Yubin Kang | Scholars@Duke

Yubin Kang
Professor of Medicine

Current Appointments & Affiliations

Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

Box 3961 Med Ctr, Durham, NC 27710
Hematologic Malignancies, Box 3961, Durham, NC 27710
yubin.kang@duke.edu (919) 668-1000

Background
Education, Training, & Certifications
- Fellow, Hematology, Oncology, Cellular Therpay, Duke University School of Medicine 2007 - 2010
- M.D., Shanghai Second Medical University (China) 1991
Previous Appointments & Affiliations
- Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2019 - 2020
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2015 - 2019
- Instructor Temporary in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2014 - 2015
Research
Selected Grants
- TAK-573-1501 awarded by Takeda Development Center Americas, Inc 2022 - 2027
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer awarded by National Institutes of Health 2019 - 2025
- Role of SLAMF7 in Racial Disparities in t(11;14) myeloma awarded by National Cancer Institute 2023 - 2025
- Investigating the Role of a Novel Dendritic Cell Subset within Sentinel Lymph Node Tissues in Immune Evasion and Melanomagenesis awarded by Department of Defense 2021 - 2024
- Role of Tumor-mediated Innate Training in the Pathogenesis of Immune-related Adverse Events awarded by Cancer Research Institute 2022 - 2024
- Investigation of T-cell fitness and mechanisms of drug resistance in selinexor treated patients with relapsed/refractory multiple myeloma awarded by Karyopharm Therapeutics 2023 - 2024
- R21 Enhancing CAR T therapy in multiple myeloma awarded by National Institutes of Health 2022 - 2024
- A Precision Oncology Micro-Organosphere-Based Platform to Guide Multiple Myeloma Therapy awarded by Xilis, Inc. 2022 - 2023
- Thioredoxin, a novel agent for mitigating radiation-induced hematopoietic injury awarded by National Institutes of Health 2022 - 2023
- Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer awarded by National Institutes of Health 2018 - 2023
- THIOREDOXIN REGULATES P53 TRANSCRIPTION IN HEMATOPOIETIC STEM CELLS awarded by American Society of Hematology 2022 - 2023
- Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2022
- A PHASE 2, MULTICENTER, MULTI-COHORT, OPEN-LABEL STUDY OF POMALIDOMIDE IN COMBINATION WITH LOW-DOSE DEXAMETHASONE OR POMALIDOMIDE IN COMBINATION WITH LOW-DOSE DEXAMETHASONE AND DARATUMUMAB IN SUBJECTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA awarded by Celgene Corporation 2017 - 2022
- Effects of PPAR agonists on response to immunomodulatory agents in patients with multiple myeloma awarded by National Institutes of Health 2019 - 2021
- Phase I study of Pomolidomide, Bortezomib, and Dexamethasone (PVD) as First-Line treatment of AL Amyloidosis or Light Chain Deposition Disease awarded by Karmanos Cancer Center 2014 - 2021
- Targeting sphingosine kinase 2 for the treatment of multiple myeloma awarded by National Institutes of Health 2015 - 2021
- Clinical characteristics, JAK2 status, and macrophage infiltration in multiple myeloma patients with marrow fibrosis awarded by Incyte Corporation 2017 - 2020
- Clinical Trial of ABC294640 in Patients with Refractory Multiple Myeloma awarded by Apogee Biotechnology Corporation 2015 - 2019
- Ph III study to evaluate the safety of ALN-TTR02 in TTR-Medicated Polyneuropathy awarded by Alnylam Pharmaceuticals 2014 - 2018
- Thioredoxin for radioprotection awarded by Columbia University 2016 - 2018
- Develop and Support of the RedCap database, bio-statistic analysis, and med writing for Dr Kang NIH SBIR award Clin Trial awarded by RedHill Biopharma Ltd. 2016 - 2018
- Plerixafor for allogeneic hematopoietic stem cell transplantation awarded by National Institutes of Health 2014 - 2016
External Relationships
- Adaptimmune Therapeutics Plc
- American Association for Cancer Research
- Blue Bird
- G1 Therapeutics, Inc.
- IONIS Pharmaceuticals
- OrPro Therapeutics Inc
- PSI Pharma Support American Inc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wu, Jian, Shengjun Fan, Daniel Feinberg, Xiaobei Wang, Shaima Jabbar, and Yubin Kang. “Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma.” Curr Oncol 30, no. 3 (March 4, 2023): 3047–63. https://doi.org/10.3390/curroncol30030231.
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  - Lin, Chenyu, Rachel A. DiCioccio, Tarek Haykal, William C. McManigle, Zhiguo Li, Sarah M. Anand, Jonathan C. Poe, et al. “A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease.” Transplant Cell Ther 29, no. 3 (March 2023): 179.e1-179.e10. https://doi.org/10.1016/j.jtct.2022.12.015.
