Yuan Wu | Scholars@Duke

Yuan Wu
Assistant Professor in Biostatistics & Bioinformatics

Survival analysis, Deep learning, Causal inference, Sequential clinical trial design, Non/Semi-parametric estimation, Statistical computing

Current Appointments & Affiliations

Assistant Professor in Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2013

Contact Information

2424 Erwin Road, 11101 Hock Plaza Suite 1102, Durham, NC 27710
Duke Box 2721, Durham, NC 27710
yuan.wu@duke.edu (919) 681-5018

Background
Education, Training, & Certifications
- Ph.D., University of Iowa 2010
Research
Selected Grants
- Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA Biomarkers awarded by National Institutes of Health 2020 - 2023
- Race-Related Alternative Splicing: Novel Targets in Prostate Cancer awarded by National Institutes of Health 2017 - 2022
- A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments awarded by National Institutes of Health 2014 - 2020
- Immune correlates of immunotherapy responses in renal cell carcinoma 2019 - 2020
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2020
- Therapeutic targeting of B7-H3 to reverse prostate cancer treatment resistance. awarded by Department of Defense 2016 - 2020
- PSA for Taofik Oyekunle 2017 - 2020
- Developing knowledge models to enable rapid learning in radiation therapy awarded by National Institutes of Health 2016 - 2020
- PSA - Lauren Howard - A Retrospective Description of Patient Characteristics, Management, and Outcomes 2017 - 2020
- Innovative Biomarker-Integrated Clinical Trial Design and Analysis awarded by University of North Carolina - Chapel Hill 2015 - 2020
- Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2020
- CTC-Immune Checkpoints 2016 - 2020
- Bayer-Exini Radium-223 Retrospective Study 2016 - 2019
- Randomized Controlled Clinical Trial of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy for Prostate Cancer awarded by University of California, Los Angeles 2017 - 2019
- Novel Immune Modulating Cellular Vaccine for Prostate Cancer Immunotherapy awarded by Department of Defense 2013 - 2017
- A Pilot Study on H.O.P.E: Helping Ovarian Cancer Patients Cope with Disease Recurrence 2014 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Holl, Eda K., Megan A. McNamara, Patrick Healy, Monika Anand, Raoul S. Concepcion, Coleman D. Breland, Igor Dumbudze, et al. “Prolonged PSA stabilization and overall survival following sipuleucel-T monotherapy in metastatic castration-resistant prostate cancer patients..” Prostate Cancer Prostatic Dis 22, no. 4 (December 2019): 588–92. https://doi.org/10.1038/s41391-019-0144-3.
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  - Zhu, Jason, Matthew Tucker, Daniele Marin, Rajan T. Gupta, Patrick Healy, Michael Humeniuk, Casey Jarvis, et al. “Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer..” Urol Oncol 37, no. 11 (November 2019): 813.e1-813.e9. https://doi.org/10.1016/j.urolonc.2019.06.015.
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  - Tucker, Matthew D., Jason Zhu, Daniele Marin, Rajan T. Gupta, Santosh Gupta, William R. Berry, Sundhar Ramalingam, et al. “Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer..” Cancer Med 8, no. 10 (August 2019): 4644–55. https://doi.org/10.1002/cam4.2375.
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  - Wu, Yuan, Christina D. Chambers, and Ronghui Xu. “Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion..” Lifetime Data Anal 25, no. 3 (July 2019): 507–28. https://doi.org/10.1007/s10985-018-9445-4.
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  - Li, Zhiguo, Xiaofei Wang, Yuan Wu, and Kouros Owzar. “Sample size calculation for studies with grouped survival data..” Stat Med 37, no. 27 (November 30, 2018): 3904–17. https://doi.org/10.1002/sim.7847.
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  - Aminsharifi, Alireza, Lauren Howard, Yuan Wu, Amanda De Hoedt, Charlotte Bailey, Stephen J. Freedland, and Thomas J. Polascik. “Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index..” J Urol 200, no. 4 (October 2018): 758–66. https://doi.org/10.1016/j.juro.2018.05.016.
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  - Tandberg, Daniel J., Taofik Oyekunle, W Robert Lee, Yuan Wu, Joseph K. Salama, and Bridget F. Koontz. “Postoperative Radiation Therapy for Prostate Cancer: Comparison of Conventional Versus Hypofractionated Radiation Regimens..” Int J Radiat Oncol Biol Phys 101, no. 2 (June 1, 2018): 396–405. https://doi.org/10.1016/j.ijrobp.2018.02.002.
