Yvonne Marie Mowery | Scholars@Duke

Yvonne Marie Mowery
Butler Harris Assistant Professor in Radiation Oncology

Current Research Interests

Head and neck cancer, sarcoma, combined radiation therapy and immunotherapy, PET imaging, primary mouse models of cancer

Current Appointments & Affiliations

Butler Harris Assistant Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 2017
Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017

Contact Information

30 Duke Medicine Circle, DUMC Box 3085, Durham, NC 27710
DUMC Box 3085, Durham, NC 27710
Duke Health Profile
Duke Radiation Oncology Faculty Webpage

Background
Education, Training, & Certifications
- Resident, Radiation Oncology, Duke University School of Medicine 2013 - 2017
- Intern, Medicine, Duke University School of Medicine 2012 - 2013
- M.D., Duke University 2012
- Ph.D., Duke University 2012
Recognition
In the News
- APR 4, 2018 Duke Med School Blog
  
  Five SoM Physician-Scientists Selected to Receive Strong Start Awards
Awards & Honors
- Conquer Cancer Foundation of ASCO Young Investigator Award. Conquer Cancer Foundation of American Society of Clinical Oncology (ASCO). 2017
Expertise
Subject Headings
Global Scholarship
- Expertise
  - United States of America (Country)
- Research
  - United States of America (Country)
- Teaching
  - United States of America (Country)
Research
Selected Grants
- The Duke Preclinical Research Resources for Quantitative Imaging Biomarkers awarded by National Institutes of Health 2017 - 2022
- Pembroluzimab and Radiation Therapy to Improve Outcome in Localized High-Risk Sarcoma awarded by Association of American Cancer Institutes 2017 - 2020
- Patient Reported Outcomes and Financial Toxicity in Head and Neck Cancer awarded by Radiation Oncology Institute 2018 - 2019
- Dissecting the Interplay between Tumor Mutational Load and the Immune System in Response of Primary Sarcomas to Radiation Therapy awarded by Conquer Cancer Foundation 2017 - 2018
- SARC Spore - Bridge Funding awarded by Sarcoma Alliance for Research Through Collaboration 2017 - 2018
- Mechanisms that Regulate Sarcoma Response to Immune Checkpoint Inhibition of PD-1 awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wisdom, AJ, Mowery, YM, Riedel, RF, and Kirsch, DG. "Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma." Cancer 124, no. 19 (October 2018): 3819-3829. (Review) Full Text
  - Carpenter, DJ, Mowery, YM, Broadwater, G, Rodrigues, A, Wisdom, AJ, Dorth, JA, Patel, PR, Shortell, CK, Clough, R, and Brizel, DM. "The risk of carotid stenosis in head and neck cancer patients after radiation therapy." Oral Oncology 80 (May 2018): 9-15. Full Text
  - Brownstein, JM, Wisdom, AJ, Castle, KD, Mowery, YM, Guida, P, Lee, C-L, Tommasino, F, Tessa, CL, Scifoni, E, Gao, J, Luo, L, Campos, LDS, Ma, Y, Williams, N, Jung, S-H, Durante, M, and Kirsch, DG. "Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma." Molecular Cancer Therapeutics 17, no. 4 (April 2018): 858-868. Full Text
  - Oellers, P, Mowery, YM, Perez, BA, Stinnett, S, Mettu, P, Vajzovic, L, Light, K, Steffey, BA, Cai, J, Dutton, JJ, Buckley, EG, Halperin, EC, Marks, LB, Kirsch, DG, and Mruthyunjaya, P. "Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma." American Journal of Ophthalmology 186 (February 2018): 32-40. Full Text
  - Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Xu, ES, Walens, A, Mowery, YM, Van Mater, D, Eward, WC, Cardona, DM, Luo, L, Ma, Y, Lopez, OM, Nelson, CE, Robinson-Hamm, JN, Reddy, A, Dave, SS, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." Nature communications 8 (July 10, 2017): 15999-. Full Text
  - Mowery, YM, Salama, JK, Zafar, SY, Moore, HG, Willett, CG, Czito, BG, Hopkins, MB, and Palta, M. "Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States." Cancer 123, no. 8 (April 2017): 1434-1441. Full Text
  - Kent, CL, Mowery, YM, Wisdom, AJ, Van Mater, D, Castle, KD, Reddy, A, Dave, SS, and Kirsch, DG. "Immune Checkpoint Inhibition and Radiation Therapy in 2 Primary Mouse Models of Soft Tissue Sarcoma: Impact of Tumor Mutational Load." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): E578-E579. Full Text
