Yongmei Liu
Professor of Medicine
Current Research Interests
Our research program is centered on genomics, especially immunogenomics, to better understand the interplay of genetic and environmental factors in the development of diabetes, atherosclerosis, and Alzheimer’s disease. We have been leading the genome-wide association study of Health, Aging and Body Composition (Health ABC) cohort, a population-based, multi-ethnic, and prospective cohort of 3,000 elders. Our grant, Epigenomic Study of Atherosclerosis in the Multi-ethnic Study of Atherosclerosis (MESA), funded through NIH RoadMap Epigenomics Initiatives in 2009 has enabled us to collect and purify high quality CD14+ monocytes and CD4+ T cells from fresh blood, drawn from 2,800 MESA participants at MESA exam 5 (2010-2012) from four out of the six communities. Our group is among the first to show that immunogenomics (e.g., DNA methylomics and transcriptomics) of purified disease-relevant cells, in a large cohort (e.g., circulating monocytes from ~1260 subjects), has robust power and promise, to discover the biology of inflammatory diseases. These published works have yielded new genes and gene pathways potentially causal to diabetes and CVD.
Our work in this area has been continuously funded by several NIH grants, including a randomized clinical trial grant. The aims of the grants are to assess the predictive power of the identified genomic features on the incidence of inflammatory diseases, and better understand the causes and consequences of the identified genomic features. We are also examining the causes of longitudinal changes of the genomic features by repeating the epigenomics and transcriptomics profiling of monocytes at MESA exam 6. Our current projects focus on the roles of transcriptomics, epigenomics (e.g., DNA methylation, histone modification, chromatin accessibility, et.al.,) and non-coding RNAs (in particular microRNAs, enhancer RNAs) in various tissue/cell types (including monoctyes, macrophages, T cells, and adipocytes), using state-of- the-art sequencing and new single-cell genomic technologies. We also conduct mechanistic and functional studies (in vitro and in vivo experiments) to follow up on most promising signals from population-based observational studies.
Office Hours
Current Appointments & Affiliations
- Professor of Medicine, Medicine, Cardiology, Medicine 2020
- Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2021
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2018
Contact Information
- 300 N. Duke Street, Durham, NC 27701
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yongmei.liu@duke.edu
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Dr. Yongmei Liu
- Background
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Education, Training, & Certifications
- Ph.D., Johns Hopkins Unversity, Bloomberg School of Public Health 2004
- M.D., Bengbu Medical College (China) 1991
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Previous Appointments & Affiliations
- Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2018 - 2020
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Academic Positions Outside Duke
- Professor, Public Health Division, Wake Forest University, School of Medicine. 2015 - 2018
- Associate Professor, Public Health Division, Wake Forest University, School of Medicine. 2009 - 2015
- Assistant Professor, Public Health Division, Wake Forest University. 2004 - 2009
- Recognition
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In the News
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NOV 18, 2014 ScienceDaily
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- Expertise
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Subject Headings
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Global Scholarship
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Research
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- Research
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Selected Grants
- Common mechanistic biomarkers of vascular and neuro-degeneration awarded by National Institutes of Health 2023 - 2027
- Trajectories of blood-based biomarkers of AD, their determinants, and ability to predict cognitive impairment awarded by National Institutes of Health 2022 - 2023
- Aging Biomarkers: Integrating Omic Profiles with Mechanistic Measures awarded by Wake Forest University School Of Medicine 2019 - 2023
- Low-level Arsenic Exposure and Cardiovascular Disease in Multi-Ethnic Adults awarded by Columbia University 2018 - 2023
- Race/Ethnicity, DNA Methylation, and Disparities in Cardiovascular Mortality: NHANES 1999-2002 awarded by University of Michigan 2017 - 2023
- Epigenetics of Weight-Loss and Glycemic Improvement awarded by Wake Forest University School Of Medicine 2019 - 2023
- A Longitudinal Epigenetic Study of Atherosclerosis awarded by National Institutes of Health 2020 - 2022
