Scholars@Duke
Yunsol Jo

Yunsol Jo

Affiliate
Pathology

Scholarly Works

DNMT3B drives neuroendocrine lineage plasticity and aggressive progression in prostate cancer.

Journal article Mol Cancer Res · July 30, 2026 Neuroendocrine prostate cancer (NEPC) is an aggressive and therapy-resistant subtype of advanced prostate cancer characterized by poor prognosis and limited treatment options. Enzalutamide, an androgen receptor (AR) pathway inhibitor, is a standard second- ... Full text Link to item Cite

Candidate Tumor Suppressor Gene EAF2 is Mutated in Colorectal and Gastric Cancers.

Journal article Pathology oncology research : POR · April 2019 Full text Cite

Immune checkpoint blockade resistance-related B2M hotspot mutations in microsatellite-unstable colorectal carcinoma.

Journal article Pathology, research and practice · January 2019 β2-microglobulin (B2M), a component of major histocompatibility complex class I, plays an important role in host immune reaction to tumor, and inactivation of B2M is known to contribute to resistance to immune checkpoint blockade (ICB) treatment. To furthe ... Full text Cite

Frameshift mutation of candidate tumor suppressor genes QK1 and TMEFF2 in gastric and colorectal cancers.

Journal article Cancer biomarkers : section A of Disease markers · January 2019 BackgroundBoth QKI and TMEFF2 genes are considered putative tumor suppressor genes (TSGs). In gastric (GC) and colorectal (CRC) cancers, downregulation of their expressions is known to be frequent. However, QKI and TMEFF2 mutations that could pote ... Full text Cite

DAB2IP with tumor-inhibiting activities exhibits frameshift mutations in gastrointestinal cancers.

Journal article Pathology, research and practice · December 2018 A scaffold protein DAB2 and its interaction partner DAB2IP have putative tumor suppressor gene (TSG) functions. Previous studies identified that both DAB2 and DAB2IP genes were inactivated by promoter hypermethylation in human cancers, but their mutational ... Full text Cite

Somatic Mutations and Intratumoral Heterogeneity of MYH11 Gene in Gastric and Colorectal Cancers.

Journal article Applied immunohistochemistry & molecular morphology : AIMM · September 2018 MYH11 functions as a contractile protein, converting chemical energy into mechanical energy through adenosine triphosphate hydrolysis. In cancers, an oncogenic fusion CBFB/MYH11 and frameshift mutations have been reported. Truncating mutants of MYH11 exhib ... Full text Cite

Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers.

Journal article Pathology oncology research : POR · July 2018 Diminished ANK3 contributes to cell survival by inhibiting detachment-induced apoptosis. TP53BP1 that interacts with p53 and MFN1 that encodes a mitochondrial membrane protein are considered to have tumor suppressor gene (TSG) functions. HACD4 involving fa ... Full text Cite

Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers.

Journal article Polish journal of pathology : official journal of the Polish Society of Pathologists · January 2017 Both CUX1 and SIRT1 are considered tumor suppressor genes (TSGs), but it is not known whether CUX1 and SIRT1 alterations are different between high microsatellite instability (MSI-H) and microsatellite stable MSI (MSS) cancers. ... Full text Cite

Candidate tumor suppressor gene MCPH1 is mutated in colorectal and gastric cancers.

Journal article International journal of colorectal disease · January 2017 Full text Cite

Frameshift Mutations of HSPA4 and MED13 in Gastric and Colorectal Cancers.

Journal article Pathology oncology research : POR · October 2016 Frameshift mutation of genes containing mononucleotide repeats is a feature of gastric (GC) and colorectal cancers (CRC) with microsatellite instability (MSI). In the public genome database, we found that human HSPA4 gene encoding a heats hock protein 70 p ... Full text Cite

Frameshift Mutations of AKAP9 Gene in Gastric and Colorectal Cancers with High Microsatellite Instability.

Journal article Pathology oncology research : POR · July 2016 A-kinase-anchoring protein 9 (AKAP9) coordinates the cellular location and function of protein kinase A. AKAP9 plays an important role in centrosome duplication, cell cycle progression and maintenance of cell membrane integrity, alterations of which contri ... Full text Cite

Frameshift mutations of OGDH, PPAT and PCCA genes in gastric and colorectal cancers.

Journal article Neoplasma · January 2016 Metabolic reprogramming is a hallmark of cancer. However, genetic alterations in metabolism-related genes are largely unknown. The aim of this study was to identify whether somatic mutations in OGDH, PPAT and PCCA genes known to be involved in amino acid o ... Full text Cite

Inactivating frameshift mutation of PBRM1, a putative tumour suppressor gene, in colorectal cancers.

Journal article Scandinavian journal of gastroenterology · January 2016 Full text Cite

Frequent frameshift mutations in 2 mononucleotide repeats of RNF43 gene and its regional heterogeneity in gastric and colorectal cancers.

Journal article Human pathology · November 2015 RNF43, an E3 ligase, inhibits Wnt signaling by removing Wnt receptors and behaves as a candidate tumor suppressor. Recent studies identified that RNF43 gene was frequently mutated in gastric (GC), colorectal (CRC), and endometrial cancers with high microsa ... Full text Cite

Mutational Heterogeneity of MED23 Gene in Colorectal Cancers.

Journal article Pathology oncology research : POR · September 2015 Full text Cite