mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma.
Publication
, Journal Article
Alvarez, JV; Perez, D; Chodosh, LA
Published in: Cancer Cell
November 2006
Mouse models that faithfully recapitulate human cancers are indispensable tools for studying the molecular mechanisms of tumorigenesis and testing potential anticancer therapies. In this issue of Cancer Cell, Derksen et al. describe a new mouse model that mimics multiple features of invasive lobular carcinoma of the breast (ILC), a histological subtype of human breast cancer for which no mouse model currently exists. This model further reveals an important causal link between E-cadherin loss and tumor initiation and metastasis and, in doing so, provides a valuable entrée into the tumor-suppressive functions of E-cadherin as well as the molecular underpinnings of ILC.
Duke Scholars
Published In
Cancer Cell
DOI
ISSN
1535-6108
Publication Date
November 2006
Volume
10
Issue
5
Start / End Page
347 / 349
Location
United States
Related Subject Headings
- Tumor Suppressor Protein p53
- Oncology & Carcinogenesis
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Mice
- Mammary Glands, Human
- Humans
- Female
- Disease Models, Animal
- Carcinoma, Lobular
Citation
APA
Chicago
ICMJE
MLA
NLM
Alvarez, J. V., Perez, D., & Chodosh, L. A. (2006). mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma. Cancer Cell, 10(5), 347–349. https://doi.org/10.1016/j.ccr.2006.10.016
Alvarez, James V., Denise Perez, and Lewis A. Chodosh. “mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma.” Cancer Cell 10, no. 5 (November 2006): 347–49. https://doi.org/10.1016/j.ccr.2006.10.016.
Alvarez JV, Perez D, Chodosh LA. mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma. Cancer Cell. 2006 Nov;10(5):347–9.
Alvarez, James V., et al. “mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma.” Cancer Cell, vol. 10, no. 5, Nov. 2006, pp. 347–49. Pubmed, doi:10.1016/j.ccr.2006.10.016.
Alvarez JV, Perez D, Chodosh LA. mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma. Cancer Cell. 2006 Nov;10(5):347–349.
Published In
Cancer Cell
DOI
ISSN
1535-6108
Publication Date
November 2006
Volume
10
Issue
5
Start / End Page
347 / 349
Location
United States
Related Subject Headings
- Tumor Suppressor Protein p53
- Oncology & Carcinogenesis
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Mice
- Mammary Glands, Human
- Humans
- Female
- Disease Models, Animal
- Carcinoma, Lobular