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  - Torok, Jordan A., Yuan Wu, Junzo Chino, Leonard R. Prosnitz, Anne W. Beaven, Grace J. Kim, and Chris R. Kelsey. “Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma..” Anticancer Res 38, no. 5 (May 2018): 2875–81. https://doi.org/10.21873/anticanres.12533.
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  - Humeniuk, Michael S., Rajan T. Gupta, Patrick Healy, Megan McNamara, Sundhar Ramalingam, Michael Harrison, Daniel George, Tian Zhang, Yuan Wu, and Andrew J. Armstrong. “Platinum sensitivity in metastatic prostate cancer: does histology matter?.” Prostate Cancer Prostatic Dis 21, no. 1 (April 2018): 92–99. https://doi.org/10.1038/s41391-017-0017-6.
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  - Song, Erin J., Jordan Torok, Yuan Wu, Junzo Chino, Leonard R. Prosnitz, Anne W. Beaven, and Chris R. Kelsey. “Consolidation Radiation Therapy for Patients With Advanced Hodgkin Lymphoma in Complete Metabolic Response According to PET-CT or Gallium Imaging..” Clin Lymphoma Myeloma Leuk 18, no. 2 (February 2018): 145–51. https://doi.org/10.1016/j.clml.2017.12.007.
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  - Ramalingam, Sundhar, Michael S. Humeniuk, Rachel Hu, Julia Rasmussen, Patrick Healy, Yuan Wu, Michael R. Harrison, Andrew J. Armstrong, Daniel J. George, and Tian Zhang. “Prostate-specific antigen response in black and white patients treated with abiraterone acetate for metastatic castrate-resistant prostate cancer..” Urol Oncol 35, no. 6 (June 2017): 418–24. https://doi.org/10.1016/j.urolonc.2016.12.016.
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  - Longo, Thomas, Kathleen F. McGinley, Jennifer A. Freedman, Wiguins Etienne, Yuan Wu, Alexander Sibley, Kouros Owzar, et al. “Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer..” Eur Urol 70, no. 5 (November 2016): 714–17. https://doi.org/10.1016/j.eururo.2016.07.049.
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  - Geradts, Joseph, Jeffrey Groth, Yuan Wu, and Genglin Jin. “Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS)..” Breast Cancer Res Treat 157, no. 3 (June 2016): 447–59. https://doi.org/10.1007/s10549-016-3838-4.
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  - Ramalingam, Sundhar, David J. Sermer, Rajan Gupta, Patrick Healy, Yuan Wu, Daniel J. George, Andrew J. Armstrong, and Michael Roger Harrison. “Changes in skeletal muscle cross sectional area (CSA) in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide (ENZ)..” Journal of Clinical Oncology 34, no. 15_suppl (May 20, 2016): e16601–e16601. https://doi.org/10.1200/jco.2016.34.15_suppl.e16601.
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  - Ludmir, Ethan B., Ritu Arya, Yuan Wu, Manisha Palta, Christopher G. Willett, and Brian G. Czito. “Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era..” Ann Surg Oncol 23, no. 3 (March 2016): 856–62. https://doi.org/10.1245/s10434-015-4907-3.
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  - Lu, Chia-Lun, Shuang Wang, Zhanglong Ji, Yuan Wu, Li Xiong, Xiaoqian Jiang, and Lucila Ohno-Machado. “WebDISCO: a web service for distributed cox model learning without patient-level data sharing..” J Am Med Inform Assoc 22, no. 6 (November 2015): 1212–19. https://doi.org/10.1093/jamia/ocv083.
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  - Torok, Jordan A., Yuan Wu, Leonard R. Prosnitz, Grace J. Kim, Anne W. Beaven, Louis F. Diehl, and Chris R. Kelsey. “Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma..” Int J Radiat Oncol Biol Phys 92, no. 1 (May 1, 2015): 54–59. https://doi.org/10.1016/j.ijrobp.2015.02.003.
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  - Wu, Yuan, Xiaoqian Jiang, Shuang Wang, Wenchao Jiang, Pinghao Li, and Lucila Ohno-Machado. “Grid multi-category response logistic models..” Bmc Med Inform Decis Mak 15 (February 18, 2015). https://doi.org/10.1186/s12911-015-0133-y.
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  - Ludmir, Ethan B., Manisha Palta, Xuefeng Zhang, Yuan Wu, Christopher G. Willett, and Brian G. Czito. “Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma..” J Gastrointest Oncol 5, no. 6 (December 2014): 401–7. https://doi.org/10.3978/j.issn.2078-6891.2014.053.
