Zhi-de Deng | Scholars@Duke

Zhi-de Deng
Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences

Current Appointments & Affiliations

Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2016
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2015

Contact Information

200 Trent Drive, Red Zone, Rm. 54238, Durham, NC 27710
3620, Durham, NC 27710
zzz.deng@duke.edu (919) 681-9948

Background
Education, Training, & Certifications
- Ph.D., Columbia University 2013
Duke Appointment History
- Medical Instructor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2014 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lisanby, Sarah H., Shawn M. McClintock, William V. McCall, Rebecca G. Knapp, C Munro Cullum, Martina Mueller, Zhi-De Deng, et al. “Longitudinal Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Pharmacotherapy in Major Depressive Disorder in Older Adults: Phase 2 of the PRIDE Study.” Am J Geriatr Psychiatry, May 17, 2021. https://doi.org/10.1016/j.jagp.2021.04.006.
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  - Abbott, Christopher C., Davin Quinn, Jeremy Miller, Enstin Ye, Sulaiman Iqbal, Megan Lloyd, Thomas R. Jones, et al. “Electroconvulsive Therapy Pulse Amplitude and Clinical Outcomes.” Am J Geriatr Psychiatry 29, no. 2 (February 2021): 166–78. https://doi.org/10.1016/j.jagp.2020.06.008.
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  - Suen, Paulo J. C., Sarah Doll, Marcelo C. Batistuzzo, Geraldo Busatto, Lais B. Razza, Frank Padberg, Eva Mezger, et al. “Association between tDCS computational modeling and clinical outcomes in depression: data from the ELECT-TDCS trial.” Eur Arch Psychiatry Clin Neurosci 271, no. 1 (February 2021): 101–10. https://doi.org/10.1007/s00406-020-01127-w.
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  - Fridgeirsson, E. A., Z. D. Deng, D. Denys, J. A. van Waarde, and G. A. van Wingen. “Electric field strength induced by electroconvulsive therapy is associated with clinical outcome.” Neuroimage: Clinical 30 (January 1, 2021). https://doi.org/10.1016/j.nicl.2021.102581.
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  - Balderston, Nicholas L., Camille Roberts, Emily M. Beydler, Zhi-De Deng, Thomas Radman, Bruce Luber, Sarah H. Lisanby, Monique Ernst, and Christian Grillon. “A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.” Nat Protoc 15, no. 11 (November 2020): 3595–3614. https://doi.org/10.1038/s41596-020-0387-4.
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  - Borrione, Lucas, Helena Bellini, Lais Boralli Razza, Ana G. Avila, Chris Baeken, Anna-Katharine Brem, Geraldo Busatto, et al. “Precision non-implantable neuromodulation therapies: a perspective for the depressed brain.” Braz J Psychiatry 42, no. 4 (August 2020): 403–19. https://doi.org/10.1590/1516-4446-2019-0741.
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  - Kadriu, Bashkim, Zhi-De Deng, Christoph Kraus, Ioline D. Henter, Sarah H. Lisanby, and Carlos A. Zarate. “Not So Fast: Recent Successes and Failures in Treating Depression.” J Clin Psychiatry 81, no. 4 (May 26, 2020). https://doi.org/10.4088/JCP.19ac13138.
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  - Cox, Morgan L., Zhi-De Deng, Hannah Palmer, Amanda Watts, Lysianne Beynel, Jonathan R. Young, Sarah H. Lisanby, John Migaly, and Lawrence G. Appelbaum. “Utilizing transcranial direct current stimulation to enhance laparoscopic technical skills training: A randomized controlled trial.” Brain Stimul 13, no. 3 (May 2020): 863–72. https://doi.org/10.1016/j.brs.2020.03.009.
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  - Aronson Fischell, Sarah, Thomas J. Ross, Zhi-De Deng, Betty Jo Salmeron, and Elliot A. Stein. “Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome.” Biol Psychiatry Cogn Neurosci Neuroimaging 5, no. 4 (April 2020): 448–60. https://doi.org/10.1016/j.bpsc.2019.12.020.