- Cell-Specific genomic features of Alzheimer's disease progression Supplment awarded by Wake Forest University Health Sciences 2019 - 2022
- Obesity-Related Epigenetic Changes and Type-2 Diabetes awarded by National Institutes of Health 2019 - 2022
- Cell-Specific genomic features of Alzheimer's disease progression awarded by Wake Forest University School Of Medicine 2019 - 2022
- miRNA Epigenetic Roles in Regulations of Cholesterol Metabolism and CVD Risk awarded by National Institutes of Health 2014 - 2019
- Aging Biomarkers: Integrating Omic Profiles with Mechanistic Measures awarded by Wake Forest University School Of Medicine 2019
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hahn, Julie, Jan Bressler, Arce Domingo-Relloso, Ming-Huei Chen, Daniel L. McCartney, Alexander Teumer, Jenny van Dongen, et al. “DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood.” J Thromb Haemost 21, no. 5 (May 2023): 1135–47. https://doi.org/10.1016/j.jtha.2023.01.015.Full Text Link to Item
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Bakker, Mark K., Jos P. Kanning, Gad Abraham, Amy E. Martinsen, Bendik S. Winsvold, John-Anker Zwart, Romain Bourcier, et al. “Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.” Stroke 54, no. 3 (March 2023): 810–18. https://doi.org/10.1161/STROKEAHA.122.040715.Full Text Link to Item
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Du, Jiacong, Xiang Zhou, Dylan Clark-Boucher, Wei Hao, Yongmei Liu, Jennifer A. Smith, and Bhramar Mukherjee. “Methods for large-scale single mediator hypothesis testing: Possible choices and comparisons.” Genet Epidemiol 47, no. 2 (March 2023): 167–84. https://doi.org/10.1002/gepi.22510.Full Text Link to Item
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Ding, Jingzhong, Kurt Lohman, Anthony Molina, Osvaldo Delbono, Alain Bertoni, Steven Shea, Wendy Post, et al. “The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA).” Geroscience 45, no. 1 (February 2023): 197–207. https://doi.org/10.1007/s11357-022-00608-1.Full Text Link to Item
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Vargas, Luciana B., Leslie A. Lange, Kendra Ferrier, François Aguet, Kristin Ardlie, Stacey Gabriel, Namrata Gupta, et al. “Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.” Int J Obes (Lond) 47, no. 2 (February 2023): 109–16. https://doi.org/10.1038/s41366-022-01240-x.Full Text Link to Item
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Buschur, Kristina L., Craig Riley, Aabida Saferali, Peter Castaldi, Grace Zhang, Francois Aguet, Kristin G. Ardlie, et al. “Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis.” Respir Res 24, no. 1 (January 25, 2023): 30. https://doi.org/10.1186/s12931-023-02316-6.Full Text Link to Item
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Li, Xihao, Corbin Quick, Hufeng Zhou, Sheila M. Gaynor, Yaowu Liu, Han Chen, Margaret Sunitha Selvaraj, et al. “Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.” Nat Genet 55, no. 1 (January 2023): 154–64. https://doi.org/10.1038/s41588-022-01225-6.Full Text Link to Item
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Xu, J., H. Si, Y. Zeng, Y. Wu, S. Zhang, Y. Liu, M. Li, and B. Shen. “Transcriptome-wide association study identifies new susceptibility genes for degenerative cervical spondylosis.” Bone and Joint Research 12, no. 1 (January 1, 2023): 80–90. https://doi.org/10.1302/2046-3758.121.BJR-2022-0225.R1.Full Text
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Liang, Jingjing, Heming Wang, Brian E. Cade, Nuzulul Kurniansyah, Karen Y. He, Jiwon Lee, Scott A. Sands, et al. “Targeted Genome Sequencing Identifies Multiple Rare Variants in Caveolin-1 Associated with Obstructive Sleep Apnea.” Am J Respir Crit Care Med 206, no. 10 (November 15, 2022): 1271–80. https://doi.org/10.1164/rccm.202203-0618OC.Full Text Link to Item
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Selvaraj, Margaret Sunitha, Xihao Li, Zilin Li, Akhil Pampana, David Y. Zhang, Joseph Park, Stella Aslibekyan, et al. “Whole genome sequence analysis of blood lipid levels in >66,000 individuals.” Nat Commun 13, no. 1 (October 11, 2022): 5995. https://doi.org/10.1038/s41467-022-33510-7.Full Text Link to Item
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Hu, Jie, Jie Yao, Shuliang Deng, Raji Balasubramanian, Monik C. Jiménez, Jun Li, Xiuqing Guo, et al. “Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts.” Circ Res 131, no. 7 (September 16, 2022): 601–15. https://doi.org/10.1161/CIRCRESAHA.121.320134.Full Text Link to Item
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Fiorito, Giovanni, Sara Pedron, Carolina Ochoa-Rosales, Cathal McCrory, Silvia Polidoro, Yan Zhang, Pierre-Antoine Dugué, et al. “The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.” J Gerontol a Biol Sci Med Sci 77, no. 9 (September 1, 2022): 1750–59. https://doi.org/10.1093/gerona/glac041.Full Text Link to Item
