Yunfeng Cui

Journal article Front Oncol · 2026 BACKGROUND: Multi-institutional clinical trials frequently use MRI imaging for critical decisions and guidance for medical treatments. Collecting and analyzing images produced by various MR vendors and models is quite difficult since image quality can be h ... Full text Link to item Cite

An introduction to radiotherapy clinical trials and design

Journal article Chinese Science Bulletin · November 1, 2025 Clinical trials are essential for advancing medical knowledge and improving patient care in different medical fields, including the field of radiotherapy. This review examines the key aspects of designing, conducting, and analyzing clinical trials in the c ... Full text Cite

Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.

Journal article Z Med Phys · August 2025 BACKGROUND: Dosimetric validation of single isocenter multi-target radiosurgery plans is difficult due to conditions of electronic disequilibrium and the simultaneous irradiation of multiple off-axis lesions dispersed throughout the volume. Here we report ... Full text Link to item Cite

Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.

Journal article Int J Radiat Oncol Biol Phys · June 1, 2025 This white paper examines the potential of pioneering technologies and artificial intelligence-driven solutions in advancing clinical trials involving radiation therapy. As the field of radiation therapy evolves, the integration of cutting-edge approaches ... Full text Link to item Cite

Dose-Incorporated Deep Ensemble Learning for Improving Brain Metastasis Stereotactic Radiosurgery Outcome Prediction.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2024 PURPOSE: To develop a novel deep ensemble learning model for accurate prediction of brain metastasis (BM) local control outcomes after stereotactic radiosurgery (SRS). METHODS AND MATERIALS: A total of 114 brain metastases (BMs) from 82 patients were evalu ... Full text Link to item Cite

Independent Monte Carlo dose calculation identifies single isocenter multi-target radiosurgery targets most likely to fail pre-treatment measurement.

Journal article J Appl Clin Med Phys · June 2024 PURPOSE: For individual targets of single isocenter multi-target (SIMT) Stereotactic radiosurgery (SRS), we assess dose difference between the treatment planning system (TPS) and independent Monte Carlo (MC), and demonstrate persistence into the pre-treatm ... Full text Link to item Cite

A structured FMEA approach to optimizing combinations of plan-specific quality assurance techniques for IMRT and VMAT QA.

Journal article Med Phys · September 2023 BACKGROUND: Many commercial tools are available for plan-specific quality assurance (QA) of radiotherapy plans, with their functionality assessed in isolation. However, multiple QA tools are required to review the full range of potential errors. It is impo ... Full text Link to item Cite

Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT.

Journal article Biomed Phys Eng Express · March 7, 2023 Objective. Dose calculation in lung stereotactic body radiation therapy (SBRT) is challenging due to the low density of the lungs and small volumes. Here we assess uncertainties associated with tissue heterogeneities using different dose calculation algori ... Full text Link to item Cite

Impact of image quality on radiomics applications.

Journal article Phys Med Biol · July 22, 2022 Radiomics features extracted from medical images have been widely reported to be useful in the patient specific outcome modeling for variety of assessment and prediction purposes. Successful application of radiomics features as imaging biomarkers, however, ... Full text Link to item Cite

The Effect of Various Dose Normalization Strategies When Implementing Linear Boltzmann Transport Equation Dose Calculation for Lung Stereotactic Body Radiation Therapy Planning.

Journal article Pract Radiat Oncol · 2022 PURPOSE: To explore implications of various plan normalizations when implementing a linear Boltzmann transport equation solver dose calculation algorithm (LBTE) for lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Eighty-seven plans ... Full text Link to item Cite

Dosimetric variation in preoperative partial breast radiosurgery assessed by deformable image registrations.

Journal article J Radiosurg SBRT · 2022 OBJECTIVE: To assess dosimetric variation caused by breast deformation in breast radiosurgery based on deformable image registration. METHODS: This study included 30 patients who were treated in the prone position for preoperative partial breast radiosurge ... Link to item Cite

Rigid and Deformable Image Registration for Radiation Therapy: A Self-Study Evaluation Guide for NRG Oncology Clinical Trial Participation.

