ConferenceJournal of Clinical Oncology · June 10, 2026
LBA9514Background:
Advanced Merkel cell carcinoma (MCC) often responds to anti-PD-(L) ...
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ConferenceJournal of Clinical Oncology · June 1, 2026
6056Background:
Lymphadenectomy remains a central component of definitive treatment f ...
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ConferenceJournal of Clinical Oncology · June 1, 2026
6053Background:
Anti-PD-1 mAb therapy is standard of care for systemic treatment for ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · April 2, 2026
The simultaneous multi-energy capability of photon-counting detectors (PCDs) enables CT imaging with multiple contrast agents, which is particularly valuable for preclinical cancer studies such as photon-counting CT (PCCT) imaging of mouse models of head a ...
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ConferenceJournal of Clinical Oncology · June 2025
TPS9598Background:
Merkel cell carcinoma (MCC) is a rare neuroendocrine skin cancer driven by UV mutations or the Merkel cell ...
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ConferenceJ Appl Clin Med Phys · January 2025
BACKGROUND AND PURPOSE: To describe the clinical commissioning of an in-house artificial intelligence (AI) treatment planning platform for head-and-neck (HN) Intensity Modulated Radiation Therapy (IMRT). MATERIALS AND METHODS: The AI planning platform has ...
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ConferenceCancer · January 1, 2025
BACKGROUND: Recipients of radiation therapy (RT) for head and neck cancer (HNC) are at significantly increased risk for carotid artery stenosis (CAS) and cerebrovascular disease (CVD). We sought to determine (1) cumulative incidences of CAS and CVD among H ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025
Micro-CT imaging studies in mouse cancer models are vital for developing therapeutics. Multi-energy CT imaging with a photon-counting detector (PCD) improves material separation in cancer studies involving nanoparticle-based contrast agents and combination ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · September 21, 2024
AbstractBackground-Human papilloma virus (HPV-positive (+)) oropharynx cancer (OPC) are a distinct neoplastic entity associated with a significant survival advantage compared to HPV- OPCs. The survival advan ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · September 21, 2024
AbstractThis abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR004) of the Conference Program/Proceedings. Cell, Molecula ...
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ConferenceMed Phys · May 2024
BACKGROUND: Delta radiomics is a high-throughput computational technique used to describe quantitative changes in serial, time-series imaging by considering the relative change in radiomic features of images extracted at two distinct time points. Recent wo ...
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ConferenceClinical Cancer Research · September 15, 2023
AbstractDespite aggressive multimodal treatment with chemoradiation or surgery and adjuvant radiation therapy (RT) +/- chemotherapy, recurrence rates approach 50% for locally advanced human papillomavirus (H ...
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ConferenceClinical Cancer Research · September 15, 2023
AbstractBackground: Present line indications for pembrolizumab are for patients with metastatic or unresectable recurrent (i.e. incurable) head and neck squamous cell carcinoma (HNSCC). However, only a minor ...
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ConferenceClinical Cancer Research · September 15, 2022
AbstractDespite aggressive conventional therapy, many patients with high-risk soft-tissue sarcoma develop metastatic disease. To investigate mechanism(s) of sarcoma metastasis, our lab has utilized genetical ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022
The photon-counting (PC) detector technology promises to enhance the number of CT applications due to the spectral information. Of high interest for the cancer research community is imaging the tumor delivery of Cisplatin (CisPt), a chemotherapeutic agent ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022
The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT with nanoparticle contrast-enhancement can differentiate tumors based on tumor-infiltrating lymphocyte (TIL) burden. High mutational load transplant soft tissue sa ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2022
Developing novel contrast agents for multi-energy photon-counting (PC)CT will require a clear translation pathway from preclinical validation to clinical applications. To begin this development, we have used a clinical PCCT scanner (Siemens NAEOTOM Alpha) ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2022
Photon-counting detector (PCD) CT promises to improve routine CT imaging applications with higher spatial resolution, lower levels of noise at fixed dose, and improved image contrast while providing spectral information with every scan. We propose and demo ...