  - Kent, CL, Mowery, YM, Wright, AO, Kim, GJ, Desjardins, A, Peters, KB, Vlahovic, G, Friedman, HS, Cummings, TJ, McLendon, RE, Friedman, AH, Sampson, JH, and Kirkpatrick, JP. "Long-Term Outcomes for Patients With Atypical or Malignant Meningiomas Treated With Radiation Therapy: A Single-Institution Retrospective Analysis." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): E83-E84. Full Text
  - Mowery, YM, Patel, K, Olson, AC, Khan, MK, Salama, JK, and Salama, AK. "Toxicity and Survival for Metastatic Melanoma Patients Treated With Anti-PD1 Therapy and Radiation Treatment." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): S158-S159. Full Text
  - Mowery, YM, Salama, JK, Zafar, SY, Moore, HG, Willett, CG, Czito, B, Hopkins, MB, and Palta, M. "Radiation Oncologists' Practice Patterns and Attitudes Regarding Neoadjuvant Short-Course Radiation Therapy for Rectal Cancer in the United States." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): S203-. Full Text
  - Mowery, YM, Vergalasova, I, Yoo, DS, Limon, D, Das, SK, Hara, WY, and Brizel, DM. "(18)F-FDG PET/CT Response at 20 Gy Predicts Treatment Outcome for Head and Neck Squamous Cell Carcinoma (HNSCC)." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): E378-. Full Text
  - Olson, AC, Patel, K, Mowery, YM, Wynne, J, Ready, N, Kirkpatrick, JP, Salama, AK, and Khan, MK. "Anti-PD-1 Therapy and Stereotactic Radiation for Melanoma and Non-Small Cell Lung Cancer Patients with Brain Metastases: A 2-Institution Series." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): E97-E98. Full Text
  - Mowery, YM, and Salama, JK. "A Multidisciplinary Approach to Larynx Cancer: One Size Does Not Fit All." Journal of Oncology Practice 12, no. 8 (August 2016): 725-726. Full Text
  - Moding, EJ, Mowery, YM, and Kirsch, DG. "Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era." Cancer journal (Sudbury, Mass.) 22, no. 4 (July 2016): 267-273. (Review) Full Text
  - Loman, K, Nawrocki, J, Hoang, J, Yoo, D, Chang, Z, Mowery, Y, Li, X, Peterson, B, Brizel, D, and Craciunescu, O. "SU-F-R-15: Establishing Relevant ADC-Based Texture Analysis Metrics for Quantifying Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma." Medical physics 43, no. 6 (June 2016): 3376-. Full Text
  - Soo, MS, Jarosz, JA, Wren, AA, Soo, AE, Mowery, YM, Johnson, KS, Yoon, SC, Kim, C, Hwang, ES, Keefe, FJ, and Shelby, RA. "Imaging-Guided Core-Needle Breast Biopsy: Impact of Meditation and Music Interventions on Patient Anxiety, Pain, and Fatigue." Journal of the American College of Radiology : JACR 13, no. 5 (May 2016): 526-534. Full Text
  - Mowery, YM. "A primer on medical education in the United States through the lens of a current resident physician." Journal of thoracic disease 7, no. 10 (October 2015): E473-E481. Full Text
  - Mowery, YM. "A primer on medical education in the United States through the lens of a current resident physician." Annals of translational medicine 3, no. 18 (October 2015): 270-. Full Text
  - Mowery, Y, and Blitzblau, R. "The UK HeartSpare Study (Stage IB): Randomised comparison of a voluntary breath-hold technique and prone radiotherapy after breast conserving surgery." Breast Diseases: A Year Book Quarterly 26, no. 3 (2015): 237-239. Full Text
  - Mowery, YM, and Blitzblau, RC. "Whole-breast radiation therapy: the long and short of it." International Journal of Radiation Oncology, Biology, Physics 90, no. 5 (December 2014): 990-992. Full Text
  - Mowery, Y, Wright, A, Desjardins, A, Peters, K, Ranjan, T, Vlahovic, G, Friedman, H, Zomorodi, A, Kaylie, D, Adogwa, O, Nimjee, S, Sperduto, W, Chagoya, G, Fatemi, P, McLendon, R, Cummings, T, Friedman, A, Sampson, J, and Kirkpatrick, J. "MS-19 * LONG-TERM OUTCOMES FOR PATIENTS WITH INTRACRANIAL MENINGIOMAS: A SINGLE-INSTITUTION RETROSPECTIVE ANALYSIS." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v130-v131. Full Text
  - Vergalasova, I, Mowery, Y, Yoo, D, Brizel, D, and Das, S. "TU-F-12A-03: Using 18F-FDG-PET-CT and Deformable Registration During Head-And-Neck Cancer (HNC) Intensity Modulated Radiotherapy (IMRT) to Predict Treatment Response." Medical Physics 41, no. 6 (June 2014): 480-481. Full Text