Journal article Pract Radiat Oncol · 2021 PURPOSE: The registration of multiple imaging studies to radiation therapy computed tomography simulation, including magnetic resonance imaging, positron emission tomography-computed tomography, etc. is a widely used strategy in radiation oncology treatmen ... Full text Link to item Cite

Benchmarking of Deformable Image Registration for Multiple Anatomic Sites Using Digital Data Sets With Ground-Truth Deformation Vector Fields.

Journal article Pract Radiat Oncol · 2021 PURPOSE: This study aimed to evaluate the accuracy of deformable image registration (DIR) algorithms using data sets with different levels of ground-truth deformation vector fields (DVFs) and to investigate the correlation between DVF errors and contour-ba ... Full text Link to item Cite

Retrospective quality metrics review of stereotactic radiosurgery plans treating multiple targets using single-isocenter volumetric modulated arc therapy.

Journal article J Appl Clin Med Phys · June 2020 PURPOSE: To characterize key plan quality metrics in multi-target stereotactic radiosurgery (SRS) plans treated using single-isocenter volumetric modulated arc therapy (VMAT) in comparison to dynamic conformal arc (DCA) plans treating single target. To inv ... Full text Link to item Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.

Journal article Front Oncol · 2020 PURPOSE: To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). METHODS ... Full text Open Access Link to item Cite

Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Journal article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study inv ... Full text Link to item Cite

Intratreatment Response Assessment With 18F-FDG PET: Correlation of Semiquantitative PET Features With Pathologic Response of Esophageal Cancer to Neoadjuvant Chemoradiotherapy.

Journal article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: This prospective study seeks to extract semiquantitative positron emission tomography (PET) features from 18F-fluorodeoxyglucose PET scans performed before and during neoadjuvant chemoradiotherapy for esophageal cancer and to compare their accurac ... Full text Link to item Cite

Impact of moving target on measurement accuracy in 3D and 4D PET imaging-a phantom study.

Journal article Adv Radiat Oncol · 2017 PURPOSE: The purpose of this study was to evaluate the impact of tumor motion on maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) measurements in both 3-dimensional and respiratory-correlated, 4-dimensional positron emission tomo ... Full text Link to item Cite

Interim FDG Positron Emission Tomography Imaging During Chemoradiation for Squamous Anal Canal Carcinoma.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2016 Full text Link to item Cite

Real-time pretreatment review limits unacceptable deviations on a cooperative group radiation therapy technique trial: quality assurance results of RTOG 0933.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2015 PURPOSE: RTOG 0933 was a phase II trial of hippocampal avoidance during whole brain radiation therapy for patients with brain metastases. The results demonstrated improvement in short-term memory decline, as compared with historical control individuals, an ... Full text Link to item Cite

Contouring variations and the role of atlas in non-small cell lung cancer radiation therapy: Analysis of a multi-institutional preclinical trial planning study.

Journal article Pract Radiat Oncol · 2015 PURPOSE: To quantify variations in target and normal structure contouring and evaluate dosimetric impact of these variations in non-small cell lung cancer (NSCLC) cases. To study whether providing an atlas can reduce potential variation. METHODS AND MATERI ... Full text Link to item Cite

(18)F-Fluorothymidine PET-CT for resected malignant gliomas before radiotherapy: tumor extent according to proliferative activity compared with MRI.

Journal article PLoS One · 2015 OBJECTIVE: To compare the presence of post-operative residual disease by magnetic resonance imaging (MRI) and [18F]fluorothymidine (FLT)-positron emission tomography (PET)-computer tomography (CT) in patients with malignant glioma and to estimate the impac ... Full text Link to item Cite

Treatment-related acute esophagitis for patients with locoregionally advanced non-small cell lung cancer treated with involved-field radiotherapy and concurrent chemotherapy.