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  - Balderston, Nicholas L., Emily M. Beydler, Camille Roberts, Zhi-De Deng, Thomas Radman, Tiffany Lago, Bruce Luber, Sarah H. Lisanby, Monique Ernst, and Christian Grillon. “Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects.” Neuropsychopharmacology 45, no. 4 (March 2020): 694–702. https://doi.org/10.1038/s41386-019-0583-5.
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  - Lisanby, Sarah H., Shawn M. McClintock, George Alexopoulos, Samuel H. Bailine, Elisabeth Bernhardt, Mimi C. Briggs, C Munro Cullum, et al. “Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study.” Am J Geriatr Psychiatry 28, no. 3 (March 2020): 304–16. https://doi.org/10.1016/j.jagp.2019.10.003.
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  - Deng, Zhi-De, Bruce Luber, Nicholas L. Balderston, Melbaliz Velez Afanador, Michelle M. Noh, Jeena Thomas, William C. Altekruse, Shannon L. Exley, Shriya Awasthi, and Sarah H. Lisanby. “Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.” Annu Rev Pharmacol Toxicol 60 (January 6, 2020): 591–614. https://doi.org/10.1146/annurev-pharmtox-010919-023253.
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  - Beynel, Lysianne, Lawrence G. Appelbaum, Bruce Luber, Courtney A. Crowell, Susan A. Hilbig, Wesley Lim, Duy Nguyen, et al. “Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies.” Neurosci Biobehav Rev 107 (December 2019): 47–58. https://doi.org/10.1016/j.neubiorev.2019.08.018.
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  - Kadriu, Bashkim, Cristan A. Farmer, Peixiong Yuan, Lawrence T. Park, Zhi-De Deng, Ruin Moaddel, Ioline D. Henter, et al. “The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response.” Mol Psychiatry, November 15, 2019. https://doi.org/10.1038/s41380-019-0589-8.
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  - Argyelan, Miklos, Leif Oltedal, Zhi-De Deng, Benjamin Wade, Marom Bikson, Andrea Joanlanne, Sohag Sanghani, et al. “Electric field causes volumetric changes in the human brain.” Elife 8 (October 23, 2019). https://doi.org/10.7554/eLife.49115.
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  - Dufor, T., S. Grehl, A. D. Tang, M. Doulazmi, M. Traoré, N. Debray, C. Dubacq, et al. “Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns.” Sci Adv 5, no. 10 (October 2019): eaav9847. https://doi.org/10.1126/sciadv.aav9847.
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  - Dubin, Marc J., Irena P. Ilieva, Zhi-De Deng, Jeena Thomas, Ashly Cochran, Kamilla Kravets, Benjamin D. Brody, et al. “A double-blind pilot dosing study of low field magnetic stimulation (LFMS) for treatment-resistant depression (TRD).” J Affect Disord 249 (April 15, 2019): 286–93. https://doi.org/10.1016/j.jad.2019.02.039.
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  - Popa, T., L. S. Morris, R. Hunt, Z. D. Deng, S. Horovitz, K. Mente, H. Shitara, K. Baek, M. Hallett, and V. Voon. “Modulation of resting connectivity between the mesial frontal cortex and basal ganglia.” Frontiers in Neurology 10, no. JUN (January 1, 2019). https://doi.org/10.3389/fneur.2019.00587.
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  - Croarkin, Paul E., Paul A. Nakonezny, Zhi-De Deng, Magdalena Romanowicz, Jennifer L Vande Voort, Deniz Doruk Camsari, Kathryn M. Schak, John D. Port, and Charles P. Lewis. “High-frequency repetitive TMS for suicidal ideation in adolescents with depression.” J Affect Disord 239 (October 15, 2018): 282–90. https://doi.org/10.1016/j.jad.2018.06.048.
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  - Wang, Boshuo, Michael R. Shen, Zhi-De Deng, J Evan Smith, Joseph J. Tharayil, Clement J. Gurrey, Luis J. Gomez, and Angel V. Peterchev. “Redesigning existing transcranial magnetic stimulation coils to reduce energy: application to low field magnetic stimulation.” J Neural Eng 15, no. 3 (June 2018): 036022. https://doi.org/10.1088/1741-2552/aaa505.
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  - Bikson, Marom, Andre R. Brunoni, Leigh E. Charvet, Vincent P. Clark, Leonardo G. Cohen, Zhi-De Deng, Jacek Dmochowski, et al. “Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop.” Brain Stimul 11, no. 3 (May 2018): 465–80. https://doi.org/10.1016/j.brs.2017.12.008.