  - Mowery, YM, and Lanasa, MC. "Clinical aspects of monoclonal B-cell lymphocytosis." Cancer control : journal of the Moffitt Cancer Center 19, no. 1 (January 2012): 8-17. (Review) Full Text
  - Misra, UK, Mowery, YM, Gawdi, G, and Pizzo, SV. "Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin." J Cell Biochem 112, no. 6 (June 2011): 1685-1695. Full Text Link to Item
  - Mowery, YM, and Pizzo, SV. "Cell surface ATP synthase: A potential target for anti-angiogenic therapy." (December 1, 2010): 139-159. (Chapter) Full Text
  - Mowery, YM, Weinberg, JB, Kennedy, MN, Bond, KM, Moore, JO, Lanasa, MC, Gockerman, JP, Diehl, LF, Pizzo, SV, Cianciolo, GJ, and Friedman, DR. "LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells." Leukemia 24, no. 9 (September 2010): 1580-1587. Full Text Link to Item
  - Ozdowski, EF, Mowery, YM, and Cronmiller, C. "Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation." Genetics 183, no. 3 (November 2009): 1027-1040. Full Text
  - Mowery, YM, and Pizzo, SV. "The antitumorigenic trifecta." Blood 114, no. 9 (August 27, 2009): 1727-1728. Full Text Link to Item
  - Misra, UK, Mowery, Y, Kaczowka, S, and Pizzo, SV. "Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis." Mol Cancer Ther 8, no. 5 (May 2009): 1350-1362. Full Text Link to Item
  - Mowery, YM, and Pizzo, SV. "Targeting cell surface F1F0 ATP synthase in cancer therapy." Cancer Biol Ther 7, no. 11 (November 2008): 1836-1838. Link to Item
  - Mowery, YM, and Pizzo, SV. "Targeting cell surface F1F0 ATP synthase in cancer therapy." Cancer Biology and Therapy 7, no. 11 (November 1, 2008): 1837-1839.
  - Chi, SL, Wahl, ML, Mowery, YM, Shan, S, Mukhopadhyay, S, Hilderbrand, SC, Kenan, DJ, Lipes, BD, Johnson, CE, Marusich, MF, Capaldi, RA, Dewhirst, MW, and Pizzo, SV. "Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase." Cancer Research 67, no. 10 (May 2007): 4716-4724. Full Text
  - Sugerman, HJ, Sugerman, EL, DeMaria, EJ, Kellum, JM, Kennedy, C, Mowery, Y, and Wolfe, LG. "Bariatric surgery for severely obese adolescents." Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract 7, no. 1 (January 2003): 102-108. Full Text
  - Ali, MR, Mowery, Y, Kaplan, B, and DeMaria, EJ. "Training the novice in laparoscopy. More challenge is better." Surgical endoscopy 16, no. 12 (December 2002): 1732-1736. Full Text
- Book Sections
  - Mowery, YM, Yu, CX, and Horton, JK. "Preoperative partial breast." In Short Course Breast Radiotherapy: A Comprehensive Review of Hypofractionation, Partial Breast, and Intra-Operative Irradiation, 415-440. January 1, 2015. Full Text
- Conference Papers
  - Marley, H, Mowery, YM, Wu, Q, and Brizel, DM. "Utilization of (18)FDG-PET-Based IMRT Planning to Spare the Most Metabolically Active Subvolume of Parotid Glands During Definitive Radiation Therapy for Head and Neck Cancer." 60th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO). San Antonio, TX. October 21, 2018 - October 24, 2018.: ELSEVIER SCIENCE INC, November 1, 2018. Full Text Link to Item
  - Rodrigues, A, Wang, C, Wu, Q, Limon, D, Mowery, YM, Niedzwiecki, D, and Brizel, DM. "Adaptive IMRT Planning Improves Pharyngeal Sparing for Oropharyngeal Cancer." 60th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO). San Antonio, TX. October 21, 2018 - October 24, 2018.: ELSEVIER SCIENCE INC, November 1, 2018. Full Text Link to Item
  - Stephens, SJ, Chino, F, Chino, JP, and Mowery, YM. "Trends in Place of Death for Head and Neck Cancer Patients in the US from 1999 to 2016 Using the CDC WONDER Database." 60th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO). San Antonio, TX. October 21, 2018 - October 24, 2018.: ELSEVIER SCIENCE INC, November 1, 2018. Full Text Link to Item
  - Wang, C, Zhang, J, Rodrigues, A, Mowery, Y, Limon, D, Yin, F, Sheng, Y, Wu, Q, and Brizel, D. "A Knowledge-Guided Planning Strategy for OAR Dose Reduction in Rapid Adaptive Planning of Oropharyngeal Cancer." 60th Annual Meeting of the American-Association-of-Physicists-in-Medicine. Nashville, TN. July 29, 2018 - August 2, 2018.: WILEY, June 1, 2018. Link to Item