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  - Kang, Yubin, Pasupathi Sundaramoorthy, Cristina Gasparetto, Daniel Feinberg, Shengjun Fan, Gwynn Long, Emily Sellars, et al. “Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma.” Ann Hematol 102, no. 2 (February 2023): 369–83. https://doi.org/10.1007/s00277-022-05056-7.
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  - Kumar, Shaji K., Natalie S. Callander, Kehinde Adekola, Larry D. Anderson, Muhamed Baljevic, Erica Campagnaro, Jorge J. Castillo, et al. “Systemic Light Chain Amyloidosis, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 21, no. 1 (January 2023): 67–81. https://doi.org/10.6004/jnccn.2023.0001.
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  - Jabbar, Shaima, Parker Mathews, Xiaobei Wang, Pasupathi Sundaramoorthy, Emily Chu, Sadhna O. Piryani, Shengli Ding, Xiling Shen, Phuong L. Doan, and Yubin Kang. “Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor.” Exp Hematol Oncol 11, no. 1 (October 31, 2022): 83. https://doi.org/10.1186/s40164-022-00329-3.
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  - Sha, Yonggang, Jian Wu, Barry Paul, Yue Zhao, Parker Mathews, Zhiguo Li, John Norris, Endi Wang, Donald P. McDonnell, and Yubin Kang. “PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo.” Cancer Lett 545 (October 1, 2022): 215832. https://doi.org/10.1016/j.canlet.2022.215832.
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  - Jabbar, Shaima, Parker Mathews, and Yubin Kang. “Emerging Evidence of the Significance of Thioredoxin-1 in Hematopoietic Stem Cell Aging.” Antioxidants (Basel) 11, no. 7 (June 29, 2022). https://doi.org/10.3390/antiox11071291.
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  - Costa, Luciano J., Yi Lin, R Frank Cornell, Thomas Martin, Saurabh Chhabra, Saad Z. Usmani, Sundar Jagannath, et al. “Comparison of Cilta-cel, an Anti-BCMA CAR-T Cell Therapy, Versus Conventional Treatment in Patients With Relapsed/Refractory Multiple Myeloma.” Clin Lymphoma Myeloma Leuk 22, no. 5 (May 2022): 326–35. https://doi.org/10.1016/j.clml.2021.10.013.
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  - Choi, Taewoong, and Yubin Kang. “Chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma.” Pharmacol Ther 232 (April 2022): 108007. https://doi.org/10.1016/j.pharmthera.2021.108007.
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  - Bal, Susan, Ehsan Malek, Ankit Kansagra, Saad Z. Usmani, Ravi Vij, Kelly N. Godby, Robert F. Cornell, et al. “Treatment outcomes of triple class refractory multiple myeloma: a benchmark for new therapies.” Leukemia 36, no. 3 (March 2022): 877–80. https://doi.org/10.1038/s41375-021-01471-3.
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  - Callander, Natalie S., Muhamed Baljevic, Kehinde Adekola, Larry D. Anderson, Erica Campagnaro, Jorge J. Castillo, Caitlin Costello, et al. “NCCN Guidelines® Insights: Multiple Myeloma, Version 3.2022.” J Natl Compr Canc Netw 20, no. 1 (January 2022): 8–19. https://doi.org/10.6004/jnccn.2022.0002.
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  - Wu, Jian, Emily Chu, Cristiana Costa Chase, Taewoong Choi, Cristina Gasparetto, Ken Young, and Yubin Kang. “Anaplastic Multiple Myeloma: Case Series and Literature Review.” Asploro J Biomed Clin Case Rep 5, no. 1 (2022): 1–11. https://doi.org/10.36502/2022/asjbccr.6255.
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  - Wu, Jian, Emily Chu, and Yubin Kang. “PIM Kinases in Multiple Myeloma.” Cancers (Basel) 13, no. 17 (August 26, 2021). https://doi.org/10.3390/cancers13174304.
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  - Maung, Ko K., Benny J. Chen, Ian Barak, Zhiguo Li, David A. Rizzieri, Cristina Gasparetto, Keith M. Sullivan, et al. “Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation.” Bone Marrow Transplant 56, no. 1 (January 2021): 137–43. https://doi.org/10.1038/s41409-020-0991-5.
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  - Cornell, Robert, Parameswaran Hari, Shijie Tang, Noa Biran, Natalie Callander, Ajai Chari, Saurabh Chhabra, et al. “Overall survival of patients with triple-class refractory multiple myeloma treated with selinexor plus dexamethasone vs standard of care in MAMMOTH.” Am J Hematol 96, no. 1 (January 2021): E5–8. https://doi.org/10.1002/ajh.26010.