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Young, William J., Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, Farah Ahmed, Jennifer A. Brody, et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nat Commun 13, no. 1 (September 1, 2022): 5144. https://doi.org/10.1038/s41467-022-32821-z.Full Text Link to Item
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Tahir, Usman A., Daniel H. Katz, Julian Avila-Pachecho, Alexander G. Bick, Akhil Pampana, Jeremy M. Robbins, Zhi Yu, et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.” Nat Commun 13, no. 1 (August 22, 2022): 4923. https://doi.org/10.1038/s41467-022-32275-3.Full Text Link to Item
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Lee, Mikyeong, Tianxiao Huan, Daniel L. McCartney, Geetha Chittoor, Maaike de Vries, Lies Lahousse, Jennifer N. Nguyen, et al. “Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.” Am J Respir Crit Care Med 206, no. 3 (August 1, 2022): 321–36. https://doi.org/10.1164/rccm.202108-1907OC.Full Text Link to Item
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Domingo-Relloso, Arce, Kiran Makhani, Angela L. Riffo-Campos, Maria Tellez-Plaza, Kathleen Oros Klein, Pooja Subedi, Jinying Zhao, et al. “Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease.” Circ Res 131, no. 2 (July 8, 2022): e51–69. https://doi.org/10.1161/CIRCRESAHA.122.320991.Full Text Link to Item
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Patel, Roshni A., Shaila A. Musharoff, Jeffrey P. Spence, Harold Pimentel, Catherine Tcheandjieu, Hakhamanesh Mostafavi, Nasa Sinnott-Armstrong, et al. “Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.” Am J Hum Genet 109, no. 7 (July 7, 2022): 1286–97. https://doi.org/10.1016/j.ajhg.2022.05.014.Full Text Link to Item
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Yang, Jiaomei, Huaidong Du, Yu Guo, Zheng Bian, Canqing Yu, Yiping Chen, Ling Yang, et al. “Coarse Grain Consumption and Risk of Cardiometabolic Diseases: A Prospective Cohort Study of Chinese Adults.” J Nutr 152, no. 6 (June 9, 2022): 1476–86. https://doi.org/10.1093/jn/nxac041.Full Text Link to Item
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Schmitz, Lauren L., Wei Zhao, Scott M. Ratliff, Julia Goodwin, Jiacheng Miao, Qiongshi Lu, Xiuqing Guo, et al. “The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study.” Epigenetics 17, no. 6 (June 2022): 589–611. https://doi.org/10.1080/15592294.2021.1939479.Full Text Link to Item
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Manichaikul, Ani, Honghuang Lin, Chansuk Kang, Chaojie Yang, Stephen S. Rich, Kent D. Taylor, Xiuqing Guo, et al. “Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program.” Commun Biol 5, no. 1 (May 2, 2022): 362. https://doi.org/10.1038/s42003-022-03304-0.Full Text Link to Item
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Mahajan, Anubha, Cassandra N. Spracklen, Weihua Zhang, Maggie C. Y. Ng, Lauren E. Petty, Hidetoshi Kitajima, Grace Z. Yu, et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nat Genet 54, no. 5 (May 2022): 560–72. https://doi.org/10.1038/s41588-022-01058-3.Full Text Link to Item
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Parker, Daniel C., Ma Wan, Kurt Lohman, Li Hou, Anh Tram Nguyen, Jingzhong Ding, Alain Bertoni, et al. “Monocyte miRNAs Are Associated With Type 2 Diabetes.” Diabetes 71, no. 4 (April 1, 2022): 853–61. https://doi.org/10.2337/db21-0704.Full Text Link to Item
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Yang, R., J. Lv, C. Yu, Y. Guo, Z. Bian, Y. Han, L. Yang, et al. “Importance of healthy lifestyle factors and ideal cardiovascular health metrics for risk of heart failure in Chinese adults.” International Journal of Epidemiology 51, no. 2 (April 1, 2022): 567–78. https://doi.org/10.1093/ije/dyab236.Full Text
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Wang, Wenxiu, Jun Lv, Canqing Yu, Yu Guo, Pei Pei, Zhenhuang Zhuang, Ling Yang, et al. “Lifestyle factors and fetal and childhood origins of type 2 diabetes: a prospective study of Chinese and European adults.” Am J Clin Nutr 115, no. 3 (March 4, 2022): 749–58. https://doi.org/10.1093/ajcn/nqab359.Full Text Link to Item
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C Chi, Gloria, Yongmei Liu, James W. MacDonald, Lindsay M Reynolds, Daniel A. Enquobahrie, Annette L Fitzpatrick, Kathleen F. Kerr, et al. “Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the Multi-Ethnic Study of Atherosclerosis.” Epigenetics 17, no. 3 (March 2022): 297–313. https://doi.org/10.1080/15592294.2021.1900028.Full Text Link to Item
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Wainschtein, Pierrick, Deepti Jain, Zhili Zheng, Zhili TOPMed Anthropometry Working Group, Zhili NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, L Adrienne Cupples, Aladdin H. Shadyab, et al. “Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.” Nat Genet 54, no. 3 (March 2022): 263–73. https://doi.org/10.1038/s41588-021-00997-7.Full Text Link to Item