  - Carpenter, DJ, Mowery, YM, Broadwater, G, Rodrigues, A, Wisdom, AJ, Clough, RW, and Brizel, DM. "The Risk of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy." Multidisciplinary Head and Neck Cancers Symposium. Scottsdale, AZ. February 15, 2018 - February 17, 2018.: ELSEVIER SCIENCE INC, April 1, 2018. Link to Item
  - Mowery, YM, Brizel, DM, Chino, JP, and Moss, H. "Reduced Uninsured Rates and Racial Disparities in Insurance Coverage for Head and Neck Cancer Patients After Medicaid Expansion." Multidisciplinary Head and Neck Cancers Symposium. Scottsdale, AZ. February 15, 2018 - February 17, 2018.: ELSEVIER SCIENCE INC, April 1, 2018. Link to Item
  - Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Xu, ES, Walens, A, Mowery, YM, Van Mater, D, Eward, WC, Cardona, DM, Luo, L, Ma, Y, Lopez, OM, Nelson, CE, Robinson-Hamm, JN, Reddy, A, Dave, SS, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR/Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." January 2018. Link to Item
  - Babatunde, O, Kent, C, Mowery, Y, McSherry, F, II, HJE, Wright, A, Clough, R, Sperduto, W, and Kirkpatrick, JP. "LONG-TERM OUTCOMES FOLLOWING SURGERY AND/OR RADIATION THERAPY IN PATIENTS WITH HIGH-GRADE MENINGIOMA." November 2017. Link to Item
  - Brownstein, JM, Rusek, A, Castle, KC, Mowery, YM, Wisdom, AJ, Williams, NT, Luo, L, Rosselot, R, and Kirsch, DG. "High LET Carbon Ion Radiation Therapy in the Treatment of a Primary Mouse Sarcoma Model at the NASA Space Radiation Laboratory." October 2017. Full Text
  - Carpenter, D, Broadwater, G, Mowery, Y, Rodrigues, A, Wisdom, A, Clough, R, and Brizel, D. "The Incidence of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy." October 2017. Full Text
  - Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Walens, A, Mowery, YM, Mater, DV, Eward, W, Cardona, DM, Luo, L, Ma, Y, Nelson, CE, Robinson-Hamm, JN, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Abstract 2810: Using CRISPR/Cas9 to generate primary soft tissue sarcoma in genetically engineered and wild-type mice." July 1, 2017. Full Text
  - Vergalasova, I, Mowery, Y, Brizel, D, and Das, S. "Predicting Treatment Response According to Metabolic Imaging Parameters Using Deformable Registration of Intra-Treatment 18F-FDG-PET-CT for Head and Neck Squamous Cell Carcinoma (HNSCC)." 59th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM). Denver, CO. July 30, 2017 - August 3, 2017.: WILEY, June 1, 2017. Link to Item
  - Mowery, Y, Vergalasova, I, Yoo, D, Das, S, Hara, W, and Brizel, D. "Correlating Clinical Outcomes With Changes in Tumor Volume and 18F-FDG PET Characteristics During Radiation Therapy for Head and Neck Squamous Cell Carcinoma (HNSCC)." March 2016. Full Text
  - Mowery, Y, Kim, G, Wright, A, Desjardins, A, Peters, K, Vlahovic, G, Friedman, H, Sampson, J, and Kirkpatrick, J. "Outcomes for Patients With Intracranial Meningiomas Treated With Radiation therapy and Bevacizumab: A Single-Institution Retrospective Analysis." November 2015. Full Text
  - Mowery, Y, Vergalasova, I, Yoo, D, Das, S, and Brizel, D. "Correlating Outcomes With Changes in Tumor Volume and 18F-FDG PET Characteristics During Radiation Therapy for Head and Neck Squamous Cell Carcinoma (HNSCC)." November 2015. Full Text
  - Mowery, YM, Greenup, RA, Houck, K, Palta, M, Horton, JK, Hwang, E-SS, Sosa, JA, and Blitzblau, RC. "Abstract P1-15-10: Low utilization of hypofractionated radiotherapy for the treatment of early-stage breast cancer in the US." May 1, 2015. Full Text
  - Mowery, Y, Vergalasova, I, Pura, J, Peterson, B, Yoo, D, Das, S, and Brizel, D. "Changes in Tumor Volumes and 18F-FDG PET Characteristics During Radiation Therapy for HPV+ and HPV- Head and Neck Squamous Cell Carcinoma (HNSCC)." September 2014. Full Text
  - Friedman, DR, Mowery, Y, Kennedy, M, Bond, KM, Weinberg, JB, and Cianciolo, GJ. "The Anti-Inflammatory Investigational Agent LMP-420 Demonstrates in Vitro Cytotoxic Activity against Chronic Lymphocytic Leukemia Cells." November 20, 2009. Link to Item

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Education, Training, & Certifications

In the News

Awards & Honors

Subject Headings

Global Scholarship

Expertise

Research

Teaching

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers