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Zahra Kabiri

Assistant Professor in Surgery
Surgery, Surgical Sciences

Current Appointments & Affiliations


Assistant Professor in Surgery · 2021 - Present Surgery, Surgical Sciences, Surgery
Assistant Professor of Pathology · 2022 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2022 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.

Journal Article PLoS Genet · December 2020 Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved Ras/mitogen-activated-protein-kinase (MAPK) pathway, which exhibits context-dependent signaling output dynamics and regulation. ... Full text Link to item Cite

Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells.

Journal Article J Clin Invest · August 31, 2018 Intestinal homeostasis depends on a slowly proliferating stem cell compartment in crypt cells, followed by rapid proliferation of committed progenitor cells in the transit amplifying (TA) compartment. The balance between proliferation and differentiation i ... Full text Open Access Link to item Cite

PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.

Journal Article Proc Natl Acad Sci U S A · April 3, 2018 Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can regulate the proliferation and differentiation of Lgr5-expressing intestinal stem ... Full text Open Access Link to item Cite
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Recent Grants


Identifying Novel Intensity-Specific Regulators of RAS Signaling

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2022 - 2025

Dynamic requirements of Ras signaling during cancer

ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2014 - 2019

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Education, Training & Certifications


National University of Singapore (Singapore) · 2014 Ph.D.
National University of Singapore (Singapore) · 2010 M.S.
Isfahan University (Iran) · 2007 M.D.