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Katz, Daniel H., Usman A. Tahir, Alexander G. Bick, Akhil Pampana, Debby Ngo, Mark D. Benson, Zhi Yu, et al. “Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease.” Circulation 145, no. 5 (February 2022): 357–70. https://doi.org/10.1161/CIRCULATIONAHA.121.055117.Full Text Link to Item
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Li, Chuan, Lili Qu, Alyssa J. Matz, Patrick A. Murphy, Yongmei Liu, Ani W. Manichaikul, Derek Aguiar, et al. “AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk.” Circulation 145, no. 3 (January 2022): 206–18. https://doi.org/10.1161/circulationaha.121.054285.Full Text
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Schubert, Ryan, Elyse Geoffroy, Isabelle Gregga, Ashley J. Mulford, Francois Aguet, Kristin Ardlie, Robert Gerszten, et al. “Protein prediction for trait mapping in diverse populations.” Plos One 17, no. 2 (2022): e0264341. https://doi.org/10.1371/journal.pone.0264341.Full Text Link to Item
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Wang, Heming, Nuzulul Kurniansyah, Brian E. Cade, Matthew O. Goodman, Han Chen, Daniel J. Gottlieb, Sina A. Gharib, et al. “Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.” Scientific Reports 12, no. 1 (January 2022): 1472. https://doi.org/10.1038/s41598-022-05415-4.Full Text
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Wang, Yi Zhe, Wei Zhao, Farah Ammous, Yanyi Song, Jiacong Du, Lulu Shang, Scott M. Ratliff, et al. “DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors.” Front Cardiovasc Med 9 (2022): 848768. https://doi.org/10.3389/fcvm.2022.848768.Full Text Link to Item
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Wang, Penglong, Christina A. Castellani, Jie Yao, Tianxiao Huan, Lawrence F. Bielak, Wei Zhao, Jeffrey Haessler, et al. “Epigenome-wide association study of mitochondrial genome copy number.” Hum Mol Genet 31, no. 2 (December 27, 2021): 309–19. https://doi.org/10.1093/hmg/ddab240.Full Text Link to Item
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Do, Whitney L., Steve Nguyen, Jie Yao, Xiuqing Guo, Eric A. Whitsel, Ellen Demerath, Jerome I. Rotter, et al. “Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes.” Clin Epigenetics 13, no. 1 (December 22, 2021): 230. https://doi.org/10.1186/s13148-021-01194-3.Full Text Link to Item
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Schlosser, Pascal, Adrienne Tin, Pamela R. Matias-Garcia, Chris H. L. Thio, Roby Joehanes, Hongbo Liu, Antoine Weihs, et al. “Meta-analyses identify DNA methylation associated with kidney function and damage.” Nat Commun 12, no. 1 (December 9, 2021): 7174. https://doi.org/10.1038/s41467-021-27234-3.Full Text Link to Item
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Luo, Yang, Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto, Kotaro Ogawa, et al. “Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet 53, no. 12 (December 2021): 1722. https://doi.org/10.1038/s41588-021-00979-9.Full Text Link to Item
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Zhuang, Zhenhuang, Meng Gao, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, et al. “Associations of toothbrushing behaviour with risks of vascular and nonvascular diseases in Chinese adults.” Eur J Clin Invest 51, no. 12 (December 2021): e13634. https://doi.org/10.1111/eci.13634.Full Text Link to Item
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Song, Yanyi, Xiang Zhou, Jian Kang, Max T. Aung, Min Zhang, Wei Zhao, Belinda L. Needham, et al. “Bayesian hierarchical models for high-dimensional mediation analysis with coordinated selection of correlated mediators.” Stat Med 40, no. 27 (November 30, 2021): 6038–56. https://doi.org/10.1002/sim.9168.Full Text Link to Item
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Sofer, Tamar, Nuzulul Kurniansyah, François Aguet, Kristin Ardlie, Peter Durda, Deborah A. Nickerson, Joshua D. Smith, et al. “Benchmarking association analyses of continuous exposures with RNA-seq in observational studies.” Brief Bioinform 22, no. 6 (November 5, 2021). https://doi.org/10.1093/bib/bbab194.Full Text Link to Item
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Shi, Hangchuan, Deborah J. Ossip, Nicole L. Mayo, Daniel A. Lopez, Robert C. Block, Wendy S. Post, Alain G. Bertoni, et al. “Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort.” Bmc Genomics 22, no. 1 (November 3, 2021): 790. https://doi.org/10.1186/s12864-021-08108-w.Full Text Link to Item
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Song, Yanyi, Xiang Zhou, Jian Kang, Max T. Aung, Min Zhang, Wei Zhao, Belinda L. Needham, et al. “Bayesian Sparse Mediation Analysis with Targeted Penalization of Natural Indirect Effects.” J R Stat Soc Ser C Appl Stat 70, no. 5 (November 2021): 1391–1412. https://doi.org/10.1111/rssc.12518.Full Text Link to Item
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Wang, Heming, Raymond Noordam, Brian E. Cade, Karen Schwander, Thomas W. Winkler, Jiwon Lee, Yun Ju Sung, et al. “Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.” Mol Psychiatry 26, no. 11 (November 2021): 6293–6304. https://doi.org/10.1038/s41380-021-01087-0.Full Text Link to Item
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Chun, Matthew, Robert Clarke, Tingting Zhu, David Clifton, Derrick Bennett, Yiping Chen, Yu Guo, et al. “Publisher Correction: Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults.” Sci Rep 11, no. 1 (October 18, 2021): 20874. https://doi.org/10.1038/s41598-021-00401-8.Full Text Link to Item
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Luo, Yang, Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto, Kotaro Ogawa, et al. “A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet 53, no. 10 (October 2021): 1504–16. https://doi.org/10.1038/s41588-021-00935-7.Full Text Link to Item
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Yang, Ruotong, Jun Lv, Canqing Yu, Yu Guo, Pei Pei, Ninghao Huang, Ling Yang, et al. “Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank.” Bmc Medicine 19, no. 1 (October 2021): 259. https://doi.org/10.1186/s12916-021-02122-1.Full Text
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Yang, Tianzhong, Victoria E. Jackson, Albert V. Smith, Han Chen, Traci M. Bartz, Colleen M. Sitlani, Bruce M. Psaty, et al. “Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.” Sci Rep 11, no. 1 (September 29, 2021): 19365. https://doi.org/10.1038/s41598-021-98120-7.Full Text Link to Item
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Cade, Brian E., Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, Sina A. Gharib, et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.” Genome Med 13, no. 1 (August 26, 2021): 136. https://doi.org/10.1186/s13073-021-00917-8.Full Text Link to Item
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Johnson, Corbin S. C., Carol A. Shively, Kristofer T. Michalson, Amanda J. Lea, Ryne J. DeBo, Timothy D. Howard, Gregory A. Hawkins, et al. “Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model.” Elife 10 (August 2, 2021). https://doi.org/10.7554/eLife.68293.Full Text Link to Item
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Ruth, Katherine S., Felix R. Day, Jazib Hussain, Ana Martínez-Marchal, Catherine E. Aiken, Ajuna Azad, Deborah J. Thompson, et al. “Genetic insights into biological mechanisms governing human ovarian ageing.” Nature 596, no. 7872 (August 2021): 393–97. https://doi.org/10.1038/s41586-021-03779-7.Full Text Link to Item
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Wang, Wenxiu, Jingjia Wang, Jun Lv, Canqing Yu, Chunli Shao, Yida Tang, Yu Guo, et al. “Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses.” Nutr Metab Cardiovasc Dis 31, no. 8 (July 22, 2021): 2328–37. https://doi.org/10.1016/j.numecd.2021.04.015.Full Text Link to Item
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Wen, Jia, Munan Xie, Bryce Rowland, Jonathan D. Rosen, Quan Sun, Jiawen Chen, Amanda L. Tapia, et al. “Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.” Genes (Basel) 12, no. 7 (July 8, 2021). https://doi.org/10.3390/genes12071049.Full Text Link to Item
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Keramati, Ali R., Ming-Huei Chen, Benjamin A. T. Rodriguez, Lisa R. Yanek, Arunoday Bhan, Brady J. Gaynor, Kathleen Ryan, et al. “Genome sequencing unveils a regulatory landscape of platelet reactivity.” Nat Commun 12, no. 1 (June 15, 2021): 3626. https://doi.org/10.1038/s41467-021-23470-9.Full Text Link to Item
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Sofer, Tamar, Xiuwen Zheng, Cecelia A. Laurie, Stephanie M. Gogarten, Jennifer A. Brody, Matthew P. Conomos, Joshua C. Bis, et al. “Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.” Nat Commun 12, no. 1 (June 9, 2021): 3506. https://doi.org/10.1038/s41467-021-23655-2.Full Text Link to Item
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Las Fuentes, Lisa de, Yun Ju Sung, Raymond Noordam, Thomas Winkler, Mary F. Feitosa, Karen Schwander, Amy R. Bentley, et al. “Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.” Mol Psychiatry 26, no. 6 (June 2021): 2111–25. https://doi.org/10.1038/s41380-020-0719-3.Full Text Link to Item
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Nachun, Daniel, Ake T. Lu, Alexander G. Bick, Pradeep Natarajan, Joshua Weinstock, Mindy D. Szeto, Sekar Kathiresan, et al. “Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.” Aging Cell 20, no. 6 (June 2021): e13366. https://doi.org/10.1111/acel.13366.Full Text Link to Item
