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Controlled release of anti-inflammatory agent alpha-MSH from neural implants.

Publication ,  Journal Article
Zhong, Y; Bellamkonda, RV
Published in: Journal of controlled release : official journal of the Controlled Release Society
September 2005

Si-multi-electrode arrays implanted into brain tissue for long-term recording lose electrical connectivity due to the post-implantation inflammatory reaction. This inflammatory reaction creates a physical and electrical gap between the electrode and the surrounding neurons. In this study, novel nitrocellulose-based coatings were developed for the sustained delivery of the anti-inflammatory neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH). alpha-MSH was incorporated in micron-scale nitrocellulose coatings and slow, sustained release over 21 days was attained in vitro. The alpha-MSH released on day 21 was still bioactive, and successfully inhibited nitric oxide (NO) production by LPS-stimulated microglia. The amount of initial drug loading directly affected the release rate, with higher initial loading increasing the mass released but not the percent of drug released. The surface morphology and thickness of the coatings were examined by scanning electron microscopy (SEM) and profilometry. In addition, impedance measurement showed that the alpha-MSH loaded nitrocellulose coatings reduced the magnitude of electrode impedance at the biologically relevant frequency of 1 kHz. In conclusion, nitrocellulose-based, bioactive coatings that release anti-inflammatory agents without increasing the impedence of the electrode were successfully fabricated. These coatings have the potential to reduce inflammation at the electrode-brain interface in vivo, and facilitate long-term recordings from Si-multi-electrode arrays.

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Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

September 2005

Volume

106

Issue

3

Start / End Page

309 / 318

Related Subject Headings

  • alpha-MSH
  • Rats, Sprague-Dawley
  • Rats
  • Pharmacology & Pharmacy
  • Nitric Oxide
  • Microglia
  • Electrodes
  • Drug Implants
  • Collodion
  • Brain
 

Citation

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Zhong, Y., & Bellamkonda, R. V. (2005). Controlled release of anti-inflammatory agent alpha-MSH from neural implants. Journal of Controlled Release : Official Journal of the Controlled Release Society, 106(3), 309–318. https://doi.org/10.1016/j.jconrel.2005.05.012
Zhong, Yinghui, and Ravi V. Bellamkonda. “Controlled release of anti-inflammatory agent alpha-MSH from neural implants.Journal of Controlled Release : Official Journal of the Controlled Release Society 106, no. 3 (September 2005): 309–18. https://doi.org/10.1016/j.jconrel.2005.05.012.
Zhong Y, Bellamkonda RV. Controlled release of anti-inflammatory agent alpha-MSH from neural implants. Journal of controlled release : official journal of the Controlled Release Society. 2005 Sep;106(3):309–18.
Zhong, Yinghui, and Ravi V. Bellamkonda. “Controlled release of anti-inflammatory agent alpha-MSH from neural implants.Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 106, no. 3, Sept. 2005, pp. 309–18. Epmc, doi:10.1016/j.jconrel.2005.05.012.
Zhong Y, Bellamkonda RV. Controlled release of anti-inflammatory agent alpha-MSH from neural implants. Journal of controlled release : official journal of the Controlled Release Society. 2005 Sep;106(3):309–318.
Journal cover image

Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

September 2005

Volume

106

Issue

3

Start / End Page

309 / 318

Related Subject Headings

  • alpha-MSH
  • Rats, Sprague-Dawley
  • Rats
  • Pharmacology & Pharmacy
  • Nitric Oxide
  • Microglia
  • Electrodes
  • Drug Implants
  • Collodion
  • Brain