Yuan Wu
Assistant Professor in Biostatistics & Bioinformatics
My research interests include survival analysis, statistical computing, non/semi-parametric estimation. My current methodological work focuses on non/semi-parametric estimation and predictive accuracy assessment for survival models with complicated data structure and their applications.
Current Appointments & Affiliations
- Assistant Professor in Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2013
Contact Information
- 2424 Erwin Road, 11101 Hock Plaza Suite 1102, Durham, NC 27710
- Duke Box 2721, Durham, NC 27710
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yuan.wu@duke.edu
(919) 681-5018
- Background
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Education, Training, & Certifications
- Ph.D., University of Iowa 2010
- Research
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Selected Grants
- Race-related alternative splicing: novel targets in prostate cancer awarded by National Institutes of Health 2017 - 2022
- Developing knowledge models to enable rapid learning in radiation therapy awarded by National Institutes of Health 2016 - 2020
- PSA - Lauren Howard - A Retrospective Description of Patient Characteristics, Management, and Outcomes awarded by Institute for Medical Research, Inc. 2017 - 2020
- Therapeutic targeting of B7-H3 to reverse prostate cancer treatment resistance. awarded by Department of Defense 2016 - 2019
- PSA for Lauren Howard awarded by Institute for Medical Research, Inc. 2014 - 2019
- Randomized Controlled Clinical Trial of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy for Prostate Cancer awarded by University of California - Los Angeles 2017 - 2019
- Innovative Biomarker-Integrated Clinical Trial Design and Analysis awarded by University of North Carolina - Chapel Hill 2015 - 2019
- Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2019
- CTC-Immune Checkpoints awarded by Janssen Research & Development, LLC 2016 - 2019
- A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments awarded by National Institutes of Health 2014 - 2018
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2018
- Bayer-Exini Radium-223 Retrospective Study awarded by Bayer Healthcare Pharmaceuticals Inc 2016 - 2018
- Novel Immune Modulating Cellular Vaccine for Prostate Cancer Immunotherapy awarded by Department of Defense 2013 - 2017
- A Pilot Study on H.O.P.E: Helping Ovarian Cancer Patients Cope with Disease Recurrence awarded by Foundation for Women's Cancer 2014 - 2016
- Publications & Artistic Works
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Selected Publications
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Conference Papers
- Ludmir, E, Palta, M, Wu, Y, Willett, C, and Czito, B. "Definitive Chemoradiation Therapy for Cervical Esophageal Carcinoma: A Single-Institution Experience." September 2014. Full Text
- Torok, J, Prosnitz, L, Palta, M, Wu, Y, Beaven, A, Diehl, L, and Kelsey, C. "Low-Dose Consolidation Radiation Therapy for Early-Stage Unfavorable Hodgkin Lymphoma." September 2014. Full Text
- Jiang, X, Kim, J, Wu, Y, and Ohno-Machado, L. "Selecting Cases for Whom Additional Tests Can Improve Prognostication." AMIA Annual Symposium Proceedings. 2012.
- Wu, Y, Jiang, X, Kim, J, and Ohno-Machado, L. "I-spline Smoothing for Calibrating Predictive Models." AMIA Joint Summits on Translational Science Proceedings. 2012.
- Wu, Y, Jiang, X, and Ohno-Machado, L. "Preserving Institutional Privacy in Distributed Binary Logistic Regression." AMIA Annual Symposium Proceedings. 2012.
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Journal Articles
- Tandberg, DJ, Oyekunle, T, Lee, WR, Wu, Y, Salama, JK, and Koontz, BF. "Postoperative Radiation Therapy for Prostate Cancer: Comparison of Conventional Versus Hypofractionated Radiation Regimens. (Accepted)" International journal of radiation oncology, biology, physics 101, no. 2 (June 2018): 396-405. Full Text
- Aminsharifi, A, Howard, L, Wu, Y, De Hoedt, A, Bailey, C, Freedland, SJ, and Polascik, TJ. "Prostate-specific antigen density as a predictor of clinically significant prostate cancer when the PSA level is in the diagnostic "grey-zone": Defining the optimum cut-point stratified by race and body mass index." The Journal of urology (May 11, 2018). Full Text
- Torok, JA, Wu, Y, Chino, J, Prosnitz, LR, Beaven, AW, Kim, GJ, and Kelsey, CR. "Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma." Anticancer research 38, no. 5 (May 2018): 2875-2881. Full Text
- Humeniuk, MS, Gupta, RT, Healy, P, McNamara, M, Ramalingam, S, Harrison, M, George, D, Zhang, T, Wu, Y, and Armstrong, AJ. "Platinum sensitivity in metastatic prostate cancer: does histology matter?." Prostate cancer and prostatic diseases 21, no. 1 (April 2018): 92-99. Full Text
- Song, EJ, Torok, J, Wu, Y, Chino, J, Prosnitz, LR, Beaven, AW, and Kelsey, CR. "Consolidation Radiation Therapy for Patients With Advanced Hodgkin Lymphoma in Complete Metabolic Response According to PET-CT or Gallium Imaging." Clinical lymphoma, myeloma & leukemia (December 30, 2017). Full Text
- Ramalingam, S, Humeniuk, MS, Hu, R, Rasmussen, J, Healy, P, Wu, Y, Harrison, MR, Armstrong, AJ, George, DJ, and Zhang, T. "Prostate-specific antigen response in black and white patients treated with abiraterone acetate for metastatic castrate-resistant prostate cancer." Urol Oncol 35, no. 6 (June 2017): 418-424. Full Text Link to Item
- Longo, T, McGinley, KF, Freedman, JA, Etienne, W, Wu, Y, Sibley, A, Owzar, K, Gresham, J, Moy, C, Szabo, S, Greshock, J, Zhou, H, Bai, Y, and Inman, BA. "Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer." European urology 70, no. 5 (November 2016): 714-717. Full Text
- Geradts, J, Groth, J, Wu, Y, and Jin, G. "Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS)." Breast cancer research and treatment 157, no. 3 (June 2016): 447-459. Full Text
- Ludmir, EB, Arya, R, Wu, Y, Palta, M, Willett, CG, and Czito, BG. "Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era." Annals of surgical oncology 23, no. 3 (March 2016): 856-862. Full Text
- Wu, Y, Jiang, X, Wang, S, Jiang, W, Li, P, and Ohno-Machado, L. "Grid multi-category response logistic models." BMC medical informatics and decision making 15, no. 1 (December 2015): 133-.