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Han, Yuting, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Yizhen Hu, Ling Yang, et al. “Development and external validation of a breast cancer absolute risk prediction model in Chinese population.” Breast Cancer Res 23, no. 1 (May 29, 2021): 62. https://doi.org/10.1186/s13058-021-01439-2.Full Text Link to Item
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Breeze, Charles E., Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. McCartney, Rong Jiang, et al. “Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.” Genome Med 13, no. 1 (April 30, 2021): 74. https://doi.org/10.1186/s13073-021-00877-z.Full Text Open Access Copy Link to Item
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Ahluwalia, Tarunveer S., Bram P. Prins, Mohammadreza Abdollahi, Nicola J. Armstrong, Stella Aslibekyan, Lisa Bain, Barbara Jefferis, et al. “Genome-wide association study of circulating interleukin 6 levels identifies novel loci.” Hum Mol Genet 30, no. 5 (April 27, 2021): 393–409. https://doi.org/10.1093/hmg/ddab023.Full Text Link to Item
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Kasela, Silva, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, et al. “Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.” Genome Med 13, no. 1 (April 21, 2021): 66. https://doi.org/10.1186/s13073-021-00866-2.Full Text Link to Item
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Natarajan, Pradeep, Akhil Pampana, Sarah E. Graham, Sanni E. Ruotsalainen, James A. Perry, Paul S. de Vries, Jai G. Broome, et al. “Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.” Nat Commun 12, no. 1 (April 12, 2021): 2182. https://doi.org/10.1038/s41467-021-22339-1.Full Text Link to Item
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Okoro, Paul C., Ryan Schubert, Xiuqing Guo, W Craig Johnson, Jerome I. Rotter, Ina Hoeschele, Yongmei Liu, et al. “Transcriptome prediction performance across machine learning models and diverse ancestries.” Hgg Adv 2, no. 2 (April 8, 2021). https://doi.org/10.1016/j.xhgg.2020.100019.Full Text Link to Item
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Graff, Mariaelisa, Anne E. Justice, Kristin L. Young, Eirini Marouli, Xinruo Zhang, Rebecca S. Fine, Elise Lim, et al. “Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.” Am J Hum Genet 108, no. 4 (April 1, 2021): 564–82. https://doi.org/10.1016/j.ajhg.2021.02.011.Full Text Link to Item
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Crews, Deidra C., Stephen M. Sozio, Yongmei Liu, Josef Coresh, and Neil R. Powe. “Inflammation and the paradox of racial differences in dialysis survival.” J Am Soc Nephrol 22, no. 12 (December 2011): 2279–86. https://doi.org/10.1681/ASN.2011030305.Full Text Link to Item
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Tranah, Gregory J., Todd M. Manini, Kurt K. Lohman, Michael A. Nalls, Stephen Kritchevsky, Anne B. Newman, Tamara B. Harris, et al. “Mitochondrial DNA variation in human metabolic rate and energy expenditure.” Mitochondrion 11, no. 6 (November 2011): 855–61. https://doi.org/10.1016/j.mito.2011.04.005.Full Text Link to Item
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Chambers, John C., Weihua Zhang, Joban Sehmi, Xinzhong Li, Mark N. Wass, Pim Van der Harst, Hilma Holm, et al. “Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.” Nat Genet 43, no. 11 (October 16, 2011): 1131–38. https://doi.org/10.1038/ng.970.Full Text Link to Item
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N’Diaye, Amidou, Gary K. Chen, Cameron D. Palmer, Bing Ge, Bamidele Tayo, Rasika A. Mathias, Jingzhong Ding, et al. “Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.” Plos Genet 7, no. 10 (October 2011): e1002298. https://doi.org/10.1371/journal.pgen.1002298.Full Text Link to Item
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Soler Artigas, María, Daan W. Loth, Louise V. Wain, Sina A. Gharib, Ma’en Obeidat, Wenbo Tang, Guangju Zhai, et al. “Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.” Nat Genet 43, no. 11 (September 25, 2011): 1082–90. https://doi.org/10.1038/ng.941.Full Text Link to Item
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International Consortium for Blood Pressure Genome-Wide Association Studies, Toby, Georg B. Ehret, Patricia B. Munroe, Kenneth M. Rice, Murielle Bochud, Andrew D. Johnson, Daniel I. Chasman, et al. “Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.” Nature 478, no. 7367 (September 11, 2011): 103–9. https://doi.org/10.1038/nature10405.Full Text Link to Item
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Kanoni, Stavroula, Jennifer A. Nettleton, Marie-France Hivert, Zheng Ye, Frank J. A. van Rooij, Dmitry Shungin, Emily Sonestedt, et al. “Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.” Diabetes 60, no. 9 (September 2011): 2407–16. https://doi.org/10.2337/db11-0176.Full Text Link to Item
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Liu, Ching-Ti, Maija K. Garnaas, Adrienne Tin, Anna Kottgen, Nora Franceschini, Carmen A. Peralta, Ian H. de Boer, et al. “Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.” Plos Genet 7, no. 9 (September 2011): e1002264. https://doi.org/10.1371/journal.pgen.1002264.Full Text Link to Item
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Hixson, James E., Lawrence C. Shimmin, May E. Montasser, Do-Kyun Kim, Yu Zhong, Heladio Ibarguen, Jack Follis, et al. “Common variants in the periostin gene influence development of atherosclerosis in young persons.” Arterioscler Thromb Vasc Biol 31, no. 7 (July 2011): 1661–67. https://doi.org/10.1161/ATVBAHA.111.224352.Full Text Link to Item
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Kilpeläinen, Tuomas O., M Carola Zillikens, Alena Stančákova, Francis M. Finucane, Janina S. Ried, Claudia Langenberg, Weihua Zhang, et al. “Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.” Nat Genet 43, no. 8 (June 26, 2011): 753–60. https://doi.org/10.1038/ng.866.Full Text Link to Item
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Nalls, Michael A., David J. Couper, Toshiko Tanaka, Frank J. A. van Rooij, Ming-Huei Chen, Albert V. Smith, Daniela Toniolo, et al. “Multiple loci are associated with white blood cell phenotypes.” Plos Genet 7, no. 6 (June 2011): e1002113. https://doi.org/10.1371/journal.pgen.1002113.Full Text Link to Item
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Reiner, Alexander P., Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean, et al. “Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).” Plos Genet 7, no. 6 (June 2011): e1002108. https://doi.org/10.1371/journal.pgen.1002108.Full Text Link to Item
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Böger, Carsten A., Ming-Huei Chen, Adrienne Tin, Matthias Olden, Anna Köttgen, Ian H. de Boer, Christian Fuchsberger, et al. “CUBN is a gene locus for albuminuria.” J Am Soc Nephrol 22, no. 3 (March 2011): 555–70. https://doi.org/10.1681/ASN.2010060598.Full Text Link to Item
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Dehghan, Abbas, Josée Dupuis, Maja Barbalic, Joshua C. Bis, Gudny Eiriksdottir, Chen Lu, Niina Pellikka, et al. “Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.” Circulation 123, no. 7 (February 22, 2011): 731–38. https://doi.org/10.1161/CIRCULATIONAHA.110.948570.Full Text Link to Item
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C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC), John, Frances Wensley, Pei Gao, Stephen Burgess, Stephen Kaptoge, Emanuele Di Angelantonio, Tina Shah, et al. “Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.” Bmj 342 (February 15, 2011): d548. https://doi.org/10.1136/bmj.d548.Full Text Link to Item
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Lettre, Guillaume, Cameron D. Palmer, Taylor Young, Kenechi G. Ejebe, Hooman Allayee, Emelia J. Benjamin, Franklyn Bennett, et al. “Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.” Plos Genet 7, no. 2 (February 10, 2011): e1001300. https://doi.org/10.1371/journal.pgen.1001300.Full Text Link to Item
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Smith, J Gustav, Jared W. Magnani, Cameron Palmer, Yan A. Meng, Elsayed Z. Soliman, Solomon K. Musani, Kathleen F. Kerr, et al. “Genome-wide association studies of the PR interval in African Americans.” Plos Genet 7, no. 2 (February 10, 2011): e1001304. https://doi.org/10.1371/journal.pgen.1001304.Full Text Link to Item
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Manning, Alisa K., Michael LaValley, Ching-Ti Liu, Kenneth Rice, Ping An, Yongmei Liu, Iva Miljkovic, et al. “Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients.” Genet Epidemiol 35, no. 1 (January 2011): 11–18. https://doi.org/10.1002/gepi.20546.Full Text Link to Item
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Nettleton, J. A., N. M. McKeown, S. Kanoni, R. N. Lemaitre, M - F. Hivert, J. Ngwa, F. J. A. Van Rooij, et al. “Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies (Diabetes Care (2010) 33 (2684-2691)).” Diabetes Care 34, no. 3 (2011): 785–86. https://doi.org/10.2337/dc11-er03.Full Text Link to Item
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Van Den Borst, B., A. Koster, B. Yu, H. R. Gosker, B. Meibohm, D. C. Bauer, S. B. Kritchevsky, et al. “Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?” Thorax 66, no. 11 (2011): 961–69. https://doi.org/10.1136/thoraxjnl-2011-200010.Full Text Link to Item
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Walter, S., G. Atzmon, E. W. Demerath, M. E. Garcia, R. C. Kaplan, M. Kumari, K. L. Lunetta, et al. “A genome-wide association study of aging.” Neurobiology of Aging 32, no. 11 (2011): 2109.e15-2109.e28. https://doi.org/10.1016/j.neurobiolaging.2011.05.026.Full Text Link to Item