Journal article Am J Clin Oncol · October 2014 PURPOSE: To explore the incidence and risk factors for treatment-related acute esophagitis associated with involved-field radiation therapy (RT) delivered concurrently with chemotherapy for patients with locoregionally advanced non-small cell lung cancer. ... Full text Link to item Cite

Prognostic value of 3'-deoxy-3'-18F-fluorothymidine ([(18)F] FLT PET) in patients with recurrent malignant gliomas.

Journal article Nucl Med Biol · September 2014 INTRODUCTION: 3'-deoxy-3'-18F-fluorothymidine ([(18)F] FLT) PET has been proven to be of value in diagnosis and assessment of glioma grading, in differentiating tumor recurrence from necrosis, in response assessment and in predicting overall survival (OS) ... Full text Link to item Cite

SU-E-CAMPUS-J-04: Image Guided Radiation Therapy (IGRT): Review of Technical Standards and Credentialing in Radiotherapy Clinical Trials.

Journal article Med Phys · June 2014 PURPOSE: To review IGRT credentialing experience and unexpected technical issues encountered in connection with advanced radiotherapy technologies as implemented in RTOG clinical trials. To update IGRT credentialing procedures with the aim of improving the ... Full text Link to item Cite

SU-C-9A-06: The Impact of CT Image Used for Attenuation Correction in 4D-PET.

Journal article Med Phys · June 2014 PURPOSE: To evaluate the appropriateness of using 3D non-gated CT image for attenuation correction (AC) in a 4D-PET (gated PET) imaging protocol used in radiotherapy treatment planning simulation. METHODS: The 4D-PET imaging protocol in a Siemens PET/CT si ... Full text Link to item Cite

SU-E-J-152: Evaluation of TrueBeam OBI V. 1.5 CBCT Performance in An Adaptive RT Environment.

Journal article Med Phys · June 2014 PURPOSE: To evaluate the image quality and imaging dose of the Varian TrueBeam OBIv.1.5 CBCT system in a clinical adaptive radiation therapy environment, simulated by changing phantom thickness. METHODS: Various OBI CBCT protocols(Head, Pelvis, Thorax, Spo ... Full text Link to item Cite

Investigation into image quality and dose for different patient geometries with multiple cone-beam CT systems.

Journal article Med Phys · March 2014 PURPOSE: To provide quantitative and qualitative image quality metrics and imaging dose for modern Varian On-board Imager (OBI) (ver. 1.5) and Elekta X-ray Volume Imager (XVI) (ver. 4.5R) cone-beam computed tomography (CBCT) systems in a clinical adaptive ... Full text Link to item Cite

A semi-automated tool for treatment plan-quality evaluation and clinical trial quality assurance.

Journal article Phys Med Biol · July 7, 2013 The goal of this work is to develop a plan-quality evaluation program for clinical routine and multi-institutional clinical trials so that the overall evaluation efficiency is improved. In multi-institutional clinical trials evaluating the plan quality is ... Full text Link to item Cite

SU-E-I-07: The Effect of Different Beam Filters On the KV CBCT Image Dose Response Curves of NanoDot OSL Dosimeters.

Journal article Med Phys · June 2013 PURPOSE: To evaluate the effect of different beam filters on the dose response curves of nanoDot OSL dosimeters at kV CBCT energy. METHODS: The InLight™ OSL dosimetry system (Landauer,Inc., Glenwood, IL, USA) consisting of nanoDot dosimeters and MicroStar ... Full text Link to item Cite

SU-E-I-09: Measurements of KV XVI CBCT Dose Profiles in Phantom Using Gafchromic XRQA2 Film.

Journal article Med Phys · June 2013 PURPOSE: To measure CBCT dose profiles inside phantom using Gafchromic XRQA2 film. METHODS: Gafchromic XRQA2 film (International Specialty Products, Wayne, NJ) whole sheets were placed between slabs of the IMRT head and torso free point phantom, model 002H ... Full text Link to item Cite

Comparative dose evaluations between XVI and OBI cone beam CT systems using Gafchromic XRQA2 film and nanoDot optical stimulated luminescence dosimeters.

