Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., University of Iowa 2010
• Research
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  Selected Grants

  • Race-Related Alternative Splicing: Novel Targets in Prostate Cancer awarded by National Institutes of Health 2017 - 2022
  • Developing knowledge models to enable rapid learning in radiation therapy awarded by National Institutes of Health 2016 - 2020
  • PSA - Lauren Howard - A Retrospective Description of Patient Characteristics, Management, and Outcomes awarded by Institute for Medical Research, Inc. 2017 - 2020
  • CTC-Immune Checkpoints awarded by Janssen Research & Development, LLC 2016 - 2020
  • A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments awarded by National Institutes of Health 2014 - 2019
  • Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2019
  • Therapeutic targeting of B7-H3 to reverse prostate cancer treatment resistance. awarded by Department of Defense 2016 - 2019
  • PSA for Taofik Oyekunle awarded by Institute for Medical Research, Inc. 2017 - 2019
  • PSA for Lauren Howard awarded by Institute for Medical Research, Inc. 2014 - 2019
  • Bayer-Exini Radium-223 Retrospective Study awarded by Bayer Healthcare Pharmaceuticals Inc 2016 - 2019
  • Randomized Controlled Clinical Trial of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy for Prostate Cancer awarded by University of California - Los Angeles 2017 - 2019
  • Innovative Biomarker-Integrated Clinical Trial Design and Analysis awarded by University of North Carolina - Chapel Hill 2015 - 2019
  • Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2019
  • Novel Immune Modulating Cellular Vaccine for Prostate Cancer Immunotherapy awarded by Department of Defense 2013 - 2017
  • A Pilot Study on H.O.P.E: Helping Ovarian Cancer Patients Cope with Disease Recurrence awarded by Foundation for Women's Cancer 2014 - 2016
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Holl, Eda K., Megan A. McNamara, Patrick Healy, Monika Anand, Raoul S. Concepcion, Coleman D. Breland, Igor Dumbudze, et al. “Prolonged PSA stabilization and overall survival following sipuleucel-T monotherapy in metastatic castration-resistant prostate cancer patients..” Prostate Cancer and Prostatic Diseases, April 12, 2019. https://doi.org/10.1038/s41391-019-0144-3.
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    • Li, Zhiguo, Xiaofei Wang, Yuan Wu, and Kouros Owzar. “Sample size calculation for studies with grouped survival data..” Statistics in Medicine 37, no. 27 (November 2018): 3904–17. https://doi.org/10.1002/sim.7847.
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    • Aminsharifi, Alireza, Lauren Howard, Yuan Wu, Amanda De Hoedt, Charlotte Bailey, Stephen J. Freedland, and Thomas J. Polascik. “Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index..” J Urol 200, no. 4 (October 2018): 758–66. https://doi.org/10.1016/j.juro.2018.05.016.
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    • Wu, Yuan, Christina D. Chambers, and Ronghui Xu. “Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion..” Lifetime Data Analysis, July 16, 2018. https://doi.org/10.1007/s10985-018-9445-4.
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    • Tandberg, Daniel J., Taofik Oyekunle, W Robert Lee, Yuan Wu, Joseph K. Salama, and Bridget F. Koontz. “Postoperative Radiation Therapy for Prostate Cancer: Comparison of Conventional Versus Hypofractionated Radiation Regimens..” International Journal of Radiation Oncology, Biology, Physics 101, no. 2 (June 2018): 396–405. https://doi.org/10.1016/j.ijrobp.2018.02.002.
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    • Torok, Jordan A., Yuan Wu, Junzo Chino, Leonard R. Prosnitz, Anne W. Beaven, Grace J. Kim, and Chris R. Kelsey. “Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma..” Anticancer Research 38, no. 5 (May 2018): 2875–81. https://doi.org/10.21873/anticanres.12533.
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    • Humeniuk, Michael S., Rajan T. Gupta, Patrick Healy, Megan McNamara, Sundhar Ramalingam, Michael Harrison, Daniel George, Tian Zhang, Yuan Wu, and Andrew J. Armstrong. “Platinum sensitivity in metastatic prostate cancer: does histology matter?.” Prostate Cancer and Prostatic Diseases 21, no. 1 (April 2018): 92–99. https://doi.org/10.1038/s41391-017-0017-6.
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    • Song, Erin J., Jordan Torok, Yuan Wu, Junzo Chino, Leonard R. Prosnitz, Anne W. Beaven, and Chris R. Kelsey. “Consolidation Radiation Therapy for Patients With Advanced Hodgkin Lymphoma in Complete Metabolic Response According to PET-CT or Gallium Imaging..” Clinical Lymphoma, Myeloma & Leukemia 18, no. 2 (February 2018): 145–51. https://doi.org/10.1016/j.clml.2017.12.007.
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    • Ramalingam, Sundhar, Michael S. Humeniuk, Rachel Hu, Julia Rasmussen, Patrick Healy, Yuan Wu, Michael R. Harrison, Andrew J. Armstrong, Daniel J. George, and Tian Zhang. “Prostate-specific antigen response in black and white patients treated with abiraterone acetate for metastatic castrate-resistant prostate cancer..” Urol Oncol 35, no. 6 (June 2017): 418–24. https://doi.org/10.1016/j.urolonc.2016.12.016.
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    • Longo, Thomas, Kathleen F. McGinley, Jennifer A. Freedman, Wiguins Etienne, Yuan Wu, Alexander Sibley, Kouros Owzar, et al. “Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer..” European Urology 70, no. 5 (November 2016): 714–17. https://doi.org/10.1016/j.eururo.2016.07.049.
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    • Geradts, Joseph, Jeffrey Groth, Yuan Wu, and Genglin Jin. “Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS)..” Breast Cancer Research and Treatment 157, no. 3 (June 2016): 447–59. https://doi.org/10.1007/s10549-016-3838-4.
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    • Ramalingam, Sundhar, David J. Sermer, Rajan Gupta, Patrick Healy, Yuan Wu, Daniel J. George, Andrew J. Armstrong, and Michael Roger Harrison. “Changes in skeletal muscle cross sectional area (CSA) in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide (ENZ)..” Journal of Clinical Oncology 34, no. 15_suppl (May 20, 2016): e16601–e16601. https://doi.org/10.1200/jco.2016.34.15_suppl.e16601.
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    • Ludmir, Ethan B., Ritu Arya, Yuan Wu, Manisha Palta, Christopher G. Willett, and Brian G. Czito. “Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era..” Annals of Surgical Oncology 23, no. 3 (March 2016): 856–62. https://doi.org/10.1245/s10434-015-4907-3.
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    • Wu, Y., X. Jiang, S. Wang, W. Jiang, P. Li, and L. Ohno-Machado. “Grid multi-category response logistic models..” Bmc Medical Informatics and Decision Making 15, no. 1 (December 2015).
    • Lu, Chia-Lun, Shuang Wang, Zhanglong Ji, Yuan Wu, Li Xiong, Xiaoqian Jiang, and Lucila Ohno-Machado. “WebDISCO: a web service for distributed cox model learning without patient-level data sharing..” Journal of the American Medical Informatics Association : Jamia 22, no. 6 (November 2015): 1212–19. https://doi.org/10.1093/jamia/ocv083.
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    • Torok, Jordan A., Yuan Wu, Leonard R. Prosnitz, Grace J. Kim, Anne W. Beaven, Louis F. Diehl, and Chris R. Kelsey. “Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma..” International Journal of Radiation Oncology, Biology, Physics 92, no. 1 (May 2015): 54–59. https://doi.org/10.1016/j.ijrobp.2015.02.003.
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    • Wu, Yuan, Xiaoqian Jiang, Shuang Wang, Wenchao Jiang, Pinghao Li, and Lucila Ohno-Machado. “Grid multi-category response logistic models..” Bmc Medical Informatics and Decision Making 15 (February 18, 2015). https://doi.org/10.1186/s12911-015-0133-y.
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    • Jiang, Xiaoqian, Yuan Wu, Keith Marsolo, and Lucila Ohno-Machado. “Development of a web service for analysis in a distributed network..” Egems (Washington, Dc) 2, no. 1 (January 2014). https://doi.org/10.13063/2327-9214.1053.
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    • Kim, J., E. Levy, A. Ferbrache, P. Stepanowsky, C. Farcas, S. Wang, S. Brunner, T. Bath, Y. Wu, and L. Ohno-Machado. “MAGI: a Node. js web service for fast MicroRNA-Seq Analysis in a GPU Infrastructure.” Bioinformatics, 2014. https://doi.org/10.1093/bioinformatics/btu377.
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    • Ludmir, E. B., M. Palta, X. Zhang, Y. Wu, C. G. Willett, and B. G. Czito. “Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.” Journal of Gastrointestinal Oncology 5, no. 6 (January 1, 2014): 401–7. https://doi.org/10.3978/j.issn.2078-6891.2014.05.
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    • Ludmir, E., M. Palta, X. Zhang, Y. Wu, C. Willett, and B. Czito. “Incidence and Prognostic Impact of High-Risk HPV Tumor Infection in Cervical Esophageal Carcinoma.” Journal of Gastrointestinal Oncology 5, no. 6 (2014): 401–7. https://doi.org/10.3978/j.issn.2078-6891.2014.053.
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    • Jiang, Wenchao, Pinghao Li, Shuang Wang, Yuan Wu, Meng Xue, Lucila Ohno-Machado, and Xiaoqian Jiang. “WebGLORE: a web service for Grid LOgistic REgression..” Bioinformatics (Oxford, England) 29, no. 24 (December 2013): 3238–40. https://doi.org/10.1093/bioinformatics/btt559.
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    • Wu, Y. “B-Spline-based sieve estimation in survival analysis.” Annals of Biometrics and Biostatistics 1, no. 1 (July 5, 2013): 1–3.
    • Wang, S., X. Jiang, Y. Wu, L. Cui, and L. Ohno-Machado. “EXpectation Propagation LOgistic REgRession (EXPLORER): Distributed Privacy-Preserving Online Model Learning.” Journal of Biomedical Informatics 46, no. 3 (2013): 480–96. https://doi.org/10.1016/j.jbi.2013.03.008.
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    • Ramirez, Marizen, Yuan Wu, Sheryl Kataoka, Marleen Wong, Jingzhen Yang, Corinne Peek-Asa, and Bradley Stein. “Youth violence across multiple dimensions: a study of violence, absenteeism, and suspensions among middle school children..” The Journal of Pediatrics 161, no. 3 (September 2012): 542-546.e2. https://doi.org/10.1016/j.jpeds.2012.03.014.
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    • Wu, Yuan, Xiaoqian Jiang, Jihoon Kim, and Lucila Ohno-Machado. “Grid Binary LOgistic REgression (GLORE): building shared models without sharing data..” Journal of the American Medical Informatics Association : Jamia 19, no. 5 (September 2012): 758–64. https://doi.org/10.1136/amiajnl-2012-000862.
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    • Wu, Y., and Y. Zhang. “Partially monotone tensor spline estimation of the joint distribution function with bivariate current status data.” Annals of Statistics 40, no. 3 (June 1, 2012): 1609–36. https://doi.org/10.1214/12-AOS1016.
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    • Wu, Y., and X. Gao. “Sieve Estimation with Bivariate Interval Censored Data.” Journal of Statistics: Advances in Theory and Applications 5 (2011): 37–61.
    • Botto, Lorenzo D., Timothy Flood, Julian Little, Mark N. Fluchel, Sergey Krikov, Marcia L. Feldkamp, Yuan Wu, Rhinda Goedken, Soman Puzhankara, and Paul A. Romitti. “Cancer Risk in Children and Adolescents with Birth Defects: A Population-Based Cohort Study.” Plos One 8, no. 7 (n.d.): e69077–e69077. https://doi.org/10.1371/journal.pone.0069077.
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  • Book Sections

