Michael Rod Zalutsky

Conference Cancer Research · July 1, 2018 AbstractPancreatic tumors remain one of the deadliest manifestations of cancer in clinical oncology. Even when tumors are diagnosed early, remain loco-regionalized, and receive cutting-edge cancer treatment, ... Full text Cite

Genomic and phenotypic evidence for prostate cancer osteomimicry in circulating tumor cells from men with metastatic castration resistant prostate cancer (mCRPC) treated with radium-223.

Conference Journal of Clinical Oncology · May 20, 2018 Full text Cite

Small Molecule Radiohalogenated (I-125/At-211), DOTA Containing PSMA Inhibitors: Metal Complexation and Competing Inhibitor Improve Biodistribution in Mice

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2018 Link to item Cite

Simplified At-211-labeling of internalizing proteins by preconjugation with the tin precursor of a residualizing prosthetic agent: Application to an anti-HER2 single domain antibody fragment

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2018 Link to item Cite

F-18-labeling of an anti-HER2 sdAb with a renal brush border enzyme-cleavable linker-containing prosthetic agent via a trans-cyclooctene (TCO)-terazine (Tz) inverse electron-demand Diels-Alder reaction (IEDDAR) for reduced renal uptake

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2018 Link to item Cite

Genomic and phenotypic evidence for prostate cancer osteomimicry in circulating tumor cells from men with metastatic castration resistant prostate cancer (mCRPC) treated with radium-223.

Conference Journal of Clinical Oncology · February 20, 2018 160 Background: Radium-223 is a targeted alpha therapy that improves survival in men with mCRPC. The biologic basis for radium-223 efficacy is not completely understood. We hypothesized that PC osteomimicry, a form of epithelial ... Full text Cite

Feasibility of 124I anti-PD-L1 PET/CT imaging in a syngeneic tumor model of breast cancer.

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2017 Link to item Cite

Labeling an anti-HER2 VHH with F-18 using a residualizing prosthetic group via strain-promoted click reaction: preliminary evaluation

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2017 Link to item Cite

Anti-HER2 Single Domain Antibody 2Rs15d Labeled with F-18 Using a Residualizing Label: Preliminary Evaluation

Conference EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · October 1, 2016 Link to item Cite

Abstract 4213: Gold nanostar as theranostic probe for brain tumor sensitive PET-optical imaging and image-guided specific photothermal therapy

Conference Cancer Research · July 15, 2016 AbstractMalignant brain tumors are one of the most lethal cancer forms causing over 14,000 deaths each year. In spite of extensive research efforts over many decades, the median overall survival (OS) still r ... Full text Cite

211At-Labeled Small-Molecule PSMA Inhibitors: Effect of Structure on Biodistribution in Mice

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2016 Link to item Cite

[211At]YC-I-27 for PSMA-Targeted Alpha-Particle Radiopharmaceutical Therapy

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2016 Link to item Cite

An Anti-HER2 Nanobody Labeled with 18F Using a Residualizing Label for Assessing HER2 Status

Conference EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · October 1, 2015 Link to item Cite

Abstract 1809: Next-generation brachytherapy: a preclinical study of a thermally stabilized biopolymer gel for delivering intratumoral radionuclide therapy in a pancreatic tumor mouse model

Conference Cancer Research · August 1, 2015 AbstractThe intratumoral delivery of radioactive therapeutics, a clinical technique known as brachytherapy, has proven very successful in treating solid cancers and become a prevalent option for treating pro ... Full text Cite

A At-211-labeled nanobody for alpha-particle therapy of HER2-expressing cancers

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2015 Link to item Cite

Abstract B48: Preclinical development of meta-[211At] astatobenzylguanidine ([211At] MABG) targeted radiotherapy for neuroblastoma

Conference Cancer Research · October 15, 2014 AbstractBackground: Neuroblastoma (NB) is a radiosensitive malignancy accounting for 10% of childhood cancer mortality. NB cells frequently express the norepinephrine transporter (NET) providing a specific m ... Full text Cite

Abstract 4583: In situ photocontrolled intratumoral depot for combined photodynamic therapy and brachytherapy for solid tumor

Conference Cancer Research · October 1, 2014 AbstractIntratumoral (i.t.) drug delivery can circumvent the transport barriers_high intratumoral fluid pressure and irregular vascularization_of solid tumors that limit the effectiveness of systemically del ... Full text Cite

PRE-CLINICAL EFFICACY STUDY OF INTRA-THECAL (IT) (LU)-L-177-DOTA-TATE (SOMATOSTATIN ANALOGUE) IN ATHYMIC RATS WITH LEPTOMENINGEAL DISEASE (LMD) FROM MEDULLOBLASTOMA (MBL)

Conference NEURO-ONCOLOGY · June 1, 2014 Link to item Cite

Radioiodinated AGI-5198 for in vivo imaging of isocitrate dehydrogenase 1 (IDH1) mutation in gliomas

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2014 Link to item Cite

Abstract C86: Tethered Hsp90 inhibitors carrying optical or radioiodinated probes reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.

Conference Molecular Cancer Therapeutics · November 1, 2013 AbstractHsp90 inhibitors have demonstrated unusual selectivity for tumor cells despite its ubiquitous expression. This phenomenon has remained unexplained but could be influenced by ectopically expressed Hsp ... Full text Cite

Modular nanotransporters efficiently deliver Auger electron emitters into nuclei of cancer cells

Conference FEBS JOURNAL · July 1, 2013 Link to item Cite

Modular nanotransporters: a versatile platform for nuclear delivery of anti-cancer pharmaceuticals

Conference FEBS JOURNAL · July 1, 2013 Link to item Cite

Abstract 5615: Evaluation of the antitumoral efficacy and toxicity of injectable, polymeric radionuclide seeds in a noninvasive preclinical prostate tumor model.

Conference Cancer Research · April 15, 2013 AbstractBrachytherapy continues to be one of the predominant radiotherapy modalities for the treatment of prostate cancer. Depending on the stage of the cancer, it is employed either as a stand-alone treatme ... Full text Cite

Abstract 4341: A novel injectable polymer liquid that self-assembles into radioactive “seeds” for brachytherapy.

Conference Cancer Research · April 15, 2013 AbstractBrachytherapy seeds are made by sealing radionuclides in metal or other non-degradable material (resin or glass) and surgically implanted into the tumor tissue. Brachytherapy has shown some efficacy ... Full text Cite