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Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.

Publication ,  Journal Article
Niewiadomski, J; Zhou, JQ; Roman, HB; Liu, X; Hirschberger, LL; Locasale, JW; Stipanuk, MH
Published in: Ann N Y Acad Sci
January 2016

To gain further insights into the effects of elevated cysteine levels on energy metabolism and the possible mechanisms underlying these effects, we conducted studies in cysteine dioxygenase (Cdo1)-null mice. Cysteine dioxygenase (CDO) catalyzes the first step of the major pathway for cysteine catabolism. When CDO is absent, tissue and plasma cysteine levels are elevated, resulting in enhanced flux of cysteine through desulfhydration reactions. When Cdo1-null mice were fed a high-fat diet, they gained more weight than their wild-type controls, regardless of whether the diet was supplemented with taurine. Cdo1-null mice had markedly lower leptin levels, higher feed intakes, and markedly higher abundance of hepatic stearoyl-CoA desaturase 1 (SCD1) compared to wild-type control mice, and these differences were not affected by the fat or taurine content of the diet. Thus, reported associations of elevated cysteine levels with greater weight gain and with elevated hepatic Scd1 expression are also seen in the Cdo1-null mouse model. Hepatic accumulation of acylcarnitines suggests impaired mitochondrial β-oxidation of fatty acids in Cdo1-null mice. The strong associations of elevated cysteine levels with excess H2 S production and impairments in energy metabolism suggest that H2 S signaling could be involved.

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Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

January 2016

Volume

1363

Issue

1

Start / End Page

99 / 115

Location

United States

Related Subject Headings

  • Taurine
  • Stearoyl-CoA Desaturase
  • Mice, Knockout
  • Mice
  • Methionine
  • Metabolomics
  • Metabolome
  • Metabolic Networks and Pathways
  • Male
  • Liver
 

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Niewiadomski, J., Zhou, J. Q., Roman, H. B., Liu, X., Hirschberger, L. L., Locasale, J. W., & Stipanuk, M. H. (2016). Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Ann N Y Acad Sci, 1363(1), 99–115. https://doi.org/10.1111/nyas.13021
Niewiadomski, Julie, James Q. Zhou, Heather B. Roman, Xiaojing Liu, Lawrence L. Hirschberger, Jason W. Locasale, and Martha H. Stipanuk. “Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.Ann N Y Acad Sci 1363, no. 1 (January 2016): 99–115. https://doi.org/10.1111/nyas.13021.
Niewiadomski J, Zhou JQ, Roman HB, Liu X, Hirschberger LL, Locasale JW, et al. Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Ann N Y Acad Sci. 2016 Jan;1363(1):99–115.
Niewiadomski, Julie, et al. “Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.Ann N Y Acad Sci, vol. 1363, no. 1, Jan. 2016, pp. 99–115. Pubmed, doi:10.1111/nyas.13021.
Niewiadomski J, Zhou JQ, Roman HB, Liu X, Hirschberger LL, Locasale JW, Stipanuk MH. Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Ann N Y Acad Sci. 2016 Jan;1363(1):99–115.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

January 2016

Volume

1363

Issue

1

Start / End Page

99 / 115

Location

United States

Related Subject Headings

  • Taurine
  • Stearoyl-CoA Desaturase
  • Mice, Knockout
  • Mice
  • Methionine
  • Metabolomics
  • Metabolome
  • Metabolic Networks and Pathways
  • Male
  • Liver