Yuan Wu | Scholars@Duke

Yuan Wu
Assistant Professor in Biostatistics & Bioinformatics

Survival analysis, Statistical computing, Non/Semi-parametric estimation, Time-dependent ROC curve

Current Appointments & Affiliations

Assistant Professor in Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2013

Contact Information

2424 Erwin Road, 11101 Hock Plaza Suite 1102, Durham, NC 27710
Duke Box 2721, Durham, NC 27710
yuan.wu@duke.edu (919) 681-5018

Background
Education, Training, & Certifications
- Ph.D., University of Iowa 2010
Research
Selected Grants
- Race-related alternative splicing: novel targets in prostate cancer awarded by National Institutes of Health 2017 - 2022
- Developing knowledge models to enable rapid learning in radiation therapy awarded by National Institutes of Health 2016 - 2020
- PSA - Lauren Howard - A Retrospective Description of Patient Characteristics, Management, and Outcomes awarded by Institute for Medical Research, Inc. 2017 - 2020
- A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments awarded by National Institutes of Health 2014 - 2019
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2019
- Therapeutic targeting of B7-H3 to reverse prostate cancer treatment resistance. awarded by Department of Defense 2016 - 2019
- PSA for Taofik Oyekunle awarded by Institute for Medical Research, Inc. 2017 - 2019
- PSA for Lauren Howard awarded by Institute for Medical Research, Inc. 2014 - 2019
- Randomized Controlled Clinical Trial of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy for Prostate Cancer awarded by University of California - Los Angeles 2017 - 2019
- Innovative Biomarker-Integrated Clinical Trial Design and Analysis awarded by University of North Carolina - Chapel Hill 2015 - 2019
- Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2019
- CTC-Immune Checkpoints awarded by Janssen Research & Development, LLC 2016 - 2019
- Bayer-Exini Radium-223 Retrospective Study awarded by Bayer Healthcare Pharmaceuticals Inc 2016 - 2018
- Novel Immune Modulating Cellular Vaccine for Prostate Cancer Immunotherapy awarded by Department of Defense 2013 - 2017
- A Pilot Study on H.O.P.E: Helping Ovarian Cancer Patients Cope with Disease Recurrence awarded by Foundation for Women's Cancer 2014 - 2016
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Ludmir, EB, Palta, M, Wu, Y, Willett, CG, and Czito, BG. "Definitive Chemoradiation Therapy for Cervical Esophageal Carcinoma: A Single-Institution Experience." September 2014. Full Text
  - Torok, J, Prosnitz, LR, Palta, M, Wu, Y, Beaven, A, Diehl, L, and Kelsey, CR. "Low-Dose Consolidation Radiation Therapy for Early-Stage Unfavorable Hodgkin Lymphoma." September 2014. Full Text
  - Jiang, X, Kim, J, Wu, Y, and Ohno-Machado, L. "Selecting Cases for Whom Additional Tests Can Improve Prognostication." AMIA Annual Symposium Proceedings. 2012.
  - Wu, Y, Jiang, X, Kim, J, and Ohno-Machado, L. "I-spline Smoothing for Calibrating Predictive Models." AMIA Joint Summits on Translational Science Proceedings. 2012.
  - Wu, Y, Jiang, X, and Ohno-Machado, L. "Preserving Institutional Privacy in Distributed Binary Logistic Regression." AMIA Annual Symposium Proceedings. 2012.
- Journal Articles
  - Li, Z, Wang, X, Wu, Y, and Owzar, K. "Sample size calculation for studies with grouped survival data." Statistics in Medicine 37, no. 27 (November 2018): 3904-3917. Full Text Open Access Copy
  - Aminsharifi, A, Howard, L, Wu, Y, De Hoedt, A, Bailey, C, Freedland, SJ, and Polascik, TJ. "Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index." The Journal of Urology 200, no. 4 (October 2018): 758-766. Full Text
  - Wu, Y, Chambers, CD, and Xu, R. "Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion." Lifetime Data Analysis (July 16, 2018). Full Text
  - Tandberg, DJ, Oyekunle, T, Lee, WR, Wu, Y, Salama, JK, and Koontz, BF. "Postoperative Radiation Therapy for Prostate Cancer: Comparison of Conventional Versus Hypofractionated Radiation Regimens." International Journal of Radiation Oncology, Biology, Physics 101, no. 2 (June 2018): 396-405. Full Text
  - Torok, JA, Wu, Y, Chino, J, Prosnitz, LR, Beaven, AW, Kim, GJ, and Kelsey, CR. "Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma." Anticancer Research 38, no. 5 (May 2018): 2875-2881. Full Text
  - Humeniuk, MS, Gupta, RT, Healy, P, McNamara, M, Ramalingam, S, Harrison, M, George, D, Zhang, T, Wu, Y, and Armstrong, AJ. "Platinum sensitivity in metastatic prostate cancer: does histology matter?." Prostate Cancer and Prostatic Diseases 21, no. 1 (April 2018): 92-99. Full Text
  - Song, EJ, Torok, J, Wu, Y, Chino, J, Prosnitz, LR, Beaven, AW, and Kelsey, CR. "Consolidation Radiation Therapy for Patients With Advanced Hodgkin Lymphoma in Complete Metabolic Response According to PET-CT or Gallium Imaging." Clinical Lymphoma, Myeloma & Leukemia 18, no. 2 (February 2018): 145-151. Full Text