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  - Zhi-De Deng, Sarah H., and Sarah H. Lisanby. “Electric field characteristics of low-field synchronized transcranial magnetic stimulation (sTMS).” Annu Int Conf Ieee Eng Med Biol Soc 2017 (July 2017): 1445–48. https://doi.org/10.1109/EMBC.2017.8037106.
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  - Goetz, Stefan M., and Zhi-De Deng. “The development and modelling of devices and paradigms for transcranial magnetic stimulation.” Int Rev Psychiatry 29, no. 2 (April 2017): 115–45. https://doi.org/10.1080/09540261.2017.1305949.
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  - Grehl, Stephanie, David Martina, Catherine Goyenvalle, Zhi-De Deng, Jennifer Rodger, and Rachel M. Sherrard. “In vitro Magnetic Stimulation: A Simple Stimulation Device to Deliver Defined Low Intensity Electromagnetic Fields.” Front Neural Circuits 10 (2016): 85. https://doi.org/10.3389/fncir.2016.00085.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “On the characterization of coils for deep transcranial magnetic stimulation.” Clin Neurophysiol 126, no. 7 (July 2015): 1456–57. https://doi.org/10.1016/j.clinph.2014.10.144.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “On the stimulation depth of transcranial magnetic stimulation coils.” Clin Neurophysiol 126, no. 4 (April 2015): 843–44. https://doi.org/10.1016/j.clinph.2014.06.048.
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  - Deng, Zhi-De, Shawn M. McClintock, Nicodemus E. Oey, Bruce Luber, and Sarah H. Lisanby. “Neuromodulation for mood and memory: from the engineering bench to the patient bedside.” Curr Opin Neurobiol 30 (February 2015): 38–43. https://doi.org/10.1016/j.conb.2014.08.015.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “Effect of anatomical variability on electric field characteristics of electroconvulsive therapy and magnetic seizure therapy: a parametric modeling study.” Ieee Trans Neural Syst Rehabil Eng 23, no. 1 (January 2015): 22–31. https://doi.org/10.1109/TNSRE.2014.2339014.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “Coil design considerations for deep transcranial magnetic stimulation.” Clin Neurophysiol 125, no. 6 (June 2014): 1202–12. https://doi.org/10.1016/j.clinph.2013.11.038.
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  - McClintock, Shawn M., Jimmy Choi, Zhi-De Deng, Lawrence G. Appelbaum, Andrew D. Krystal, and Sarah H. Lisanby. “Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.” J Ect 30, no. 2 (June 2014): 165–76. https://doi.org/10.1097/YCT.0000000000000137.
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  - Mueller, J. K., E. M. Grigsby, V. Prevosto, F. W. Petraglia, H. Rao, Z. D. Deng, A. V. Peterchev, et al. “Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.” Nature Neuroscience 17, no. 8 (January 1, 2014): 1130–36. https://doi.org/10.1038/nn.3751.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “Controlling stimulation strength and focality in electroconvulsive therapy via current amplitude and electrode size and spacing: comparison with magnetic seizure therapy.” J Ect 29, no. 4 (December 2013): 325–35. https://doi.org/10.1097/YCT.10.1097/YCT.0b013e3182a4b4a7.
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  - Deng, Z. D., S. H. Lisanby, and A. V. Peterchev. “Controlling Stimulation Strength and Focality in Electroconvulsive Therapy via Current Amplitude and Electrode Size and Spacing: Comparison With Magnetic Seizure Therapy.” J Ect, November 7, 2013. https://doi.org/10.1097/YCT.0b013e3182a4b4a7.
