Hopkins University 2003
  • Ph.D., University of Pennsylvania 2002
• 

  Duke Appointment History

  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 2010 - 2018
  • Instructor Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2010
• Research
• 

  Selected Grants

  • Exploiting MTAP deletion for GBM therapeutics awarded by National Institutes of Health 2017 - 2022
  • Repurposing Remyelination Drugs for Oligodendroglioma Therapeutics 2019 - 2020
  • Exploiting MTAP for more effective treatment of glioblastoma with temozolomide 2016 - 2017
  • Developing novel mouse models for medulloblastoma 2013 - 2017
  • Automated Library Preparation System for Next-Generation Sequencing 2014 - 2015
• 

  Industry Relationships

  • Genetron Health
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Moure, Casey J., Bill H. Diplas, Lee H. Chen, Rui Yang, Christopher J. Pirozzi, Zhaohui Wang, Ivan Spasojevic, Matthew S. Waitkus, Yiping He, and Hai Yan. “CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP..” Mol Cancer Res 17, no. 10 (October 2019): 2042–50. https://doi.org/10.1158/1541-7786.MCR-19-0309.
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    • Du, Changzheng, Landon J. Hansen, Simranjit X. Singh, Feiyifan Wang, Ran Sun, Casey J. Moure, Kristen Roso, Paula K. Greer, Hai Yan, and Yiping He. “A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis..” Cell Rep 28, no. 12 (September 17, 2019): 3199-3211.e5. https://doi.org/10.1016/j.celrep.2019.08.031.
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    • Hansen, Landon J., Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, et al. “MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation..” Cancer Res 79, no. 13 (July 1, 2019): 3383–94. https://doi.org/10.1158/0008-5472.CAN-18-1010.
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    • Baig, Shahid Mahmood, Ambrin Fatima, Muhammad Tariq, Tahir Naeem Khan, Zafar Ali, Mohammad Faheem, Humera Mahmood, et al. “Hereditary brain tumor with a homozygous germline mutation in PMS2: pedigree analysis and prenatal screening in a family with constitutional mismatch repair deficiency (CMMRD) syndrome..” Fam Cancer 18, no. 2 (April 2019): 261–65. https://doi.org/10.1007/s10689-018-0112-4.
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    • Diplas, Bill H., Heng Liu, Rui Yang, Landon J. Hansen, Alexis L. Zachem, Fangping Zhao, Darell D. Bigner, et al. “Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas..” Neuro Oncol 21, no. 4 (March 18, 2019): 440–50. https://doi.org/10.1093/neuonc/noy167.
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    • Lei, Kefeng, Ran Sun, Lee H. Chen, Bill H. Diplas, Casey J. Moure, Wenzhe Wang, Landon J. Hansen, et al. “Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells..” Sci Rep 8, no. 1 (August 21, 2018). https://doi.org/10.1038/s41598-018-30062-z.
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    • Diplas, Bill H., Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, et al. “The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma..” Nat Commun 9, no. 1 (May 25, 2018). https://doi.org/10.1038/s41467-018-04448-6.
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    • Waitkus, Matthew S., Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, et al. “Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities..” Cancer Res 78, no. 1 (January 1, 2018): 36–50. https://doi.org/10.1158/0008-5472.CAN-17-1352.
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    • Yang, Rui, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, et al. “Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation..” Cancer Res 77, no. 22 (November 15, 2017): 6097–6108. https://doi.org/10.1158/0008-5472.CAN-17-1018.
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    • Xu, Cheng, Xiaoqing Liu, Yibo Geng, Qingran Bai, Changcun Pan, Yu Sun, Xin Chen, et al. “Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors..” Oncotarget 8, no. 44 (September 29, 2017): 76644–55. https://doi.org/10.18632/oncotarget.19656.
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    • Xu, Cheng, Xiaoqing Liu, Yibo Geng, Qingran Bai, Changcun Pan, Yu Sun, Xin Chen, et al. “Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors..” Oncotarget, July 28, 2017. https://doi.org/10.18632/oncotarget.19656.
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    • Pirozzi, Christopher J., Austin B. Carpenter, Matthew S. Waitkus, Catherine Y. Wang, Huishan Zhu, Landon J. Hansen, Lee H. Chen, et al. “Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression..” Mol Cancer Res 15, no. 5 (May 2017): 507–20. https://doi.org/10.1158/1541-7786.MCR-16-0485.
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    • Feng, Ninghan, Yu Yin, Yiping He, and Jiaoti Huang. “Alternative Splicing Provides a Novel Molecular Mechanism for Prostatic Small-cell Neuroendocrine Carcinoma..” Eur Urol 71, no. 1 (January 2017): 79–80. https://doi.org/10.1016/j.eururo.2016.07.046.
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    • Yin, Yu, Qingfu Zhang, Hong Zhang, Yiping He, and Jiaoti Huang. “Molecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk..” Clin Cancer Res 23, no. 1 (January 1, 2017): 6–8. https://doi.org/10.1158/1078-0432.CCR-16-2400.
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    • Huang, Dong-Sheng, Hou-Quan Tao, Xu-Jun He, Ming Long, Sheng Yu, Ying-Jie Xia, Zhang Wei, et al. “Prevalence of deleterious ATM germline mutations in gastric cancer patients..” Oncotarget 6, no. 38 (December 1, 2015): 40953–58. https://doi.org/10.18632/oncotarget.5944.