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ConferenceInternational journal of radiation oncology, biology, physics · November 2021
Purpose/objective(s)Mortality prediction is critical to appropriate cancer care planning. This has become a topic of interest, with machine learning (ML) tools demonstrating accurate binary predictions for mortality at specific time points. There ...
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ConferenceInternational journal of radiation oncology, biology, physics · November 2021
Purpose/objective(s)Prevention/mitigation of oral mucositis (OM) and xerostomia are challenges to the use of chemoradiation (CRT) for advanced head and neck squamous ca (HNSCC). MnTnBuOE-2-PyP5+(BMX-001) is a lipophilic manganese metall ...
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ConferenceInternational journal of radiation oncology, biology, physics · November 2021
Purpose/objective(s)Radiation is increasingly used to treat oligometastatic patients (OM). Following metastasis directed radiation therapy, progression in nearby nodal basins or bones is common. We previously reported clinical outcomes of OM treat ...
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ConferenceInternational journal of radiation oncology, biology, physics · November 2021
Purpose/objective(s)Preclinical studies using transplant tumor models have shown promising results for immunotherapy combined with radiotherapy (RT). However, research using primary tumor models is limited, and results from tumors using transplant ...
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ConferenceJournal of Clinical Oncology · October 1, 2021
56 Background: Cancer patients face considerable financial burden, but few studies have explored associations between radiation therapy (RT) and financial toxicity. This study assessed financial toxicity, patient-reported outcome ...
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ConferenceJournal of Clinical Oncology · May 20, 2021
1509 Background: SHIELD-RT was a randomized controlled quality improvement study (NCT03775265) that implemented electronic health record-based machine learning (ML) to direct supplemental visits for high risk (HR) patients underg ...
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ConferenceFront Oncol · 2021
PURPOSE: Due to the low incidence of intracranial disease among patients with esophageal cancer (EC), optimal management for these patients has not been established. The aim of this real-world study is to describe the clinical characteristics, treatment ap ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2021
We are developing imaging methods for the preclinical arm of a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform in vivo micro-CT of mouse lungs to detect lung metastasis after treatment. This work explores deep lea ...
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ConferenceFrontiers in oncology · January 2020
Purpose To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). Methods ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020
Radiomics provide an exciting approach to developing imaging biomarkers in the context of precision medicine. We focus on the preclinical arm of a co-clinical trial investigating synergy of immunotherapy combined with radiation therapy (RT) and surgical re ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020
High-Z based nanoparticles (NP) are emerging as promising agents for both cancer radiotherapy (RT) and CT imaging. NPs can be delivered to tumors via the enhanced permeability and retention (EPR) effect and they preferentially accumulate in tumor's perivas ...
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ConferenceBlood · November 13, 2019
Introduction: While hematopoietic stem cell transplantation (HSCT) has great therapeutic potential, intensive conditioning regimens and variability in time to stem cell engraftment result in a period of pancytopenia and immunosuppression in which p ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging is faced with unique challenges that emphasize the gap between mouse and man. One exam ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
Small animal imaging is essential in building a bridge from basic science to the clinic by providing the confidence necessary to move new cancer therapies to patients. However, there is considerable variability in preclinical imaging, including tumor volum ...
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ConferenceClinical Cancer Research · January 15, 2018
AbstractGenetically engineered mouse models (GEMMs) that employ site-specific recombinase (SSR) technology are important tools for cancer research, and recently the CRISPR/Cas9 system has been increasingly u ...
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ConferenceCancer Research · July 1, 2017
AbstractGenetically engineered mouse models (GEMMs) that employ site-specific recombinase (SSR) technology are important tools for pre-clinical studies, but this approach is costly and time-consuming. Here, ...
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ConferenceCancer Research · May 1, 2015
AbstractBackground: Large randomized controlled trials have shown that hypofractionated whole breast irradiation (HF-WBI) is not inferior to or more toxic than conventionally fractionated whole breast irradi ...
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