Overview
Dr. Yongmei Liu is a genetic epidemiologist with appointments in Cardiology/Medicine and Neurology. Her primary interests are to better understand the molecular mechanisms of aging-related inflammatory diseases including diabetes, atherosclerosis, and Alzheimer’s disease by studying genome, the interplay of genetic and environmental factors, and epigenomic and transcriptomic profiles. The combination of an unbiased genome-wide search in large sample sizes of disease relevant tissues/cells with longitudinal and randomized clinical trial designs, followed up by in vitro and in vivo experiments, is providing novel biomarkers for risk prediction and new insights into mechanisms that are involved in inflammatory diseases.
Current Appointments & Affiliations
Professor of Medicine
·
2020 - Present
Medicine, Cardiology,
Medicine
Professor in Population Health Sciences
·
2021 - Present
Population Health Sciences,
Basic Science Departments
Member of Duke Molecular Physiology Institute
·
2018 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations.
Journal Article Epigenetics · December 2024 Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation ... Full text Link to item CiteImmune and inflammation features of severe and critical Omicron infected patients during Omicron wave in China
Journal Article BMC Infectious Diseases · December 1, 2024 Objective: The current study aimed to investigate the baseline immune and inflammatory features and in-hospital outcomes of patients infected with the Omicron variant (PIWO) who presented with different disease severities during the first wave of mass Omic ... Full text CiteIncrease in Mitochondrial Mass of Lymphocyte Subsets in Anti-MDA5 and TIF1-γ-Positive Dermatomyositis Patients.
Journal Article Immunol Invest · November 2024 OBJECTIVES: The mitochondrial function in anti-MDA5 and TIF1-γ-positive dermatomyositis (DM) is relatively unknown. This study attempted to explore mitochondrial mass within the peripheral lymphocyte subsets of anti-MDA5 and TIF1-γ-positive DM. METHODS: Th ... Full text Link to item CiteRecent Grants
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD
ResearchPrincipal Investigator · Awarded by Wake Forest University · 2024 - 2029T helper cells in development of chronic inflammation and multi-morbidity
ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2023 - 2028Common mechanistic biomarkers of vascular and neuro-degeneration
ResearchPrincipal Investigator · Awarded by National Institute on Aging · 2023 - 2027View All Grants
Education, Training & Certifications
Johns Hopkins Unversity, Bloomberg School of Public Health ·
2004
Ph.D.
Bengbu Medical College (China) ·
1991
M.D.