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  - Kumar, Shaji K., Natalie S. Callander, Kehinde Adekola, Larry Anderson, Muhamed Baljevic, Erica Campagnaro, Jorge J. Castillo, et al. “Multiple Myeloma, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 18, no. 12 (December 2, 2020): 1685–1717. https://doi.org/10.6004/jnccn.2020.0057.
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  - Dupuis, Megan M., Barry Paul, Gavin Loitsch, Parker Mathews, Daniel Feinberg, Ian Barak, Zhiguo Li, Sascha A. Tuchman, and Yubin Kang. “Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma.” Jco Oncol Pract 16, no. 8 (August 2020): e751–57. https://doi.org/10.1200/JOP.19.00517.
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  - Paul, Barry, Yue Zhao, Gavin Loitsch, Daniel Feinberg, Parker Mathews, Ian Barak, Megan Dupuis, et al. “The impact of bone marrow fibrosis and JAK2 expression on clinical outcomes in patients with newly diagnosed multiple myeloma treated with immunomodulatory agents and/or proteasome inhibitors.” Cancer Med 9, no. 16 (August 2020): 5869–80. https://doi.org/10.1002/cam4.3265.
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  - Theivanthiran, Balamayoora, Kathy S. Evans, Nicholas C. DeVito, Michael Plebanek, Michael Sturdivant, Luke P. Wachsmuth, April Ks Salama, et al. “A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.” J Clin Invest 130, no. 5 (May 1, 2020): 2570–86. https://doi.org/10.1172/JCI133055.
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  - Huang, Qiang, Malkiel A. Cohen, Fernando C. Alsina, Garth Devlin, Aliesha Garrett, Jennifer McKey, Patrick Havlik, et al. “Intravital imaging of mouse embryos.” Science 368, no. 6487 (April 10, 2020): 181–86. https://doi.org/10.1126/science.aba0210.
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  - Fan, Shengjun, Trevor Price, Wei Huang, Michelle Plue, Jonathan Warren, Pasupathi Sundaramoorthy, Barry Paul, et al. “PINK1-Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B-Mediated Hippo-YAP/TAZ Pathway.” Adv Sci (Weinh) 7, no. 5 (March 2020): 1900860. https://doi.org/10.1002/advs.201900860.
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  - Feinberg, Daniel, Barry Paul, and Yubin Kang. “The promise of chimeric antigen receptor (CAR) T cell therapy in multiple myeloma.” Cell Immunol 345 (November 2019): 103964. https://doi.org/10.1016/j.cellimm.2019.103964.
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  - Kumar, Shaji K., Natalie S. Callander, Jens Hillengass, Michaela Liedtke, Muhamed Baljevic, Erica Campagnaro, Jorge J. Castillo, et al. “NCCN Guidelines Insights: Multiple Myeloma, Version 1.2020.” J Natl Compr Canc Netw 17, no. 10 (October 1, 2019): 1154–65. https://doi.org/10.6004/jnccn.2019.0049.
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  - Gandhi, Ujjawal H., Robert F. Cornell, Arjun Lakshman, Zhubin J. Gahvari, Elizabeth McGehee, Megan H. Jagosky, Ridhi Gupta, et al. “Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy.” Leukemia 33, no. 9 (September 2019): 2266–75. https://doi.org/10.1038/s41375-019-0435-7.
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  - Rizzieri, Dustin, Barry Paul, and Yubin Kang. “Metabolic alterations and the potential for targeting metabolic pathways in the treatment of multiple myeloma.” J Cancer Metastasis Treat 5 (2019). https://doi.org/10.20517/2394-4722.2019.05.
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  - Zheng, Jing, Yonggang Sha, Logan Roof, Oded Foreman, John Lazarchick, Jagadish Kummetha Venkta, Cleopatra Kozlowski, et al. “Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade.” Cancer Lett 440–441 (January 2019): 1–10. https://doi.org/10.1016/j.canlet.2018.10.003.
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  - Paul, Barry, Shuqi Kang, Zhihong Zheng, and Yubin Kang. “The challenges of checkpoint inhibition in the treatment of multiple myeloma.” Cell Immunol 334 (December 2018): 87–98. https://doi.org/10.1016/j.cellimm.2018.10.003.
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  - Sivaraj, Dharshan, Michael M. Green, Yubin Kang, Gwynn D. Long, David A. Rizzieri, Zhiguo Li, Anderson H. Garrett, Jackie L. McIntyre, Nelson J. Chao, and Cristina Gasparetto. “Bendamustine, pomalidomide, and dexamethasone for relapsed and/or refractory multiple myeloma.” Blood Cancer J 8, no. 8 (July 31, 2018): 71. https://doi.org/10.1038/s41408-018-0104-5.