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    • Zhang, Liwei, Lee H. Chen, Hong Wan, Rui Yang, Zhaohui Wang, Jie Feng, Shaohua Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas..” Nat Genet 46, no. 7 (July 2014): 726–30. https://doi.org/10.1038/ng.2995.
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    • Killela, Patrick J., Christopher J. Pirozzi, Patrick Healy, Zachary J. Reitman, Eric Lipp, B Ahmed Rasheed, Rui Yang, et al. “Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas..” Oncotarget 5, no. 6 (March 30, 2014): 1515–25. https://doi.org/10.18632/oncotarget.1765.
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    • Killela, Patrick J., Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B Ahmed Rasheed, Eric Lipp, Henry Friedman, et al. “The genetic landscape of anaplastic astrocytoma..” Oncotarget 5, no. 6 (March 30, 2014): 1452–57. https://doi.org/10.18632/oncotarget.1505.
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    • López, G. Y., G. A. Grant, H. E. Fuchs, L. G. Leithe, S. Gururangan, D. D. Bigner, H. Yan, R. E. McLendon, and Y. He. “Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations..” Neuropathol Appl Neurobiol 40, no. 2 (February 2014): 217–20. https://doi.org/10.1111/nan.12060.
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    • Wortham, Matthew, Changcun Guo, Monica Zhang, Lingyun Song, Bum-Kyu Lee, Vishwanath R. Iyer, Terrence S. Furey, Gregory E. Crawford, Hai Yan, and Yiping He. “Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma..” Plos One 9, no. 9 (2014). https://doi.org/10.1371/journal.pone.0107156.
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    • Zhang, L., L. H. Chen, H. Wan, R. Yang, Z. Wang, J. Feng, S. Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.” Nature Genetics 46, no. 7 (January 1, 2014): 726–30. https://doi.org/10.1038/ng.2995.
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    • Guo, Changcun, Lee H. Chen, Yafen Huang, Chun-Chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, et al. “KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation..” Oncotarget 4, no. 11 (November 2013): 2144–53. https://doi.org/10.18632/oncotarget.1555.
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    • Killela, Patrick J., Zachary J. Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A. Diaz, Allan H. Friedman, et al. “TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal..” Proc Natl Acad Sci U S A 110, no. 15 (April 9, 2013): 6021–26. https://doi.org/10.1073/pnas.1303607110.
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    • Jin, Genglin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B Ahmed Rasheed, Rui Yang, et al. “Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas..” Cancer Res 73, no. 2 (January 15, 2013): 496–501. https://doi.org/10.1158/0008-5472.CAN-12-2852.
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    • Guo, Changcun, Chun-Chi Chang, Matthew Wortham, Lee H. Chen, Dawn N. Kernagis, Xiaoxia Qin, Young-Wook Cho, et al. “Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways..” Proc Natl Acad Sci U S A 109, no. 43 (October 23, 2012): 17603–8. https://doi.org/10.1073/pnas.1208807109.
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    • Jin, Genglin, Christopher J. Pirozzi, Lee H. Chen, Giselle Y. Lopez, Christopher G. Duncan, Jie Feng, Ivan Spasojevic, Darell D. Bigner, Yiping He, and Hai Yan. “Mutant IDH1 is required for IDH1 mutated tumor cell growth..” Oncotarget 3, no. 8 (August 2012): 774–82. https://doi.org/10.18632/oncotarget.577.
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    • Jiao, Yuchen, Patrick J. Killela, Zachary J. Reitman, Ahmed B. Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, et al. “Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas..” Oncotarget 3, no. 7 (July 2012): 709–22. https://doi.org/10.18632/oncotarget.588.
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    • Wortham, Matthew, Genglin Jin, Julia Lailai Sun, Darell D. Bigner, Yiping He, and Hai Yan. “Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells..” Plos One 7, no. 4 (2012). https://doi.org/10.1371/journal.pone.0036211.
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    • Heaphy, Christopher M., Roeland F. de Wilde, Yuchen Jiao, Alison P. Klein, Barish H. Edil, Chanjuan Shi, Chetan Bettegowda, et al. “Altered telomeres in tumors with ATRX and DAXX mutations..” Science 333, no. 6041 (July 22, 2011). https://doi.org/10.1126/science.1207313.
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    • Reitman, Zachary J., Genglin Jin, Edward D. Karoly, Ivan Spasojevic, Jian Yang, Kenneth W. Kinzler, Yiping He, Darell D. Bigner, Bert Vogelstein, and Hai Yan. “Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome..” Proc Natl Acad Sci U S A 108, no. 8 (February 22, 2011): 3270–75. https://doi.org/10.1073/pnas.1019393108.
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    • Parsons, D Williams, Meng Li, Xiaosong Zhang, Siân Jones, Rebecca J. Leary, Jimmy Cheng-Ho Lin, Simina M. Boca, et al. “The genetic landscape of the childhood cancer medulloblastoma..” Science 331, no. 6016 (January 28, 2011): 435–39. https://doi.org/10.1126/science.1198056.