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  - Luber, Bruce, Jason Steffener, Adrienne Tucker, Christian Habeck, Angel V. Peterchev, Zhi-De Deng, Robert C. Basner, Yaakov Stern, and Sarah H. Lisanby. “Extended remediation of sleep deprived-induced working memory deficits using fMRI-guided transcranial magnetic stimulation.” Sleep 36, no. 6 (June 1, 2013): 857–71. https://doi.org/10.5665/sleep.2712.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “Electric field depth-focality tradeoff in transcranial magnetic stimulation: simulation comparison of 50 coil designs.” Brain Stimul 6, no. 1 (January 2013): 1–13. https://doi.org/10.1016/j.brs.2012.02.005.
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  - Lee, Won Hee, Zhi-De Deng, Tae-Seong Kim, Andrew F. Laine, Sarah H. Lisanby, and Angel V. Peterchev. “Regional electric field induced by electroconvulsive therapy in a realistic finite element head model: influence of white matter anisotropic conductivity.” Neuroimage 59, no. 3 (February 1, 2012): 2110–23. https://doi.org/10.1016/j.neuroimage.2011.10.029.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “Electric field strength and focality in electroconvulsive therapy and magnetic seizure therapy: a finite element simulation study.” J Neural Eng 8, no. 1 (February 2011): 016007. https://doi.org/10.1088/1741-2560/8/1/016007.
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  - Deng, Zhi-De, and Angel V. Peterchev. “Transcranial magnetic stimulation coil with electronically switchable active and sham modes.” Annu Int Conf Ieee Eng Med Biol Soc 2011 (2011): 1993–96. https://doi.org/10.1109/IEMBS.2011.6090561.
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  - Lee, Won Hee, Zhi-De Deng, Andrew F. Laine, Sarah H. Lisanby, and Angel V. Peterchev. “Influence of white matter conductivity anisotropy on electric field strength induced by electroconvulsive therapy.” Annu Int Conf Ieee Eng Med Biol Soc 2011 (2011): 5473–76. https://doi.org/10.1109/IEMBS.2011.6091396.
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  - Deng, Z. D., D. E. Hardesty, S. H. Lisanby, and A. V. Peterchev. “Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, December 1, 2010, 2049–52.
  - Deng, Z. D., S. H. Lisanby, and A. V. Peterchev. “Transcranial magnetic stimulation in the presence of deep brain stimulation implants: Induced electrode currents.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, December 1, 2010, 6821–24.
  - Lee, W. H., Z. D. Deng, T. S. Kim, A. F. Laine, S. H. Lisanby, and A. V. Peterchev. “Regional electric field induced by electroconvulsive therapy: a finite element simulation study.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, December 1, 2010, 2045–48.
  - Peterchev, Angel V., Moacyr A. Rosa, Zhi-De Deng, Joan Prudic, and Sarah H. Lisanby. “Electroconvulsive therapy stimulus parameters: rethinking dosage.” J Ect 26, no. 3 (September 2010): 159–74. https://doi.org/10.1097/YCT.0b013e3181e48165.
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  - Deng, Z. D., D. E. Hardesty, S. H. Lisanby, and A. V. Peterchev. “Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference 2010 (2010): 2049–52.
  - Deng, Zhi-De, David E. Hardesty, Sarah H. Lisanby, and Angel V. Peterchev. “Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.” Annu Int Conf Ieee Eng Med Biol Soc 2010 (2010): 2049–52. https://doi.org/10.1109/IEMBS.2010.5626517.
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  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “Transcranial magnetic stimulation in the presence of deep brain stimulation implants: Induced electrode currents.” Annu Int Conf Ieee Eng Med Biol Soc 2010 (2010): 6821–24. https://doi.org/10.1109/IEMBS.2010.5625958.
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  - Lee, Won Hee, Zhi-De Deng, Tae-Seong Kim, Andrew F. Laine, Sarah H. Lisanby, and Angel V. Peterchev. “Regional electric field induced by electroconvulsive therapy: a finite element simulation study.” Annu Int Conf Ieee Eng Med Biol Soc 2010 (2010): 2045–48. https://doi.org/10.1109/IEMBS.2010.5626553.
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  - Deng, Z. D., S. H. Lisanby, and A. V. Peterchev. “Effect of anatomical variability on neural stimulation strength and focality in electroconvulsive therapy (ECT) and magnetic seizure therapy (MST).” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, December 1, 2009, 682–88.