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  - Sundaramoorthy, Pasupathi, Cristina Gasparetto, and Yubin Kang. “The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl-2 inhibitor (ABT-199) displays synergistic anti-myeloma effects in myeloma cells without a t(11;14) translocation.” Cancer Med 7, no. 7 (July 2018): 3257–68. https://doi.org/10.1002/cam4.1543.
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  - Zheng, Zhihong, Shengjun Fan, Jing Zheng, Wei Huang, Cristina Gasparetto, Nelson J. Chao, Jianda Hu, and Yubin Kang. “Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma.” J Hematol Oncol 11, no. 1 (February 27, 2018): 29. https://doi.org/10.1186/s13045-018-0575-7.
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  - Kumar, Shaji K., Natalie S. Callander, Melissa Alsina, Djordje Atanackovic, J Sybil Biermann, Jorge Castillo, Jason C. Chandler, et al. “NCCN Guidelines Insights: Multiple Myeloma, Version 3.2018.” J Natl Compr Canc Netw 16, no. 1 (January 2018): 11–20. https://doi.org/10.6004/jnccn.2018.0002.
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  - Sivaraj, D., W. Bacon, G. D. Long, D. A. Rizzieri, M. E. Horwitz, K. M. Sullivan, Y. Kang, Z. Li, N. J. Chao, and C. Gasparetto. “High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma.” Bone Marrow Transplant 53, no. 1 (January 2018): 34–38. https://doi.org/10.1038/bmt.2017.208.
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  - Sundaramoorthy, Pasupathi, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao, and Yubin Kang. “Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.” Stem Cell Res Ther 8, no. 1 (November 15, 2017): 263. https://doi.org/10.1186/s13287-017-0711-2.
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  - Tuchman, Sascha A., Joseph O. Moore, Carlos D. DeCastro, Zhiguo Li, Emily Sellars, Yubin Kang, Gwynn Long, and Cristina G. Gasparetto. “Phase II study of dose-attenuated bortezomib, cyclophosphamide and dexamethasone ("VCD-Lite") in very old or otherwise toxicity-vulnerable adults with newly diagnosed multiple myeloma.” J Geriatr Oncol 8, no. 3 (May 2017): 165–69. https://doi.org/10.1016/j.jgo.2017.02.004.
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  - Sivaraj, Dharshan, Michael M. Green, Zhiguo Li, Anthony D. Sung, Stefanie Sarantopoulos, Yubin Kang, Gwynn D. Long, et al. “Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma.” Biol Blood Marrow Transplant 23, no. 2 (February 2017): 262–68. https://doi.org/10.1016/j.bbmt.2016.11.010.
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  - Green, Michael M. B., Nelson Chao, Saurabh Chhabra, Kelly Corbet, Cristina Gasparetto, Ari Horwitz, Zhiguo Li, et al. “Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.” J Hematol Oncol 9, no. 1 (August 17, 2016): 71. https://doi.org/10.1186/s13045-016-0301-2.
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  - An, Ningfei, Bo Cen, Houjian Cai, Jin H. Song, Andrew Kraft, and Yubin Kang. “Pim1 kinase regulates c-Kit gene translation.” Exp Hematol Oncol 5 (2016): 31. https://doi.org/10.1186/s40164-016-0060-3.
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  - Schade, Henning, Saurabh Chhabra, Yubin Kang, Robert K. Stuart, Kathy H. Edwards, Cindy Kramer, Coleen Butcher, et al. “Similar dynamics of intraapheresis autologous CD34+ recruitment and collection efficiency in patients undergoing mobilization with or without plerixafor.” Transfusion 54, no. 12 (December 2014): 3131–37. https://doi.org/10.1111/trf.12761.
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  - Venkata, Jagadish Kummetha, Ningfei An, Robert Stuart, Luciano J. Costa, Houjian Cai, Woodrow Coker, Jin H. Song, et al. “Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.” Blood 124, no. 12 (September 18, 2014): 1915–25. https://doi.org/10.1182/blood-2014-03-559385.
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  - Venkata, Jagadish Kummetha, Ningfei An, Robert Stuart, Luciano J. Costa, Houjian Cai, Woodrow Coker, Jin H. Song, et al. “Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.” Blood 124, no. 12 (September 18, 2014): 1915–25. https://doi.org/10.1182/blood-2014-03559385.
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  - Costa, Luciano J., Elizabeth J. Nista, Francis K. Buadi, Martha Q. Lacy, Angela Dispenzieri, Cindy P. Kramer, Kathy H. Edwards, et al. “Prediction of Poor Mobilization of Autologous CD34+ Cells with Growth Factor in Multiple Myeloma Patients: Implications for Risk-Stratification.” Biology of Blood and Marrow Transplantation 20, no. 2 (February 2014): 222–28. https://doi.org/10.1016/j.bbmt.2013.11.003.
