Metabolic interactions with cancer epigenetics.
Publication
, Journal Article
Gao, X; Reid, MA; Kong, M; Locasale, JW
Published in: Mol Aspects Med
April 2017
Cancer cells have epigenetic alterations that are known to drive cancer progression. The reversibility of the epigenetic posttranslational modifications on chromatin and DNA renders targeting these modifications an attractive means for cancer therapy. Cellular epigenetic status interacts with cell metabolism, and we are now beginning to understand the nature of how this interaction occurs and the biological contexts that mediate its function. Given the tremendous interest in understanding and targeting metabolic reprogramming in cancer, this nexus also provides opportunities for exploring the liabilities of cancers. This review summarizes recent developments in our understanding of the interaction of cancer metabolism and epigenetics.
Duke Scholars
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Published In
Mol Aspects Med
DOI
EISSN
1872-9452
Publication Date
April 2017
Volume
54
Start / End Page
50 / 57
Location
England
Related Subject Headings
- Neoplasms
- Models, Biological
- Metabolome
- Humans
- Histones
- Epigenesis, Genetic
- DNA Methylation
- Biochemistry & Molecular Biology
- Animals
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Gao, X., Reid, M. A., Kong, M., & Locasale, J. W. (2017). Metabolic interactions with cancer epigenetics. Mol Aspects Med, 54, 50–57. https://doi.org/10.1016/j.mam.2016.09.001
Gao, Xia, Michael A. Reid, Mei Kong, and Jason W. Locasale. “Metabolic interactions with cancer epigenetics.” Mol Aspects Med 54 (April 2017): 50–57. https://doi.org/10.1016/j.mam.2016.09.001.
Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Mol Aspects Med. 2017 Apr;54:50–7.
Gao, Xia, et al. “Metabolic interactions with cancer epigenetics.” Mol Aspects Med, vol. 54, Apr. 2017, pp. 50–57. Pubmed, doi:10.1016/j.mam.2016.09.001.
Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Mol Aspects Med. 2017 Apr;54:50–57.
Published In
Mol Aspects Med
DOI
EISSN
1872-9452
Publication Date
April 2017
Volume
54
Start / End Page
50 / 57
Location
England
Related Subject Headings
- Neoplasms
- Models, Biological
- Metabolome
- Humans
- Histones
- Epigenesis, Genetic
- DNA Methylation
- Biochemistry & Molecular Biology
- Animals
- 11 Medical and Health Sciences