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    • He, Yiping, Jian Wu, Devin C. Dressman, Christine Iacobuzio-Donahue, Sanford D. Markowitz, Victor E. Velculescu, Luis A. Diaz, Kenneth W. Kinzler, Bert Vogelstein, and Nickolas Papadopoulos. “Heteroplasmic mitochondrial DNA mutations in normal and tumour cells..” Nature 464, no. 7288 (March 25, 2010): 610–14. https://doi.org/10.1038/nature08802.
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    • Li, Meng, Wei-Dong Chen, Nickolas Papadopoulos, Steven N. Goodman, Niels Christian Bjerregaard, Søren Laurberg, Bernard Levin, et al. “Sensitive digital quantification of DNA methylation in clinical samples..” Nat Biotechnol 27, no. 9 (September 2009): 858–63. https://doi.org/10.1038/nbt.1559.
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    • Yashiro-Ohtani, Yumi, Yiping He, Takuya Ohtani, Mary E. Jones, Olga Shestova, Lanwei Xu, Terry C. Fang, et al. “Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A..” Genes Dev 23, no. 14 (July 15, 2009): 1665–76. https://doi.org/10.1101/gad.1793709.
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    • He, Yiping, Bert Vogelstein, Victor E. Velculescu, Nickolas Papadopoulos, and Kenneth W. Kinzler. “The antisense transcriptomes of human cells..” Science 322, no. 5909 (December 19, 2008): 1855–57. https://doi.org/10.1126/science.1163853.
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    • Michie, Alison M., Angela C. Chan, Maria Ciofani, Michael Carleton, Juliette M. Lefebvre, Yiping He, David M. Allman, David L. Wiest, Juan Carlos Zúñiga-Pflücker, and David J. Izon. “Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals..” Int Immunol 19, no. 12 (December 2007): 1421–30. https://doi.org/10.1093/intimm/dxm113.
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    • Wouters, Bas J., Meritxell Alberich Jordà, Karen Keeshan, Irene Louwers, Claudia A. J. Erpelinck-Verschueren, Dennis Tielemans, Anton W. Langerak, et al. “Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1..” Blood 110, no. 10 (November 15, 2007): 3706–14. https://doi.org/10.1182/blood-2007-02-073486.
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    • Keeshan, Karen, Yiping He, Bas J. Wouters, Olga Shestova, Lanwei Xu, Hong Sai, Carlos G. Rodriguez, et al. “Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia..” Cancer Cell 10, no. 5 (November 2006): 401–11. https://doi.org/10.1016/j.ccr.2006.09.012.
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    • Diehl, Frank, Meng Li, Yiping He, Kenneth W. Kinzler, Bert Vogelstein, and Devin Dressman. “BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions..” Nat Methods 3, no. 7 (July 2006): 551–59. https://doi.org/10.1038/nmeth898.
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    • Cummins, Jordan M., Yiping He, Rebecca J. Leary, Ray Pagliarini, Luis A. Diaz, Tobias Sjoblom, Omer Barad, et al. “The colorectal microRNAome..” Proc Natl Acad Sci U S A 103, no. 10 (March 7, 2006): 3687–92. https://doi.org/10.1073/pnas.0511155103.
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    • Zweidler-McKay, Patrick A., Yiping He, Lanwei Xu, Carlos G. Rodriguez, Fredrick G. Karnell, Andrea C. Carpenter, Jon C. Aster, David Allman, and Warren S. Pear. “Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies..” Blood 106, no. 12 (December 2005): 3898–3906. https://doi.org/10.1182/blood-2005-01-0355.
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    • Diehl, Frank, Meng Li, Devin Dressman, Yiping He, Dong Shen, Steve Szabo, Luis A. Diaz, et al. “Detection and quantification of mutations in the plasma of patients with colorectal tumors..” Proc Natl Acad Sci U S A 102, no. 45 (November 8, 2005): 16368–73. https://doi.org/10.1073/pnas.0507904102.
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    • Eagar, Todd N., Qizhi Tang, Michael Wolfe, Yiping He, Warren S. Pear, and Jeffrey A. Bluestone. “Notch 1 signaling regulates peripheral T cell activation..” Immunity 20, no. 4 (April 2004): 407–15. https://doi.org/10.1016/s1074-7613(04)00081-0.
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    • Maillard, Ivan, Yiping He, and Warren S. Pear. “From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis..” Immunity 18, no. 5 (May 2003): 587–89. https://doi.org/10.1016/s1074-7613(03)00119-5.
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    • He, Yiping, and Warren S. Pear. “Notch signalling in B cells..” Seminars in Cell & Developmental Biology 14, no. 2 (April 2003): 135–42. https://doi.org/10.1016/s1084-9521(02)00182-9.
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    • Wertheim, Jason A., Juli P. Miller, Lanwei Xu, Yiping He, and Warren S. Pear. “The biology of chronic myelogenous leukemia:mouse models and cell adhesion..” Oncogene 21, no. 56 (December 9, 2002): 8612–28. https://doi.org/10.1038/sj.onc.1206089.
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    • He, Yiping, Jason A. Wertheim, Lanwei Xu, Juli P. Miller, Fredrick G. Karnell, John K. Choi, Ruibao Ren, and Warren S. Pear. “The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl..” Blood 99, no. 8 (April 15, 2002): 2957–68. https://doi.org/10.1182/blood.v99.8.2957.
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    • Izon, David J., Jon C. Aster, Yiping He, Andrew Weng, Fredrick G. Karnell, Vytas Patriub, Lanwei Xu, et al. “Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1..” Immunity 16, no. 2 (February 2002): 231–43. https://doi.org/10.1016/s1074-7613(02)00271-6.
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  • Book Sections