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  - Roof, Logan, Woodrow J. Coker, John Lazarchick, and Yubin Kang. “Senile transthyretin cardiac amyloidosis in patients with plasma cell dyscrasias: importance of cardiac biopsy for making the correct diagnosis.” Aperito J Cell Mol Biol 1, no. 1 (2014).
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  - An, Ningfei, and Yubin Kang. “Thioredoxin and hematologic malignancies.” Adv Cancer Res 122 (2014): 245–79. https://doi.org/10.1016/B978-0-12-420117-0.00007-4.
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  - An, Ningfei, Andrew S. Kraft, and Yubin Kang. “Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.” Journal of Hematology &Amp; Oncology 6, no. 1 (December 2013). https://doi.org/10.1186/1756-8722-6-12.
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  - Coker, Woodrow J., Ashley Jeter, Henning Schade, and Yubin Kang. “Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms.” Biomarker Research 1, no. 1 (December 2013). https://doi.org/10.1186/2050-7771-1-8.
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  - Kellner, Joshua, Bei Liu, Yubin Kang, and Zihai Li. “Fact or fiction - identifying the elusive multiple myeloma stem cell.” Journal of Hematology &Amp; Oncology 6, no. 1 (December 2013). https://doi.org/10.1186/1756-8722-6-91.
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  - An, Ningfei, Michael G. Janech, Alison M. Bland, John Lazarchick, John M. Arthur, and Yubin Kang. “Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution.” Experimental Hematology 41, no. 11 (November 2013): 944–56. https://doi.org/10.1016/j.exphem.2013.08.004.
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  - An, Ningfei, Ying-Wei Lin, Sandeep Mahajan, Joshua N. Kellner, Yong Wang, Zihai Li, Andrew S. Kraft, and Yubin Kang. “Pim1 Serine/Threonine Kinase Regulates the Number and Functions of Murine Hematopoietic Stem Cells.” Stem Cells 31, no. 6 (June 1, 2013): 1202–12. https://doi.org/10.1002/stem.1369.
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  - Zhou, Dunhua, Divino Deoliveira, Yubin Kang, Seung S. Choi, Zhiguo Li, Nelson J. Chao, and Benny J. Chen. “Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation.” Int J Radiat Oncol Biol Phys 85, no. 4 (March 15, 2013): 1141–48. https://doi.org/10.1016/j.ijrobp.2012.08.014.
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  - An, Ningfei, and Yubin Kang. “Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model.” Journal of Visualized Experiments, no. 73 (March 7, 2013). https://doi.org/10.3791/50193.
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  - Butler, Charles, Daynna J. Wolff, Yubin Kang, Robert K. Stuart, and Luciano J. Costa. “Association of age with fluorescencein situhybridization abnormalities in multiple myeloma reveals higher rate ofIGHtranslocations among older patients.” Leukemia &Amp; Lymphoma 53, no. 12 (December 2012): 2444–48. https://doi.org/10.3109/10428194.2012.691483.
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  - Jeter, Ashley, and Yubin Kang. “Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy.” Experimental Hematology &Amp; Oncology 1, no. 1 (December 2012). https://doi.org/10.1186/2162-3619-1-20.
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  - Costa, L. J., J. Abbas, K. R. Hogan, C. Kramer, K. McDonald, C. D. Butcher, A. Littleton, K. Shoptaw, Y. Kang, and R. K. Stuart. “Growth factor plus preemptive (‘just-in-time’) plerixafor successfully mobilizes hematopoietic stem cells in multiple myeloma patients despite prior lenalidomide exposure.” Bone Marrow Transplantation 47, no. 11 (November 2012): 1403–8. https://doi.org/10.1038/bmt.2012.60.
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  - Costa, Luciano J., Cindy Kramer, Kathy R. Hogan, Coleen D. Butcher, Amanda L. Littleton, Katie B. Shoptaw, Yubin Kang, and Robert K. Stuart. “Pegfilgrastim- versus filgrastim-based autologous hematopoietic stem cell mobilization in the setting of preemptive use of plerixafor: efficacy and cost analysis.” Transfusion 52, no. 11 (November 2012): 2375–81. https://doi.org/10.1111/j.1537-2995.2012.03579.x.
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  - Costa, Luciano J., Jonathan Abbas, Karen L. Ortiz-Cruz, Yubin Kang, and Robert K. Stuart. “Outcomes of patients with multiple myeloma and renal impairment treated with bortezomib, cyclophosphamide, and dexamethasone without plasma exchange.” European Journal of Haematology 89, no. 5 (November 2012): 432–34. https://doi.org/10.1111/ejh.12008.
