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Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design?

Publication ,  Journal Article
Bonsignori, M
Published in: Expert review of vaccines
November 2014

The induction of HIV-1 broadly neutralizing antibodies (bnAbs) remains the primary goal of a preventive HIV-1 vaccine but no HIV-1 vaccine candidate has succeeded in inducing bnAbs. All the bnAbs isolated from chronically HIV-1 infected subjects display one or more traits associated with control by host tolerance and immunoregulatory mechanisms, including reactivity against self antigens. Recent studies on a HIV-1 patient with concurrent systemic lupus erythematosus have informed on how similar bnAbs are to typical autoantibodies controlled by immune tolerance mechanisms. Future studies aimed at elucidating the intersection between autoantibodies generated in the context of systemic lupus erythematosus and the development of HIV-1 bnAbs will further our knowledge of specific roadblocks that hamper the production of bnAbs and, ultimately, inform us on how to implement vaccine strategies to circumvent them.

Published In

Expert review of vaccines

DOI

EISSN

1744-8395

ISSN

1476-0584

Publication Date

November 2014

Volume

13

Issue

11

Start / End Page

1271 / 1273

Related Subject Headings

  • Virology
  • Lupus Erythematosus, Systemic
  • Immune Tolerance
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Autoantibodies
  • Antibodies, Neutralizing
  • AIDS Vaccines
 

Citation

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Bonsignori, M. (2014). Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design? Expert Review of Vaccines, 13(11), 1271–1273. https://doi.org/10.1586/14760584.2014.938056
Bonsignori, Mattia. “Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design?Expert Review of Vaccines 13, no. 11 (November 2014): 1271–73. https://doi.org/10.1586/14760584.2014.938056.
Bonsignori, Mattia. “Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design?Expert Review of Vaccines, vol. 13, no. 11, Nov. 2014, pp. 1271–73. Epmc, doi:10.1586/14760584.2014.938056.
Bonsignori M. Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design? Expert review of vaccines. 2014 Nov;13(11):1271–1273.
Journal cover image

Published In

Expert review of vaccines

DOI

EISSN

1744-8395

ISSN

1476-0584

Publication Date

November 2014

Volume

13

Issue

11

Start / End Page

1271 / 1273

Related Subject Headings

  • Virology
  • Lupus Erythematosus, Systemic
  • Immune Tolerance
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Autoantibodies
  • Antibodies, Neutralizing
  • AIDS Vaccines