- Lu, C-L, Wang, S, Ji, Z, Wu, Y, Xiong, L, Jiang, X, and Ohno-Machado, L. "WebDISCO: a web service for distributed cox model learning without patient-level data sharing." Journal of the American Medical Informatics Association 22, no. 6 (November 2015): 1212-1219. Full Text
- Torok, JA, Wu, Y, Prosnitz, LR, Kim, GJ, Beaven, AW, Diehl, LF, and Kelsey, CR. "Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma." International journal of radiation oncology, biology, physics 92, no. 1 (May 2015): 54-59. Full Text
- Wu, Y, Jiang, X, Wang, S, Jiang, W, Li, P, and Ohno-Machado, L. "Grid multi-category response logistic models." BMC medical informatics and decision making 15 (February 18, 2015): 10-. Full Text
- Jiang, X, Wu, Y, Marsolo, K, and Ohno-Machado, L. "Development of a web service for analysis in a distributed network." EGEMS (Washington, DC) 2, no. 1 (January 2014): 1053-. Full Text Open Access Copy
- Kim, J, Levy, E, Ferbrache, A, Stepanowsky, P, Farcas, C, Wang, S, Brunner, S, Bath, T, Wu, Y, and Ohno-Machado, L. "MAGI: a Node. js web service for fast MicroRNA-Seq Analysis in a GPU Infrastructure." Bioinformatics (2014). Full Text
- Ludmir, E, Palta, M, Zhang, X, Wu, Y, Willett, C, and Czito, B. "Incidence and Prognostic Impact of High-Risk HPV Tumor Infection in Cervical Esophageal Carcinoma." Journal of Gastrointestinal Oncology 5, no. 6 (2014): 401-407. Full Text
- Ludmir, EB, Palta, M, Zhang, X, Wu, Y, Willett, CG, and Czito, BG. "Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma." Journal of Gastrointestinal Oncology 5, no. 6 (January 1, 2014): 401-407. Full Text
- Botto, L, Flood, T, Little, J, Fluchel, M, Krikov, S, Feldkamp, M, Wu, Y, Geodken, R, Puzhankara, S, and Romitti, P. "Cancer risk in children and adolescents with birth defects: a population-based cohort study." PLoS One 8, no. 7 (July 17, 2013). Full Text
- Wu, Y. "B-Spline-based sieve estimation in survival analysis." Annals of Biometrics and Biostatistics 1, no. 1 (July 5, 2013): 1-3. (Review)
- Jiang, W, Li, P, Wang, S, Wu, Y, Xue, M, Ohno-Machado, L, and Jiang, X. "WebGLORE: A Webservice for Grid LOgistic REgression." Bioinformatics 29, no. 24 (2013): 3238-3240. Full Text
- Wang, S, Jiang, X, Wu, Y, Cui, L, Ohno-Machado, L, Wang, S, Jiang, X, Wu, Y, Cui, L, Ohno-Machado, L, Wang, S, Jiang, X, Wu, Y, Cui, L, and Ohno-Machado, L. "EXpectation Propagation LOgistic REgRession (EXPLORER): Distributed Privacy-Preserving Online Model LearningEXpectation Propagation LOgistic REgRession (EXPLORER): Distributed Privacy-Preserving Online Model LearningEXpectation Propagation LOgistic REgRession (EXPLORER): Distributed Privacy-Preserving Online Model Learning (PublishedAccepted)." Journal of Biomedical Informatics 46, no. 3 (2013): 480-496. Full Text
- Ramirez, M, Wu, Y, Kataoka, S, Wong, M, Yang, J, Peek-Asa, C, and Stein, B. "Youth violence across multiple dimension: A study of violence, absenteeism and suspensions among middle school children." Journal of Pediatrics 161 (2012): 542-546. Full Text
- Wu, Y, Jiang, X, Kim, J, and Ohno-Machado, L. "Grid binary LOgistic REgression (GLORE): Building Shared Models Without Sharing Data." Journal of the American Medical Informatics Association 19 (2012): 758-764. Full Text
- Wu, Y, and Zhang, Y. "Partially Monotone Tensor Spline Estimation of the Joint Distribution Function with Bivariate Current Status Data." Annals of Statistics 40, no. 3 (2012): 1609-1636. Full Text Open Access Copy
- Wu, Y, Gao, X, Wu, Y, and Gao, X. "Sieve Estimation with Bivariate Interval Censored DataSieve Estimation with Bivariate Interval Censored Data." Journal of Statistical: Theory and Applications 5 (2011): 37-61.
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- Teaching & Mentoring
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Recent Courses
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