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  - Kang, Yubin, Benny J. Chen, Divino Deoliveira, Jeffrey Mito, and Nelson J. Chao. “Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.” Plos One 5, no. 6 (June 28, 2010): e11316. https://doi.org/10.1371/journal.pone.0011316.
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  - Kang, Yubin, Nelson J. Chao, and Franco Aversa. “Unmanipulated or CD34 selected haplotype mismatched transplants.” Curr Opin Hematol 15, no. 6 (November 2008): 561–67. https://doi.org/10.1097/MOH.0b013e32831366eb.
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  - Kang, Yubin, Christopher J. Moressi, Todd E. Scheetz, Litao Xie, Diane Thi Tran, Thomas L. Casavant, Prashanth Ak, Craig J. Benham, Beverly L. Davidson, and Paul B. McCray. “Integration Site Choice of a Feline Immunodeficiency Virus Vector.” Journal of Virology 80, no. 17 (September 2006): 8820–23. https://doi.org/10.1128/jvi.00719-06.
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  - Kang, Yubin, Litao Xie, Diane Thi Tran, Colleen S. Stein, Melissa Hickey, Beverly L. Davidson, and Paul B. McCray. “Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer.” Blood 106, no. 5 (September 1, 2005): 1552–58. https://doi.org/10.1182/blood-2004-11-4358.
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  - Song, L., J. Wang, R. Wang, M. Yu, Y. Sun, G. Han, Y. Li, et al. “Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-β?” Gene Therapy 11, no. 20 (October 1, 2004): 1487–96. https://doi.org/10.1038/sj.gt.3302327.
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  - Starner, Timothy D., Carrie K. Barker, Hong Peng Jia, Yubin Kang, and Paul B. McCray. “CCL20 Is an Inducible Product of Human Airway Epithelia with Innate Immune Properties.” American Journal of Respiratory Cell and Molecular Biology 29, no. 5 (November 2003): 627–33. https://doi.org/10.1165/rcmb.2002-0272oc.
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  - Kang, Yubin, Colleen S. Stein, Jason A. Heth, Patrick L. Sinn, Andrea K. Penisten, Patrick D. Staber, Kenneth L. Ratliff, et al. “In Vivo Gene Transfer Using a Nonprimate Lentiviral Vector Pseudotyped with Ross River Virus Glycoproteins.” Journal of Virology 76, no. 18 (September 15, 2002): 9378–88. https://doi.org/10.1128/jvi.76.18.9378-9388.2002.
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  - Melo, M. E. F., J. Qian, M. El-Amine, N. Soukhareva, Y. Kang, and D. W. Scott. “Gene transfer of immunoglobulin-fusion proteins prevents and treats autoimmune diseases.” J. Immunol 168, no. 9 (2002): 4788–95.
  - Stein, C. S., Y. Kang, S. L. Sauter, K. Townsend, P. Staber, T. A. Derken, I. Martins, J. Qian, B. L. Davidson, and P. B. McCray. “In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using non-primate lentiviral vectors.” Molecular Therapy 3 (2001): 850–56.
  - Agarwal, Rajeev K., Yubin Kang, Elias Zambidis, David W. Scott, Chi-Chao Chan, and Rachel R. Caspi. “Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis.” Journal of Clinical Investigation 106, no. 2 (July 15, 2000): 245–52. https://doi.org/10.1172/jci9168.
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  - El-Amine, M., M. E. F. Melo, Y. Kang, J. Qian, and D. W. Scott. “Mechanisms of tolerance induction by an Ig-peptide molecule expressed and secreted by B cells.” Journal of Immunology (Baltimore, Md. : 1950) 165 (2000): 5631–36.
  - Kang, Yubin, Marco Melo, Edward Deng, Roland Tisch, Moustapha El-Amine, and David W. Scott. “Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: The IgG scaffold is important for induction and maintenance of immune hyporesponsiveness.” Proceedings of the National Academy of Sciences 96, no. 15 (July 20, 1999): 8609–14. https://doi.org/10.1073/pnas.96.15.8609.
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  - Kang, Y., M. E. F. Melo, and D. W. Scott. “An Ongoing Immune Response to HIV Envelope gp120 in Human CD4 Transgenic Mice Contributes to T Cell Decline upon Intravenous Administration of gp120.” European Journal of Immunology 28 (1998): 2253–64.
  - Thornalley, P. J., L. G. Edwards, Y. Kang, C. Wyatt, N. Davies, M. J. Ladan, and J. Double. “Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis.” Biochem Pharmacol 51, no. 10 (May 17, 1996): 1365–72. https://doi.org/10.1016/0006-2952(96)00059-7.
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  - Thornalley, P. J., M. Ladan, S. Ridgeway, and Y. Kang. “Anti-tumor Activity of S-(p-bromobenzyl)glutathione Diesters in vitro: a Structure-Activity Study.” Journal of Medicinal Chemistry 39, no. 17 (1996): 3409–11.
