Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellowship, University of North Carolina - Chapel Hill 2006 - 2008
  • Postdoctoral Fellowship, University of Wurzburg (Germany) 2003 - 2006
  • Ph.D., Lanzhou University (China) 2003
• 

  Previous Appointments & Affiliations

  • Associate Professor of Neurology, Neurology, Headache and Pain, Neurology 2022
  • Assistant Professor in Pathology, Pathology, Clinical Science Departments 2020 - 2022
  • Assistant Professor in Neurology, Neurology, Headache and Pain, Neurology 2021 - 2022
  • Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2021 - 2022
  • Assistant Professor in Neurology, Neurology, Headache and Pain, Neurology 2018 - 2020
  • Assistant Professor in Neurology, Neurology, Headache and Pain, Neurology 2016 - 2017
• Recognition
• 

  In the News

  • APR 5, 2021

    Maddening Itch of Liver Disease Comes from a Surprising Source
• 

  Awards & Honors

  • Outstanding-Poster Award. the 1st Duke-Kunshan University Translational Pain Research Symposium. 2017
  • Travel Award for the 8th Scientific Meeting of the Temporomandibular Joint Association. The TMJ Association. 2016
  • Stephen B. Milam Award for Excellence in Temporomandibular Disorders Research. The TMJ Association. 2014
  • Travel Award for the 7th Scientific Meeting of the Temporomandibular Joint Association. The TMJ Association. 2014
  • Leon-Goldberg Fellowship. Nicholas School for the Environment. 2010
  • Leon-Goldberg Fellowship. Nicholas School for the Environment. 2009
  • Jiuyuan Scholarship of Life Sciences. Tan Jiazhen Foundation. 2002
  • The Best Poster Award. The 7th International Chinese Peptide Symposium. 2002
  • Haizheng Scholarship. Lanzhou University. 2001
  • Haizheng Scholarship. Lanzhou University. 2000
• Research
• 

  Selected Grants

  • Neural Architecture of the Murine and Human Temporomandibular Joint awarded by National Institutes of Health 2022 - 2025
  • Deconstructing Cartilage Mechanotransduction by Piezo Channels awarded by Washington University in St. Louis 2021 - 2023
  • Modeling temporomandibular joint pain: role of transient receptor potential channels awarded by National Institutes of Health 2018 - 2023
  • Biomedical Researcher Development Scholarship (BRDS) Research Career Development Award (K12) awarded by University of North Carolina - Chapel Hill 2015 - 2018
  • Masticatory sensitization of trigeminal ganglion sensory neurons awarded by National Institutes of Health 2014 - 2016
  • Control of trigeminal touch sensory circuit assembly awarded by National Institutes of Health 2009 - 2016
  • Small Molecule Therapy to Inhibit Osteoarthritis Progression in the Aging awarded by Cytex Therapeutics Inc. 2013 - 2015
  • Mechanical and Osmotic Signaling in Chondrocytes awarded by National Institutes of Health 2001 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Suttle, Abbie, Peng Wang, Fabiana C. Dias, Qiaojuan Zhang, Yuhui Luo, Lauren Simmons, Andrey Bortsov, Inna E. Tchivileva, Andrea G. Nackley, and Yong Chen. “Sensory Neuron-TRPV4 Modulates Temporomandibular Disorder Pain Via CGRP in Mice.” J Pain 24, no. 5 (May 2023): 782–95. https://doi.org/10.1016/j.jpain.2022.12.001.
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    • Wang, Peng, Qiaojuan Zhang, Fabiana C. Dias, Abbie Suttle, Xinzhong Dong, and Yong Chen. “TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain.” Front Mol Neurosci 16 (2023): 1160206. https://doi.org/10.3389/fnmol.2023.1160206.
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    • Zhang, Yang, Pengfei Liang, Liheng Yang, Ke Zoe Shan, Liping Feng, Yong Chen, Wolfgang Liedtke, Carolyn B. Coyne, and Huanghe Yang. “Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.” Elife 11 (June 7, 2022). https://doi.org/10.7554/eLife.78840.
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    • Zhang, Qiaojuan, Fabiana Dias, Quan Fang, Gwendolyn Henry, Zilong Wang, Abbie Suttle, and Yong Chen. “Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours.” Acta Derm Venereol 102 (February 22, 2022): adv00651. https://doi.org/10.2340/actadv.v102.1621.
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    • Yeo, Michele, Qiaojuan Zhang, LeAnne Ding, Xiangjun Shen, Yong Chen, and Wolfgang Liedtke. “Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments.” Front Mol Neurosci 15 (2022): 911606. https://doi.org/10.3389/fnmol.2022.911606.
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    • Yeo, Michele, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, et al. “Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.” Nat Commun 12, no. 1 (October 27, 2021): 6208. https://doi.org/10.1038/s41467-021-26270-3.
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    • Luo, Xin, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, et al. “IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.” Neuron 109, no. 17 (September 1, 2021): 2691-2706.e5. https://doi.org/10.1016/j.neuron.2021.06.015.
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    • Zhang, Qiaojuan, Gwendolyn Henry, and Yong Chen. “Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch.” Int J Mol Sci 22, no. 14 (July 15, 2021). https://doi.org/10.3390/ijms22147591.
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    • Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.
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    • Luo, Yuhui, Abbie Suttle, Qiaojuan Zhang, Peng Wang, and Yong Chen. “Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain.” Mol Neurobiol 58, no. 6 (June 2021): 2836–50. https://doi.org/10.1007/s12035-021-02284-2.
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    • Lee, Whasil, Robert J. Nims, Alireza Savadipour, Qiaojuan Zhang, Holly A. Leddy, Fang Liu, Amy L. McNulty, Yong Chen, Farshid Guilak, and Wolfgang B. Liedtke. “Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.” Proc Natl Acad Sci U S A 118, no. 13 (March 30, 2021). https://doi.org/10.1073/pnas.2001611118.
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    • Hua, Thuy, Bin Chen, Dongye Lu, Katsuyasu Sakurai, Shengli Zhao, Bao-Xia Han, Jiwoo Kim, et al. “General anesthetics activate a potent central pain-suppression circuit in the amygdala.” Nat Neurosci 23, no. 7 (July 2020): 854–68. https://doi.org/10.1038/s41593-020-0632-8.
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    • Xu, Biao, Mengna Zhang, Xuerui Shi, Run Zhang, Dan Chen, Yong Chen, Zilong Wang, et al. “The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.” Br J Pharmacol 177, no. 1 (January 2020): 93–109. https://doi.org/10.1111/bph.14848.
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    • Zhang, Ting, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, et al. “Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.” J Neuroinflammation 15, no. 1 (November 15, 2018): 320. https://doi.org/10.1186/s12974-018-1358-3.
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    • Moore, Carlene, Rupali Gupta, Sven-Eric Jordt, Yong Chen, and Wolfgang B. Liedtke. “Regulation of Pain and Itch by TRP Channels.” Neurosci Bull 34, no. 1 (February 2018): 120–42. https://doi.org/10.1007/s12264-017-0200-8.
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    • Rodriguez, Erica, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, et al. “A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci 20, no. 12 (December 2017): 1734–43. https://doi.org/10.1038/s41593-017-0012-1.
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    • Chen, Yong, Carlene D. Moore, Jennifer Y. Zhang, Russell P. Hall, Amanda S. MacLeod, and Wolfgang Liedtke. “TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.” J Invest Dermatol 137, no. 4 (April 2017): 801–4. https://doi.org/10.1016/j.jid.2016.12.013.
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    • Kanju, Patrick, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, et al. “Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.” Sci Rep 6 (June 1, 2016): 26894. https://doi.org/10.1038/srep26894.
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    • Chen, Yong, Quan Fang, Zilong Wang, Jennifer Y. Zhang, Amanda S. MacLeod, Russell P. Hall, and Wolfgang B. Liedtke. “Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.” J Biol Chem 291, no. 19 (May 6, 2016): 10252–62. https://doi.org/10.1074/jbc.M116.716464.
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    • Zhang, Yi, Yong Chen, Wolfgang Liedtke, and Fan Wang. “Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.” Mol Pain 11 (April 10, 2015): 18. https://doi.org/10.1186/s12990-015-0017-2.