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  - Jiang, Xiaoqian, Yuan Wu, Keith Marsolo, and Lucila Ohno-Machado. “Development of a web service for analysis in a distributed network..” Egems (Wash Dc) 2, no. 1 (2014). https://doi.org/10.13063/2327-9214.1053.
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  - Kim, J., E. Levy, A. Ferbrache, P. Stepanowsky, C. Farcas, S. Wang, S. Brunner, T. Bath, Y. Wu, and L. Ohno-Machado. “MAGI: a Node. js web service for fast MicroRNA-Seq Analysis in a GPU Infrastructure.” Bioinformatics, 2014. https://doi.org/10.1093/bioinformatics/btu377.
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  - Ludmir, E. B., M. Palta, X. Zhang, Y. Wu, C. G. Willett, and B. G. Czito. “Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.” Journal of Gastrointestinal Oncology 5, no. 6 (January 1, 2014): 401–7. https://doi.org/10.3978/j.issn.2078-6891.2014.05.
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  - Jiang, Wenchao, Pinghao Li, Shuang Wang, Yuan Wu, Meng Xue, Lucila Ohno-Machado, and Xiaoqian Jiang. “WebGLORE: a web service for Grid LOgistic REgression..” Bioinformatics 29, no. 24 (December 15, 2013): 3238–40. https://doi.org/10.1093/bioinformatics/btt559.
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  - Wu, Y. “B-Spline-based sieve estimation in survival analysis.” Annals of Biometrics and Biostatistics 1, no. 1 (July 5, 2013): 1–3.
  - Wang, Shuang, Xiaoqian Jiang, Yuan Wu, Lijuan Cui, Samuel Cheng, and Lucila Ohno-Machado. “EXpectation Propagation LOgistic REgRession (EXPLORER): distributed privacy-preserving online model learning..” J Biomed Inform 46, no. 3 (June 2013): 480–96. https://doi.org/10.1016/j.jbi.2013.03.008.
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  - Ramirez, Marizen, Yuan Wu, Sheryl Kataoka, Marleen Wong, Jingzhen Yang, Corinne Peek-Asa, and Bradley Stein. “Youth violence across multiple dimensions: a study of violence, absenteeism, and suspensions among middle school children..” J Pediatr 161, no. 3 (September 2012): 542-546.e2. https://doi.org/10.1016/j.jpeds.2012.03.014.
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  - Wu, Yuan, Xiaoqian Jiang, Jihoon Kim, and Lucila Ohno-Machado. “Grid Binary LOgistic REgression (GLORE): building shared models without sharing data..” J Am Med Inform Assoc 19, no. 5 (September 2012): 758–64. https://doi.org/10.1136/amiajnl-2012-000862.
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  - Wu, Y., and Y. Zhang. “Partially monotone tensor spline estimation of the joint distribution function with bivariate current status data.” Annals of Statistics 40, no. 3 (June 1, 2012): 1609–36. https://doi.org/10.1214/12-AOS1016.
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  - Wu, Y., and X. Gao. “Sieve Estimation with Bivariate Interval Censored Data.” Journal of Statistics: Advances in Theory and Applications 5 (2011): 37–61.
  - Botto, Lorenzo D., Timothy Flood, Julian Little, Mark N. Fluchel, Sergey Krikov, Marcia L. Feldkamp, Yuan Wu, Rhinda Goedken, Soman Puzhankara, and Paul A. Romitti. “Cancer Risk in Children and Adolescents with Birth Defects: A Population-Based Cohort Study.” Plos One 8, no. 7 (n.d.): e69077–e69077. https://doi.org/10.1371/journal.pone.0069077.
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- Book Sections
  - Wu, Yuan, and Susan Halabi. “Interval Censoring.” In Textbook of Clinical Trials in Oncology A Statistical Perspective, edited by Susan Halabi and Stefan Michiels, 493–510. CRC Press, 2019.
- Conference Papers
  - Mara, Alexandria, Jason Zhu, Yuan Wu, Tom Callis, Shan Yang, Edward D. Esplin, Robert L. Nussbaum, et al. “Prevalence of pathogenic germline variants in DNA repair by race, age, and ethnicity in men with prostate cancer..” In Journal of Clinical Oncology, 37:5062–5062. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.5062.
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  - Zhang, Tian, Bridget F. Koontz, Scott T. Tagawa, Himanshu Nagar, Rhonda L. Bitting, Bart Frizzell, Julia Rasmussen, et al. “A phase II Salvage Trial of AR Inhibition with ADT and Apalutamide with Radiation therapy followed by docetaxel in men with PSA recurrent prostate cancer (PC) after radical prostatectomy (STARTAR)..” In Journal of Clinical Oncology, 37:TPS5097–TPS5097. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.tps5097.