  - Deng, Zhi-De, Sarah H. Lisanby, and Angel V. Peterchev. “Effect of anatomical variability on neural stimulation strength and focality in electroconvulsive therapy (ECT) and magnetic seizure therapy (MST).” Annu Int Conf Ieee Eng Med Biol Soc 2009 (2009): 682–88. https://doi.org/10.1109/IEMBS.2009.5334091.
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  - Deng, Z. D., A. V. Peterchev, and S. H. Lisanby. “Coil design considerations for deep-brain transcranial magnetic stimulation (dTMS).” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, December 1, 2008, 5675–79.
  - Arzeno, Natalia M., Zhi-De Deng, and Chi-Sang Poon. “Analysis of first-derivative based QRS detection algorithms.” Ieee Trans Biomed Eng 55, no. 2 Pt 1 (February 2008): 478–84. https://doi.org/10.1109/TBME.2007.912658.
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  - Deng, Zhi-De, Angel V. Peterchev, and Sarah H. Lisanby. “Coil design considerations for deep-brain transcranial magnetic stimulation (dTMS).” Annu Int Conf Ieee Eng Med Biol Soc 2008 (2008): 5675–79. https://doi.org/10.1109/IEMBS.2008.4650502.
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  - Arzeno, N. M., C. -. S. Poon, and Z. -. D. Deng. “Quantitative analysis of QRS detection algorithms based on the first derivative of the ECG.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 2006, 1788–91.
  - Arzeno, Natalia M., Chi-Sang Poon, and Zhi-De Deng. “Quantitative analysis of QRS detection algorithms based on the first derivative of the ECG.” Conf Proc Ieee Eng Med Biol Soc 2006 (2006): 1788–91. https://doi.org/10.1109/IEMBS.2006.260051.
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  - Deng, Z. -. D., C. -. S. Poon, N. M. Arzeno, and E. S. Katz. “Heart rate variability in pediatric obstructive sleep apnea.” Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference, 2006, 3565–68.
  - Deng, Zhi-De, Chi-Sang Poon, Natalia M. Arzeno, and Eliot S. Katz. “Heart rate variability in pediatric obstructive sleep apnea.” Conf Proc Ieee Eng Med Biol Soc 2006 (2006): 3565–68. https://doi.org/10.1109/IEMBS.2006.260139.
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- Book Sections
  - Luber, B., and Z. D. Deng. “Application of non-invasive brain stimulation in psychophysiology.” In Handbook of Psychophysiology, Fourth Edition, 116–50, 2016. https://doi.org/10.1017/9781107415782.007.
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  - Lisanby, S. H., and Z. D. Deng. “Magnetic Seizure Therapy for the Treatment of Depression.” In Brain Stimulation: Methodologies and Interventions, 123–48, 2015. https://doi.org/10.1002/9781118568323.ch8.
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  - Peterchev, A. V., Z. D. Deng, and S. M. Goetz. “Advances in Transcranial Magnetic Stimulation Technology.” In Brain Stimulation: Methodologies and Interventions, 165–89, 2015. https://doi.org/10.1002/9781118568323.ch10.
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- Conference Papers
  - Deng, Zhi-De, Shawn M. McClinctock, and Sarah H. Lisanby. “Brain network properties in depressed patients receiving seizure therapy: A graph theoretical analysis of peri-treatment resting EEG.” In Annu Int Conf Ieee Eng Med Biol Soc, 2015:2203–6, 2015. https://doi.org/10.1109/EMBC.2015.7318828.
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  - Deng, Z. D., A. V. Peterchev, A. D. Krystal, B. Luber, S. M. McClintock, M. M. Husain, and S. H. Lisanby. “Topography of seizures induced by electroconvulsive therapy and magnetic seizure therapy.” In International Ieee/Embs Conference on Neural Engineering, Ner, 577–80, 2013. https://doi.org/10.1109/NER.2013.6696000.
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Education, Training, & Certifications

Duke Appointment History

Selected Publications

Academic Articles

Book Sections

Conference Papers