The final touches make perfect the peptide-MHC class I repertoire.
Publication
, Journal Article
Hammer, GE; Kanaseki, T; Shastri, N
Published in: Immunity
April 2007
Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.
Duke Scholars
Published In
Immunity
DOI
ISSN
1074-7613
Publication Date
April 2007
Volume
26
Issue
4
Start / End Page
397 / 406
Location
United States
Related Subject Headings
- Protein Disulfide-Isomerases
- Peptides
- Oxidation-Reduction
- Membrane Transport Proteins
- Leucyl Aminopeptidase
- Immunology
- Humans
- Histocompatibility Antigens Class I
- Endoplasmic Reticulum
- Cytoplasm
Citation
APA
Chicago
ICMJE
MLA
NLM
Hammer, G. E., Kanaseki, T., & Shastri, N. (2007). The final touches make perfect the peptide-MHC class I repertoire. Immunity, 26(4), 397–406. https://doi.org/10.1016/j.immuni.2007.04.003
Hammer, Gianna Elena, Takayuki Kanaseki, and Nilabh Shastri. “The final touches make perfect the peptide-MHC class I repertoire.” Immunity 26, no. 4 (April 2007): 397–406. https://doi.org/10.1016/j.immuni.2007.04.003.
Hammer GE, Kanaseki T, Shastri N. The final touches make perfect the peptide-MHC class I repertoire. Immunity. 2007 Apr;26(4):397–406.
Hammer, Gianna Elena, et al. “The final touches make perfect the peptide-MHC class I repertoire.” Immunity, vol. 26, no. 4, Apr. 2007, pp. 397–406. Pubmed, doi:10.1016/j.immuni.2007.04.003.
Hammer GE, Kanaseki T, Shastri N. The final touches make perfect the peptide-MHC class I repertoire. Immunity. 2007 Apr;26(4):397–406.
Published In
Immunity
DOI
ISSN
1074-7613
Publication Date
April 2007
Volume
26
Issue
4
Start / End Page
397 / 406
Location
United States
Related Subject Headings
- Protein Disulfide-Isomerases
- Peptides
- Oxidation-Reduction
- Membrane Transport Proteins
- Leucyl Aminopeptidase
- Immunology
- Humans
- Histocompatibility Antigens Class I
- Endoplasmic Reticulum
- Cytoplasm