Journal article Med Phys · June 2013 PURPOSE: To investigate the effect of energy (kVp) and filters (no filter, half Bowtie, and full Bowtie) on the dose response curves of the Gafchromic XRQA2 film and nanoDot optical stimulated luminescence dosimeters (OSLDs) in CBCT dose fields. To measure ... Full text Link to item Cite

Surface dose measurements of kV XVI cone-beam CT system using NanoDot optical stimulated luminescence dosimeters

Journal article Ifmbe Proceedings · April 16, 2013 Surface doses received during seven different imaging protocols (using the kV XVI imager) were measured on a Rando phantom surface using nanoDot optical stimulated luminescence dosimeters (OSLD) for three different body regions (head and neck, chest and pe ... Full text Cite

SU‐E‐T‐234: An Automated Tool for Treatment Plan Quality Evaluation and Clinical Trial Quality Assurance

Journal article Medical Physics · January 1, 2013 Purpose: Develop an automated plan‐quality evaluation program for multi‐institutional clinical trials to improve case review efficiency. This program is generally applicable to routine clinical process to raise practice quality level. Methods: In this stud ... Full text Cite

Implementation of remote 3-dimensional image guided radiation therapy quality assurance for radiation therapy oncology group clinical trials.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2013 PURPOSE: To report the process and initial experience of remote credentialing of three-dimensional (3D) image guided radiation therapy (IGRT) as part of the quality assurance (QA) of submitted data for Radiation Therapy Oncology Group (RTOG) clinical trial ... Full text Link to item Cite

Application of Dempster-Shafer theory in dose response outcome analysis.

Journal article Phys Med Biol · September 7, 2012 The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) reviews summarize the currently available three-dimensional dose/volume/outcome data from multi-institutions and numerous articles to update and refine the normal tissue dose/volume ... Full text Link to item Cite

SU-E-J-50: Measurement of the HVL Value for the 120keV Photon Beam of the X-Ray Volume Imager (XVI) Using Ionization Chamber, Gafchromic Film XRQA2 and Diode.

Journal article Med Phys · June 2012 PURPOSE: The value of Half Value Layer (HVL) is essential in quantifying the ability of an x-ray beam to penetrate the material being studied. This paper examines the use of three different types of detectors for measuring HVL of the 120keV photon beam of ... Full text Link to item Cite

SU-E-I-08: KV XVI Cone Beam-CT Dose Measurement Using Gafchromic XRQA2 Film.

Journal article Med Phys · June 2012 PURPOSE: To study the effect of different filters on the dose response curves of the Gafchromic XRQA2 film. To measure the kV XVI cone-beam CT (CBCT) surface dose received during 3D and 4D imaging protocols in three body regions (head and neck, chest and p ... Full text Link to item Cite

SU-E-T-284: Surface Dose Evaluation for Beams with and without Flattening Filter in Breast Cancer Treatment.

Journal article Med Phys · June 2012 PURPOSE: To evaluate surface doses for beams with and without flattening filter (FF and FFF) in breast cancer treatment plans. Measurements were performed for validation. Delivery:TrueBeam, used in this study, is a linear accelerator newly designed to deli ... Full text Link to item Cite

Characteristics of Gafchromic XRQA2 films for kV image dose measurement.

Journal article Med Phys · February 2012 PURPOSE: In this study, the relevant characteristics of the new Gafchromic XRQA2 film for its application in measuring kV cone beam computed tomography (CBCT) image doses were thoroughly investigated. METHODS: The film was calibrated free in air to air ker ... Full text Link to item Cite

Determination of internal target volume using selective phases of a 4-dimensional computed tomography scan.