  - Huang, L. A., P. L. Meng, Y. Kang, Q. S. Cheng, and B. T. Liu. “Clinical Observation and Prevention of Coagulation Abnormality in 7 Cases of Patients with Acute Radiation Sickness.” Edited by B. T. Liu and G. Y. Ye, 1994, 348–56.
  - Huang, L. A., Q. S. Cheng, Y. Kang, and Y. H. Li. “Cytomegalovirus Infection in Bone Marrow Transplant Patients with Acute Radiation Sickness.” Edited by B. T. Liu and G. Y. Ye, 1994, 315–19.
  - Kang, Y., C. N. Gu, P. L. Meng, L. X. Cao, and L. A. Huang. “Monitoring of Blood Cyclosporine A Concentration and Clinical Observation in Patients with HLA-semimatched Bone Marrow Transplantation.” Edited by B. T. Liu and G. Y. Ye, 1994, 402–9.
  - Kang, Y., S. W. Zing, P. L. Meng, L. X. Cao, and L. A. Huang. “Capillary Leakage Syndrome Associated with Acute Radiation Disease.” Edited by B. T. Liu and G. Y. Ye, 1994, 311–14.
  - Kang, Y., R. Q. Yu, and X. T. Kong. “Tumor Cell Surface Markers and Differentiation on Multiple Myeloma.” Chinese Journal of Hematology 7 (1992): 384–87.
  - Kang, Y., and R. Q. Yu. “Hypertension Associated with Cyclosporine A Treatment in Bone Marrow Transplantation.” Foreign Medicine (Blood Transfusion & Hematology) 5 (1991): 288–91.
  - Kang, Y., and R. Q. Yu. “Therapeutic Progress in Multiple Myeloma.” Foreign Medicine (Blood Transfusion & Hematology) 3 (1990): 140–43.
  - Kang, Y., L. Edwards, and P. J. Thornalley. “Effect of Methylglyoxal on Human Leukemia 60 Cell Growth: Modification of DNA, G1 Growth Arrest and Induction of Apoptosis.” Leukemia Research 20, no. 5 (n.d.): 397–405.
- Book Sections
  - Kang, Y., and N. J. Chao. “Strategies to enhance hematopoietic stem cell engraftment following transplantation.” In Novel Developments in Stem Cell Mobilization Focus on CXCR4, 439–56. Springer Science & Business Media, 2012.
  - Kang, Y., and N. Chao. “Immune reconstitution.” In Hematopoietic Stem Cell Transplantation A Handbook for Clinicians, edited by J. R. Wingard, D. Gastineau, H. Leather, E. C. Snyder, and Z. M. Szczepiokowski, 181–96. Bethesda, MD: AABB Press, 2010.
  - Kang, Y., and J. He. “Interleukin-4.” In A Handbook of Human Cytokines, edited by J. He and D. X. Wang, 97–112. China: Tong Zi University Press, 1996.
  - Kang, Y., and Y. B. Cheng. “A Handbook of Human Cytokines.” In Interleukin-3, edited by J. He and D. X. Wang, 79–96. China: Tong Zi University Press, 1996.
- Digital Publications
  - An, N., and Y. Kang. “In vivo BrdU Incorporation Assay for Murine Hematopioetic Stem Cells.” Bio-Protocol, 2013.
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- Conference Papers
  - Costa, Luciano J., Robert Frank Cornell, Natalie S. Callander, Saurabh Chhabra, Michaela Liedtke, Ankit Kansagra, Kelly N. Godby, et al. “Efficacy of Treatments for Patients with Triple-Class Refractory (TCR) Multiple Myeloma (MM): Benchmark for New Agents Utilizing Real-World Data (RWD).” In Blood, 138:3786–3786. American Society of Hematology, 2021. https://doi.org/10.1182/blood-2021-144387.
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  - Theivanthiran, Balamayooran, Kathy Evans, Nicholas DeVito, Michael Plebanek, Michael Sturdivant, Alisha Holtzhausen, Luke Wachsmuth, et al. “A tumor PD-L1-NLRP3 inflammasome signaling axis drives adaptive resistance to anti-PD-1 immunotherapy.” In Journal for Immunotherapy of Cancer, Vol. 7. BMC, 2019.
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  - Cornell, Robert, Hari Parameswaran, Shijie Tang, Alyssa Barnstead, Noa Biran, Natalie Callander, Ajai Chari, et al. “Real world vs. clinical trial outcomes of triple class refractory penta-exposed multiple myeloma (MM).” In Clinical Lymphoma Myeloma and Leukemia, 19:e115–16. Elsevier BV, 2019. https://doi.org/10.1016/j.clml.2019.09.191.