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Wang, T. J., F. Zhang, J. B. Richards, B. Kestenbaum, J. B. Van Meurs, D. Berry, D. P. Kiel, et al. “Common genetic determinants of vitamin D insufficiency: A genome-wide association study.” Obstetrical and Gynecological Survey 66, no. 2 (2011): 91–93. https://doi.org/10.1097/OGX.0b013e318216b03d.Full Text Link to Item
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Nettleton, Jennifer A., Nicola M. McKeown, Stavroula Kanoni, Rozenn N. Lemaitre, Marie-France Hivert, Julius Ngwa, Frank J. A. van Rooij, et al. “Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.” Diabetes Care 33, no. 12 (December 2010): 2684–91. https://doi.org/10.2337/dc10-1150.Full Text Link to Item
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O’Seaghdha, Conall M., Qiong Yang, Nicole L. Glazer, Tennille S. Leak, Abbas Dehghan, Albert V. Smith, WH Linda Kao, et al. “Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.” Hum Mol Genet 19, no. 21 (November 1, 2010): 4296–4303. https://doi.org/10.1093/hmg/ddq342.Full Text Link to Item
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Wang, Thomas J., Feng Zhang, J Brent Richards, Bryan Kestenbaum, Joyce B. van Meurs, Diane Berry, Douglas P. Kiel, et al. “Common genetic determinants of vitamin D insufficiency: a genome-wide association study.” Lancet 376, no. 9736 (July 17, 2010): 180–88. https://doi.org/10.1016/S0140-6736(10)60588-0.Full Text Link to Item
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Liu, Yongmei, David Herrington, Kathryn P. Burdon, Carl D. Langefeld, Stephen S. Rich, Donald W. Bowden, Barry I. Freedman, and Lynne E. Wagenknecht. “A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study.” Eur J Cardiovasc Prev Rehabil 13, no. 4 (August 2006): 655–57. https://doi.org/10.1097/01.hjr.0000214610.83866.2e.Full Text Link to Item
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Zhang, Lin, WH Linda Kao, Yvette Berthier-Schaad, Yongmei Liu, Laura Plantinga, Bernard G. Jaar, Nancy Fink, et al. “Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients.” J Am Soc Nephrol 17, no. 8 (August 2006): 2285–92. https://doi.org/10.1681/ASN.2005090985.Full Text Link to Item
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Boulware, L Ebony, Yongmei Liu, Nancy E. Fink, Josef Coresh, Daniel E. Ford, Michael J. Klag, and Neil R. Powe. “Temporal relation among depression symptoms, cardiovascular disease events, and mortality in end-stage renal disease: contribution of reverse causality.” Clin J Am Soc Nephrol 1, no. 3 (May 2006): 496–504. https://doi.org/10.2215/CJN.00030505.Full Text Link to Item
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Conference Papers
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Ding, Jingzhong, Kurt Lohman, Alain Bertoni, Steven Shea, Wendy Post, James Pankow, Stephen Kritchevsky, and Yongmei Liu. “AGING-RELATED HUMAN MONOCYTE TRANSCRIPTOMIC PATHWAYS PREDICT WORSENING MULTIMORBIDITY.” In Innovation in Aging, 6:213–14, 2022.Link to Item
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Subedi, Pooja, Huaizhen Qin, Shelley A. Cole, Maria T. Plaza, Arce Domingo-Relloso, Karin Haack, Danielle Fallin, et al. “Abstract P146: Telomere Length, DNA Methylation, and Risk of Cardiovascular Diseases: Meta-EWAS of Four Multi-ethnic Prospective Cohorts.” In Circulation, Vol. 141. Ovid Technologies (Wolters Kluwer Health), 2020. https://doi.org/10.1161/circ.141.suppl_1.p146.Full Text
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Kachroo, Priyadarshini, Julian Hecker, Bo L. Chawes, Tarunveer S. Ahluwalia, Michael H. Cho, Dandi Qiao, Rachel S. Kelly, et al. “Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.” In Chest, 156:1068–79, 2019. https://doi.org/10.1016/j.chest.2019.08.2202.Full Text Link to Item
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Ding, Jingzhong, Lindsay M. Reynolds, Tanja Zeller, Christian Muller, Kurt Lohman, Zhiqing Huang, Alberto de la Fuente, et al. “Alterations of a Cellular Cholesterol Metabolism Network is a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.Link to Item
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Ohlsson, Claes, Henri Wallaschofski, Kathryn L. Lunetta, Lisette Stolk, John R. B. Perry, Annemarie Koster, Ann-Kristin Petersen, et al. “Genetic determinants of serum testosterone concentrations in men.” In Plos Genet, 7:e1002313, 2011. https://doi.org/10.1371/journal.pgen.1002313.Full Text Link to Item
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Zhai, Guangju, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster, et al. “Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.” In Plos Genet, 7:e1002025, 2011. https://doi.org/10.1371/journal.pgen.1002025.Full Text Link to Item
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Ngo, Debby, Katherine A. Pratte, Claudia Flexeder, Hans Petersen, Hong Dang, Yanlin Ma, Michelle J. Keyes, et al. “Systemic Biomarkers of Lung Function and FEV 1 Decline Across Multiple Cohorts,” n.d.
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