Journal article Pract Radiat Oncol · 2012 PURPOSE: Internal target volume (ITV) is frequently determined by contouring of gross tumor volumes (GTV) on 10 phases of a 4-dimensional computed tomography (4DCT) study set for lung cancer radiotherapy. This study aimed to investigate the possibility of ... Full text Link to item Cite

Process and Initial Experience of Remote Credentialing of 3D IGRT Data for Institutions Participating in RTOG Clinical Trials

Journal article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Multi-system verification of registrations for image-guided radiotherapy in clinical trials.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2011 PURPOSE: To provide quantitative information on the image registration differences from multiple systems for image-guided radiotherapy (IGRT) credentialing and margin reduction in clinical trials. METHODS AND MATERIALS: Images and IGRT shift results from t ... Full text Link to item Cite

SU‐E‐T‐291: How Many Sets of Four‐Dimensional Computed Tomography (4DCT) Images Are Needed to Determine the Internal Target Volume (ITV) for Lung Radiation Therapy?

Journal article Medical Physics · January 1, 2011 Purpose: For the treatment of patients with lung cancer, internal target volume (ITV) is frequently determined by contouring of gross tumor volumes (GTV) on 10 phases of a four‐dimensional computed tomography (4DCT) scan. This study investigated the possib ... Full text Cite

Application of evidence theory in radiation oncology outcome analysis

Journal article Proceedings 2010 3rd International Conference on Biomedical Engineering and Informatics Bmei 2010 · January 1, 2010 In this paper, we apply the Dempster-Shafer theory to outcome analysis in radiation oncology. Evidence from different sources, some of them inconsistent, is combined by Dempster's rule to provide an innovative method for radiotherapy outcome analysis. ©201 ... Full text Cite

Malignant lesion segmentation in contrast-enhanced breast MR images based on the marker-controlled watershed.

Journal article Med Phys · October 2009 Breast tumor volume measured on MRI has been used to assess response to neoadjuvant chemotherapy. However, accurate and reproducible delineation of breast lesions can be challenging, since the lesions may have complicated topological structures and heterog ... Full text Link to item Cite

CT-guided, automated detection of lung tumors on PET images

Journal article Progress in Biomedical Optics and Imaging Proceedings of SPIE · June 2, 2008 The calculation of standardized uptake values (SUVs) in tumors on serial [18F]2-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET) images is often used for the assessment of therapy response. We present a computeriz ... Full text Cite

Kinetic model parameter estimates of liver FDG metabolism

Journal article Qinghua Daxue Xuebao Journal of Tsinghua University · March 1, 2007 Liver kinetic studies of [18F]2-fluoro-2-deoxy-D-glucose (FDG) metabolism are important tools for functional information modeling and hepatic glucose metabolic rate estimates. Kinetic parameter estimates require the arterial blood time-activity ... Cite

A digital model framework of metabolic system based on visible human data set

Journal article International Journal of Image and Graphics · January 1, 2007 Digital model of human metabolic system incorporated with real anatomical structure can be seen as an important tool in order to understand and study the processes of metabolism. This paper presented a whole body digital model framework of [18F] ... Full text Cite

Parameter estimation for whole-body kinetic model of FDG metabolism

Journal article Progress in Natural Science Materials International · January 1, 2006 Based on the radioactive tracer [18F] 2-fluoro-2-deoxy-D-glucose (FDG), positron emission tomography (PET), and compartment model, the tracer kinetic study has become an important method to investigate the glucose metabolic kinetics in human bod ... Full text Cite

Comparison of parameter estimations using dual-input and arterial-input in liver kinetic studies of FDG metabolism

Journal article Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings · December 1, 2005 Liver kinetic study of [18F]2-fluoro-2-deoxy-D-glucose (FDG) metabolism in human body is an important tool for functional modeling and glucose metabolic rate estimation. In general, the arterial blood time-activity curve (TAC) and the tissue TAC ... Cite

Method of simulation and visualization of FDG metabolism based on VHP image

Journal article Progress in Biomedical Optics and Imaging Proceedings of SPIE · August 16, 2005 FDG ([18F] 2-fluoro-2-deoxy-D-glucose) is the typical tracer used in clinical PET (positron emission tomography) studies. The FDG-PET is an important imaging tool for early diagnosis and treatment of malignant tumor and functional disease. The m ... Full text Cite