    • Chandramohan, V., L. Sanchez-Perez, Y. He, C. J. Pirozzi, K. L. Congdon, and D. D. Bigner. “Preclinical Immunotherapeutic Animal Models for Brain Tumors.” In Translational Immunotherapy of Brain Tumors, 111–47, 2017. https://doi.org/10.1016/B978-0-12-802420-1.00006-5.
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  • Conference Papers

    • Guo, Changcun, Lee H. Chen, Yafen Huang, Chun-chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, et al. “MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation.” In Cancer Research, Vol. 74, 2014. https://doi.org/10.1158/1538-7445.AM2014-LB-82.
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    • Pirozzi, Christopher J., Catherine Y. Wang, Austin B. Carpenter, Huishan Zhu, Paula K. Greer, Roger E. McLendon, Darell D. Bigner, Yiping He, and Hai Yan. “Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma.” In Tumor Biology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-63.
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    • Guo, Changcun, Chun-Chi Chang, Matthew Wortham, Lee Chen, Dawn Kernagis, Xiaoxia Qin, Young-wook Cho, et al. “GLOBAL IDENTIFICATION OF MLL2-TARGETED LOCI REVEALS MLL2'S ROLE IN DIVERSE SIGNALING PATHWAYS.” In Neuro Oncology, 15:9–9. OXFORD UNIV PRESS INC, 2013.
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    • Wortham, Matthew, Zach Reitman, Yiping He, Darell Bigner, and Hai Yan. “ABERRANT Otx2 EXPRESSION ENHANCES MIGRATION AND INDUCES ECTOPIC PROLIFERATION OF HINDBRAIN NEURONAL PROGENITOR CELLS.” In Neuro Oncology, 15:2–2. OXFORD UNIV PRESS INC, 2013.
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    • Reitman, Zachary J., Genglin Jin, Edward D. Karoly, Ivan Spasojevic, Jian Yang, Kenneth W. Kinzler, Yiping He, Darell D. Bigner, Bert Vogelstein, and Hai Yan. “METABOLOMIC PROFILING OF A GLIOMA CELL LINE EXPRESSING IDH1 AND IDH2 MUTANTS.” In Neuro Oncology, 13:I22–23. OXFORD UNIV PRESS INC, 2011.
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    • Yan, Hai, Zachary J. Reitman, Genglin Jin, Ivan Spasojevic, Yiping He, Dare D. Bigner, Edward D. Karoly, Jian Yang, Kenneth W. Kinzler, and Bert Vogelstein. “Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome.” In Cancer Research, Vol. 71, 2011. https://doi.org/10.1158/1538-7445.AM2011-LB-257.
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• Teaching & Mentoring
• 

  Recent Courses

  • PATHOL 293: Research Independent Study 2019
  • PATHOL 785: Molecular Aspects of Disease 2019
  • PATHOL 793: Research Independent Study 2019
  • NEUROSCI 150: Research Practicum 2018

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