Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Hong Kong (China) 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Chia, Po Ying, et al. “Clinical features of patients with Zika and dengue virus co-infection in Singapore.” The Journal of Infection, vol. 74, no. 6, June 2017, pp. 611–15. Epmc, doi:10.1016/j.jinf.2017.03.007.
       Full Text
    • Ching, Kuan-Chieh, et al. “Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus.” Journal of Medicinal Chemistry, vol. 60, no. 7, Apr. 2017, pp. 3165–86. Epmc, doi:10.1021/acs.jmedchem.7b00180.
       Full Text
    • Her, Zhisheng, et al. “Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.” The Journal of Infectious Diseases, vol. 215, no. 1, Jan. 2017, pp. 42–51. Epmc, doi:10.1093/infdis/jiw494.
       Full Text
    • Simarmata, Diane, et al. “Early clearance of Chikungunya virus in children is associated with a strong innate immune response.” Scientific Reports, vol. 6, May 2016, p. 26097. Epmc, doi:10.1038/srep26097.
       Full Text
    • Ching, Kuan-Chieh, et al. “Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses.” Journal of Medicinal Chemistry, vol. 58, no. 23, Dec. 2015, pp. 9196–213. Epmc, doi:10.1021/acs.jmedchem.5b01047.
       Full Text
    • Goh, Lucas Y. H., et al. “A sensitive epitope-blocking ELISA for the detection of Chikungunya virus-specific antibodies in patients.” Journal of Virological Methods, vol. 222, Sept. 2015, pp. 55–61. Epmc, doi:10.1016/j.jviromet.2015.05.011.
       Full Text
    • Lee, Wendy W. L., et al. “Expanding regulatory T cells alleviates chikungunya virus-induced pathology in mice.” Journal of Virology, vol. 89, no. 15, Aug. 2015, pp. 7893–904. Epmc, doi:10.1128/jvi.00998-15.
       Full Text
    • Teo, Teck-Hui, et al. “Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.” Journal of Virology, vol. 89, no. 15, Aug. 2015, pp. 7955–69. Epmc, doi:10.1128/jvi.00909-15.
       Full Text
    • Teng, Terk-Shin, et al. “A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection.” The Journal of Infectious Diseases, vol. 211, no. 12, June 2015, pp. 1925–35. Epmc, doi:10.1093/infdis/jiv049.
       Full Text
    • Her, Zhisheng, et al. “Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.” Embo Molecular Medicine, vol. 7, no. 1, Jan. 2015, pp. 24–41. Epmc, doi:10.15252/emmm.201404459.
       Full Text
    • Kam, Yiu-Wing, et al. “Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patients.” Plos Neglected Tropical Diseases, vol. 9, no. 1, Jan. 2015, p. e3445. Epmc, doi:10.1371/journal.pntd.0003445.
       Full Text
    • Kam, Yiu-Wing, et al. “Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development.” Plos One, vol. 9, no. 4, Jan. 2014, p. e95647. Epmc, doi:10.1371/journal.pone.0095647.
       Full Text
    • Lum, Fok-Moon, et al. “An essential role of antibodies in the control of Chikungunya virus infection.” Journal of Immunology (Baltimore, Md. : 1950), vol. 190, no. 12, June 2013, pp. 6295–302. Epmc, doi:10.4049/jimmunol.1300304.
       Full Text
    • Chen, Karen Caiyun, et al. “Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage.” Virology Journal, vol. 10, May 2013, p. 169. Epmc, doi:10.1186/1743-422x-10-169.
       Full Text
    • Kam, Yiu-Wing, et al. “Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine development.” Journal of Virology, vol. 86, no. 23, Dec. 2012, pp. 13005–15. Epmc, doi:10.1128/jvi.01780-12.
       Full Text
    • Kam, Yiu-Wing, et al. “Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.” The Journal of Infectious Diseases, vol. 205, no. 7, Apr. 2012, pp. 1147–54. Epmc, doi:10.1093/infdis/jis033.
       Full Text
    • Kam, Yiu-Wing, et al. “Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein.” Embo Molecular Medicine, vol. 4, no. 4, Apr. 2012, pp. 330–43. Epmc, doi:10.1002/emmm.201200213.
       Full Text
    • Lee, Chia Yin, et al. “Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants.” Plos Pathogens, vol. 7, no. 12, Dec. 2011, p. e1002390. Epmc, doi:10.1371/journal.ppat.1002390.
       Full Text
    • Wee, Lawrence J. K., et al. “SVM-based prediction of linear B-cell epitopes using Bayes Feature Extraction.” Bmc Genomics, vol. 11 Suppl 4, Dec. 2010, p. S21. Epmc, doi:10.1186/1471-2164-11-s4-s21.
       Full Text
    • Her, Zhisheng, et al. “Chikungunya: a bending reality.” Microbes and Infection, vol. 11, no. 14–15, Dec. 2009, pp. 1165–76. Epmc, doi:10.1016/j.micinf.2009.09.004.
       Full Text
    • Kam, Yiu-Wing, et al. “Immuno-biology of Chikungunya and implications for disease intervention.” Microbes and Infection, vol. 11, no. 14–15, Dec. 2009, pp. 1186–96. Epmc, doi:10.1016/j.micinf.2009.09.003.
       Full Text
    • Kam, Yiu-Wing, et al. “Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro.” Plos One, vol. 4, no. 11, Nov. 2009, p. e7870. Epmc, doi:10.1371/journal.pone.0007870.
       Full Text
    • Ho, Joanna W., et al. “H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.” Journal of Virology, vol. 82, no. 4, Feb. 2008, pp. 2028–32. Epmc, doi:10.1128/jvi.02065-07.
       Full Text
    • Kam, Yiu Wing, et al. “Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro.” Vaccine, vol. 25, no. 4, Jan. 2007, pp. 729–40. Epmc, doi:10.1016/j.vaccine.2006.08.011.
       Full Text

  • Conference Papers

    • Chan, S. .. Y., et al. “Challenges in serological screening for recent Zika infections in pregnancy: Results of a hospital-based cohort in dengue-endemic Singapore.” Bjog an International Journal of Obstetrics and Gynaecology, vol. 125, WILEY, 2018, pp. 113–113.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.