Current Appointments & Affiliations
Assistant Professor in Surgery
·
2021 - Present
Surgery, Surgical Sciences,
Surgery
Assistant Professor of Pathology
·
2022 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.
Journal Article PLoS Genet · December 2020 Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved Ras/mitogen-activated-protein-kinase (MAPK) pathway, which exhibits context-dependent signaling output dynamics and regulation. ... Full text Link to item CiteWnt signaling suppresses MAPK-driven proliferation of intestinal stem cells.
Journal Article J Clin Invest · August 31, 2018 Intestinal homeostasis depends on a slowly proliferating stem cell compartment in crypt cells, followed by rapid proliferation of committed progenitor cells in the transit amplifying (TA) compartment. The balance between proliferation and differentiation i ... Full text Open Access Link to item CitePDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.
Journal Article Proc Natl Acad Sci U S A · April 3, 2018 Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can regulate the proliferation and differentiation of Lgr5-expressing intestinal stem ... Full text Open Access Link to item CiteRecent Grants
Identifying Novel Intensity-Specific Regulators of RAS Signaling
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2022 - 2025Dynamic requirements of Ras signaling during cancer
ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2014 - 2019View All Grants
Education, Training & Certifications
National University of Singapore (Singapore) ·
2014
Ph.D.
National University of Singapore (Singapore) ·
2010
M.S.
Isfahan University (Iran) ·
2007
M.D.