  - Ramalingam, S, Humeniuk, MS, Hu, R, Rasmussen, J, Healy, P, Wu, Y, Harrison, MR, Armstrong, AJ, George, DJ, and Zhang, T. "Prostate-specific antigen response in black and white patients treated with abiraterone acetate for metastatic castrate-resistant prostate cancer." Urol Oncol 35, no. 6 (June 2017): 418-424. Full Text Link to Item
  - Longo, T, McGinley, KF, Freedman, JA, Etienne, W, Wu, Y, Sibley, A, Owzar, K, Gresham, J, Moy, C, Szabo, S, Greshock, J, Zhou, H, Bai, Y, and Inman, BA. "Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer." European Urology 70, no. 5 (November 2016): 714-717. Full Text
  - Geradts, J, Groth, J, Wu, Y, and Jin, G. "Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS)." Breast Cancer Research and Treatment 157, no. 3 (June 2016): 447-459. Full Text
  - Ludmir, EB, Arya, R, Wu, Y, Palta, M, Willett, CG, and Czito, BG. "Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era." Annals of Surgical Oncology 23, no. 3 (March 2016): 856-862. Full Text
  - Wu, Y, Jiang, X, Wang, S, Jiang, W, Li, P, and Ohno-Machado, L. "Grid multi-category response logistic models." Bmc Medical Informatics and Decision Making 15, no. 1 (December 2015): 133-null.
  - Lu, C-L, Wang, S, Ji, Z, Wu, Y, Xiong, L, Jiang, X, and Ohno-Machado, L. "WebDISCO: a web service for distributed cox model learning without patient-level data sharing." Journal of the American Medical Informatics Association : Jamia 22, no. 6 (November 2015): 1212-1219. Full Text
  - Torok, JA, Wu, Y, Prosnitz, LR, Kim, GJ, Beaven, AW, Diehl, LF, and Kelsey, CR. "Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma." International Journal of Radiation Oncology, Biology, Physics 92, no. 1 (May 2015): 54-59. Full Text
  - Wu, Y, Jiang, X, Wang, S, Jiang, W, Li, P, and Ohno-Machado, L. "Grid multi-category response logistic models." Bmc Medical Informatics and Decision Making 15 (February 18, 2015): 10-null. Full Text
  - Jiang, X, Wu, Y, Marsolo, K, and Ohno-Machado, L. "Development of a web service for analysis in a distributed network." Egems (Washington, Dc) 2, no. 1 (January 2014): 1053-null. Full Text Open Access Copy
  - Kim, J, Levy, E, Ferbrache, A, Stepanowsky, P, Farcas, C, Wang, S, Brunner, S, Bath, T, Wu, Y, and Ohno-Machado, L. "MAGI: a Node. js web service for fast MicroRNA-Seq Analysis in a GPU Infrastructure." Bioinformatics (2014). Full Text
  - Ludmir, E, Palta, M, Zhang, X, Wu, Y, Willett, C, and Czito, B. "Incidence and Prognostic Impact of High-Risk HPV Tumor Infection in Cervical Esophageal Carcinoma." Journal of Gastrointestinal Oncology 5, no. 6 (2014): 401-407. Full Text
  - Ludmir, EB, Palta, M, Zhang, X, Wu, Y, Willett, CG, and Czito, BG. "Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma." Journal of Gastrointestinal Oncology 5, no. 6 (January 1, 2014): 401-407. Full Text
  - Jiang, W, Li, P, Wang, S, Wu, Y, Xue, M, Ohno-Machado, L, and Jiang, X. "WebGLORE: a web service for Grid LOgistic REgression." Bioinformatics (Oxford, England) 29, no. 24 (December 2013): 3238-3240. Full Text
  - Botto, LD, Flood, T, Little, J, Fluchel, MN, Krikov, S, Feldkamp, ML, Wu, Y, Goedken, R, Puzhankara, S, and Romitti, PA. "Cancer Risk in Children and Adolescents with Birth Defects: A Population-Based Cohort Study." Edited by Huang, L-M. Plos One 8, no. 7 (July 17, 2013): e69077-e69077. Full Text
  - Wu, Y. "B-Spline-based sieve estimation in survival analysis." Annals of Biometrics and Biostatistics 1, no. 1 (July 5, 2013): 1-3. (Review)
  - Wang, S, Jiang, X, Wu, Y, Cui, L, and Ohno-Machado, L. "EXpectation Propagation LOgistic REgRession (EXPLORER): Distributed Privacy-Preserving Online Model Learning." Journal of Biomedical Informatics 46, no. 3 (2013): 480-496. Full Text
  - Ramirez, M, Wu, Y, Kataoka, S, Wong, M, Yang, J, Peek-Asa, C, and Stein, B. "Youth violence across multiple dimensions: a study of violence, absenteeism, and suspensions among middle school children." The Journal of Pediatrics 161, no. 3 (September 2012): 542-546.e2. Full Text
  - Wu, Y, Jiang, X, Kim, J, and Ohno-Machado, L. "Grid Binary LOgistic REgression (GLORE): building shared models without sharing data." Journal of the American Medical Informatics Association : Jamia 19, no. 5 (September 2012): 758-764. Full Text
  - Wu, Y, and Zhang, Y. "Partially monotone tensor spline estimation of the joint distribution function with bivariate current status data." The Annals of Statistics 40, no. 3 (June 2012): 1609-1636. Full Text Open Access Copy
  - Wu, Y, and Gao, X. "Sieve Estimation with Bivariate Interval Censored Data." Journal of Statistics: Advances in Theory and Applications 5 (2011): 37-61.
  - Ramalingam, S, Sermer, D, Gupta, R, Healy, P, Wu, Y, George, D, Armstrong, A, and Harrison, MR. "Changes in skeletal muscle cross sectional area (CSA) in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide (ENZ)." Journal of Clinical Oncology 34. Full Text Link to Item
Teaching & Mentoring
Recent Courses
- BIOSTAT 903: Advanced Survival Analysis 2016

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Education, Training, & Certifications

Selected Grants

Selected Publications

Conference Papers

Journal Articles

Recent Courses