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    • Chen, Yong, Patrick Kanju, Quan Fang, Suk Hee Lee, Puja K. Parekh, Whasil Lee, Carlene Moore, et al. “TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.” Pain 155, no. 12 (December 2014): 2662–72. https://doi.org/10.1016/j.pain.2014.09.033.
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    • Lee, Whasil, Holly A. Leddy, Yong Chen, Suk Hee Lee, Nicole A. Zelenski, Amy L. McNulty, Jason Wu, et al. “Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.” Proc Natl Acad Sci U S A 111, no. 47 (November 25, 2014): E5114–22. https://doi.org/10.1073/pnas.1414298111.
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    • Moore, Carlene, Ferda Cevikbas, H Amalia Pasolli, Yong Chen, Wei Kong, Cordula Kempkes, Puja Parekh, et al. “UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.” Proc Natl Acad Sci U S A 110, no. 34 (August 20, 2013): E3225–34. https://doi.org/10.1073/pnas.1312933110.
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    • Chen, Yong, Susan H. Williams, Amy L. McNulty, Ji Hee Hong, Suk Hee Lee, Nicole E. Rothfusz, Puja K. Parekh, et al. “Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.” Pain 154, no. 8 (August 2013): 1295–1304. https://doi.org/10.1016/j.pain.2013.04.004.
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    • Chen, Yong, Florian Palm, Klaus-Peter Lesch, Manfred Gerlach, Rainald Moessner, and Claudia Sommer. “5-Hydroxyindolacetic Acid (5-HIAA), a Main Metabolite of Serotonin, is Responsible for Complete Freund's Adjuvant-Induced Thermal Hyperalgesia in Mice.” Molecular Pain 7 (January 1, 2011). https://doi.org/10.1186/1744-8069-7-21.
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    • Willcockson, Helen H., Yong Chen, Ji Eun Han, and Juli G. Valtschanoff. “Effect of genetic deletion of the vanilloid receptor TRPV1 on the expression of Substance P in sensory neurons of mice with adjuvant-induced arthritis.” Neuropeptides 44, no. 4 (August 2010): 293–97. https://doi.org/10.1016/j.npep.2010.02.003.
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    • Chen, Yong, Michael K. Boettger, Andreas Reif, Angelika Schmitt, Nurcan Üçeyler, and Claudia Sommer. “Nitric Oxide Synthase Modulates CFA-Induced Thermal Hyperalgesia through Cytokine Regulation in Mice.” Molecular Pain 6 (January 1, 2010). https://doi.org/10.1186/1744-8069-6-13.
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    • Chen, Yong, Helen H. Willcockson, and Juli G. Valtschanoff. “Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain.” Experimental Neurology 220, no. 2 (December 2009): 383–90. https://doi.org/10.1016/j.expneurol.2009.09.030.
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    • Chen, Yong, and Claudia Sommer. “The role of mitogen-activated protein kinase (MAPK) in morphine tolerance and dependence.” Mol Neurobiol 40, no. 2 (October 2009): 101–7. https://doi.org/10.1007/s12035-009-8074-z.
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    • Chen, Y., H. H. Willcockson, and J. G. Valtschanoff. “Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritis.” Osteoarthritis and Cartilage 17, no. 2 (February 2009): 244–51. https://doi.org/10.1016/j.joca.2008.06.015.
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    • Chen, Yong, Helen H. Willcockson, and Juli G. Valtschanoff. “Increased expression of CGRP in sensory afferents of arthritic mice – effect of genetic deletion of the vanilloid receptor TRPV1.” Neuropeptides 42, no. 5–6 (October 2008): 551–56. https://doi.org/10.1016/j.npep.2008.08.001.
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    • Palm, Florian, Rainald Mössner, Yong Chen, Lan He, Manfred Gerlach, Stefan Bischofs, Peter Riederer, Klaus-Peter Lesch, and Claudia Sommer. “Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter.” European Journal of Pain 12, no. 6 (August 2008): 790–97. https://doi.org/10.1016/j.ejpain.2007.11.009.
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    • Chen, Yong, Christian Geis, and Claudia Sommer. “Activation of TRPV1 Contributes to Morphine Tolerance: Involvement of the Mitogen-Activated Protein Kinase Signaling Pathway.” The Journal of Neuroscience 28, no. 22 (May 28, 2008): 5836–45. https://doi.org/10.1523/jneurosci.4170-07.2008.
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    • Boettger, Michael Karl, Nurcan Üceyler, Marek Zelenka, Angelika Schmitt, Andreas Reif, Yong Chen, and Claudia Sommer. “Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice.” European Journal of Pain 11, no. 7 (October 2007): 810–18. https://doi.org/10.1016/j.ejpain.2006.12.008.
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    • Chen, Yong, and Claudia Sommer. “Activation of the nociceptin opioid system in rat sensory neurons produces antinociceptive effects in inflammatory pain: Involvement of inflammatory mediators.” Journal of Neuroscience Research 85, no. 7 (May 15, 2007): 1478–88. https://doi.org/10.1002/jnr.21272.
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    • Chen, Yong, and Claudia Sommer. “Nociceptin and its receptor in rat dorsal root ganglion neurons in neuropathic and inflammatory pain models: implications on pain processing.” Journal of the Peripheral Nervous System 11, no. 3 (September 2006): 232–40. https://doi.org/10.1111/j.1529-8027.2006.0093.x.
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    • Yang, Qi, Yong Chen, Caiyun Fu, Min Chang, Yali Peng, and Rui Wang. “Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.” Protein Pept Lett 13, no. 2 (2006): 185–88. https://doi.org/10.2174/092986606775101706.
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    • Chen, Li-xiang, Quan Fang, Qiang Chen, Jia Guo, Zhuan-zi Wang, Yong Chen, and Rui Wang. “Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.” Peptides 25, no. 8 (August 2004): 1349–54. https://doi.org/10.1016/j.peptides.2004.05.012.
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    • Chen, L. X., Y. Chen, Y. L. Peng, Z. Z. Wang, Q. Chen, and R. Wang. “Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice.” Yaoxue Xuebao 37, no. 11 (November 1, 2002): 837–40.
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    • Chen, Li-Xiang, Zhuan-Zi Wang, Hua Wu, Quan Fang, Yong Chen, and Rui Wang. “Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice.” Neurosci Lett 331, no. 2 (October 11, 2002): 95–98. https://doi.org/10.1016/s0304-3940(02)00844-3.
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    • Chen, Y., M. Chang, Z. Z. Wang, L. X. Chen, Q. Yang, Y. M. Qi, and R. Wang. “[Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat.” Can J Physiol Pharmacol 80, no. 1 (January 2002): 31–35. https://doi.org/10.1139/y02-003.
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    • Chen, Q., Y. Chen, L. Chen, D. Yang, S. Dong, and R. Wang. “The effects of the synthetic nocistatin on blood vessel activities.” Chinese Science Bulletin 46, no. 8 (January 1, 2001): 675–78. https://doi.org/10.1007/BF03182834.
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