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  - Zhu, Jason, Matthew D. Tucker, Chester Kao, Matthew Labriola, Sachica Cheris, Michael B. Datto, Yuan Wu, et al. “Immune checkpoint inhibitor response in tumors with LRP1B variants..” In Journal of Clinical Oncology, 37:e14291–e14291. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.e14291.
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  - Armstrong, Andrew J., Rhonda L. Bitting, Patrick Healy, Daniel J. George, Sung Kim, Tina M. Mayer, Carolyn Winters, et al. “Phase II trial enzalutamide and androgen deprivation therapy (ADT) with salvage radiation in men with high-risk PSA recurrent prostate cancer (PC): The STREAM trial..” In Journal of Clinical Oncology, 37:29–29. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.7_suppl.29.
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  - Harrison, Michael Roger, Michel Khouri, Andrew J. Armstrong, Tian Zhang, Megan Ann McNamara, Monika Anand, Ellen Bratt, et al. “PEAX: Men with metastatic castrate-resistant prostate cancer (mCRPC) treated with either sipuleucel-T (SIP-T), enzalutamide (ENZA) or abiraterone acetate (ABI) undergoing cardiopulmonary exercise testing (CPET)..” In Journal of Clinical Oncology, 37:281–281. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.7_suppl.281.
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  - Jacobs, Corbin, Jacob Trotter, Manisha Palta, Yuan Wu, Christopher Willett, W Robert Lee, and Brian G. Czito. “Multi-institutional analysis of synchronous prostate and rectosigmoid cancers..” In Journal of Clinical Oncology, 37:33–33. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.7_suppl.33.
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  - Tucker, Matthew D., Jason Zhu, William R. Berry, Sundhar Ramalingam, Tian Zhang, Michael Roger Harrison, Yuan Wu, Patrick Healy, Daniel J. George, and Andrew J. Armstrong. “Pembrolizumab in men with heavily treated metastatic castration-resistant prostate cancer (mCRPC)..” In Journal of Clinical Oncology, 37:172–172. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.7_suppl.172.
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  - Humeniuk, Michael Sandon, Rajan T. Gupta, Megan Ann McNamara, Sundhar Ramalingam, Michael Roger Harrison, Daniel J. George, Yuan Wu, Patrick Healy, and Andrew J. Armstrong. “Association of neuroendocrine phenotype with platinum chemotherapy outcomes in men with metastatic prostate cancer..” In Journal of Clinical Oncology, 35:e16532–e16532. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.e16532.
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  - Ludmir, E. B., M. Palta, Y. Wu, C. G. Willett, and B. G. Czito. “Definitive Chemoradiation Therapy for Cervical Esophageal Carcinoma: A Single-Institution Experience.” In International Journal of Radiation Oncology*Biology*Physics, 90:S348–S348. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.1135.
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  - Torok, J., L. R. Prosnitz, M. Palta, Y. Wu, A. Beaven, L. Diehl, and C. R. Kelsey. “Low-Dose Consolidation Radiation Therapy for Early-Stage Unfavorable Hodgkin Lymphoma.” In International Journal of Radiation Oncology*Biology*Physics, 90:S672–73. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.1979.
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  - Jiang, Xiaoqian, Jihoon Kim, Yuan Wu, Shuang Wang, and Lucila Ohno-Machado. “Selecting cases for whom additional tests can improve prognostication..” In Amia Annu Symp Proc, 2012:1260–68, 2012.
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  - Wu, Y., X. Jiang, J. Kim, and L. Ohno-Machado. “I-spline Smoothing for Calibrating Predictive Models,” 39–46, 2012.
  - Wu, Yuan, Xiaoqian Jiang, and Lucila Ohno-Machado. “Preserving Institutional Privacy in Distributed binary Logistic Regression..” In Amia Annu Symp Proc, 2012:1450–58, 2012.
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Teaching & Mentoring
Recent Courses
- BIOSTAT 903: Advanced Survival Analysis 2019

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Education, Training, & Certifications

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses