Skip to main content
Journal cover image

Long-circulating liposomal contrast agents for magnetic resonance imaging.

Publication ,  Journal Article
Ayyagari, AL; Zhang, X; Ghaghada, KB; Annapragada, A; Hu, X; Bellamkonda, RV
Published in: Magnetic resonance in medicine
May 2006

Contrast-enhanced magnetic resonance imaging (CE-MRI) is a dynamic technique for imaging vasculature. However, the currently used gadolinium (Gd) chelates, such as Gd-DTPA, restrict the time window for image acquisition due to their rapid elimination from blood and their rapid diffusion into the extravascular space, which prevents their use in steady-state imaging, particularly for MR angiography (MRA). The goal of this study was to prepare long-circulating polyethylene glycol-bearing ((PEG)ylated) liposomes encapsulating Gd chelate, and characterize and demonstrate their utility for MRA. The liposomes were prepared by hydrating a mixture of lipids with gadodiamide (Omniscan). The liposomes were sized down to around 100 nm by extruder and exhaustively dialysed to remove the unencapsulated gadodiamide. The Gd liposomes exhibited a significant sustained (>4 hr) contrast enhancement of the vasculature with improved spatial details in a rat model with little leakage relative to Gd-DTPA controls as shown by MRI. We suggest that such long-circulating liposomal formulations allow for high spatial resolution imaging without the confounding effects of clearance and extravascular diffusion of the agent complicating the data and image analysis.

Duke Scholars

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

May 2006

Volume

55

Issue

5

Start / End Page

1023 / 1029

Related Subject Headings

  • Time Factors
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Rats, Inbred F344
  • Rats
  • Polyethylene Glycols
  • Particle Size
  • Nuclear Medicine & Medical Imaging
  • Nanostructures
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ayyagari, A. L., Zhang, X., Ghaghada, K. B., Annapragada, A., Hu, X., & Bellamkonda, R. V. (2006). Long-circulating liposomal contrast agents for magnetic resonance imaging. Magnetic Resonance in Medicine, 55(5), 1023–1029. https://doi.org/10.1002/mrm.20846
Ayyagari, Ananta Laxmi, Xiaodong Zhang, Ketan B. Ghaghada, Ananth Annapragada, Xiaoping Hu, and Ravi V. Bellamkonda. “Long-circulating liposomal contrast agents for magnetic resonance imaging.Magnetic Resonance in Medicine 55, no. 5 (May 2006): 1023–29. https://doi.org/10.1002/mrm.20846.
Ayyagari AL, Zhang X, Ghaghada KB, Annapragada A, Hu X, Bellamkonda RV. Long-circulating liposomal contrast agents for magnetic resonance imaging. Magnetic resonance in medicine. 2006 May;55(5):1023–9.
Ayyagari, Ananta Laxmi, et al. “Long-circulating liposomal contrast agents for magnetic resonance imaging.Magnetic Resonance in Medicine, vol. 55, no. 5, May 2006, pp. 1023–29. Epmc, doi:10.1002/mrm.20846.
Ayyagari AL, Zhang X, Ghaghada KB, Annapragada A, Hu X, Bellamkonda RV. Long-circulating liposomal contrast agents for magnetic resonance imaging. Magnetic resonance in medicine. 2006 May;55(5):1023–1029.
Journal cover image

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

May 2006

Volume

55

Issue

5

Start / End Page

1023 / 1029

Related Subject Headings

  • Time Factors
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Rats, Inbred F344
  • Rats
  • Polyethylene Glycols
  • Particle Size
  • Nuclear Medicine & Medical Imaging
  • Nanostructures
  • Male