    • Wu, Yuan. “Interval Censoring.” In Textbook of Clinical Trials in Oncology A Statistical Perspective, edited by Susan Halabi and Stefan Michiels, 493–510. CRC Press, 2019.

  • Conference Papers

    • Ludmir, E. B., M. Palta, Y. Wu, C. G. Willett, and B. G. Czito. “Definitive Chemoradiation Therapy for Cervical Esophageal Carcinoma: A Single-Institution Experience.” In International Journal of Radiation Oncology*Biology*Physics, 90:S348–S348. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.1135.
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    • Torok, J., L. R. Prosnitz, M. Palta, Y. Wu, A. Beaven, L. Diehl, and C. R. Kelsey. “Low-Dose Consolidation Radiation Therapy for Early-Stage Unfavorable Hodgkin Lymphoma.” In International Journal of Radiation Oncology*Biology*Physics, 90:S672–73. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.1979.
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    • Jiang, X., J. Kim, Y. Wu, and L. Ohno-Machado. “Selecting Cases for Whom Additional Tests Can Improve Prognostication,” 1260–68, 2012.
    • Wu, Y., X. Jiang, J. Kim, and L. Ohno-Machado. “I-spline Smoothing for Calibrating Predictive Models,” 39–46, 2012.
    • Wu, Y., X. Jiang, and L. Ohno-Machado. “Preserving Institutional Privacy in Distributed Binary Logistic Regression,” 1450–58, 2012.
• Teaching & Mentoring
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  Recent Courses

  • BIOSTAT 903: Advanced Survival Analysis 2019

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