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  - Paul, Barry, Gavin Loitsch, Daniel Feinberg, Ian Barak, Zhiguo Li, Endi Wang, Yue Zhao, Megan Dupuis, and Yubin Kang. “The presence of bone marrow fibrosis is associated with poorer prognosis in newly diagnosed multiple myeloma treated with immunomodulatory agents and/or proteasome inhibitors.” In Journal of Clinical Oncology, Vol. 37. AMER SOC CLINICAL ONCOLOGY, 2019.
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  - Maung, Ko Ko, Benny J. Chen, David A. Rizzieri, Cristina Gasparetto, Keith Sullivan, Gwynn D. Long, Ashley Morris Engemann, et al. “Phase I, Dose Escalation Study of Naive T-Cell Depleted Donor Lymphocyte Infusion Following Allogeneic Stem Cell Transplantation.” In Biology of Blood and Marrow Transplantation, Vol. 25, 2019.
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  - Kang, Y., S. Fan, P. Sundaramoorthy, C. Gasparetto, G. Long, A. Garrett, E. Sellars, et al. “Sphingosine kinase 2 (SK2) targeting in the treatment of multiple myeloma: preclinical and phase I studies of opaganib, an SK 2 inhibitor, in multiple myeloma.” In European Journal of Cancer, 103:E124–E124. ELSEVIER SCI LTD, 2018.
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  - Paul, Barry, Daniel Feinberg, Pasupathi Sundaramoorthy, J Brice Weinberg, and Yubin Kang. “Relationship of acquired resistance of myeloma cells to bortezomib with Lyn and Src induced inhibition of PP2A and effect of treatment with the tyrosine kinase inhibitor dasatinib.” In Journal of Clinical Oncology, 36:8047–8047. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.8047.
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  - Sung, Anthony D., Carlos M. de Castro, Thomas W. LeBlanc, Gwynn D. Long, Donna B. Adams, Danielle M. Brander, Sandeep Dave, et al. “Clinical Outcomes of Microtransplantation for Older Adults with Acute Myeloid Leukemia.” In Blood, Vol. 130. AMER SOC HEMATOLOGY, 2017.
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  - Sivaraj, Dharshan, Michael M. Green, Yubin Kang, David Rizzieri, Louis F. Diehl, Anne W. Beaven, Zhiguo Li, et al. “Phase I/II dose expansion of a trial investigating bendamustine and pomalidomide with dexamethasone (BPd) in patients with relapsed/refractory multiple myeloma.” In Journal of Clinical Oncology, 35:8008–8008. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.8008.
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  - Gasparetto, Cristina, Michael Green, Anandgopal Srinivasan, Yubin Kang, David A. Rizzieri, Carlos Decastro, Louis F. Diehl, et al. “A Phase I-II Study of the Combination of Bendamustine and Pomalidomide with Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma.” In Blood, 126:1857–1857. American Society of Hematology, 2015. https://doi.org/10.1182/blood.v126.23.1857.1857.
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  - Green, Michael M. B., Mitchell E. Horwitz, Yubin Kang, Nelson J. Chao, Gwynn D. Long, David Rizzieri, Cristina Gasparetto, et al. “Administration of Plerixafor (a CXCR4 antagonist) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation Enhances Platelet Recovery in a Phase I/II Trial.” In Biology of Blood and Marrow Transplantation, 21:S31–32. Elsevier BV, 2015. https://doi.org/10.1016/j.bbmt.2014.11.024.
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  - Zhou, Dunhua, Divino Deoliveira, Yubin Kang, Seung S. Choi, Nelson J. Chao, and Benny J. Chen. “Insulin-Like Growth Factor 1 Mitigates Hematopoietic Toxicity After Lethal Total Body Irradiation.” In Biology of Blood and Marrow Transplantation, 19:S198–S198. Elsevier BV, 2013. https://doi.org/10.1016/j.bbmt.2012.11.214.
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  - An, Ningfei, Yeong-Bin Im, Yingwei Lin, Cristina Gasparetto, Luciano J. Costa, Robert K. Stuart, Charles Smith, Andrew Kraft, and Yubin Kang. “Characterization of Pim Protein Kinases and Evaluation of Small Molecule Inhibitors in Multiple Myeloma.” In Blood, 118:1254–55. AMER SOC HEMATOLOGY, 2011.
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  - Kang, Y., A. DeOliveira, L. E. Peel, D. -. F. Chen, and N. Chao. “A Prospective Study Of Donor Immuknow® As A Biomarker For Acute GvHD In Hematopoietic Cell Transplantation Recipients.” In Biology of Blood and Marrow Transplantation, 16:S311–S311. Elsevier BV, 2010. https://doi.org/10.1016/j.bbmt.2009.12.463.
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